Amino acid dipepetide frequency for Streptococcus phage Javan161

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.168AlaAla: 4.168 ± 1.288
0.315AlaCys: 0.315 ± 0.157
4.404AlaAsp: 4.404 ± 0.581
6.213AlaGlu: 6.213 ± 0.858
1.258AlaPhe: 1.258 ± 0.315
3.696AlaGly: 3.696 ± 0.732
1.73AlaHis: 1.73 ± 0.449
5.269AlaIle: 5.269 ± 0.693
6.527AlaLys: 6.527 ± 0.639
6.842AlaLeu: 6.842 ± 1.009
2.202AlaMet: 2.202 ± 0.463
4.011AlaAsn: 4.011 ± 0.636
2.281AlaPro: 2.281 ± 0.432
3.696AlaGln: 3.696 ± 0.778
2.752AlaArg: 2.752 ± 0.437
5.584AlaSer: 5.584 ± 1.177
4.64AlaThr: 4.64 ± 0.802
4.797AlaVal: 4.797 ± 0.866
0.944AlaTrp: 0.944 ± 0.281
2.281AlaTyr: 2.281 ± 0.327
0.0AlaXaa: 0.0 ± 0.0
Cys
0.472CysAla: 0.472 ± 0.182
0.079CysCys: 0.079 ± 0.079
0.315CysAsp: 0.315 ± 0.161
0.629CysGlu: 0.629 ± 0.284
0.393CysPhe: 0.393 ± 0.153
0.472CysGly: 0.472 ± 0.22
0.079CysHis: 0.079 ± 0.08
0.393CysIle: 0.393 ± 0.211
0.472CysLys: 0.472 ± 0.172
0.393CysLeu: 0.393 ± 0.171
0.157CysMet: 0.157 ± 0.1
0.393CysAsn: 0.393 ± 0.178
0.079CysPro: 0.079 ± 0.078
0.236CysGln: 0.236 ± 0.108
0.157CysArg: 0.157 ± 0.113
0.315CysSer: 0.315 ± 0.152
0.236CysThr: 0.236 ± 0.159
0.393CysVal: 0.393 ± 0.214
0.315CysTrp: 0.315 ± 0.15
0.079CysTyr: 0.079 ± 0.08
0.0CysXaa: 0.0 ± 0.0
Asp
3.696AspAla: 3.696 ± 0.544
0.786AspCys: 0.786 ± 0.265
4.404AspAsp: 4.404 ± 0.535
5.19AspGlu: 5.19 ± 0.642
2.91AspPhe: 2.91 ± 0.431
5.112AspGly: 5.112 ± 0.856
0.472AspHis: 0.472 ± 0.186
4.954AspIle: 4.954 ± 0.76
6.92AspLys: 6.92 ± 0.609
7.314AspLeu: 7.314 ± 0.734
1.101AspMet: 1.101 ± 0.346
3.775AspAsn: 3.775 ± 0.537
1.887AspPro: 1.887 ± 0.335
1.73AspGln: 1.73 ± 0.36
2.123AspArg: 2.123 ± 0.332
3.617AspSer: 3.617 ± 0.477
3.853AspThr: 3.853 ± 0.621
3.224AspVal: 3.224 ± 0.589
0.865AspTrp: 0.865 ± 0.247
3.853AspTyr: 3.853 ± 0.741
0.0AspXaa: 0.0 ± 0.0
Glu
4.561GluAla: 4.561 ± 0.72
0.315GluCys: 0.315 ± 0.172
3.067GluAsp: 3.067 ± 0.559
5.662GluGlu: 5.662 ± 0.928
2.91GluPhe: 2.91 ± 0.482
3.146GluGly: 3.146 ± 0.529
0.786GluHis: 0.786 ± 0.299
7.078GluIle: 7.078 ± 0.831
6.842GluLys: 6.842 ± 0.735
8.1GluLeu: 8.1 ± 1.003
1.966GluMet: 1.966 ± 0.382
2.831GluAsn: 2.831 ± 0.542
2.045GluPro: 2.045 ± 0.433
2.831GluGln: 2.831 ± 0.374
2.831GluArg: 2.831 ± 0.472
4.797GluSer: 4.797 ± 0.714
4.011GluThr: 4.011 ± 0.573
5.898GluVal: 5.898 ± 1.223
1.101GluTrp: 1.101 ± 0.303
2.517GluTyr: 2.517 ± 0.495
0.0GluXaa: 0.0 ± 0.0
Phe
3.224PheAla: 3.224 ± 0.507
0.157PheCys: 0.157 ± 0.126
3.46PheAsp: 3.46 ± 0.503
3.224PheGlu: 3.224 ± 0.543
1.101PhePhe: 1.101 ± 0.353
3.146PheGly: 3.146 ± 0.47
0.157PheHis: 0.157 ± 0.105
2.045PheIle: 2.045 ± 0.472
3.224PheLys: 3.224 ± 0.472
1.73PheLeu: 1.73 ± 0.428
0.944PheMet: 0.944 ± 0.251
2.123PheAsn: 2.123 ± 0.398
1.416PhePro: 1.416 ± 0.4
0.629PheGln: 0.629 ± 0.221
1.573PheArg: 1.573 ± 0.345
1.966PheSer: 1.966 ± 0.446
2.674PheThr: 2.674 ± 0.447
1.966PheVal: 1.966 ± 0.381
0.315PheTrp: 0.315 ± 0.201
1.101PheTyr: 1.101 ± 0.285
0.0PheXaa: 0.0 ± 0.0
Gly
3.46GlyAla: 3.46 ± 0.689
0.472GlyCys: 0.472 ± 0.18
4.325GlyAsp: 4.325 ± 0.544
3.617GlyGlu: 3.617 ± 0.47
2.831GlyPhe: 2.831 ± 0.488
4.404GlyGly: 4.404 ± 0.57
1.18GlyHis: 1.18 ± 0.313
4.797GlyIle: 4.797 ± 0.693
5.819GlyLys: 5.819 ± 0.728
6.449GlyLeu: 6.449 ± 1.27
1.73GlyMet: 1.73 ± 0.373
3.853GlyAsn: 3.853 ± 0.555
1.022GlyPro: 1.022 ± 0.336
2.831GlyGln: 2.831 ± 0.488
2.359GlyArg: 2.359 ± 0.361
2.752GlySer: 2.752 ± 0.434
2.91GlyThr: 2.91 ± 0.516
4.483GlyVal: 4.483 ± 0.479
1.651GlyTrp: 1.651 ± 0.389
2.988GlyTyr: 2.988 ± 0.574
0.0GlyXaa: 0.0 ± 0.0
His
0.865HisAla: 0.865 ± 0.259
0.079HisCys: 0.079 ± 0.066
1.022HisAsp: 1.022 ± 0.307
1.494HisGlu: 1.494 ± 0.42
0.786HisPhe: 0.786 ± 0.223
0.944HisGly: 0.944 ± 0.233
0.393HisHis: 0.393 ± 0.178
0.55HisIle: 0.55 ± 0.207
0.865HisLys: 0.865 ± 0.259
0.708HisLeu: 0.708 ± 0.261
0.079HisMet: 0.079 ± 0.073
0.865HisAsn: 0.865 ± 0.242
0.708HisPro: 0.708 ± 0.201
0.472HisGln: 0.472 ± 0.235
0.944HisArg: 0.944 ± 0.295
0.786HisSer: 0.786 ± 0.261
0.944HisThr: 0.944 ± 0.297
0.786HisVal: 0.786 ± 0.272
0.079HisTrp: 0.079 ± 0.075
0.55HisTyr: 0.55 ± 0.249
0.0HisXaa: 0.0 ± 0.0
Ile
5.662IleAla: 5.662 ± 0.567
0.472IleCys: 0.472 ± 0.17
5.741IleAsp: 5.741 ± 0.793
6.213IleGlu: 6.213 ± 0.67
1.651IlePhe: 1.651 ± 0.353
3.775IleGly: 3.775 ± 0.476
1.022IleHis: 1.022 ± 0.322
3.46IleIle: 3.46 ± 0.56
7.078IleLys: 7.078 ± 0.918
5.19IleLeu: 5.19 ± 0.932
1.022IleMet: 1.022 ± 0.342
3.775IleAsn: 3.775 ± 0.624
1.966IlePro: 1.966 ± 0.465
1.887IleGln: 1.887 ± 0.395
2.281IleArg: 2.281 ± 0.403
3.067IleSer: 3.067 ± 0.415
4.64IleThr: 4.64 ± 0.641
4.247IleVal: 4.247 ± 0.444
1.18IleTrp: 1.18 ± 0.302
2.752IleTyr: 2.752 ± 0.429
0.0IleXaa: 0.0 ± 0.0
Lys
7.864LysAla: 7.864 ± 0.736
0.865LysCys: 0.865 ± 0.326
4.954LysAsp: 4.954 ± 0.7
6.92LysGlu: 6.92 ± 1.019
2.988LysPhe: 2.988 ± 0.473
5.898LysGly: 5.898 ± 0.78
1.022LysHis: 1.022 ± 0.256
5.505LysIle: 5.505 ± 0.819
6.92LysLys: 6.92 ± 0.901
6.684LysLeu: 6.684 ± 0.825
2.752LysMet: 2.752 ± 0.385
5.112LysAsn: 5.112 ± 0.556
2.831LysPro: 2.831 ± 0.52
4.797LysGln: 4.797 ± 0.676
3.775LysArg: 3.775 ± 0.634
4.089LysSer: 4.089 ± 0.597
5.269LysThr: 5.269 ± 0.679
5.819LysVal: 5.819 ± 0.597
0.865LysTrp: 0.865 ± 0.259
2.752LysTyr: 2.752 ± 0.505
0.0LysXaa: 0.0 ± 0.0
Leu
7.392LeuAla: 7.392 ± 1.065
0.55LeuCys: 0.55 ± 0.235
7.55LeuAsp: 7.55 ± 0.853
6.291LeuGlu: 6.291 ± 1.014
2.988LeuPhe: 2.988 ± 0.578
5.819LeuGly: 5.819 ± 0.649
1.101LeuHis: 1.101 ± 0.266
5.662LeuIle: 5.662 ± 0.925
7.707LeuLys: 7.707 ± 0.9
6.684LeuLeu: 6.684 ± 0.604
1.651LeuMet: 1.651 ± 0.31
5.033LeuAsn: 5.033 ± 0.666
3.382LeuPro: 3.382 ± 0.477
3.539LeuGln: 3.539 ± 0.766
3.696LeuArg: 3.696 ± 0.574
5.662LeuSer: 5.662 ± 0.943
6.055LeuThr: 6.055 ± 0.749
4.168LeuVal: 4.168 ± 0.466
0.236LeuTrp: 0.236 ± 0.129
2.517LeuTyr: 2.517 ± 0.448
0.0LeuXaa: 0.0 ± 0.0
Met
1.73MetAla: 1.73 ± 0.356
0.236MetCys: 0.236 ± 0.136
1.494MetAsp: 1.494 ± 0.413
1.573MetGlu: 1.573 ± 0.364
0.786MetPhe: 0.786 ± 0.218
0.786MetGly: 0.786 ± 0.218
0.236MetHis: 0.236 ± 0.139
1.887MetIle: 1.887 ± 0.32
1.416MetLys: 1.416 ± 0.329
2.202MetLeu: 2.202 ± 0.488
0.55MetMet: 0.55 ± 0.213
0.944MetAsn: 0.944 ± 0.27
0.472MetPro: 0.472 ± 0.184
1.022MetGln: 1.022 ± 0.278
1.416MetArg: 1.416 ± 0.256
1.887MetSer: 1.887 ± 0.48
2.202MetThr: 2.202 ± 0.446
1.966MetVal: 1.966 ± 0.48
0.393MetTrp: 0.393 ± 0.156
0.315MetTyr: 0.315 ± 0.188
0.0MetXaa: 0.0 ± 0.0
Asn
3.617AsnAla: 3.617 ± 0.66
0.157AsnCys: 0.157 ± 0.109
3.696AsnAsp: 3.696 ± 0.525
2.831AsnGlu: 2.831 ± 0.624
2.595AsnPhe: 2.595 ± 0.502
4.954AsnGly: 4.954 ± 0.621
0.55AsnHis: 0.55 ± 0.197
2.91AsnIle: 2.91 ± 0.596
3.617AsnLys: 3.617 ± 0.522
4.64AsnLeu: 4.64 ± 0.453
1.651AsnMet: 1.651 ± 0.422
2.988AsnAsn: 2.988 ± 0.476
2.359AsnPro: 2.359 ± 0.461
2.123AsnGln: 2.123 ± 0.421
2.438AsnArg: 2.438 ± 0.401
2.91AsnSer: 2.91 ± 0.652
2.752AsnThr: 2.752 ± 0.466
3.617AsnVal: 3.617 ± 0.517
1.101AsnTrp: 1.101 ± 0.272
2.517AsnTyr: 2.517 ± 0.407
0.0AsnXaa: 0.0 ± 0.0
Pro
1.651ProAla: 1.651 ± 0.451
0.0ProCys: 0.0 ± 0.0
2.595ProAsp: 2.595 ± 0.479
2.281ProGlu: 2.281 ± 0.468
1.101ProPhe: 1.101 ± 0.288
1.022ProGly: 1.022 ± 0.283
0.472ProHis: 0.472 ± 0.178
1.494ProIle: 1.494 ± 0.327
2.831ProLys: 2.831 ± 0.577
3.382ProLeu: 3.382 ± 0.601
0.55ProMet: 0.55 ± 0.22
1.494ProAsn: 1.494 ± 0.372
0.708ProPro: 0.708 ± 0.228
1.966ProGln: 1.966 ± 0.535
1.18ProArg: 1.18 ± 0.409
1.651ProSer: 1.651 ± 0.323
2.831ProThr: 2.831 ± 0.472
2.123ProVal: 2.123 ± 0.432
0.157ProTrp: 0.157 ± 0.128
1.18ProTyr: 1.18 ± 0.363
0.0ProXaa: 0.0 ± 0.0
Gln
2.438GlnAla: 2.438 ± 0.425
0.157GlnCys: 0.157 ± 0.104
1.887GlnAsp: 1.887 ± 0.445
2.91GlnGlu: 2.91 ± 0.447
2.045GlnPhe: 2.045 ± 0.353
2.438GlnGly: 2.438 ± 0.494
0.865GlnHis: 0.865 ± 0.252
3.382GlnIle: 3.382 ± 0.483
4.247GlnLys: 4.247 ± 0.534
4.089GlnLeu: 4.089 ± 0.746
1.573GlnMet: 1.573 ± 0.352
2.045GlnAsn: 2.045 ± 0.354
1.73GlnPro: 1.73 ± 0.648
2.517GlnGln: 2.517 ± 0.684
1.809GlnArg: 1.809 ± 0.356
2.91GlnSer: 2.91 ± 0.502
2.674GlnThr: 2.674 ± 0.495
1.651GlnVal: 1.651 ± 0.431
0.786GlnTrp: 0.786 ± 0.254
1.337GlnTyr: 1.337 ± 0.328
0.0GlnXaa: 0.0 ± 0.0
Arg
2.831ArgAla: 2.831 ± 0.42
0.079ArgCys: 0.079 ± 0.096
2.123ArgAsp: 2.123 ± 0.403
2.595ArgGlu: 2.595 ± 0.491
1.18ArgPhe: 1.18 ± 0.386
2.752ArgGly: 2.752 ± 0.74
0.786ArgHis: 0.786 ± 0.242
2.988ArgIle: 2.988 ± 0.466
4.011ArgLys: 4.011 ± 0.477
4.089ArgLeu: 4.089 ± 0.564
0.944ArgMet: 0.944 ± 0.238
2.517ArgAsn: 2.517 ± 0.507
0.629ArgPro: 0.629 ± 0.223
2.045ArgGln: 2.045 ± 0.424
1.887ArgArg: 1.887 ± 0.436
1.416ArgSer: 1.416 ± 0.312
1.887ArgThr: 1.887 ± 0.398
2.91ArgVal: 2.91 ± 0.412
0.393ArgTrp: 0.393 ± 0.176
1.966ArgTyr: 1.966 ± 0.481
0.0ArgXaa: 0.0 ± 0.0
Ser
5.741SerAla: 5.741 ± 1.172
0.236SerCys: 0.236 ± 0.135
4.168SerAsp: 4.168 ± 0.631
3.696SerGlu: 3.696 ± 0.484
2.674SerPhe: 2.674 ± 0.416
4.168SerGly: 4.168 ± 0.737
0.786SerHis: 0.786 ± 0.219
3.775SerIle: 3.775 ± 0.767
4.797SerLys: 4.797 ± 0.563
4.011SerLeu: 4.011 ± 0.39
1.416SerMet: 1.416 ± 0.281
2.988SerAsn: 2.988 ± 0.555
1.416SerPro: 1.416 ± 0.328
3.382SerGln: 3.382 ± 0.478
1.887SerArg: 1.887 ± 0.479
3.46SerSer: 3.46 ± 0.58
2.91SerThr: 2.91 ± 0.484
3.303SerVal: 3.303 ± 0.438
0.708SerTrp: 0.708 ± 0.274
1.966SerTyr: 1.966 ± 0.415
0.0SerXaa: 0.0 ± 0.0
Thr
6.055ThrAla: 6.055 ± 0.891
0.315ThrCys: 0.315 ± 0.155
3.067ThrAsp: 3.067 ± 0.43
3.696ThrGlu: 3.696 ± 0.741
1.809ThrPhe: 1.809 ± 0.348
5.112ThrGly: 5.112 ± 0.576
0.629ThrHis: 0.629 ± 0.25
4.64ThrIle: 4.64 ± 0.595
4.64ThrLys: 4.64 ± 0.604
4.797ThrLeu: 4.797 ± 0.544
1.494ThrMet: 1.494 ± 0.368
2.752ThrAsn: 2.752 ± 0.495
2.438ThrPro: 2.438 ± 0.434
2.674ThrGln: 2.674 ± 0.547
1.73ThrArg: 1.73 ± 0.395
4.325ThrSer: 4.325 ± 0.652
3.46ThrThr: 3.46 ± 0.726
4.561ThrVal: 4.561 ± 0.666
0.55ThrTrp: 0.55 ± 0.157
2.045ThrTyr: 2.045 ± 0.427
0.0ThrXaa: 0.0 ± 0.0
Val
5.033ValAla: 5.033 ± 0.949
0.393ValCys: 0.393 ± 0.184
5.112ValAsp: 5.112 ± 0.638
4.876ValGlu: 4.876 ± 0.679
2.281ValPhe: 2.281 ± 0.489
3.775ValGly: 3.775 ± 0.373
0.708ValHis: 0.708 ± 0.292
2.988ValIle: 2.988 ± 0.371
5.662ValLys: 5.662 ± 0.763
6.291ValLeu: 6.291 ± 0.76
0.786ValMet: 0.786 ± 0.309
3.932ValAsn: 3.932 ± 0.54
1.494ValPro: 1.494 ± 0.254
1.416ValGln: 1.416 ± 0.286
2.752ValArg: 2.752 ± 0.486
4.404ValSer: 4.404 ± 0.558
4.247ValThr: 4.247 ± 0.608
3.617ValVal: 3.617 ± 0.577
0.944ValTrp: 0.944 ± 0.321
2.123ValTyr: 2.123 ± 0.513
0.0ValXaa: 0.0 ± 0.0
Trp
0.865TrpAla: 0.865 ± 0.233
0.079TrpCys: 0.079 ± 0.087
1.573TrpAsp: 1.573 ± 0.378
0.865TrpGlu: 0.865 ± 0.248
0.55TrpPhe: 0.55 ± 0.194
0.708TrpGly: 0.708 ± 0.257
0.393TrpHis: 0.393 ± 0.148
1.101TrpIle: 1.101 ± 0.338
1.101TrpLys: 1.101 ± 0.271
1.337TrpLeu: 1.337 ± 0.359
0.157TrpMet: 0.157 ± 0.121
0.708TrpAsn: 0.708 ± 0.224
0.157TrpPro: 0.157 ± 0.112
0.629TrpGln: 0.629 ± 0.21
0.865TrpArg: 0.865 ± 0.302
0.472TrpSer: 0.472 ± 0.204
0.393TrpThr: 0.393 ± 0.182
0.708TrpVal: 0.708 ± 0.245
0.0TrpTrp: 0.0 ± 0.0
0.315TrpTyr: 0.315 ± 0.167
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.281TyrAla: 2.281 ± 0.371
0.315TyrCys: 0.315 ± 0.124
2.831TyrAsp: 2.831 ± 0.451
2.517TyrGlu: 2.517 ± 0.421
1.337TyrPhe: 1.337 ± 0.368
1.809TyrGly: 1.809 ± 0.347
0.55TyrHis: 0.55 ± 0.184
2.202TyrIle: 2.202 ± 0.517
2.988TyrLys: 2.988 ± 0.562
2.752TyrLeu: 2.752 ± 0.53
0.708TyrMet: 0.708 ± 0.244
1.887TyrAsn: 1.887 ± 0.479
1.651TyrPro: 1.651 ± 0.431
3.067TyrGln: 3.067 ± 0.799
1.573TyrArg: 1.573 ± 0.359
1.494TyrSer: 1.494 ± 0.294
2.202TyrThr: 2.202 ± 0.521
2.595TyrVal: 2.595 ± 0.468
0.393TyrTrp: 0.393 ± 0.189
1.809TyrTyr: 1.809 ± 0.319
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 62 proteins (12717 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski