Amino acid dipepetide frequency for Acinetobacter phage vB_AbaM_Acibel004

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.068AlaAla: 0.068 ± 0.049
0.576AlaCys: 0.576 ± 0.141
3.592AlaAsp: 3.592 ± 0.443
3.728AlaGlu: 3.728 ± 0.375
3.016AlaPhe: 3.016 ± 0.373
3.524AlaGly: 3.524 ± 0.519
0.949AlaHis: 0.949 ± 0.156
4.676AlaIle: 4.676 ± 0.375
5.998AlaLys: 5.998 ± 0.414
5.93AlaLeu: 5.93 ± 0.534
2.169AlaMet: 2.169 ± 0.338
2.88AlaAsn: 2.88 ± 0.376
1.423AlaPro: 1.423 ± 0.238
2.338AlaGln: 2.338 ± 0.383
2.27AlaArg: 2.27 ± 0.252
4.371AlaSer: 4.371 ± 0.631
4.202AlaThr: 4.202 ± 0.417
4.575AlaVal: 4.575 ± 0.495
0.847AlaTrp: 0.847 ± 0.16
2.44AlaTyr: 2.44 ± 0.368
0.0AlaXaa: 0.0 ± 0.0
Cys
0.881CysAla: 0.881 ± 0.167
0.237CysCys: 0.237 ± 0.094
0.644CysAsp: 0.644 ± 0.155
0.678CysGlu: 0.678 ± 0.146
0.712CysPhe: 0.712 ± 0.16
0.949CysGly: 0.949 ± 0.177
0.305CysHis: 0.305 ± 0.11
0.678CysIle: 0.678 ± 0.159
1.118CysLys: 1.118 ± 0.186
0.678CysLeu: 0.678 ± 0.174
0.203CysMet: 0.203 ± 0.08
0.576CysAsn: 0.576 ± 0.171
0.441CysPro: 0.441 ± 0.142
0.339CysGln: 0.339 ± 0.105
0.712CysArg: 0.712 ± 0.175
0.779CysSer: 0.779 ± 0.164
0.847CysThr: 0.847 ± 0.178
1.05CysVal: 1.05 ± 0.215
0.136CysTrp: 0.136 ± 0.061
0.712CysTyr: 0.712 ± 0.17
0.0CysXaa: 0.0 ± 0.0
Asp
4.609AspAla: 4.609 ± 0.445
0.881AspCys: 0.881 ± 0.158
3.999AspAsp: 3.999 ± 0.383
4.778AspGlu: 4.778 ± 0.513
3.863AspPhe: 3.863 ± 0.383
4.846AspGly: 4.846 ± 0.422
1.152AspHis: 1.152 ± 0.217
3.931AspIle: 3.931 ± 0.391
5.49AspLys: 5.49 ± 0.481
6.472AspLeu: 6.472 ± 0.608
1.999AspMet: 1.999 ± 0.273
2.779AspAsn: 2.779 ± 0.325
2.135AspPro: 2.135 ± 0.366
1.898AspGln: 1.898 ± 0.242
2.643AspArg: 2.643 ± 0.375
3.965AspSer: 3.965 ± 0.41
3.084AspThr: 3.084 ± 0.259
4.744AspVal: 4.744 ± 0.432
1.152AspTrp: 1.152 ± 0.208
2.237AspTyr: 2.237 ± 0.286
0.0AspXaa: 0.0 ± 0.0
Glu
4.914GluAla: 4.914 ± 0.471
0.983GluCys: 0.983 ± 0.214
5.456GluAsp: 5.456 ± 0.549
5.422GluGlu: 5.422 ± 0.504
2.846GluPhe: 2.846 ± 0.357
3.863GluGly: 3.863 ± 0.329
1.355GluHis: 1.355 ± 0.22
4.88GluIle: 4.88 ± 0.435
4.88GluLys: 4.88 ± 0.418
6.337GluLeu: 6.337 ± 0.419
2.237GluMet: 2.237 ± 0.308
3.965GluAsn: 3.965 ± 0.327
1.83GluPro: 1.83 ± 0.306
2.542GluGln: 2.542 ± 0.283
2.304GluArg: 2.304 ± 0.247
3.592GluSer: 3.592 ± 0.292
3.118GluThr: 3.118 ± 0.335
5.049GluVal: 5.049 ± 0.335
1.186GluTrp: 1.186 ± 0.218
3.558GluTyr: 3.558 ± 0.366
0.0GluXaa: 0.0 ± 0.0
Phe
2.711PheAla: 2.711 ± 0.31
0.712PheCys: 0.712 ± 0.151
3.456PheAsp: 3.456 ± 0.389
3.728PheGlu: 3.728 ± 0.365
1.559PhePhe: 1.559 ± 0.295
2.914PheGly: 2.914 ± 0.332
0.983PheHis: 0.983 ± 0.23
2.813PheIle: 2.813 ± 0.36
4.236PheLys: 4.236 ± 0.384
3.151PheLeu: 3.151 ± 0.341
1.525PheMet: 1.525 ± 0.249
3.016PheAsn: 3.016 ± 0.305
1.593PhePro: 1.593 ± 0.215
1.355PheGln: 1.355 ± 0.22
1.389PheArg: 1.389 ± 0.229
3.219PheSer: 3.219 ± 0.349
3.185PheThr: 3.185 ± 0.355
2.44PheVal: 2.44 ± 0.288
0.305PheTrp: 0.305 ± 0.106
1.728PheTyr: 1.728 ± 0.259
0.0PheXaa: 0.0 ± 0.0
Gly
3.728GlyAla: 3.728 ± 0.42
0.678GlyCys: 0.678 ± 0.151
4.236GlyAsp: 4.236 ± 0.381
4.338GlyGlu: 4.338 ± 0.413
3.423GlyPhe: 3.423 ± 0.349
4.846GlyGly: 4.846 ± 0.424
1.017GlyHis: 1.017 ± 0.266
4.541GlyIle: 4.541 ± 0.446
5.354GlyLys: 5.354 ± 0.637
5.49GlyLeu: 5.49 ± 0.486
1.864GlyMet: 1.864 ± 0.231
3.456GlyAsn: 3.456 ± 0.376
0.034GlyPro: 0.034 ± 0.032
2.27GlyGln: 2.27 ± 0.387
3.05GlyArg: 3.05 ± 0.317
4.778GlySer: 4.778 ± 0.401
4.27GlyThr: 4.27 ± 0.441
5.524GlyVal: 5.524 ± 0.485
0.915GlyTrp: 0.915 ± 0.166
2.914GlyTyr: 2.914 ± 0.389
0.0GlyXaa: 0.0 ± 0.0
His
0.813HisAla: 0.813 ± 0.195
0.271HisCys: 0.271 ± 0.111
1.017HisAsp: 1.017 ± 0.202
1.322HisGlu: 1.322 ± 0.205
0.983HisPhe: 0.983 ± 0.179
1.355HisGly: 1.355 ± 0.212
0.271HisHis: 0.271 ± 0.095
1.152HisIle: 1.152 ± 0.22
1.355HisLys: 1.355 ± 0.212
1.694HisLeu: 1.694 ± 0.309
0.271HisMet: 0.271 ± 0.097
0.949HisAsn: 0.949 ± 0.209
0.779HisPro: 0.779 ± 0.162
0.441HisGln: 0.441 ± 0.126
1.152HisArg: 1.152 ± 0.206
1.22HisSer: 1.22 ± 0.196
1.186HisThr: 1.186 ± 0.204
1.22HisVal: 1.22 ± 0.171
0.237HisTrp: 0.237 ± 0.084
0.508HisTyr: 0.508 ± 0.133
0.0HisXaa: 0.0 ± 0.0
Ile
3.66IleAla: 3.66 ± 0.405
0.712IleCys: 0.712 ± 0.158
4.812IleAsp: 4.812 ± 0.355
4.914IleGlu: 4.914 ± 0.429
2.203IlePhe: 2.203 ± 0.261
3.761IleGly: 3.761 ± 0.321
1.186IleHis: 1.186 ± 0.195
3.728IleIle: 3.728 ± 0.421
6.303IleLys: 6.303 ± 0.31
4.88IleLeu: 4.88 ± 0.566
1.898IleMet: 1.898 ± 0.241
3.66IleAsn: 3.66 ± 0.309
2.338IlePro: 2.338 ± 0.277
2.237IleGln: 2.237 ± 0.278
2.474IleArg: 2.474 ± 0.25
4.27IleSer: 4.27 ± 0.339
4.304IleThr: 4.304 ± 0.474
4.405IleVal: 4.405 ± 0.408
0.474IleTrp: 0.474 ± 0.127
2.135IleTyr: 2.135 ± 0.34
0.0IleXaa: 0.0 ± 0.0
Lys
6.777LysAla: 6.777 ± 0.94
0.847LysCys: 0.847 ± 0.191
5.286LysAsp: 5.286 ± 0.408
5.727LysGlu: 5.727 ± 0.445
4.033LysPhe: 4.033 ± 0.392
5.32LysGly: 5.32 ± 0.482
1.525LysHis: 1.525 ± 0.216
4.981LysIle: 4.981 ± 0.365
6.472LysLys: 6.472 ± 0.535
6.472LysLeu: 6.472 ± 0.473
2.406LysMet: 2.406 ± 0.291
3.626LysAsn: 3.626 ± 0.335
2.542LysPro: 2.542 ± 0.362
3.287LysGln: 3.287 ± 0.336
3.456LysArg: 3.456 ± 0.339
5.117LysSer: 5.117 ± 0.34
4.744LysThr: 4.744 ± 0.511
8.201LysVal: 8.201 ± 0.52
0.712LysTrp: 0.712 ± 0.133
2.88LysTyr: 2.88 ± 0.281
0.0LysXaa: 0.0 ± 0.0
Leu
5.049LeuAla: 5.049 ± 0.499
1.288LeuCys: 1.288 ± 0.271
5.286LeuAsp: 5.286 ± 0.381
6.777LeuGlu: 6.777 ± 0.499
3.456LeuPhe: 3.456 ± 0.417
5.557LeuGly: 5.557 ± 0.457
1.288LeuHis: 1.288 ± 0.235
5.219LeuIle: 5.219 ± 0.474
7.184LeuLys: 7.184 ± 0.531
6.066LeuLeu: 6.066 ± 0.447
1.728LeuMet: 1.728 ± 0.301
5.185LeuAsn: 5.185 ± 0.411
2.135LeuPro: 2.135 ± 0.249
2.643LeuGln: 2.643 ± 0.274
3.219LeuArg: 3.219 ± 0.398
4.846LeuSer: 4.846 ± 0.368
5.388LeuThr: 5.388 ± 0.465
4.88LeuVal: 4.88 ± 0.43
0.915LeuTrp: 0.915 ± 0.195
3.05LeuTyr: 3.05 ± 0.329
0.0LeuXaa: 0.0 ± 0.0
Met
2.745MetAla: 2.745 ± 0.335
0.373MetCys: 0.373 ± 0.117
1.525MetAsp: 1.525 ± 0.22
1.559MetGlu: 1.559 ± 0.296
1.627MetPhe: 1.627 ± 0.224
1.389MetGly: 1.389 ± 0.254
0.271MetHis: 0.271 ± 0.104
1.864MetIle: 1.864 ± 0.265
2.745MetLys: 2.745 ± 0.299
2.067MetLeu: 2.067 ± 0.256
0.678MetMet: 0.678 ± 0.152
1.559MetAsn: 1.559 ± 0.248
0.61MetPro: 0.61 ± 0.157
0.576MetGln: 0.576 ± 0.146
0.915MetArg: 0.915 ± 0.205
2.406MetSer: 2.406 ± 0.284
1.322MetThr: 1.322 ± 0.199
1.559MetVal: 1.559 ± 0.229
0.271MetTrp: 0.271 ± 0.101
0.915MetTyr: 0.915 ± 0.157
0.0MetXaa: 0.0 ± 0.0
Asn
3.219AsnAla: 3.219 ± 0.306
0.644AsnCys: 0.644 ± 0.165
3.118AsnAsp: 3.118 ± 0.334
3.931AsnGlu: 3.931 ± 0.312
2.44AsnPhe: 2.44 ± 0.307
4.371AsnGly: 4.371 ± 0.332
0.847AsnHis: 0.847 ± 0.152
2.982AsnIle: 2.982 ± 0.357
4.168AsnLys: 4.168 ± 0.4
4.473AsnLeu: 4.473 ± 0.4
1.389AsnMet: 1.389 ± 0.196
2.474AsnAsn: 2.474 ± 0.296
1.83AsnPro: 1.83 ± 0.255
2.033AsnGln: 2.033 ± 0.243
2.406AsnArg: 2.406 ± 0.272
3.592AsnSer: 3.592 ± 0.5
2.948AsnThr: 2.948 ± 0.31
3.321AsnVal: 3.321 ± 0.378
0.813AsnTrp: 0.813 ± 0.173
1.864AsnTyr: 1.864 ± 0.255
0.0AsnXaa: 0.0 ± 0.0
Pro
1.491ProAla: 1.491 ± 0.195
0.339ProCys: 0.339 ± 0.097
2.101ProAsp: 2.101 ± 0.362
2.27ProGlu: 2.27 ± 0.287
0.915ProPhe: 0.915 ± 0.194
0.0ProGly: 0.0 ± 0.0
0.61ProHis: 0.61 ± 0.145
1.965ProIle: 1.965 ± 0.267
3.118ProLys: 3.118 ± 0.311
2.372ProLeu: 2.372 ± 0.245
0.678ProMet: 0.678 ± 0.153
1.66ProAsn: 1.66 ± 0.232
0.61ProPro: 0.61 ± 0.209
0.813ProGln: 0.813 ± 0.149
1.084ProArg: 1.084 ± 0.212
2.033ProSer: 2.033 ± 0.245
2.101ProThr: 2.101 ± 0.212
1.898ProVal: 1.898 ± 0.221
0.034ProTrp: 0.034 ± 0.03
1.017ProTyr: 1.017 ± 0.17
0.0ProXaa: 0.0 ± 0.0
Gln
2.338GlnAla: 2.338 ± 0.333
0.339GlnCys: 0.339 ± 0.116
1.355GlnAsp: 1.355 ± 0.201
2.27GlnGlu: 2.27 ± 0.261
1.525GlnPhe: 1.525 ± 0.274
3.321GlnGly: 3.321 ± 0.781
0.542GlnHis: 0.542 ± 0.129
2.542GlnIle: 2.542 ± 0.417
2.406GlnLys: 2.406 ± 0.339
2.813GlnLeu: 2.813 ± 0.311
1.152GlnMet: 1.152 ± 0.276
1.627GlnAsn: 1.627 ± 0.21
0.339GlnPro: 0.339 ± 0.102
1.254GlnGln: 1.254 ± 0.314
1.694GlnArg: 1.694 ± 0.245
1.491GlnSer: 1.491 ± 0.281
1.83GlnThr: 1.83 ± 0.293
2.779GlnVal: 2.779 ± 0.37
0.508GlnTrp: 0.508 ± 0.128
1.559GlnTyr: 1.559 ± 0.242
0.0GlnXaa: 0.0 ± 0.0
Arg
1.83ArgAla: 1.83 ± 0.246
0.542ArgCys: 0.542 ± 0.142
2.44ArgAsp: 2.44 ± 0.367
2.372ArgGlu: 2.372 ± 0.264
2.203ArgPhe: 2.203 ± 0.277
2.745ArgGly: 2.745 ± 0.327
1.118ArgHis: 1.118 ± 0.163
2.813ArgIle: 2.813 ± 0.34
3.761ArgLys: 3.761 ± 0.368
3.49ArgLeu: 3.49 ± 0.345
0.915ArgMet: 0.915 ± 0.162
2.542ArgAsn: 2.542 ± 0.258
1.05ArgPro: 1.05 ± 0.185
1.05ArgGln: 1.05 ± 0.185
1.965ArgArg: 1.965 ± 0.252
2.542ArgSer: 2.542 ± 0.311
1.965ArgThr: 1.965 ± 0.249
3.49ArgVal: 3.49 ± 0.393
0.474ArgTrp: 0.474 ± 0.1
1.355ArgTyr: 1.355 ± 0.246
0.0ArgXaa: 0.0 ± 0.0
Ser
3.355SerAla: 3.355 ± 0.541
0.915SerCys: 0.915 ± 0.164
3.795SerAsp: 3.795 ± 0.257
4.405SerGlu: 4.405 ± 0.377
3.05SerPhe: 3.05 ± 0.321
5.625SerGly: 5.625 ± 0.388
1.22SerHis: 1.22 ± 0.219
4.338SerIle: 4.338 ± 0.434
5.422SerLys: 5.422 ± 0.364
5.185SerLeu: 5.185 ± 0.457
1.525SerMet: 1.525 ± 0.262
3.287SerAsn: 3.287 ± 0.355
1.796SerPro: 1.796 ± 0.264
2.643SerGln: 2.643 ± 0.342
2.542SerArg: 2.542 ± 0.39
4.304SerSer: 4.304 ± 0.447
3.287SerThr: 3.287 ± 0.419
4.914SerVal: 4.914 ± 0.471
0.881SerTrp: 0.881 ± 0.176
2.033SerTyr: 2.033 ± 0.276
0.0SerXaa: 0.0 ± 0.0
Thr
4.507ThrAla: 4.507 ± 0.87
0.813ThrCys: 0.813 ± 0.182
3.999ThrAsp: 3.999 ± 0.319
3.694ThrGlu: 3.694 ± 0.402
2.677ThrPhe: 2.677 ± 0.273
4.202ThrGly: 4.202 ± 0.447
1.389ThrHis: 1.389 ± 0.215
3.423ThrIle: 3.423 ± 0.32
4.236ThrLys: 4.236 ± 0.49
4.778ThrLeu: 4.778 ± 0.384
1.457ThrMet: 1.457 ± 0.254
2.914ThrAsn: 2.914 ± 0.378
1.999ThrPro: 1.999 ± 0.269
2.033ThrGln: 2.033 ± 0.412
2.27ThrArg: 2.27 ± 0.298
3.626ThrSer: 3.626 ± 0.309
2.982ThrThr: 2.982 ± 0.422
4.439ThrVal: 4.439 ± 0.497
0.915ThrTrp: 0.915 ± 0.194
2.372ThrTyr: 2.372 ± 0.297
0.0ThrXaa: 0.0 ± 0.0
Val
4.473ValAla: 4.473 ± 0.375
0.949ValCys: 0.949 ± 0.183
6.134ValAsp: 6.134 ± 0.584
4.981ValGlu: 4.981 ± 0.44
3.456ValPhe: 3.456 ± 0.351
4.812ValGly: 4.812 ± 0.424
1.322ValHis: 1.322 ± 0.186
4.202ValIle: 4.202 ± 0.407
5.795ValLys: 5.795 ± 0.448
5.252ValLeu: 5.252 ± 0.451
1.694ValMet: 1.694 ± 0.272
3.897ValAsn: 3.897 ± 0.474
2.575ValPro: 2.575 ± 0.26
1.932ValGln: 1.932 ± 0.247
3.084ValArg: 3.084 ± 0.293
4.439ValSer: 4.439 ± 0.447
5.422ValThr: 5.422 ± 0.691
6.438ValVal: 6.438 ± 0.677
0.746ValTrp: 0.746 ± 0.147
2.948ValTyr: 2.948 ± 0.305
0.0ValXaa: 0.0 ± 0.0
Trp
0.644TrpAla: 0.644 ± 0.156
0.136TrpCys: 0.136 ± 0.071
1.423TrpAsp: 1.423 ± 0.253
0.983TrpGlu: 0.983 ± 0.197
0.61TrpPhe: 0.61 ± 0.134
0.474TrpGly: 0.474 ± 0.119
0.203TrpHis: 0.203 ± 0.115
0.949TrpIle: 0.949 ± 0.172
0.915TrpLys: 0.915 ± 0.213
0.779TrpLeu: 0.779 ± 0.194
0.373TrpMet: 0.373 ± 0.124
0.542TrpAsn: 0.542 ± 0.147
0.0TrpPro: 0.0 ± 0.0
0.407TrpGln: 0.407 ± 0.108
0.508TrpArg: 0.508 ± 0.126
1.152TrpSer: 1.152 ± 0.188
0.61TrpThr: 0.61 ± 0.149
1.017TrpVal: 1.017 ± 0.188
0.169TrpTrp: 0.169 ± 0.076
0.644TrpTyr: 0.644 ± 0.206
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.762TyrAla: 1.762 ± 0.307
0.441TyrCys: 0.441 ± 0.106
2.982TyrAsp: 2.982 ± 0.358
2.44TyrGlu: 2.44 ± 0.291
1.457TyrPhe: 1.457 ± 0.258
2.846TyrGly: 2.846 ± 0.282
0.644TyrHis: 0.644 ± 0.154
2.677TyrIle: 2.677 ± 0.358
3.456TyrLys: 3.456 ± 0.33
2.779TyrLeu: 2.779 ± 0.329
0.779TyrMet: 0.779 ± 0.162
2.27TyrAsn: 2.27 ± 0.321
1.05TyrPro: 1.05 ± 0.212
1.593TyrGln: 1.593 ± 0.258
1.525TyrArg: 1.525 ± 0.264
2.779TyrSer: 2.779 ± 0.387
1.932TyrThr: 1.932 ± 0.231
2.609TyrVal: 2.609 ± 0.31
0.847TyrTrp: 0.847 ± 0.19
1.423TyrTyr: 1.423 ± 0.267
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 156 proteins (29511 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski