Amino acid dipepetide frequency for Burkholderia phage KS10

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.257AlaAla: 17.257 ± 2.059
1.167AlaCys: 1.167 ± 0.427
8.587AlaAsp: 8.587 ± 0.938
7.336AlaGlu: 7.336 ± 1.122
3.918AlaPhe: 3.918 ± 0.628
10.754AlaGly: 10.754 ± 2.036
1.917AlaHis: 1.917 ± 0.426
4.669AlaIle: 4.669 ± 0.615
4.252AlaLys: 4.252 ± 0.631
10.921AlaLeu: 10.921 ± 1.046
3.668AlaMet: 3.668 ± 0.561
4.669AlaAsn: 4.669 ± 0.44
4.585AlaPro: 4.585 ± 0.598
5.919AlaGln: 5.919 ± 0.567
8.587AlaArg: 8.587 ± 0.728
6.169AlaSer: 6.169 ± 0.742
7.17AlaThr: 7.17 ± 0.728
8.837AlaVal: 8.837 ± 0.915
1.584AlaTrp: 1.584 ± 0.296
2.584AlaTyr: 2.584 ± 0.441
0.0AlaXaa: 0.0 ± 0.0
Cys
1.251CysAla: 1.251 ± 0.43
0.25CysCys: 0.25 ± 0.144
0.917CysAsp: 0.917 ± 0.301
1.0CysGlu: 1.0 ± 0.312
0.167CysPhe: 0.167 ± 0.121
1.0CysGly: 1.0 ± 0.292
0.167CysHis: 0.167 ± 0.095
0.333CysIle: 0.333 ± 0.149
0.25CysLys: 0.25 ± 0.148
1.0CysLeu: 1.0 ± 0.258
0.083CysMet: 0.083 ± 0.086
0.0CysAsn: 0.0 ± 0.0
0.25CysPro: 0.25 ± 0.2
0.333CysGln: 0.333 ± 0.161
0.333CysArg: 0.333 ± 0.171
0.584CysSer: 0.584 ± 0.219
0.75CysThr: 0.75 ± 0.193
0.834CysVal: 0.834 ± 0.3
0.083CysTrp: 0.083 ± 0.076
0.333CysTyr: 0.333 ± 0.144
0.0CysXaa: 0.0 ± 0.0
Asp
9.004AspAla: 9.004 ± 0.962
0.75AspCys: 0.75 ± 0.205
4.419AspAsp: 4.419 ± 0.599
2.668AspGlu: 2.668 ± 0.477
1.501AspPhe: 1.501 ± 0.354
4.419AspGly: 4.419 ± 0.616
1.501AspHis: 1.501 ± 0.316
4.002AspIle: 4.002 ± 0.601
2.251AspLys: 2.251 ± 0.385
5.669AspLeu: 5.669 ± 0.795
1.917AspMet: 1.917 ± 0.452
2.168AspAsn: 2.168 ± 0.45
3.335AspPro: 3.335 ± 0.468
2.668AspGln: 2.668 ± 0.575
5.002AspArg: 5.002 ± 0.731
3.918AspSer: 3.918 ± 0.512
3.501AspThr: 3.501 ± 0.485
4.335AspVal: 4.335 ± 0.558
1.167AspTrp: 1.167 ± 0.234
1.917AspTyr: 1.917 ± 0.439
0.0AspXaa: 0.0 ± 0.0
Glu
7.503GluAla: 7.503 ± 0.793
0.667GluCys: 0.667 ± 0.299
1.834GluAsp: 1.834 ± 0.484
2.668GluGlu: 2.668 ± 0.538
3.501GluPhe: 3.501 ± 0.673
3.001GluGly: 3.001 ± 0.435
1.0GluHis: 1.0 ± 0.297
2.168GluIle: 2.168 ± 0.489
1.334GluLys: 1.334 ± 0.379
5.919GluLeu: 5.919 ± 0.694
2.001GluMet: 2.001 ± 0.307
1.917GluAsn: 1.917 ± 0.286
2.334GluPro: 2.334 ± 0.36
2.835GluGln: 2.835 ± 0.483
4.502GluArg: 4.502 ± 0.714
2.668GluSer: 2.668 ± 0.366
3.001GluThr: 3.001 ± 0.386
3.251GluVal: 3.251 ± 0.573
1.251GluTrp: 1.251 ± 0.275
1.667GluTyr: 1.667 ± 0.365
0.0GluXaa: 0.0 ± 0.0
Phe
3.918PheAla: 3.918 ± 0.493
0.417PheCys: 0.417 ± 0.165
2.334PheAsp: 2.334 ± 0.451
1.667PheGlu: 1.667 ± 0.425
0.917PhePhe: 0.917 ± 0.374
2.835PheGly: 2.835 ± 0.416
0.167PheHis: 0.167 ± 0.105
1.167PheIle: 1.167 ± 0.259
0.584PheLys: 0.584 ± 0.224
1.584PheLeu: 1.584 ± 0.295
0.834PheMet: 0.834 ± 0.317
0.333PheAsn: 0.333 ± 0.168
1.0PhePro: 1.0 ± 0.217
1.584PheGln: 1.584 ± 0.407
1.917PheArg: 1.917 ± 0.326
2.001PheSer: 2.001 ± 0.544
2.251PheThr: 2.251 ± 0.413
2.751PheVal: 2.751 ± 0.511
0.5PheTrp: 0.5 ± 0.189
0.834PheTyr: 0.834 ± 0.318
0.0PheXaa: 0.0 ± 0.0
Gly
8.754GlyAla: 8.754 ± 1.411
0.5GlyCys: 0.5 ± 0.192
4.585GlyAsp: 4.585 ± 0.646
4.835GlyGlu: 4.835 ± 0.581
2.668GlyPhe: 2.668 ± 0.495
6.336GlyGly: 6.336 ± 1.397
1.251GlyHis: 1.251 ± 0.367
3.335GlyIle: 3.335 ± 0.443
4.502GlyLys: 4.502 ± 0.756
6.086GlyLeu: 6.086 ± 0.758
1.834GlyMet: 1.834 ± 0.376
2.835GlyAsn: 2.835 ± 0.438
2.084GlyPro: 2.084 ± 0.441
4.002GlyGln: 4.002 ± 0.525
5.252GlyArg: 5.252 ± 0.499
4.419GlySer: 4.419 ± 0.624
4.168GlyThr: 4.168 ± 0.768
5.419GlyVal: 5.419 ± 0.619
2.501GlyTrp: 2.501 ± 0.518
2.251GlyTyr: 2.251 ± 0.453
0.0GlyXaa: 0.0 ± 0.0
His
1.501HisAla: 1.501 ± 0.326
0.25HisCys: 0.25 ± 0.129
1.667HisAsp: 1.667 ± 0.428
0.75HisGlu: 0.75 ± 0.244
0.167HisPhe: 0.167 ± 0.117
1.584HisGly: 1.584 ± 0.351
0.25HisHis: 0.25 ± 0.123
0.417HisIle: 0.417 ± 0.186
1.084HisLys: 1.084 ± 0.334
1.584HisLeu: 1.584 ± 0.387
0.25HisMet: 0.25 ± 0.136
0.584HisAsn: 0.584 ± 0.216
1.0HisPro: 1.0 ± 0.319
0.584HisGln: 0.584 ± 0.21
1.084HisArg: 1.084 ± 0.236
0.834HisSer: 0.834 ± 0.257
1.084HisThr: 1.084 ± 0.353
1.501HisVal: 1.501 ± 0.332
0.083HisTrp: 0.083 ± 0.081
0.667HisTyr: 0.667 ± 0.337
0.0HisXaa: 0.0 ± 0.0
Ile
5.336IleAla: 5.336 ± 0.647
0.417IleCys: 0.417 ± 0.226
3.918IleAsp: 3.918 ± 0.423
3.335IleGlu: 3.335 ± 0.544
0.834IlePhe: 0.834 ± 0.289
4.502IleGly: 4.502 ± 0.636
0.75IleHis: 0.75 ± 0.25
1.417IleIle: 1.417 ± 0.482
1.501IleLys: 1.501 ± 0.385
2.418IleLeu: 2.418 ± 0.518
0.834IleMet: 0.834 ± 0.244
1.584IleAsn: 1.584 ± 0.423
2.168IlePro: 2.168 ± 0.529
1.917IleGln: 1.917 ± 0.412
2.918IleArg: 2.918 ± 0.435
2.334IleSer: 2.334 ± 0.471
2.418IleThr: 2.418 ± 0.407
3.335IleVal: 3.335 ± 0.555
0.417IleTrp: 0.417 ± 0.178
0.584IleTyr: 0.584 ± 0.172
0.0IleXaa: 0.0 ± 0.0
Lys
4.168LysAla: 4.168 ± 0.713
0.167LysCys: 0.167 ± 0.126
1.917LysAsp: 1.917 ± 0.437
1.417LysGlu: 1.417 ± 0.25
1.084LysPhe: 1.084 ± 0.284
2.334LysGly: 2.334 ± 0.443
0.584LysHis: 0.584 ± 0.189
1.751LysIle: 1.751 ± 0.487
1.334LysLys: 1.334 ± 0.383
3.168LysLeu: 3.168 ± 0.535
0.917LysMet: 0.917 ± 0.232
0.917LysAsn: 0.917 ± 0.257
1.667LysPro: 1.667 ± 0.368
1.084LysGln: 1.084 ± 0.271
3.251LysArg: 3.251 ± 0.577
3.835LysSer: 3.835 ± 0.56
3.168LysThr: 3.168 ± 0.357
2.251LysVal: 2.251 ± 0.447
0.5LysTrp: 0.5 ± 0.19
1.084LysTyr: 1.084 ± 0.359
0.0LysXaa: 0.0 ± 0.0
Leu
9.004LeuAla: 9.004 ± 0.856
0.75LeuCys: 0.75 ± 0.265
5.669LeuAsp: 5.669 ± 0.635
5.669LeuGlu: 5.669 ± 0.63
1.501LeuPhe: 1.501 ± 0.3
5.752LeuGly: 5.752 ± 1.03
1.584LeuHis: 1.584 ± 0.422
4.168LeuIle: 4.168 ± 0.53
3.835LeuLys: 3.835 ± 0.675
6.836LeuLeu: 6.836 ± 0.817
1.917LeuMet: 1.917 ± 0.411
2.501LeuAsn: 2.501 ± 0.364
4.835LeuPro: 4.835 ± 0.607
3.501LeuGln: 3.501 ± 0.374
7.753LeuArg: 7.753 ± 0.732
6.336LeuSer: 6.336 ± 0.774
5.336LeuThr: 5.336 ± 0.743
6.086LeuVal: 6.086 ± 0.728
1.167LeuTrp: 1.167 ± 0.309
1.667LeuTyr: 1.667 ± 0.42
0.0LeuXaa: 0.0 ± 0.0
Met
4.002MetAla: 4.002 ± 0.575
0.167MetCys: 0.167 ± 0.118
1.751MetAsp: 1.751 ± 0.416
1.0MetGlu: 1.0 ± 0.316
0.333MetPhe: 0.333 ± 0.169
1.0MetGly: 1.0 ± 0.252
0.834MetHis: 0.834 ± 0.273
0.917MetIle: 0.917 ± 0.29
1.417MetLys: 1.417 ± 0.323
3.418MetLeu: 3.418 ± 0.645
0.584MetMet: 0.584 ± 0.214
0.917MetAsn: 0.917 ± 0.271
1.334MetPro: 1.334 ± 0.368
1.084MetGln: 1.084 ± 0.422
2.001MetArg: 2.001 ± 0.368
2.668MetSer: 2.668 ± 0.449
1.751MetThr: 1.751 ± 0.352
1.667MetVal: 1.667 ± 0.39
0.167MetTrp: 0.167 ± 0.113
0.083MetTyr: 0.083 ± 0.076
0.0MetXaa: 0.0 ± 0.0
Asn
4.502AsnAla: 4.502 ± 0.64
0.167AsnCys: 0.167 ± 0.118
2.334AsnAsp: 2.334 ± 0.4
1.334AsnGlu: 1.334 ± 0.355
1.084AsnPhe: 1.084 ± 0.235
2.918AsnGly: 2.918 ± 0.578
0.667AsnHis: 0.667 ± 0.233
0.917AsnIle: 0.917 ± 0.328
0.917AsnLys: 0.917 ± 0.316
2.251AsnLeu: 2.251 ± 0.443
1.667AsnMet: 1.667 ± 0.449
1.501AsnAsn: 1.501 ± 0.28
2.418AsnPro: 2.418 ± 0.377
1.501AsnGln: 1.501 ± 0.353
2.001AsnArg: 2.001 ± 0.339
1.584AsnSer: 1.584 ± 0.346
1.167AsnThr: 1.167 ± 0.206
2.501AsnVal: 2.501 ± 0.398
0.667AsnTrp: 0.667 ± 0.25
1.084AsnTyr: 1.084 ± 0.318
0.0AsnXaa: 0.0 ± 0.0
Pro
6.169ProAla: 6.169 ± 0.703
0.333ProCys: 0.333 ± 0.13
3.418ProAsp: 3.418 ± 0.568
2.584ProGlu: 2.584 ± 0.366
1.667ProPhe: 1.667 ± 0.367
3.501ProGly: 3.501 ± 0.643
0.917ProHis: 0.917 ± 0.252
1.501ProIle: 1.501 ± 0.314
1.251ProLys: 1.251 ± 0.31
3.501ProLeu: 3.501 ± 0.458
0.417ProMet: 0.417 ± 0.175
1.334ProAsn: 1.334 ± 0.404
2.001ProPro: 2.001 ± 0.482
2.334ProGln: 2.334 ± 0.424
3.001ProArg: 3.001 ± 0.48
2.584ProSer: 2.584 ± 0.469
2.668ProThr: 2.668 ± 0.491
5.252ProVal: 5.252 ± 0.651
0.584ProTrp: 0.584 ± 0.197
1.084ProTyr: 1.084 ± 0.334
0.0ProXaa: 0.0 ± 0.0
Gln
5.752GlnAla: 5.752 ± 0.878
0.333GlnCys: 0.333 ± 0.164
2.251GlnAsp: 2.251 ± 0.447
1.917GlnGlu: 1.917 ± 0.418
1.751GlnPhe: 1.751 ± 0.479
2.084GlnGly: 2.084 ± 0.383
0.917GlnHis: 0.917 ± 0.261
2.584GlnIle: 2.584 ± 0.474
1.334GlnLys: 1.334 ± 0.417
3.585GlnLeu: 3.585 ± 0.552
0.75GlnMet: 0.75 ± 0.209
1.084GlnAsn: 1.084 ± 0.302
1.584GlnPro: 1.584 ± 0.438
2.001GlnGln: 2.001 ± 0.363
3.668GlnArg: 3.668 ± 0.454
2.584GlnSer: 2.584 ± 0.409
2.584GlnThr: 2.584 ± 0.435
3.418GlnVal: 3.418 ± 0.533
0.917GlnTrp: 0.917 ± 0.267
1.084GlnTyr: 1.084 ± 0.336
0.0GlnXaa: 0.0 ± 0.0
Arg
9.337ArgAla: 9.337 ± 0.791
0.75ArgCys: 0.75 ± 0.284
5.419ArgAsp: 5.419 ± 0.609
3.835ArgGlu: 3.835 ± 0.524
2.501ArgPhe: 2.501 ± 0.414
4.669ArgGly: 4.669 ± 0.615
1.417ArgHis: 1.417 ± 0.363
3.168ArgIle: 3.168 ± 0.534
2.334ArgLys: 2.334 ± 0.393
7.586ArgLeu: 7.586 ± 0.698
3.251ArgMet: 3.251 ± 0.558
2.584ArgAsn: 2.584 ± 0.436
2.584ArgPro: 2.584 ± 0.485
2.001ArgGln: 2.001 ± 0.414
4.919ArgArg: 4.919 ± 0.686
3.918ArgSer: 3.918 ± 0.597
3.835ArgThr: 3.835 ± 0.651
6.336ArgVal: 6.336 ± 0.712
1.251ArgTrp: 1.251 ± 0.344
1.917ArgTyr: 1.917 ± 0.306
0.0ArgXaa: 0.0 ± 0.0
Ser
7.17SerAla: 7.17 ± 0.76
0.584SerCys: 0.584 ± 0.203
3.668SerAsp: 3.668 ± 0.468
3.001SerGlu: 3.001 ± 0.408
1.334SerPhe: 1.334 ± 0.344
5.836SerGly: 5.836 ± 0.5
1.0SerHis: 1.0 ± 0.266
3.001SerIle: 3.001 ± 0.429
2.001SerLys: 2.001 ± 0.323
4.252SerLeu: 4.252 ± 0.656
2.418SerMet: 2.418 ± 0.422
1.834SerAsn: 1.834 ± 0.316
2.835SerPro: 2.835 ± 0.578
2.334SerGln: 2.334 ± 0.352
4.252SerArg: 4.252 ± 0.577
2.918SerSer: 2.918 ± 0.591
2.501SerThr: 2.501 ± 0.412
4.252SerVal: 4.252 ± 0.515
1.334SerTrp: 1.334 ± 0.356
1.667SerTyr: 1.667 ± 0.364
0.0SerXaa: 0.0 ± 0.0
Thr
6.586ThrAla: 6.586 ± 1.009
0.667ThrCys: 0.667 ± 0.26
4.335ThrAsp: 4.335 ± 0.46
2.835ThrGlu: 2.835 ± 0.506
1.501ThrPhe: 1.501 ± 0.324
5.085ThrGly: 5.085 ± 0.56
0.667ThrHis: 0.667 ± 0.228
3.168ThrIle: 3.168 ± 0.582
2.168ThrLys: 2.168 ± 0.442
4.168ThrLeu: 4.168 ± 0.562
1.084ThrMet: 1.084 ± 0.309
2.334ThrAsn: 2.334 ± 0.52
3.418ThrPro: 3.418 ± 0.5
1.834ThrGln: 1.834 ± 0.356
3.251ThrArg: 3.251 ± 0.407
3.168ThrSer: 3.168 ± 0.561
3.918ThrThr: 3.918 ± 0.537
5.085ThrVal: 5.085 ± 0.544
0.584ThrTrp: 0.584 ± 0.193
1.834ThrTyr: 1.834 ± 0.411
0.0ThrXaa: 0.0 ± 0.0
Val
8.837ValAla: 8.837 ± 0.787
0.834ValCys: 0.834 ± 0.238
4.835ValAsp: 4.835 ± 0.632
4.585ValGlu: 4.585 ± 0.586
1.917ValPhe: 1.917 ± 0.385
6.419ValGly: 6.419 ± 0.859
1.0ValHis: 1.0 ± 0.316
3.418ValIle: 3.418 ± 0.456
2.668ValLys: 2.668 ± 0.44
7.503ValLeu: 7.503 ± 0.618
1.417ValMet: 1.417 ± 0.36
2.584ValAsn: 2.584 ± 0.567
4.419ValPro: 4.419 ± 0.453
2.584ValGln: 2.584 ± 0.591
5.919ValArg: 5.919 ± 0.663
4.252ValSer: 4.252 ± 0.436
4.585ValThr: 4.585 ± 0.682
5.836ValVal: 5.836 ± 0.703
0.917ValTrp: 0.917 ± 0.314
1.584ValTyr: 1.584 ± 0.293
0.0ValXaa: 0.0 ± 0.0
Trp
1.667TrpAla: 1.667 ± 0.337
0.333TrpCys: 0.333 ± 0.149
0.834TrpAsp: 0.834 ± 0.267
1.334TrpGlu: 1.334 ± 0.329
0.5TrpPhe: 0.5 ± 0.18
1.084TrpGly: 1.084 ± 0.281
0.25TrpHis: 0.25 ± 0.163
0.584TrpIle: 0.584 ± 0.211
0.5TrpLys: 0.5 ± 0.178
2.418TrpLeu: 2.418 ± 0.457
0.5TrpMet: 0.5 ± 0.179
0.834TrpAsn: 0.834 ± 0.249
0.75TrpPro: 0.75 ± 0.309
0.917TrpGln: 0.917 ± 0.245
1.417TrpArg: 1.417 ± 0.383
0.75TrpSer: 0.75 ± 0.281
0.5TrpThr: 0.5 ± 0.18
0.75TrpVal: 0.75 ± 0.236
0.083TrpTrp: 0.083 ± 0.073
0.083TrpTyr: 0.083 ± 0.069
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.835TyrAla: 2.835 ± 0.391
0.417TyrCys: 0.417 ± 0.165
1.417TyrAsp: 1.417 ± 0.341
1.251TyrGlu: 1.251 ± 0.366
0.75TyrPhe: 0.75 ± 0.26
2.501TyrGly: 2.501 ± 0.422
0.083TyrHis: 0.083 ± 0.081
0.333TyrIle: 0.333 ± 0.149
1.084TyrLys: 1.084 ± 0.279
2.001TyrLeu: 2.001 ± 0.392
0.667TyrMet: 0.667 ± 0.199
0.667TyrAsn: 0.667 ± 0.265
1.501TyrPro: 1.501 ± 0.493
1.167TyrGln: 1.167 ± 0.307
2.584TyrArg: 2.584 ± 0.56
0.667TyrSer: 0.667 ± 0.242
1.334TyrThr: 1.334 ± 0.35
2.418TyrVal: 2.418 ± 0.34
0.333TyrTrp: 0.333 ± 0.159
0.584TyrTyr: 0.584 ± 0.207
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 49 proteins (11996 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski