Amino acid dipepetide frequency for Vibrio xiamenensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.963AlaAla: 7.963 ± 0.09	0.977AlaCys: 0.977 ± 0.028	4.533AlaAsp: 4.533 ± 0.064	5.236AlaGlu: 5.236 ± 0.066	3.418AlaPhe: 3.418 ± 0.058	5.73AlaGly: 5.73 ± 0.062	1.803AlaHis: 1.803 ± 0.029	5.833AlaIle: 5.833 ± 0.065	5.214AlaLys: 5.214 ± 0.064	10.474AlaLeu: 10.474 ± 0.109	2.878AlaMet: 2.878 ± 0.052	3.659AlaAsn: 3.659 ± 0.046	3.117AlaPro: 3.117 ± 0.053	4.442AlaGln: 4.442 ± 0.062	3.782AlaArg: 3.782 ± 0.056	5.754AlaSer: 5.754 ± 0.073	4.481AlaThr: 4.481 ± 0.055	5.845AlaVal: 5.845 ± 0.073	1.026AlaTrp: 1.026 ± 0.027	2.407AlaTyr: 2.407 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.874CysAla: 0.874 ± 0.023	0.162CysCys: 0.162 ± 0.01	0.68CysAsp: 0.68 ± 0.022	0.65CysGlu: 0.65 ± 0.021	0.478CysPhe: 0.478 ± 0.018	0.94CysGly: 0.94 ± 0.024	0.347CysHis: 0.347 ± 0.016	0.599CysIle: 0.599 ± 0.02	0.355CysLys: 0.355 ± 0.017	1.008CysLeu: 1.008 ± 0.026	0.242CysMet: 0.242 ± 0.013	0.357CysAsn: 0.357 ± 0.015	0.438CysPro: 0.438 ± 0.019	0.538CysGln: 0.538 ± 0.019	0.502CysArg: 0.502 ± 0.018	0.769CysSer: 0.769 ± 0.021	0.453CysThr: 0.453 ± 0.018	0.744CysVal: 0.744 ± 0.021	0.144CysTrp: 0.144 ± 0.009	0.361CysTyr: 0.361 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	4.74AspAla: 4.74 ± 0.062	0.54AspCys: 0.54 ± 0.021	3.388AspAsp: 3.388 ± 0.068	3.765AspGlu: 3.765 ± 0.06	2.439AspPhe: 2.439 ± 0.038	3.873AspGly: 3.873 ± 0.066	1.152AspHis: 1.152 ± 0.033	4.002AspIle: 4.002 ± 0.06	3.068AspLys: 3.068 ± 0.046	5.154AspLeu: 5.154 ± 0.059	1.442AspMet: 1.442 ± 0.033	2.467AspAsn: 2.467 ± 0.037	2.018AspPro: 2.018 ± 0.036	2.191AspGln: 2.191 ± 0.036	2.118AspArg: 2.118 ± 0.041	3.725AspSer: 3.725 ± 0.065	2.73AspThr: 2.73 ± 0.047	4.094AspVal: 4.094 ± 0.055	0.92AspTrp: 0.92 ± 0.025	2.24AspTyr: 2.24 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	4.753GluAla: 4.753 ± 0.055	0.55GluCys: 0.55 ± 0.019	2.57GluAsp: 2.57 ± 0.047	3.18GluGlu: 3.18 ± 0.058	2.538GluPhe: 2.538 ± 0.047	3.04GluGly: 3.04 ± 0.046	1.741GluHis: 1.741 ± 0.035	3.462GluIle: 3.462 ± 0.046	3.302GluLys: 3.302 ± 0.053	7.045GluLeu: 7.045 ± 0.083	1.687GluMet: 1.687 ± 0.037	2.433GluAsn: 2.433 ± 0.041	2.166GluPro: 2.166 ± 0.052	4.38GluGln: 4.38 ± 0.073	3.374GluArg: 3.374 ± 0.051	3.552GluSer: 3.552 ± 0.058	2.942GluThr: 2.942 ± 0.04	4.083GluVal: 4.083 ± 0.054	0.777GluTrp: 0.777 ± 0.024	1.801GluTyr: 1.801 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	3.809PheAla: 3.809 ± 0.058	0.527PheCys: 0.527 ± 0.021	2.878PheAsp: 2.878 ± 0.043	2.526PheGlu: 2.526 ± 0.042	1.664PhePhe: 1.664 ± 0.038	3.238PheGly: 3.238 ± 0.053	0.886PheHis: 0.886 ± 0.024	2.75PheIle: 2.75 ± 0.051	1.841PheLys: 1.841 ± 0.042	3.305PheLeu: 3.305 ± 0.055	0.977PheMet: 0.977 ± 0.028	1.913PheAsn: 1.913 ± 0.032	1.372PhePro: 1.372 ± 0.029	1.274PheGln: 1.274 ± 0.026	1.52PheArg: 1.52 ± 0.032	3.398PheSer: 3.398 ± 0.048	2.288PheThr: 2.288 ± 0.044	2.89PheVal: 2.89 ± 0.046	0.507PheTrp: 0.507 ± 0.018	1.352PheTyr: 1.352 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	5.47GlyAla: 5.47 ± 0.067	0.935GlyCys: 0.935 ± 0.027	3.825GlyAsp: 3.825 ± 0.066	4.44GlyGlu: 4.44 ± 0.056	3.262GlyPhe: 3.262 ± 0.048	4.675GlyGly: 4.675 ± 0.07	1.563GlyHis: 1.563 ± 0.031	4.507GlyIle: 4.507 ± 0.066	3.693GlyLys: 3.693 ± 0.044	6.739GlyLeu: 6.739 ± 0.074	1.91GlyMet: 1.91 ± 0.041	2.435GlyAsn: 2.435 ± 0.04	1.594GlyPro: 1.594 ± 0.034	2.941GlyGln: 2.941 ± 0.044	3.015GlyArg: 3.015 ± 0.047	4.116GlySer: 4.116 ± 0.063	3.215GlyThr: 3.215 ± 0.052	5.254GlyVal: 5.254 ± 0.067	0.972GlyTrp: 0.972 ± 0.026	2.645GlyTyr: 2.645 ± 0.046	0.001GlyXaa: 0.001 ± 0.001
His	1.773HisAla: 1.773 ± 0.032	0.332HisCys: 0.332 ± 0.013	1.27HisAsp: 1.27 ± 0.031	1.059HisGlu: 1.059 ± 0.026	1.123HisPhe: 1.123 ± 0.025	1.582HisGly: 1.582 ± 0.032	0.79HisHis: 0.79 ± 0.027	1.495HisIle: 1.495 ± 0.03	0.957HisLys: 0.957 ± 0.023	2.392HisLeu: 2.392 ± 0.046	0.516HisMet: 0.516 ± 0.018	0.97HisAsn: 0.97 ± 0.026	1.15HisPro: 1.15 ± 0.03	1.498HisGln: 1.498 ± 0.036	1.076HisArg: 1.076 ± 0.03	1.643HisSer: 1.643 ± 0.037	1.102HisThr: 1.102 ± 0.026	1.312HisVal: 1.312 ± 0.032	0.387HisTrp: 0.387 ± 0.016	0.914HisTyr: 0.914 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.405IleAla: 6.405 ± 0.068	0.689IleCys: 0.689 ± 0.023	4.314IleAsp: 4.314 ± 0.056	4.619IleGlu: 4.619 ± 0.059	2.138IlePhe: 2.138 ± 0.049	4.7IleGly: 4.7 ± 0.063	1.313IleHis: 1.313 ± 0.032	3.416IleIle: 3.416 ± 0.057	3.057IleLys: 3.057 ± 0.049	4.99IleLeu: 4.99 ± 0.062	1.237IleMet: 1.237 ± 0.03	2.694IleAsn: 2.694 ± 0.044	2.51IlePro: 2.51 ± 0.037	2.341IleGln: 2.341 ± 0.04	2.781IleArg: 2.781 ± 0.048	4.489IleSer: 4.489 ± 0.063	3.563IleThr: 3.563 ± 0.053	4.174IleVal: 4.174 ± 0.054	0.611IleTrp: 0.611 ± 0.02	1.722IleTyr: 1.722 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	4.713LysAla: 4.713 ± 0.065	0.317LysCys: 0.317 ± 0.014	2.529LysAsp: 2.529 ± 0.046	2.757LysGlu: 2.757 ± 0.057	1.519LysPhe: 1.519 ± 0.037	3.081LysGly: 3.081 ± 0.043	1.326LysHis: 1.326 ± 0.029	2.675LysIle: 2.675 ± 0.042	2.513LysLys: 2.513 ± 0.052	5.314LysLeu: 5.314 ± 0.058	1.351LysMet: 1.351 ± 0.027	2.022LysAsn: 2.022 ± 0.047	2.413LysPro: 2.413 ± 0.038	3.133LysGln: 3.133 ± 0.047	2.757LysArg: 2.757 ± 0.041	3.039LysSer: 3.039 ± 0.044	2.796LysThr: 2.796 ± 0.043	3.734LysVal: 3.734 ± 0.049	0.595LysTrp: 0.595 ± 0.02	1.414LysTyr: 1.414 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	10.186LeuAla: 10.186 ± 0.096	1.19LeuCys: 1.19 ± 0.029	6.004LeuAsp: 6.004 ± 0.068	6.122LeuGlu: 6.122 ± 0.071	4.323LeuPhe: 4.323 ± 0.07	7.032LeuGly: 7.032 ± 0.077	2.044LeuHis: 2.044 ± 0.036	6.004LeuIle: 6.004 ± 0.069	5.35LeuLys: 5.35 ± 0.07	10.255LeuLeu: 10.255 ± 0.129	2.843LeuMet: 2.843 ± 0.049	4.739LeuAsn: 4.739 ± 0.055	4.602LeuPro: 4.602 ± 0.06	3.653LeuGln: 3.653 ± 0.055	4.323LeuArg: 4.323 ± 0.07	8.245LeuSer: 8.245 ± 0.09	5.933LeuThr: 5.933 ± 0.061	7.254LeuVal: 7.254 ± 0.078	1.077LeuTrp: 1.077 ± 0.024	2.722LeuTyr: 2.722 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	2.621MetAla: 2.621 ± 0.041	0.237MetCys: 0.237 ± 0.012	1.283MetAsp: 1.283 ± 0.029	1.254MetGlu: 1.254 ± 0.027	0.971MetPhe: 0.971 ± 0.027	1.718MetGly: 1.718 ± 0.04	0.503MetHis: 0.503 ± 0.017	1.539MetIle: 1.539 ± 0.036	1.397MetLys: 1.397 ± 0.028	2.889MetLeu: 2.889 ± 0.048	0.815MetMet: 0.815 ± 0.023	1.132MetAsn: 1.132 ± 0.027	1.266MetPro: 1.266 ± 0.029	1.184MetGln: 1.184 ± 0.028	1.267MetArg: 1.267 ± 0.03	2.047MetSer: 2.047 ± 0.035	1.658MetThr: 1.658 ± 0.038	1.938MetVal: 1.938 ± 0.039	0.239MetTrp: 0.239 ± 0.013	0.565MetTyr: 0.565 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.551AsnAla: 3.551 ± 0.048	0.367AsnCys: 0.367 ± 0.016	2.277AsnAsp: 2.277 ± 0.04	2.145AsnGlu: 2.145 ± 0.039	1.508AsnPhe: 1.508 ± 0.032	2.927AsnGly: 2.927 ± 0.049	1.05AsnHis: 1.05 ± 0.026	2.694AsnIle: 2.694 ± 0.042	2.023AsnLys: 2.023 ± 0.037	4.013AsnLeu: 4.013 ± 0.059	1.015AsnMet: 1.015 ± 0.027	1.78AsnAsn: 1.78 ± 0.036	2.071AsnPro: 2.071 ± 0.036	2.475AsnGln: 2.475 ± 0.044	1.934AsnArg: 1.934 ± 0.033	2.634AsnSer: 2.634 ± 0.05	2.177AsnThr: 2.177 ± 0.038	2.763AsnVal: 2.763 ± 0.048	0.573AsnTrp: 0.573 ± 0.018	1.397AsnTyr: 1.397 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	3.052ProAla: 3.052 ± 0.047	0.358ProCys: 0.358 ± 0.019	2.209ProAsp: 2.209 ± 0.04	2.87ProGlu: 2.87 ± 0.048	1.689ProPhe: 1.689 ± 0.036	2.216ProGly: 2.216 ± 0.042	0.857ProHis: 0.857 ± 0.022	2.472ProIle: 2.472 ± 0.044	2.029ProLys: 2.029 ± 0.04	4.154ProLeu: 4.154 ± 0.063	1.083ProMet: 1.083 ± 0.026	1.86ProAsn: 1.86 ± 0.036	1.09ProPro: 1.09 ± 0.031	1.987ProGln: 1.987 ± 0.04	1.416ProArg: 1.416 ± 0.032	2.827ProSer: 2.827 ± 0.047	2.111ProThr: 2.111 ± 0.034	2.89ProVal: 2.89 ± 0.045	0.514ProTrp: 0.514 ± 0.018	1.328ProTyr: 1.328 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	4.817GlnAla: 4.817 ± 0.061	0.458GlnCys: 0.458 ± 0.017	2.308GlnAsp: 2.308 ± 0.044	2.339GlnGlu: 2.339 ± 0.046	1.928GlnPhe: 1.928 ± 0.036	3.316GlnGly: 3.316 ± 0.049	1.303GlnHis: 1.303 ± 0.035	2.776GlnIle: 2.776 ± 0.043	2.06GlnLys: 2.06 ± 0.04	5.384GlnLeu: 5.384 ± 0.074	1.257GlnMet: 1.257 ± 0.032	1.785GlnAsn: 1.785 ± 0.038	1.876GlnPro: 1.876 ± 0.042	3.537GlnGln: 3.537 ± 0.073	2.605GlnArg: 2.605 ± 0.041	3.242GlnSer: 3.242 ± 0.056	2.67GlnThr: 2.67 ± 0.044	3.515GlnVal: 3.515 ± 0.054	0.649GlnTrp: 0.649 ± 0.019	1.518GlnTyr: 1.518 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	3.554ArgAla: 3.554 ± 0.052	0.507ArgCys: 0.507 ± 0.019	2.513ArgAsp: 2.513 ± 0.046	2.854ArgGlu: 2.854 ± 0.048	2.228ArgPhe: 2.228 ± 0.038	2.607ArgGly: 2.607 ± 0.039	1.202ArgHis: 1.202 ± 0.031	2.976ArgIle: 2.976 ± 0.048	2.258ArgLys: 2.258 ± 0.047	4.999ArgLeu: 4.999 ± 0.062	1.184ArgMet: 1.184 ± 0.031	1.85ArgAsn: 1.85 ± 0.037	1.553ArgPro: 1.553 ± 0.034	2.33ArgGln: 2.33 ± 0.042	2.445ArgArg: 2.445 ± 0.05	2.748ArgSer: 2.748 ± 0.044	2.011ArgThr: 2.011 ± 0.034	3.171ArgVal: 3.171 ± 0.05	0.65ArgTrp: 0.65 ± 0.021	1.855ArgTyr: 1.855 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	6.078SerAla: 6.078 ± 0.072	0.649SerCys: 0.649 ± 0.023	4.175SerAsp: 4.175 ± 0.074	4.101SerGlu: 4.101 ± 0.058	2.742SerPhe: 2.742 ± 0.041	5.194SerGly: 5.194 ± 0.067	1.628SerHis: 1.628 ± 0.035	4.11SerIle: 4.11 ± 0.058	3.217SerLys: 3.217 ± 0.045	7.253SerLeu: 7.253 ± 0.068	1.805SerMet: 1.805 ± 0.035	2.705SerAsn: 2.705 ± 0.053	2.526SerPro: 2.526 ± 0.04	3.342SerGln: 3.342 ± 0.052	2.967SerArg: 2.967 ± 0.051	4.846SerSer: 4.846 ± 0.079	3.372SerThr: 3.372 ± 0.057	4.931SerVal: 4.931 ± 0.072	0.881SerTrp: 0.881 ± 0.026	2.217SerTyr: 2.217 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	4.331ThrAla: 4.331 ± 0.064	0.481ThrCys: 0.481 ± 0.017	2.76ThrAsp: 2.76 ± 0.047	2.85ThrGlu: 2.85 ± 0.038	2.021ThrPhe: 2.021 ± 0.041	3.728ThrGly: 3.728 ± 0.05	1.278ThrHis: 1.278 ± 0.031	3.345ThrIle: 3.345 ± 0.049	2.284ThrLys: 2.284 ± 0.046	6.462ThrLeu: 6.462 ± 0.073	1.237ThrMet: 1.237 ± 0.032	2.017ThrAsn: 2.017 ± 0.041	2.794ThrPro: 2.794 ± 0.046	2.635ThrGln: 2.635 ± 0.046	2.209ThrArg: 2.209 ± 0.038	3.518ThrSer: 3.518 ± 0.058	2.978ThrThr: 2.978 ± 0.052	3.706ThrVal: 3.706 ± 0.065	0.629ThrTrp: 0.629 ± 0.022	1.51ThrTyr: 1.51 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	6.605ValAla: 6.605 ± 0.076	0.832ValCys: 0.832 ± 0.024	4.217ValAsp: 4.217 ± 0.056	4.653ValGlu: 4.653 ± 0.063	2.89ValPhe: 2.89 ± 0.052	4.7ValGly: 4.7 ± 0.061	1.296ValHis: 1.296 ± 0.028	4.746ValIle: 4.746 ± 0.057	3.606ValLys: 3.606 ± 0.054	6.853ValLeu: 6.853 ± 0.075	2.043ValMet: 2.043 ± 0.038	2.939ValAsn: 2.939 ± 0.041	2.574ValPro: 2.574 ± 0.036	2.22ValGln: 2.22 ± 0.039	2.921ValArg: 2.921 ± 0.045	5.17ValSer: 5.17 ± 0.064	4.185ValThr: 4.185 ± 0.072	5.598ValVal: 5.598 ± 0.075	0.795ValTrp: 0.795 ± 0.027	1.971ValTyr: 1.971 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	0.842TrpAla: 0.842 ± 0.018	0.151TrpCys: 0.151 ± 0.01	0.602TrpAsp: 0.602 ± 0.02	0.504TrpGlu: 0.504 ± 0.02	0.587TrpPhe: 0.587 ± 0.021	0.804TrpGly: 0.804 ± 0.024	0.365TrpHis: 0.365 ± 0.016	0.687TrpIle: 0.687 ± 0.022	0.479TrpLys: 0.479 ± 0.018	1.823TrpLeu: 1.823 ± 0.036	0.35TrpMet: 0.35 ± 0.014	0.467TrpAsn: 0.467 ± 0.016	0.509TrpPro: 0.509 ± 0.019	0.992TrpGln: 0.992 ± 0.026	0.685TrpArg: 0.685 ± 0.02	0.806TrpSer: 0.806 ± 0.025	0.51TrpThr: 0.51 ± 0.018	0.888TrpVal: 0.888 ± 0.026	0.215TrpTrp: 0.215 ± 0.012	0.403TrpTyr: 0.403 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.432TyrAla: 2.432 ± 0.039	0.381TyrCys: 0.381 ± 0.016	1.731TyrAsp: 1.731 ± 0.035	1.453TyrGlu: 1.453 ± 0.038	1.453TyrPhe: 1.453 ± 0.031	2.104TyrGly: 2.104 ± 0.039	0.896TyrHis: 0.896 ± 0.024	1.676TyrIle: 1.676 ± 0.034	1.296TyrLys: 1.296 ± 0.031	3.398TyrLeu: 3.398 ± 0.046	0.649TyrMet: 0.649 ± 0.019	1.152TyrAsn: 1.152 ± 0.031	1.374TyrPro: 1.374 ± 0.033	2.249TyrGln: 2.249 ± 0.043	1.795TyrArg: 1.795 ± 0.036	2.169TyrSer: 2.169 ± 0.036	1.596TyrThr: 1.596 ± 0.034	2.03TyrVal: 2.03 ± 0.038	0.509TyrTrp: 0.509 ± 0.018	1.125TyrTyr: 1.125 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 4859 proteins (1549248 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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