Amino acid dipepetide frequency for Pediococcus stilesii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.57AlaAla: 5.57 ± 0.153
0.27AlaCys: 0.27 ± 0.023
4.033AlaAsp: 4.033 ± 0.089
4.352AlaGlu: 4.352 ± 0.113
3.074AlaPhe: 3.074 ± 0.081
5.373AlaGly: 5.373 ± 0.121
1.287AlaHis: 1.287 ± 0.049
6.049AlaIle: 6.049 ± 0.12
5.206AlaLys: 5.206 ± 0.122
7.076AlaLeu: 7.076 ± 0.136
2.042AlaMet: 2.042 ± 0.064
3.277AlaAsn: 3.277 ± 0.074
2.096AlaPro: 2.096 ± 0.072
2.73AlaGln: 2.73 ± 0.085
2.606AlaArg: 2.606 ± 0.072
4.105AlaSer: 4.105 ± 0.084
4.225AlaThr: 4.225 ± 0.098
5.077AlaVal: 5.077 ± 0.11
0.568AlaTrp: 0.568 ± 0.032
2.158AlaTyr: 2.158 ± 0.068
0.0AlaXaa: 0.0 ± 0.0
Cys
0.255CysAla: 0.255 ± 0.023
0.045CysCys: 0.045 ± 0.01
0.219CysAsp: 0.219 ± 0.02
0.178CysGlu: 0.178 ± 0.019
0.15CysPhe: 0.15 ± 0.017
0.414CysGly: 0.414 ± 0.032
0.09CysHis: 0.09 ± 0.013
0.236CysIle: 0.236 ± 0.022
0.144CysLys: 0.144 ± 0.019
0.408CysLeu: 0.408 ± 0.031
0.088CysMet: 0.088 ± 0.013
0.157CysAsn: 0.157 ± 0.017
0.172CysPro: 0.172 ± 0.019
0.146CysGln: 0.146 ± 0.017
0.139CysArg: 0.139 ± 0.015
0.223CysSer: 0.223 ± 0.021
0.184CysThr: 0.184 ± 0.019
0.225CysVal: 0.225 ± 0.02
0.049CysTrp: 0.049 ± 0.008
0.122CysTyr: 0.122 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
4.125AspAla: 4.125 ± 0.097
0.165AspCys: 0.165 ± 0.02
3.642AspAsp: 3.642 ± 0.105
4.474AspGlu: 4.474 ± 0.114
2.834AspPhe: 2.834 ± 0.079
4.099AspGly: 4.099 ± 0.097
1.332AspHis: 1.332 ± 0.052
4.062AspIle: 4.062 ± 0.081
3.293AspLys: 3.293 ± 0.093
5.637AspLeu: 5.637 ± 0.105
1.39AspMet: 1.39 ± 0.055
2.606AspAsn: 2.606 ± 0.062
2.154AspPro: 2.154 ± 0.077
3.438AspGln: 3.438 ± 0.091
2.565AspArg: 2.565 ± 0.073
3.305AspSer: 3.305 ± 0.082
2.81AspThr: 2.81 ± 0.067
4.322AspVal: 4.322 ± 0.104
0.673AspTrp: 0.673 ± 0.038
2.372AspTyr: 2.372 ± 0.072
0.0AspXaa: 0.0 ± 0.0
Glu
4.118GluAla: 4.118 ± 0.117
0.185GluCys: 0.185 ± 0.021
3.436GluAsp: 3.436 ± 0.092
4.38GluGlu: 4.38 ± 0.113
2.505GluPhe: 2.505 ± 0.07
3.127GluGly: 3.127 ± 0.085
1.227GluHis: 1.227 ± 0.048
4.905GluIle: 4.905 ± 0.117
5.034GluLys: 5.034 ± 0.124
6.401GluLeu: 6.401 ± 0.121
1.92GluMet: 1.92 ± 0.06
3.608GluAsn: 3.608 ± 0.087
1.602GluPro: 1.602 ± 0.059
2.814GluGln: 2.814 ± 0.084
2.825GluArg: 2.825 ± 0.08
3.14GluSer: 3.14 ± 0.083
3.129GluThr: 3.129 ± 0.077
4.206GluVal: 4.206 ± 0.101
0.588GluTrp: 0.588 ± 0.032
2.042GluTyr: 2.042 ± 0.064
0.0GluXaa: 0.0 ± 0.0
Phe
2.909PheAla: 2.909 ± 0.084
0.197PheCys: 0.197 ± 0.02
3.05PheAsp: 3.05 ± 0.071
2.688PheGlu: 2.688 ± 0.076
2.192PhePhe: 2.192 ± 0.073
3.29PheGly: 3.29 ± 0.081
0.721PheHis: 0.721 ± 0.032
3.464PheIle: 3.464 ± 0.085
3.018PheLys: 3.018 ± 0.079
4.178PheLeu: 4.178 ± 0.092
1.132PheMet: 1.132 ± 0.043
2.617PheAsn: 2.617 ± 0.073
1.495PhePro: 1.495 ± 0.048
1.435PheGln: 1.435 ± 0.056
1.441PheArg: 1.441 ± 0.049
3.217PheSer: 3.217 ± 0.092
2.432PheThr: 2.432 ± 0.067
3.072PheVal: 3.072 ± 0.081
0.519PheTrp: 0.519 ± 0.035
1.609PheTyr: 1.609 ± 0.049
0.0PheXaa: 0.0 ± 0.0
Gly
4.714GlyAla: 4.714 ± 0.106
0.315GlyCys: 0.315 ± 0.024
3.408GlyAsp: 3.408 ± 0.089
3.535GlyGlu: 3.535 ± 0.088
3.123GlyPhe: 3.123 ± 0.085
4.558GlyGly: 4.558 ± 0.12
1.281GlyHis: 1.281 ± 0.055
6.199GlyIle: 6.199 ± 0.128
4.824GlyLys: 4.824 ± 0.108
6.523GlyLeu: 6.523 ± 0.118
2.239GlyMet: 2.239 ± 0.072
3.007GlyAsn: 3.007 ± 0.078
1.576GlyPro: 1.576 ± 0.059
2.568GlyGln: 2.568 ± 0.076
2.748GlyArg: 2.748 ± 0.077
4.38GlySer: 4.38 ± 0.101
4.168GlyThr: 4.168 ± 0.094
5.135GlyVal: 5.135 ± 0.103
0.691GlyTrp: 0.691 ± 0.039
2.638GlyTyr: 2.638 ± 0.074
0.0GlyXaa: 0.0 ± 0.0
His
1.246HisAla: 1.246 ± 0.041
0.084HisCys: 0.084 ± 0.012
1.102HisAsp: 1.102 ± 0.049
1.132HisGlu: 1.132 ± 0.051
1.025HisPhe: 1.025 ± 0.04
1.383HisGly: 1.383 ± 0.047
0.566HisHis: 0.566 ± 0.033
1.238HisIle: 1.238 ± 0.052
0.875HisLys: 0.875 ± 0.039
1.821HisLeu: 1.821 ± 0.059
0.437HisMet: 0.437 ± 0.026
0.824HisAsn: 0.824 ± 0.036
1.029HisPro: 1.029 ± 0.047
1.004HisGln: 1.004 ± 0.041
0.851HisArg: 0.851 ± 0.04
1.055HisSer: 1.055 ± 0.045
0.772HisThr: 0.772 ± 0.037
1.255HisVal: 1.255 ± 0.047
0.204HisTrp: 0.204 ± 0.019
0.736HisTyr: 0.736 ± 0.038
0.0HisXaa: 0.0 ± 0.0
Ile
6.154IleAla: 6.154 ± 0.134
0.42IleCys: 0.42 ± 0.028
5.15IleAsp: 5.15 ± 0.111
4.8IleGlu: 4.8 ± 0.097
3.659IlePhe: 3.659 ± 0.107
5.907IleGly: 5.907 ± 0.129
1.328IleHis: 1.328 ± 0.059
6.238IleIle: 6.238 ± 0.133
5.35IleLys: 5.35 ± 0.112
7.411IleLeu: 7.411 ± 0.137
1.96IleMet: 1.96 ± 0.075
4.29IleAsn: 4.29 ± 0.104
3.035IlePro: 3.035 ± 0.074
2.984IleGln: 2.984 ± 0.084
2.992IleArg: 2.992 ± 0.087
5.283IleSer: 5.283 ± 0.109
4.515IleThr: 4.515 ± 0.099
5.538IleVal: 5.538 ± 0.116
0.701IleTrp: 0.701 ± 0.035
2.336IleTyr: 2.336 ± 0.069
0.0IleXaa: 0.0 ± 0.0
Lys
4.545LysAla: 4.545 ± 0.106
0.139LysCys: 0.139 ± 0.017
4.067LysAsp: 4.067 ± 0.103
4.53LysGlu: 4.53 ± 0.105
2.428LysPhe: 2.428 ± 0.062
3.546LysGly: 3.546 ± 0.098
1.111LysHis: 1.111 ± 0.049
5.753LysIle: 5.753 ± 0.098
6.059LysLys: 6.059 ± 0.138
6.04LysLeu: 6.04 ± 0.107
2.612LysMet: 2.612 ± 0.064
4.474LysAsn: 4.474 ± 0.107
1.993LysPro: 1.993 ± 0.058
3.08LysGln: 3.08 ± 0.091
3.121LysArg: 3.121 ± 0.073
4.039LysSer: 4.039 ± 0.087
4.039LysThr: 4.039 ± 0.091
4.725LysVal: 4.725 ± 0.106
0.609LysTrp: 0.609 ± 0.034
2.6LysTyr: 2.6 ± 0.075
0.0LysXaa: 0.0 ± 0.0
Leu
7.02LeuAla: 7.02 ± 0.119
0.356LeuCys: 0.356 ± 0.028
5.498LeuAsp: 5.498 ± 0.115
5.261LeuGlu: 5.261 ± 0.114
4.196LeuPhe: 4.196 ± 0.102
6.46LeuGly: 6.46 ± 0.132
1.508LeuHis: 1.508 ± 0.052
7.986LeuIle: 7.986 ± 0.166
7.1LeuLys: 7.1 ± 0.116
8.625LeuLeu: 8.625 ± 0.17
2.593LeuMet: 2.593 ± 0.075
5.407LeuAsn: 5.407 ± 0.106
3.543LeuPro: 3.543 ± 0.075
3.376LeuGln: 3.376 ± 0.084
3.606LeuArg: 3.606 ± 0.096
6.651LeuSer: 6.651 ± 0.114
5.817LeuThr: 5.817 ± 0.106
6.52LeuVal: 6.52 ± 0.129
0.736LeuTrp: 0.736 ± 0.038
2.497LeuTyr: 2.497 ± 0.076
0.0LeuXaa: 0.0 ± 0.0
Met
2.316MetAla: 2.316 ± 0.072
0.09MetCys: 0.09 ± 0.014
1.645MetAsp: 1.645 ± 0.058
1.547MetGlu: 1.547 ± 0.053
1.117MetPhe: 1.117 ± 0.049
1.915MetGly: 1.915 ± 0.056
0.463MetHis: 0.463 ± 0.026
2.269MetIle: 2.269 ± 0.068
1.984MetLys: 1.984 ± 0.069
2.509MetLeu: 2.509 ± 0.073
0.907MetMet: 0.907 ± 0.043
1.694MetAsn: 1.694 ± 0.058
1.057MetPro: 1.057 ± 0.042
1.098MetGln: 1.098 ± 0.046
1.008MetArg: 1.008 ± 0.045
1.664MetSer: 1.664 ± 0.059
1.662MetThr: 1.662 ± 0.053
1.99MetVal: 1.99 ± 0.068
0.212MetTrp: 0.212 ± 0.019
0.723MetTyr: 0.723 ± 0.034
0.0MetXaa: 0.0 ± 0.0
Asn
3.73AsnAla: 3.73 ± 0.078
0.199AsnCys: 0.199 ± 0.022
3.196AsnAsp: 3.196 ± 0.083
3.419AsnGlu: 3.419 ± 0.076
2.415AsnPhe: 2.415 ± 0.065
3.942AsnGly: 3.942 ± 0.085
1.178AsnHis: 1.178 ± 0.041
3.717AsnIle: 3.717 ± 0.09
3.035AsnLys: 3.035 ± 0.088
4.8AsnLeu: 4.8 ± 0.098
1.265AsnMet: 1.265 ± 0.047
2.855AsnAsn: 2.855 ± 0.076
2.205AsnPro: 2.205 ± 0.067
2.848AsnGln: 2.848 ± 0.086
2.227AsnArg: 2.227 ± 0.075
3.204AsnSer: 3.204 ± 0.084
2.523AsnThr: 2.523 ± 0.073
3.625AsnVal: 3.625 ± 0.091
0.629AsnTrp: 0.629 ± 0.035
1.935AsnTyr: 1.935 ± 0.068
0.0AsnXaa: 0.0 ± 0.0
Pro
2.299ProAla: 2.299 ± 0.07
0.071ProCys: 0.071 ± 0.011
2.211ProAsp: 2.211 ± 0.068
2.776ProGlu: 2.776 ± 0.085
1.607ProPhe: 1.607 ± 0.058
2.029ProGly: 2.029 ± 0.068
0.654ProHis: 0.654 ± 0.037
2.816ProIle: 2.816 ± 0.086
2.179ProLys: 2.179 ± 0.068
3.007ProLeu: 3.007 ± 0.072
0.781ProMet: 0.781 ± 0.033
1.761ProAsn: 1.761 ± 0.056
0.558ProPro: 0.558 ± 0.034
1.332ProGln: 1.332 ± 0.047
1.088ProArg: 1.088 ± 0.038
2.076ProSer: 2.076 ± 0.064
2.143ProThr: 2.143 ± 0.063
2.636ProVal: 2.636 ± 0.069
0.287ProTrp: 0.287 ± 0.027
1.148ProTyr: 1.148 ± 0.049
0.0ProXaa: 0.0 ± 0.0
Gln
2.812GlnAla: 2.812 ± 0.077
0.082GlnCys: 0.082 ± 0.013
2.016GlnAsp: 2.016 ± 0.076
2.211GlnGlu: 2.211 ± 0.073
1.694GlnPhe: 1.694 ± 0.058
2.113GlnGly: 2.113 ± 0.065
0.789GlnHis: 0.789 ± 0.035
3.67GlnIle: 3.67 ± 0.087
3.458GlnLys: 3.458 ± 0.086
4.596GlnLeu: 4.596 ± 0.113
1.193GlnMet: 1.193 ± 0.044
2.439GlnAsn: 2.439 ± 0.077
1.293GlnPro: 1.293 ± 0.05
1.808GlnGln: 1.808 ± 0.08
1.946GlnArg: 1.946 ± 0.061
2.527GlnSer: 2.527 ± 0.067
2.349GlnThr: 2.349 ± 0.065
2.958GlnVal: 2.958 ± 0.077
0.386GlnTrp: 0.386 ± 0.028
1.398GlnTyr: 1.398 ± 0.051
0.0GlnXaa: 0.0 ± 0.0
Arg
2.523ArgAla: 2.523 ± 0.075
0.146ArgCys: 0.146 ± 0.016
2.271ArgAsp: 2.271 ± 0.068
2.552ArgGlu: 2.552 ± 0.073
1.918ArgPhe: 1.918 ± 0.063
2.419ArgGly: 2.419 ± 0.069
0.854ArgHis: 0.854 ± 0.041
3.144ArgIle: 3.144 ± 0.08
2.752ArgLys: 2.752 ± 0.075
3.807ArgLeu: 3.807 ± 0.093
1.25ArgMet: 1.25 ± 0.052
1.911ArgAsn: 1.911 ± 0.064
1.339ArgPro: 1.339 ± 0.056
1.963ArgGln: 1.963 ± 0.06
2.235ArgArg: 2.235 ± 0.071
2.334ArgSer: 2.334 ± 0.073
2.091ArgThr: 2.091 ± 0.064
2.763ArgVal: 2.763 ± 0.079
0.392ArgTrp: 0.392 ± 0.028
1.557ArgTyr: 1.557 ± 0.058
0.0ArgXaa: 0.0 ± 0.0
Ser
4.371SerAla: 4.371 ± 0.115
0.206SerCys: 0.206 ± 0.025
3.721SerAsp: 3.721 ± 0.084
3.82SerGlu: 3.82 ± 0.079
3.104SerPhe: 3.104 ± 0.073
4.577SerGly: 4.577 ± 0.1
1.103SerHis: 1.103 ± 0.046
4.835SerIle: 4.835 ± 0.098
4.573SerLys: 4.573 ± 0.103
5.347SerLeu: 5.347 ± 0.103
1.643SerMet: 1.643 ± 0.063
3.35SerAsn: 3.35 ± 0.086
1.791SerPro: 1.791 ± 0.066
2.426SerGln: 2.426 ± 0.065
2.441SerArg: 2.441 ± 0.071
4.549SerSer: 4.549 ± 0.171
3.586SerThr: 3.586 ± 0.091
4.378SerVal: 4.378 ± 0.09
0.596SerTrp: 0.596 ± 0.038
2.186SerTyr: 2.186 ± 0.069
0.0SerXaa: 0.0 ± 0.0
Thr
4.232ThrAla: 4.232 ± 0.098
0.178ThrCys: 0.178 ± 0.02
3.473ThrAsp: 3.473 ± 0.082
2.992ThrGlu: 2.992 ± 0.076
2.479ThrPhe: 2.479 ± 0.065
4.408ThrGly: 4.408 ± 0.093
0.995ThrHis: 0.995 ± 0.041
4.714ThrIle: 4.714 ± 0.096
3.627ThrLys: 3.627 ± 0.079
5.229ThrLeu: 5.229 ± 0.098
1.401ThrMet: 1.401 ± 0.05
2.928ThrAsn: 2.928 ± 0.08
2.379ThrPro: 2.379 ± 0.077
1.86ThrGln: 1.86 ± 0.061
1.892ThrArg: 1.892 ± 0.064
3.53ThrSer: 3.53 ± 0.088
3.543ThrThr: 3.543 ± 0.088
4.251ThrVal: 4.251 ± 0.101
0.562ThrTrp: 0.562 ± 0.032
1.808ThrTyr: 1.808 ± 0.062
0.0ThrXaa: 0.0 ± 0.0
Val
5.42ValAla: 5.42 ± 0.103
0.332ValCys: 0.332 ± 0.028
4.487ValAsp: 4.487 ± 0.107
4.354ValGlu: 4.354 ± 0.096
2.904ValPhe: 2.904 ± 0.093
5.03ValGly: 5.03 ± 0.104
1.154ValHis: 1.154 ± 0.051
5.695ValIle: 5.695 ± 0.117
4.616ValLys: 4.616 ± 0.097
6.551ValLeu: 6.551 ± 0.126
1.885ValMet: 1.885 ± 0.063
3.554ValAsn: 3.554 ± 0.082
2.608ValPro: 2.608 ± 0.067
2.587ValGln: 2.587 ± 0.082
2.54ValArg: 2.54 ± 0.082
4.772ValSer: 4.772 ± 0.106
4.292ValThr: 4.292 ± 0.078
5.474ValVal: 5.474 ± 0.111
0.581ValTrp: 0.581 ± 0.032
2.119ValTyr: 2.119 ± 0.054
0.0ValXaa: 0.0 ± 0.0
Trp
0.577TrpAla: 0.577 ± 0.033
0.034TrpCys: 0.034 ± 0.008
0.504TrpAsp: 0.504 ± 0.031
0.395TrpGlu: 0.395 ± 0.028
0.476TrpPhe: 0.476 ± 0.036
0.631TrpGly: 0.631 ± 0.04
0.255TrpHis: 0.255 ± 0.019
0.892TrpIle: 0.892 ± 0.043
0.573TrpLys: 0.573 ± 0.035
1.098TrpLeu: 1.098 ± 0.054
0.315TrpMet: 0.315 ± 0.025
0.599TrpAsn: 0.599 ± 0.034
0.272TrpPro: 0.272 ± 0.023
0.466TrpGln: 0.466 ± 0.03
0.375TrpArg: 0.375 ± 0.027
0.556TrpSer: 0.556 ± 0.035
0.5TrpThr: 0.5 ± 0.032
0.568TrpVal: 0.568 ± 0.033
0.12TrpTrp: 0.12 ± 0.016
0.296TrpTyr: 0.296 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.239TyrAla: 2.239 ± 0.061
0.131TyrCys: 0.131 ± 0.017
2.169TyrAsp: 2.169 ± 0.062
1.797TyrGlu: 1.797 ± 0.066
1.776TyrPhe: 1.776 ± 0.068
2.411TyrGly: 2.411 ± 0.062
0.74TyrHis: 0.74 ± 0.04
2.169TyrIle: 2.169 ± 0.073
1.808TyrLys: 1.808 ± 0.065
3.693TyrLeu: 3.693 ± 0.093
0.813TyrMet: 0.813 ± 0.046
1.591TyrAsn: 1.591 ± 0.055
1.263TyrPro: 1.263 ± 0.056
1.774TyrGln: 1.774 ± 0.058
1.574TyrArg: 1.574 ± 0.058
1.995TyrSer: 1.995 ± 0.069
1.701TyrThr: 1.701 ± 0.056
2.237TyrVal: 2.237 ± 0.053
0.401TyrTrp: 0.401 ± 0.028
1.386TyrTyr: 1.386 ± 0.062
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1784 proteins (533784 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski