Amino acid dipepetide frequency for Vagococcus vulneris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.995AlaAla: 4.995 ± 0.119
0.526AlaCys: 0.526 ± 0.027
3.846AlaAsp: 3.846 ± 0.078
4.419AlaGlu: 4.419 ± 0.099
2.729AlaPhe: 2.729 ± 0.075
4.334AlaGly: 4.334 ± 0.094
1.057AlaHis: 1.057 ± 0.041
5.567AlaIle: 5.567 ± 0.104
4.709AlaLys: 4.709 ± 0.104
6.033AlaLeu: 6.033 ± 0.112
1.869AlaMet: 1.869 ± 0.053
2.9AlaAsn: 2.9 ± 0.068
1.73AlaPro: 1.73 ± 0.056
2.172AlaGln: 2.172 ± 0.054
2.177AlaArg: 2.177 ± 0.063
3.776AlaSer: 3.776 ± 0.081
3.631AlaThr: 3.631 ± 0.073
4.866AlaVal: 4.866 ± 0.088
0.527AlaTrp: 0.527 ± 0.032
2.238AlaTyr: 2.238 ± 0.06
0.0AlaXaa: 0.0 ± 0.0
Cys
0.435CysAla: 0.435 ± 0.028
0.1CysCys: 0.1 ± 0.013
0.415CysAsp: 0.415 ± 0.025
0.387CysGlu: 0.387 ± 0.024
0.345CysPhe: 0.345 ± 0.026
0.616CysGly: 0.616 ± 0.03
0.213CysHis: 0.213 ± 0.019
0.49CysIle: 0.49 ± 0.027
0.317CysLys: 0.317 ± 0.021
0.822CysLeu: 0.822 ± 0.035
0.164CysMet: 0.164 ± 0.013
0.223CysAsn: 0.223 ± 0.017
0.28CysPro: 0.28 ± 0.022
0.326CysGln: 0.326 ± 0.022
0.277CysArg: 0.277 ± 0.023
0.412CysSer: 0.412 ± 0.029
0.322CysThr: 0.322 ± 0.024
0.43CysVal: 0.43 ± 0.026
0.051CysTrp: 0.051 ± 0.008
0.275CysTyr: 0.275 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
3.314AspAla: 3.314 ± 0.092
0.356AspCys: 0.356 ± 0.023
3.214AspAsp: 3.214 ± 0.083
4.203AspGlu: 4.203 ± 0.089
2.844AspPhe: 2.844 ± 0.065
3.526AspGly: 3.526 ± 0.086
0.941AspHis: 0.941 ± 0.038
4.825AspIle: 4.825 ± 0.09
4.23AspLys: 4.23 ± 0.1
5.415AspLeu: 5.415 ± 0.108
1.679AspMet: 1.679 ± 0.046
2.894AspAsn: 2.894 ± 0.074
1.595AspPro: 1.595 ± 0.047
1.834AspGln: 1.834 ± 0.057
1.994AspArg: 1.994 ± 0.058
3.252AspSer: 3.252 ± 0.072
3.158AspThr: 3.158 ± 0.079
4.205AspVal: 4.205 ± 0.09
0.631AspTrp: 0.631 ± 0.035
2.737AspTyr: 2.737 ± 0.073
0.0AspXaa: 0.0 ± 0.0
Glu
4.681GluAla: 4.681 ± 0.086
0.386GluCys: 0.386 ± 0.025
3.471GluAsp: 3.471 ± 0.078
5.137GluGlu: 5.137 ± 0.105
2.698GluPhe: 2.698 ± 0.063
3.558GluGly: 3.558 ± 0.069
1.255GluHis: 1.255 ± 0.042
5.151GluIle: 5.151 ± 0.096
6.211GluLys: 6.211 ± 0.115
7.245GluLeu: 7.245 ± 0.134
2.117GluMet: 2.117 ± 0.059
3.588GluAsn: 3.588 ± 0.079
1.751GluPro: 1.751 ± 0.069
3.049GluGln: 3.049 ± 0.076
2.888GluArg: 2.888 ± 0.068
3.709GluSer: 3.709 ± 0.084
3.978GluThr: 3.978 ± 0.081
4.346GluVal: 4.346 ± 0.096
0.59GluTrp: 0.59 ± 0.028
2.218GluTyr: 2.218 ± 0.056
0.0GluXaa: 0.0 ± 0.0
Phe
2.536PheAla: 2.536 ± 0.07
0.39PheCys: 0.39 ± 0.026
2.768PheAsp: 2.768 ± 0.072
2.567PheGlu: 2.567 ± 0.06
2.436PhePhe: 2.436 ± 0.088
3.238PheGly: 3.238 ± 0.077
0.707PheHis: 0.707 ± 0.031
4.248PheIle: 4.248 ± 0.106
3.143PheLys: 3.143 ± 0.075
4.385PheLeu: 4.385 ± 0.102
1.224PheMet: 1.224 ± 0.046
2.466PheAsn: 2.466 ± 0.062
1.52PhePro: 1.52 ± 0.049
1.413PheGln: 1.413 ± 0.049
1.383PheArg: 1.383 ± 0.051
3.514PheSer: 3.514 ± 0.076
2.381PheThr: 2.381 ± 0.072
2.972PheVal: 2.972 ± 0.072
0.438PheTrp: 0.438 ± 0.026
1.916PheTyr: 1.916 ± 0.054
0.0PheXaa: 0.0 ± 0.0
Gly
4.124GlyAla: 4.124 ± 0.093
0.57GlyCys: 0.57 ± 0.031
3.2GlyAsp: 3.2 ± 0.074
3.808GlyGlu: 3.808 ± 0.08
3.146GlyPhe: 3.146 ± 0.076
4.327GlyGly: 4.327 ± 0.093
1.245GlyHis: 1.245 ± 0.044
6.04GlyIle: 6.04 ± 0.103
4.726GlyLys: 4.726 ± 0.096
6.302GlyLeu: 6.302 ± 0.108
1.944GlyMet: 1.944 ± 0.052
2.781GlyAsn: 2.781 ± 0.064
1.432GlyPro: 1.432 ± 0.048
2.385GlyGln: 2.385 ± 0.064
2.279GlyArg: 2.279 ± 0.075
3.837GlySer: 3.837 ± 0.095
3.969GlyThr: 3.969 ± 0.083
4.534GlyVal: 4.534 ± 0.093
0.593GlyTrp: 0.593 ± 0.031
2.747GlyTyr: 2.747 ± 0.068
0.0GlyXaa: 0.0 ± 0.0
His
1.109HisAla: 1.109 ± 0.037
0.162HisCys: 0.162 ± 0.015
1.026HisAsp: 1.026 ± 0.038
1.099HisGlu: 1.099 ± 0.044
0.928HisPhe: 0.928 ± 0.041
1.204HisGly: 1.204 ± 0.047
0.566HisHis: 0.566 ± 0.031
1.361HisIle: 1.361 ± 0.044
0.931HisLys: 0.931 ± 0.038
1.854HisLeu: 1.854 ± 0.06
0.453HisMet: 0.453 ± 0.024
0.673HisAsn: 0.673 ± 0.036
0.884HisPro: 0.884 ± 0.038
0.907HisGln: 0.907 ± 0.034
0.794HisArg: 0.794 ± 0.036
1.088HisSer: 1.088 ± 0.048
0.942HisThr: 0.942 ± 0.035
1.248HisVal: 1.248 ± 0.041
0.161HisTrp: 0.161 ± 0.015
0.82HisTyr: 0.82 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
5.521IleAla: 5.521 ± 0.109
0.682IleCys: 0.682 ± 0.035
5.09IleAsp: 5.09 ± 0.094
5.492IleGlu: 5.492 ± 0.084
3.782IlePhe: 3.782 ± 0.079
5.799IleGly: 5.799 ± 0.123
1.361IleHis: 1.361 ± 0.048
6.935IleIle: 6.935 ± 0.133
5.647IleLys: 5.647 ± 0.1
7.587IleLeu: 7.587 ± 0.151
2.031IleMet: 2.031 ± 0.055
4.414IleAsn: 4.414 ± 0.085
3.316IlePro: 3.316 ± 0.076
2.957IleGln: 2.957 ± 0.071
2.937IleArg: 2.937 ± 0.07
5.64IleSer: 5.64 ± 0.105
4.537IleThr: 4.537 ± 0.082
5.603IleVal: 5.603 ± 0.107
0.619IleTrp: 0.619 ± 0.033
2.707IleTyr: 2.707 ± 0.071
0.0IleXaa: 0.0 ± 0.0
Lys
4.06LysAla: 4.06 ± 0.074
0.269LysCys: 0.269 ± 0.018
4.474LysAsp: 4.474 ± 0.105
6.747LysGlu: 6.747 ± 0.12
2.276LysPhe: 2.276 ± 0.06
3.951LysGly: 3.951 ± 0.077
1.234LysHis: 1.234 ± 0.051
5.677LysIle: 5.677 ± 0.096
7.161LysLys: 7.161 ± 0.127
6.225LysLeu: 6.225 ± 0.109
2.415LysMet: 2.415 ± 0.061
4.565LysAsn: 4.565 ± 0.097
2.044LysPro: 2.044 ± 0.049
3.575LysGln: 3.575 ± 0.076
3.283LysArg: 3.283 ± 0.084
4.132LysSer: 4.132 ± 0.088
4.222LysThr: 4.222 ± 0.087
4.574LysVal: 4.574 ± 0.09
0.686LysTrp: 0.686 ± 0.033
2.543LysTyr: 2.543 ± 0.07
0.0LysXaa: 0.0 ± 0.0
Leu
6.989LeuAla: 6.989 ± 0.107
0.666LeuCys: 0.666 ± 0.038
5.343LeuAsp: 5.343 ± 0.103
5.903LeuGlu: 5.903 ± 0.114
4.794LeuPhe: 4.794 ± 0.116
6.089LeuGly: 6.089 ± 0.112
1.417LeuHis: 1.417 ± 0.046
8.084LeuIle: 8.084 ± 0.148
6.82LeuLys: 6.82 ± 0.111
9.353LeuLeu: 9.353 ± 0.169
2.543LeuMet: 2.543 ± 0.064
5.11LeuAsn: 5.11 ± 0.103
3.837LeuPro: 3.837 ± 0.076
2.966LeuGln: 2.966 ± 0.071
3.17LeuArg: 3.17 ± 0.072
7.279LeuSer: 7.279 ± 0.122
6.45LeuThr: 6.45 ± 0.099
6.341LeuVal: 6.341 ± 0.107
0.724LeuTrp: 0.724 ± 0.037
3.003LeuTyr: 3.003 ± 0.071
0.0LeuXaa: 0.0 ± 0.0
Met
1.88MetAla: 1.88 ± 0.057
0.133MetCys: 0.133 ± 0.015
1.413MetAsp: 1.413 ± 0.042
1.612MetGlu: 1.612 ± 0.046
1.054MetPhe: 1.054 ± 0.041
1.682MetGly: 1.682 ± 0.049
0.417MetHis: 0.417 ± 0.025
2.326MetIle: 2.326 ± 0.065
2.187MetLys: 2.187 ± 0.052
2.495MetLeu: 2.495 ± 0.063
0.901MetMet: 0.901 ± 0.039
1.548MetAsn: 1.548 ± 0.049
0.936MetPro: 0.936 ± 0.037
0.919MetGln: 0.919 ± 0.034
1.03MetArg: 1.03 ± 0.039
1.997MetSer: 1.997 ± 0.06
2.157MetThr: 2.157 ± 0.049
1.845MetVal: 1.845 ± 0.051
0.167MetTrp: 0.167 ± 0.014
0.843MetTyr: 0.843 ± 0.037
0.0MetXaa: 0.0 ± 0.0
Asn
2.613AsnAla: 2.613 ± 0.062
0.356AsnCys: 0.356 ± 0.024
2.917AsnAsp: 2.917 ± 0.082
3.328AsnGlu: 3.328 ± 0.075
1.992AsnPhe: 1.992 ± 0.063
3.281AsnGly: 3.281 ± 0.072
1.216AsnHis: 1.216 ± 0.044
3.835AsnIle: 3.835 ± 0.075
3.884AsnLys: 3.884 ± 0.084
4.554AsnLeu: 4.554 ± 0.08
1.344AsnMet: 1.344 ± 0.046
2.79AsnAsn: 2.79 ± 0.086
2.074AsnPro: 2.074 ± 0.053
2.842AsnGln: 2.842 ± 0.068
2.18AsnArg: 2.18 ± 0.057
2.826AsnSer: 2.826 ± 0.081
2.515AsnThr: 2.515 ± 0.071
3.079AsnVal: 3.079 ± 0.066
0.524AsnTrp: 0.524 ± 0.032
2.25AsnTyr: 2.25 ± 0.061
0.0AsnXaa: 0.0 ± 0.0
Pro
1.933ProAla: 1.933 ± 0.062
0.173ProCys: 0.173 ± 0.015
1.968ProAsp: 1.968 ± 0.05
2.664ProGlu: 2.664 ± 0.072
1.742ProPhe: 1.742 ± 0.054
1.818ProGly: 1.818 ± 0.06
0.576ProHis: 0.576 ± 0.033
2.859ProIle: 2.859 ± 0.066
2.448ProLys: 2.448 ± 0.059
3.089ProLeu: 3.089 ± 0.073
0.832ProMet: 0.832 ± 0.033
1.779ProAsn: 1.779 ± 0.049
0.624ProPro: 0.624 ± 0.031
1.124ProGln: 1.124 ± 0.042
0.917ProArg: 0.917 ± 0.036
1.971ProSer: 1.971 ± 0.062
2.134ProThr: 2.134 ± 0.08
2.61ProVal: 2.61 ± 0.062
0.244ProTrp: 0.244 ± 0.021
1.3ProTyr: 1.3 ± 0.056
0.0ProXaa: 0.0 ± 0.0
Gln
2.741GlnAla: 2.741 ± 0.062
0.201GlnCys: 0.201 ± 0.02
1.793GlnAsp: 1.793 ± 0.057
2.789GlnGlu: 2.789 ± 0.07
1.595GlnPhe: 1.595 ± 0.05
2.147GlnGly: 2.147 ± 0.056
0.756GlnHis: 0.756 ± 0.035
2.912GlnIle: 2.912 ± 0.061
3.067GlnLys: 3.067 ± 0.069
4.379GlnLeu: 4.379 ± 0.117
1.102GlnMet: 1.102 ± 0.038
1.749GlnAsn: 1.749 ± 0.058
1.324GlnPro: 1.324 ± 0.047
2.069GlnGln: 2.069 ± 0.074
1.584GlnArg: 1.584 ± 0.052
2.457GlnSer: 2.457 ± 0.057
2.455GlnThr: 2.455 ± 0.062
2.568GlnVal: 2.568 ± 0.074
0.331GlnTrp: 0.331 ± 0.023
1.196GlnTyr: 1.196 ± 0.037
0.0GlnXaa: 0.0 ± 0.0
Arg
1.956ArgAla: 1.956 ± 0.061
0.258ArgCys: 0.258 ± 0.021
2.075ArgAsp: 2.075 ± 0.054
2.774ArgGlu: 2.774 ± 0.076
1.736ArgPhe: 1.736 ± 0.047
2.104ArgGly: 2.104 ± 0.064
0.758ArgHis: 0.758 ± 0.034
2.902ArgIle: 2.902 ± 0.07
2.838ArgLys: 2.838 ± 0.073
3.875ArgLeu: 3.875 ± 0.084
1.091ArgMet: 1.091 ± 0.04
1.676ArgAsn: 1.676 ± 0.055
1.197ArgPro: 1.197 ± 0.044
1.781ArgGln: 1.781 ± 0.055
1.72ArgArg: 1.72 ± 0.054
1.93ArgSer: 1.93 ± 0.058
1.806ArgThr: 1.806 ± 0.057
2.568ArgVal: 2.568 ± 0.06
0.299ArgTrp: 0.299 ± 0.023
1.514ArgTyr: 1.514 ± 0.053
0.0ArgXaa: 0.0 ± 0.0
Ser
3.761SerAla: 3.761 ± 0.085
0.411SerCys: 0.411 ± 0.025
3.724SerAsp: 3.724 ± 0.082
4.257SerGlu: 4.257 ± 0.1
3.271SerPhe: 3.271 ± 0.066
4.599SerGly: 4.599 ± 0.089
1.212SerHis: 1.212 ± 0.042
5.419SerIle: 5.419 ± 0.087
4.45SerLys: 4.45 ± 0.075
6.275SerLeu: 6.275 ± 0.118
1.548SerMet: 1.548 ± 0.048
2.991SerAsn: 2.991 ± 0.068
1.879SerPro: 1.879 ± 0.05
2.6SerGln: 2.6 ± 0.065
2.311SerArg: 2.311 ± 0.065
4.205SerSer: 4.205 ± 0.096
3.406SerThr: 3.406 ± 0.091
4.222SerVal: 4.222 ± 0.086
0.543SerTrp: 0.543 ± 0.03
2.415SerTyr: 2.415 ± 0.055
0.0SerXaa: 0.0 ± 0.0
Thr
4.051ThrAla: 4.051 ± 0.085
0.381ThrCys: 0.381 ± 0.028
3.478ThrAsp: 3.478 ± 0.072
3.789ThrGlu: 3.789 ± 0.092
2.783ThrPhe: 2.783 ± 0.073
4.169ThrGly: 4.169 ± 0.087
1.12ThrHis: 1.12 ± 0.037
5.059ThrIle: 5.059 ± 0.075
3.995ThrLys: 3.995 ± 0.069
5.403ThrLeu: 5.403 ± 0.101
1.376ThrMet: 1.376 ± 0.046
2.978ThrAsn: 2.978 ± 0.072
2.332ThrPro: 2.332 ± 0.063
1.842ThrGln: 1.842 ± 0.059
1.757ThrArg: 1.757 ± 0.053
3.634ThrSer: 3.634 ± 0.095
3.549ThrThr: 3.549 ± 0.1
4.303ThrVal: 4.303 ± 0.092
0.433ThrTrp: 0.433 ± 0.028
2.046ThrTyr: 2.046 ± 0.059
0.0ThrXaa: 0.0 ± 0.0
Val
4.807ValAla: 4.807 ± 0.106
0.54ValCys: 0.54 ± 0.03
3.951ValAsp: 3.951 ± 0.074
4.184ValGlu: 4.184 ± 0.1
3.016ValPhe: 3.016 ± 0.074
4.557ValGly: 4.557 ± 0.083
1.063ValHis: 1.063 ± 0.04
5.823ValIle: 5.823 ± 0.112
4.738ValLys: 4.738 ± 0.084
6.445ValLeu: 6.445 ± 0.118
1.83ValMet: 1.83 ± 0.048
3.167ValAsn: 3.167 ± 0.071
2.482ValPro: 2.482 ± 0.065
1.977ValGln: 1.977 ± 0.059
2.187ValArg: 2.187 ± 0.068
5.041ValSer: 5.041 ± 0.087
4.371ValThr: 4.371 ± 0.077
5.017ValVal: 5.017 ± 0.1
0.526ValTrp: 0.526 ± 0.029
2.403ValTyr: 2.403 ± 0.062
0.0ValXaa: 0.0 ± 0.0
Trp
0.418TrpAla: 0.418 ± 0.025
0.061TrpCys: 0.061 ± 0.01
0.46TrpAsp: 0.46 ± 0.028
0.512TrpGlu: 0.512 ± 0.029
0.463TrpPhe: 0.463 ± 0.032
0.509TrpGly: 0.509 ± 0.028
0.197TrpHis: 0.197 ± 0.019
0.61TrpIle: 0.61 ± 0.03
0.578TrpLys: 0.578 ± 0.033
1.093TrpLeu: 1.093 ± 0.046
0.237TrpMet: 0.237 ± 0.022
0.45TrpAsn: 0.45 ± 0.027
0.197TrpPro: 0.197 ± 0.018
0.46TrpGln: 0.46 ± 0.029
0.329TrpArg: 0.329 ± 0.021
0.534TrpSer: 0.534 ± 0.03
0.451TrpThr: 0.451 ± 0.029
0.505TrpVal: 0.505 ± 0.031
0.113TrpTrp: 0.113 ± 0.015
0.383TrpTyr: 0.383 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.175TyrAla: 2.175 ± 0.056
0.281TyrCys: 0.281 ± 0.022
2.221TyrAsp: 2.221 ± 0.065
2.357TyrGlu: 2.357 ± 0.068
2.013TyrPhe: 2.013 ± 0.066
2.479TyrGly: 2.479 ± 0.063
0.898TyrHis: 0.898 ± 0.037
2.533TyrIle: 2.533 ± 0.071
2.035TyrLys: 2.035 ± 0.062
4.051TyrLeu: 4.051 ± 0.08
0.841TyrMet: 0.841 ± 0.034
1.657TyrAsn: 1.657 ± 0.051
1.371TyrPro: 1.371 ± 0.047
2.016TyrGln: 2.016 ± 0.058
1.662TyrArg: 1.662 ± 0.051
2.268TyrSer: 2.268 ± 0.062
2.041TyrThr: 2.041 ± 0.058
2.293TyrVal: 2.293 ± 0.059
0.36TyrTrp: 0.36 ± 0.023
1.603TyrTyr: 1.603 ± 0.057
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2196 proteins (671661 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski