Amino acid dipepetide frequency for Mangrovimonas sp. DI 80

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.398AlaAla: 4.398 ± 0.095	0.546AlaCys: 0.546 ± 0.024	3.304AlaAsp: 3.304 ± 0.05	4.228AlaGlu: 4.228 ± 0.084	3.381AlaPhe: 3.381 ± 0.059	3.97AlaGly: 3.97 ± 0.073	1.182AlaHis: 1.182 ± 0.031	5.363AlaIle: 5.363 ± 0.077	4.548AlaLys: 4.548 ± 0.091	6.686AlaLeu: 6.686 ± 0.1	1.669AlaMet: 1.669 ± 0.046	3.676AlaAsn: 3.676 ± 0.064	2.114AlaPro: 2.114 ± 0.05	2.577AlaGln: 2.577 ± 0.053	1.94AlaArg: 1.94 ± 0.051	4.418AlaSer: 4.418 ± 0.07	3.867AlaThr: 3.867 ± 0.082	4.117AlaVal: 4.117 ± 0.064	0.63AlaTrp: 0.63 ± 0.026	2.699AlaTyr: 2.699 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.5CysAla: 0.5 ± 0.022	0.098CysCys: 0.098 ± 0.011	0.447CysAsp: 0.447 ± 0.025	0.485CysGlu: 0.485 ± 0.025	0.447CysPhe: 0.447 ± 0.022	0.663CysGly: 0.663 ± 0.035	0.188CysHis: 0.188 ± 0.017	0.56CysIle: 0.56 ± 0.021	0.483CysLys: 0.483 ± 0.022	0.672CysLeu: 0.672 ± 0.028	0.173CysMet: 0.173 ± 0.012	0.445CysAsn: 0.445 ± 0.019	0.347CysPro: 0.347 ± 0.022	0.255CysGln: 0.255 ± 0.016	0.208CysArg: 0.208 ± 0.013	0.593CysSer: 0.593 ± 0.03	0.43CysThr: 0.43 ± 0.02	0.474CysVal: 0.474 ± 0.022	0.075CysTrp: 0.075 ± 0.008	0.345CysTyr: 0.345 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.806AspAla: 3.806 ± 0.064	0.466AspCys: 0.466 ± 0.027	3.026AspAsp: 3.026 ± 0.062	3.714AspGlu: 3.714 ± 0.06	3.508AspPhe: 3.508 ± 0.048	3.743AspGly: 3.743 ± 0.068	1.009AspHis: 1.009 ± 0.033	4.528AspIle: 4.528 ± 0.072	3.824AspLys: 3.824 ± 0.066	5.398AspLeu: 5.398 ± 0.076	1.324AspMet: 1.324 ± 0.035	3.173AspAsn: 3.173 ± 0.065	1.866AspPro: 1.866 ± 0.05	1.655AspGln: 1.655 ± 0.045	1.896AspArg: 1.896 ± 0.045	3.345AspSer: 3.345 ± 0.066	3.012AspThr: 3.012 ± 0.059	3.745AspVal: 3.745 ± 0.064	0.79AspTrp: 0.79 ± 0.029	2.966AspTyr: 2.966 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	5.277GluAla: 5.277 ± 0.078	0.389GluCys: 0.389 ± 0.026	4.009GluAsp: 4.009 ± 0.061	5.117GluGlu: 5.117 ± 0.084	3.167GluPhe: 3.167 ± 0.059	4.211GluGly: 4.211 ± 0.07	1.404GluHis: 1.404 ± 0.035	4.99GluIle: 4.99 ± 0.068	4.71GluLys: 4.71 ± 0.075	6.463GluLeu: 6.463 ± 0.083	1.6GluMet: 1.6 ± 0.041	4.105GluAsn: 4.105 ± 0.069	1.754GluPro: 1.754 ± 0.039	2.573GluGln: 2.573 ± 0.05	2.651GluArg: 2.651 ± 0.063	3.423GluSer: 3.423 ± 0.055	3.99GluThr: 3.99 ± 0.061	4.655GluVal: 4.655 ± 0.072	0.675GluTrp: 0.675 ± 0.026	2.453GluTyr: 2.453 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	2.985PheAla: 2.985 ± 0.056	0.454PheCys: 0.454 ± 0.019	3.272PheAsp: 3.272 ± 0.057	3.566PheGlu: 3.566 ± 0.053	2.55PhePhe: 2.55 ± 0.058	3.856PheGly: 3.856 ± 0.065	0.853PheHis: 0.853 ± 0.027	3.497PheIle: 3.497 ± 0.065	3.794PheLys: 3.794 ± 0.065	4.52PheLeu: 4.52 ± 0.089	1.208PheMet: 1.208 ± 0.036	3.268PheAsn: 3.268 ± 0.06	1.698PhePro: 1.698 ± 0.032	1.668PheGln: 1.668 ± 0.039	1.535PheArg: 1.535 ± 0.037	3.85PheSer: 3.85 ± 0.064	3.049PheThr: 3.049 ± 0.065	3.149PheVal: 3.149 ± 0.062	0.604PheTrp: 0.604 ± 0.023	2.18PheTyr: 2.18 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	4.401GlyAla: 4.401 ± 0.076	0.689GlyCys: 0.689 ± 0.029	3.667GlyAsp: 3.667 ± 0.066	3.84GlyGlu: 3.84 ± 0.073	3.661GlyPhe: 3.661 ± 0.066	4.531GlyGly: 4.531 ± 0.085	1.259GlyHis: 1.259 ± 0.032	5.2GlyIle: 5.2 ± 0.073	4.421GlyLys: 4.421 ± 0.076	6.01GlyLeu: 6.01 ± 0.078	1.687GlyMet: 1.687 ± 0.044	3.696GlyAsn: 3.696 ± 0.078	1.539GlyPro: 1.539 ± 0.043	2.034GlyGln: 2.034 ± 0.048	2.025GlyArg: 2.025 ± 0.046	4.061GlySer: 4.061 ± 0.071	4.201GlyThr: 4.201 ± 0.101	4.507GlyVal: 4.507 ± 0.071	0.837GlyTrp: 0.837 ± 0.031	3.047GlyTyr: 3.047 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	0.951HisAla: 0.951 ± 0.033	0.185HisCys: 0.185 ± 0.014	0.971HisAsp: 0.971 ± 0.031	1.088HisGlu: 1.088 ± 0.034	1.19HisPhe: 1.19 ± 0.033	1.177HisGly: 1.177 ± 0.033	0.562HisHis: 0.562 ± 0.029	1.515HisIle: 1.515 ± 0.036	1.216HisLys: 1.216 ± 0.036	1.877HisLeu: 1.877 ± 0.048	0.401HisMet: 0.401 ± 0.019	1.077HisAsn: 1.077 ± 0.031	0.979HisPro: 0.979 ± 0.037	0.718HisGln: 0.718 ± 0.023	0.676HisArg: 0.676 ± 0.023	1.095HisSer: 1.095 ± 0.035	1.036HisThr: 1.036 ± 0.031	1.051HisVal: 1.051 ± 0.034	0.262HisTrp: 0.262 ± 0.019	0.884HisTyr: 0.884 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.345IleAla: 5.345 ± 0.074	0.646IleCys: 0.646 ± 0.029	4.674IleAsp: 4.674 ± 0.068	5.18IleGlu: 5.18 ± 0.069	3.288IlePhe: 3.288 ± 0.061	4.929IleGly: 4.929 ± 0.075	1.316IleHis: 1.316 ± 0.033	5.222IleIle: 5.222 ± 0.089	5.168IleLys: 5.168 ± 0.085	6.572IleLeu: 6.572 ± 0.093	1.422IleMet: 1.422 ± 0.041	4.183IleAsn: 4.183 ± 0.069	3.224IlePro: 3.224 ± 0.055	2.486IleGln: 2.486 ± 0.05	2.242IleArg: 2.242 ± 0.043	5.49IleSer: 5.49 ± 0.078	4.72IleThr: 4.72 ± 0.078	4.704IleVal: 4.704 ± 0.066	0.676IleTrp: 0.676 ± 0.024	2.688IleTyr: 2.688 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	4.913LysAla: 4.913 ± 0.081	0.336LysCys: 0.336 ± 0.017	4.326LysAsp: 4.326 ± 0.07	5.715LysGlu: 5.715 ± 0.086	2.799LysPhe: 2.799 ± 0.056	4.427LysGly: 4.427 ± 0.069	1.504LysHis: 1.504 ± 0.037	4.988LysIle: 4.988 ± 0.077	5.297LysLys: 5.297 ± 0.08	6.247LysLeu: 6.247 ± 0.092	1.773LysMet: 1.773 ± 0.038	4.184LysAsn: 4.184 ± 0.073	2.291LysPro: 2.291 ± 0.044	2.8LysGln: 2.8 ± 0.061	2.836LysArg: 2.836 ± 0.061	4.11LysSer: 4.11 ± 0.067	4.372LysThr: 4.372 ± 0.07	4.677LysVal: 4.677 ± 0.076	0.691LysTrp: 0.691 ± 0.027	2.798LysTyr: 2.798 ± 0.053	0.0LysXaa: 0.0 ± 0.0
Leu	5.877LeuAla: 5.877 ± 0.094	0.761LeuCys: 0.761 ± 0.028	5.362LeuAsp: 5.362 ± 0.076	6.491LeuGlu: 6.491 ± 0.078	4.758LeuPhe: 4.758 ± 0.079	6.251LeuGly: 6.251 ± 0.085	1.622LeuHis: 1.622 ± 0.047	6.476LeuIle: 6.476 ± 0.096	7.602LeuLys: 7.602 ± 0.097	8.881LeuLeu: 8.881 ± 0.121	2.183LeuMet: 2.183 ± 0.046	5.573LeuAsn: 5.573 ± 0.092	3.7LeuPro: 3.7 ± 0.072	3.372LeuGln: 3.372 ± 0.072	3.162LeuArg: 3.162 ± 0.059	6.728LeuSer: 6.728 ± 0.085	5.056LeuThr: 5.056 ± 0.067	5.697LeuVal: 5.697 ± 0.08	0.869LeuTrp: 0.869 ± 0.033	3.416LeuTyr: 3.416 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	1.86MetAla: 1.86 ± 0.049	0.15MetCys: 0.15 ± 0.011	1.351MetAsp: 1.351 ± 0.032	1.636MetGlu: 1.636 ± 0.039	0.952MetPhe: 0.952 ± 0.036	1.458MetGly: 1.458 ± 0.037	0.429MetHis: 0.429 ± 0.022	1.393MetIle: 1.393 ± 0.038	2.052MetLys: 2.052 ± 0.041	2.078MetLeu: 2.078 ± 0.044	0.581MetMet: 0.581 ± 0.026	1.213MetAsn: 1.213 ± 0.032	0.942MetPro: 0.942 ± 0.034	0.821MetGln: 0.821 ± 0.027	0.818MetArg: 0.818 ± 0.027	1.489MetSer: 1.489 ± 0.04	1.283MetThr: 1.283 ± 0.032	1.527MetVal: 1.527 ± 0.037	0.179MetTrp: 0.179 ± 0.012	0.779MetTyr: 0.779 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	3.779AsnAla: 3.779 ± 0.069	0.492AsnCys: 0.492 ± 0.029	3.231AsnAsp: 3.231 ± 0.055	3.477AsnGlu: 3.477 ± 0.056	3.055AsnPhe: 3.055 ± 0.059	3.994AsnGly: 3.994 ± 0.084	1.059AsnHis: 1.059 ± 0.033	4.495AsnIle: 4.495 ± 0.072	3.657AsnLys: 3.657 ± 0.067	5.393AsnLeu: 5.393 ± 0.091	1.331AsnMet: 1.331 ± 0.038	3.525AsnAsn: 3.525 ± 0.071	2.773AsnPro: 2.773 ± 0.058	2.008AsnGln: 2.008 ± 0.042	1.992AsnArg: 1.992 ± 0.041	3.807AsnSer: 3.807 ± 0.079	3.731AsnThr: 3.731 ± 0.069	3.662AsnVal: 3.662 ± 0.066	0.774AsnTrp: 0.774 ± 0.034	2.922AsnTyr: 2.922 ± 0.065	0.0AsnXaa: 0.0 ± 0.0
Pro	1.861ProAla: 1.861 ± 0.06	0.228ProCys: 0.228 ± 0.019	2.101ProAsp: 2.101 ± 0.046	3.139ProGlu: 3.139 ± 0.055	1.971ProPhe: 1.971 ± 0.044	1.928ProGly: 1.928 ± 0.048	0.677ProHis: 0.677 ± 0.026	2.784ProIle: 2.784 ± 0.055	2.667ProLys: 2.667 ± 0.058	3.108ProLeu: 3.108 ± 0.055	0.829ProMet: 0.829 ± 0.03	2.446ProAsn: 2.446 ± 0.059	0.915ProPro: 0.915 ± 0.032	1.23ProGln: 1.23 ± 0.031	0.954ProArg: 0.954 ± 0.031	2.363ProSer: 2.363 ± 0.055	2.109ProThr: 2.109 ± 0.049	2.321ProVal: 2.321 ± 0.047	0.389ProTrp: 0.389 ± 0.02	1.521ProTyr: 1.521 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	2.115GlnAla: 2.115 ± 0.048	0.206GlnCys: 0.206 ± 0.014	1.856GlnAsp: 1.856 ± 0.044	2.477GlnGlu: 2.477 ± 0.052	1.787GlnPhe: 1.787 ± 0.039	2.023GlnGly: 2.023 ± 0.047	0.7GlnHis: 0.7 ± 0.027	2.489GlnIle: 2.489 ± 0.05	2.598GlnLys: 2.598 ± 0.055	3.762GlnLeu: 3.762 ± 0.058	0.891GlnMet: 0.891 ± 0.029	2.118GlnAsn: 2.118 ± 0.048	1.276GlnPro: 1.276 ± 0.042	1.528GlnGln: 1.528 ± 0.04	1.276GlnArg: 1.276 ± 0.033	1.983GlnSer: 1.983 ± 0.046	2.076GlnThr: 2.076 ± 0.044	2.023GlnVal: 2.023 ± 0.044	0.412GlnTrp: 0.412 ± 0.019	1.448GlnTyr: 1.448 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	2.09ArgAla: 2.09 ± 0.052	0.21ArgCys: 0.21 ± 0.014	1.759ArgAsp: 1.759 ± 0.041	2.179ArgGlu: 2.179 ± 0.045	1.845ArgPhe: 1.845 ± 0.045	1.835ArgGly: 1.835 ± 0.045	0.663ArgHis: 0.663 ± 0.028	2.667ArgIle: 2.667 ± 0.048	2.408ArgLys: 2.408 ± 0.055	3.234ArgLeu: 3.234 ± 0.065	0.842ArgMet: 0.842 ± 0.026	1.973ArgAsn: 1.973 ± 0.041	1.113ArgPro: 1.113 ± 0.032	1.145ArgGln: 1.145 ± 0.035	1.291ArgArg: 1.291 ± 0.043	1.868ArgSer: 1.868 ± 0.044	1.798ArgThr: 1.798 ± 0.046	2.076ArgVal: 2.076 ± 0.049	0.401ArgTrp: 0.401 ± 0.019	1.577ArgTyr: 1.577 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	3.764SerAla: 3.764 ± 0.061	0.625SerCys: 0.625 ± 0.027	3.331SerAsp: 3.331 ± 0.062	4.272SerGlu: 4.272 ± 0.061	3.697SerPhe: 3.697 ± 0.053	4.662SerGly: 4.662 ± 0.083	1.171SerHis: 1.171 ± 0.037	5.083SerIle: 5.083 ± 0.075	4.855SerLys: 4.855 ± 0.078	6.078SerLeu: 6.078 ± 0.09	1.378SerMet: 1.378 ± 0.032	4.051SerAsn: 4.051 ± 0.076	2.195SerPro: 2.195 ± 0.045	2.319SerGln: 2.319 ± 0.044	1.983SerArg: 1.983 ± 0.047	4.365SerSer: 4.365 ± 0.077	3.547SerThr: 3.547 ± 0.068	4.104SerVal: 4.104 ± 0.068	0.746SerTrp: 0.746 ± 0.028	2.843SerTyr: 2.843 ± 0.059	0.0SerXaa: 0.0 ± 0.0
Thr	3.825ThrAla: 3.825 ± 0.083	0.398ThrCys: 0.398 ± 0.021	3.285ThrAsp: 3.285 ± 0.074	3.535ThrGlu: 3.535 ± 0.055	3.099ThrPhe: 3.099 ± 0.057	4.054ThrGly: 4.054 ± 0.093	1.086ThrHis: 1.086 ± 0.035	4.774ThrIle: 4.774 ± 0.093	3.718ThrLys: 3.718 ± 0.064	5.6ThrLeu: 5.6 ± 0.083	1.111ThrMet: 1.111 ± 0.033	3.314ThrAsn: 3.314 ± 0.064	2.677ThrPro: 2.677 ± 0.065	1.916ThrGln: 1.916 ± 0.042	1.555ThrArg: 1.555 ± 0.04	4.044ThrSer: 4.044 ± 0.074	3.599ThrThr: 3.599 ± 0.085	4.165ThrVal: 4.165 ± 0.109	0.607ThrTrp: 0.607 ± 0.029	2.784ThrTyr: 2.784 ± 0.065	0.0ThrXaa: 0.0 ± 0.0
Val	4.386ValAla: 4.386 ± 0.078	0.534ValCys: 0.534 ± 0.024	3.765ValAsp: 3.765 ± 0.055	4.31ValGlu: 4.31 ± 0.061	3.417ValPhe: 3.417 ± 0.059	4.071ValGly: 4.071 ± 0.062	1.094ValHis: 1.094 ± 0.03	4.679ValIle: 4.679 ± 0.067	4.306ValLys: 4.306 ± 0.058	6.216ValLeu: 6.216 ± 0.073	1.445ValMet: 1.445 ± 0.042	3.611ValAsn: 3.611 ± 0.061	2.337ValPro: 2.337 ± 0.053	1.855ValGln: 1.855 ± 0.046	1.934ValArg: 1.934 ± 0.047	4.615ValSer: 4.615 ± 0.07	4.048ValThr: 4.048 ± 0.11	4.61ValVal: 4.61 ± 0.073	0.618ValTrp: 0.618 ± 0.025	2.513ValTyr: 2.513 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.657TrpAla: 0.657 ± 0.028	0.113TrpCys: 0.113 ± 0.01	0.624TrpAsp: 0.624 ± 0.031	0.694TrpGlu: 0.694 ± 0.023	0.546TrpPhe: 0.546 ± 0.028	0.725TrpGly: 0.725 ± 0.029	0.265TrpHis: 0.265 ± 0.016	0.737TrpIle: 0.737 ± 0.027	0.747TrpLys: 0.747 ± 0.029	1.029TrpLeu: 1.029 ± 0.03	0.318TrpMet: 0.318 ± 0.017	0.747TrpAsn: 0.747 ± 0.035	0.27TrpPro: 0.27 ± 0.017	0.408TrpGln: 0.408 ± 0.019	0.387TrpArg: 0.387 ± 0.019	0.691TrpSer: 0.691 ± 0.029	0.618TrpThr: 0.618 ± 0.029	0.683TrpVal: 0.683 ± 0.026	0.17TrpTrp: 0.17 ± 0.012	0.479TrpTyr: 0.479 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.522TyrAla: 2.522 ± 0.053	0.362TyrCys: 0.362 ± 0.02	2.433TyrAsp: 2.433 ± 0.05	2.474TyrGlu: 2.474 ± 0.052	2.437TyrPhe: 2.437 ± 0.049	2.806TyrGly: 2.806 ± 0.058	0.869TyrHis: 0.869 ± 0.028	2.737TyrIle: 2.737 ± 0.05	3.014TyrLys: 3.014 ± 0.053	4.013TyrLeu: 4.013 ± 0.073	0.823TyrMet: 0.823 ± 0.027	2.778TyrAsn: 2.778 ± 0.059	1.53TyrPro: 1.53 ± 0.041	1.673TyrGln: 1.673 ± 0.045	1.614TyrArg: 1.614 ± 0.045	2.732TyrSer: 2.732 ± 0.057	2.603TyrThr: 2.603 ± 0.061	2.417TyrVal: 2.417 ± 0.046	0.504TyrTrp: 0.504 ± 0.022	1.973TyrTyr: 1.973 ± 0.05	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3194 proteins (1127307 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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