Amino acid dipepetide frequency for Urbanus proteus nucleopolyhedrovirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.237AlaAla: 2.237 ± 0.31
0.95AlaCys: 0.95 ± 0.174
1.716AlaAsp: 1.716 ± 0.242
1.501AlaGlu: 1.501 ± 0.209
1.685AlaPhe: 1.685 ± 0.239
1.225AlaGly: 1.225 ± 0.181
1.44AlaHis: 1.44 ± 0.189
2.788AlaIle: 2.788 ± 0.269
3.309AlaLys: 3.309 ± 0.35
4.167AlaLeu: 4.167 ± 0.382
1.011AlaMet: 1.011 ± 0.179
3.799AlaAsn: 3.799 ± 0.394
1.808AlaPro: 1.808 ± 0.251
1.9AlaGln: 1.9 ± 0.282
1.624AlaArg: 1.624 ± 0.203
2.298AlaSer: 2.298 ± 0.298
2.328AlaThr: 2.328 ± 0.275
2.635AlaVal: 2.635 ± 0.251
0.429AlaTrp: 0.429 ± 0.126
1.624AlaTyr: 1.624 ± 0.245
0.0AlaXaa: 0.0 ± 0.0
Cys
1.379CysAla: 1.379 ± 0.203
0.766CysCys: 0.766 ± 0.182
2.42CysAsp: 2.42 ± 0.263
1.409CysGlu: 1.409 ± 0.237
0.98CysPhe: 0.98 ± 0.191
0.674CysGly: 0.674 ± 0.171
0.398CysHis: 0.398 ± 0.097
1.991CysIle: 1.991 ± 0.278
2.267CysLys: 2.267 ± 0.289
2.053CysLeu: 2.053 ± 0.243
0.46CysMet: 0.46 ± 0.105
2.298CysAsn: 2.298 ± 0.259
0.858CysPro: 0.858 ± 0.175
0.98CysGln: 0.98 ± 0.173
1.042CysArg: 1.042 ± 0.179
1.593CysSer: 1.593 ± 0.237
1.562CysThr: 1.562 ± 0.223
2.696CysVal: 2.696 ± 0.293
0.153CysTrp: 0.153 ± 0.058
1.072CysTyr: 1.072 ± 0.159
0.0CysXaa: 0.0 ± 0.0
Asp
2.788AspAla: 2.788 ± 0.328
1.379AspCys: 1.379 ± 0.195
4.412AspAsp: 4.412 ± 0.457
4.35AspGlu: 4.35 ± 0.362
2.512AspPhe: 2.512 ± 0.29
1.593AspGly: 1.593 ± 0.271
1.317AspHis: 1.317 ± 0.179
4.197AspIle: 4.197 ± 0.348
4.534AspLys: 4.534 ± 0.35
4.963AspLeu: 4.963 ± 0.383
1.409AspMet: 1.409 ± 0.247
4.657AspAsn: 4.657 ± 0.345
1.256AspPro: 1.256 ± 0.216
1.869AspGln: 1.869 ± 0.228
1.869AspArg: 1.869 ± 0.26
3.217AspSer: 3.217 ± 0.259
3.585AspThr: 3.585 ± 0.358
3.952AspVal: 3.952 ± 0.406
0.398AspTrp: 0.398 ± 0.12
3.922AspTyr: 3.922 ± 0.383
0.0AspXaa: 0.0 ± 0.0
Glu
1.9GluAla: 1.9 ± 0.25
1.716GluCys: 1.716 ± 0.26
2.482GluAsp: 2.482 ± 0.345
2.574GluGlu: 2.574 ± 0.322
2.543GluPhe: 2.543 ± 0.282
0.919GluGly: 0.919 ± 0.148
1.501GluHis: 1.501 ± 0.218
4.105GluIle: 4.105 ± 0.378
3.676GluLys: 3.676 ± 0.333
5.208GluLeu: 5.208 ± 0.442
1.746GluMet: 1.746 ± 0.234
4.779GluAsn: 4.779 ± 0.382
0.98GluPro: 0.98 ± 0.151
2.42GluGln: 2.42 ± 0.249
2.39GluArg: 2.39 ± 0.255
3.339GluSer: 3.339 ± 0.308
4.259GluThr: 4.259 ± 0.377
1.746GluVal: 1.746 ± 0.215
0.306GluTrp: 0.306 ± 0.095
2.941GluTyr: 2.941 ± 0.294
0.0GluXaa: 0.0 ± 0.0
Phe
2.114PheAla: 2.114 ± 0.221
1.379PheCys: 1.379 ± 0.218
4.718PheAsp: 4.718 ± 0.418
3.37PheGlu: 3.37 ± 0.289
2.083PhePhe: 2.083 ± 0.224
1.072PheGly: 1.072 ± 0.194
0.551PheHis: 0.551 ± 0.136
4.197PheIle: 4.197 ± 0.442
4.534PheLys: 4.534 ± 0.407
4.779PheLeu: 4.779 ± 0.328
1.195PheMet: 1.195 ± 0.196
5.392PheAsn: 5.392 ± 0.399
1.164PhePro: 1.164 ± 0.185
1.44PheGln: 1.44 ± 0.217
1.685PheArg: 1.685 ± 0.22
2.665PheSer: 2.665 ± 0.286
2.083PheThr: 2.083 ± 0.288
4.902PheVal: 4.902 ± 0.386
0.245PheTrp: 0.245 ± 0.084
3.002PheTyr: 3.002 ± 0.332
0.0PheXaa: 0.0 ± 0.0
Gly
1.103GlyAla: 1.103 ± 0.183
0.429GlyCys: 0.429 ± 0.122
2.053GlyAsp: 2.053 ± 0.26
1.379GlyGlu: 1.379 ± 0.22
1.471GlyPhe: 1.471 ± 0.266
1.256GlyGly: 1.256 ± 0.223
0.613GlyHis: 0.613 ± 0.11
1.256GlyIle: 1.256 ± 0.19
1.287GlyLys: 1.287 ± 0.25
1.9GlyLeu: 1.9 ± 0.237
0.705GlyMet: 0.705 ± 0.117
1.624GlyAsn: 1.624 ± 0.271
0.49GlyPro: 0.49 ± 0.145
1.011GlyGln: 1.011 ± 0.198
1.134GlyArg: 1.134 ± 0.193
1.287GlySer: 1.287 ± 0.194
1.593GlyThr: 1.593 ± 0.224
2.237GlyVal: 2.237 ± 0.231
0.184GlyTrp: 0.184 ± 0.062
1.256GlyTyr: 1.256 ± 0.173
0.0GlyXaa: 0.0 ± 0.0
His
0.98HisAla: 0.98 ± 0.191
0.674HisCys: 0.674 ± 0.132
1.9HisAsp: 1.9 ± 0.247
1.348HisGlu: 1.348 ± 0.224
1.072HisPhe: 1.072 ± 0.164
0.429HisGly: 0.429 ± 0.125
0.521HisHis: 0.521 ± 0.136
1.471HisIle: 1.471 ± 0.189
2.053HisLys: 2.053 ± 0.271
2.022HisLeu: 2.022 ± 0.224
0.766HisMet: 0.766 ± 0.135
2.665HisAsn: 2.665 ± 0.306
0.858HisPro: 0.858 ± 0.175
0.797HisGln: 0.797 ± 0.144
0.46HisArg: 0.46 ± 0.108
1.562HisSer: 1.562 ± 0.16
1.562HisThr: 1.562 ± 0.205
2.175HisVal: 2.175 ± 0.252
0.092HisTrp: 0.092 ± 0.051
1.409HisTyr: 1.409 ± 0.216
0.0HisXaa: 0.0 ± 0.0
Ile
3.278IleAla: 3.278 ± 0.296
1.838IleCys: 1.838 ± 0.252
5.423IleAsp: 5.423 ± 0.421
4.105IleGlu: 4.105 ± 0.393
3.86IlePhe: 3.86 ± 0.327
1.44IleGly: 1.44 ± 0.27
1.348IleHis: 1.348 ± 0.179
6.648IleIle: 6.648 ± 0.483
6.771IleLys: 6.771 ± 0.506
6.924IleLeu: 6.924 ± 0.433
1.593IleMet: 1.593 ± 0.246
8.854IleAsn: 8.854 ± 0.549
1.562IlePro: 1.562 ± 0.192
2.451IleGln: 2.451 ± 0.25
2.359IleArg: 2.359 ± 0.285
3.585IleSer: 3.585 ± 0.305
4.228IleThr: 4.228 ± 0.341
5.76IleVal: 5.76 ± 0.361
0.214IleTrp: 0.214 ± 0.085
3.523IleTyr: 3.523 ± 0.437
0.0IleXaa: 0.0 ± 0.0
Lys
2.114LysAla: 2.114 ± 0.312
2.482LysCys: 2.482 ± 0.268
2.911LysAsp: 2.911 ± 0.275
3.094LysGlu: 3.094 ± 0.321
4.841LysPhe: 4.841 ± 0.461
1.195LysGly: 1.195 ± 0.211
2.819LysHis: 2.819 ± 0.289
7.475LysIle: 7.475 ± 0.516
6.832LysLys: 6.832 ± 0.732
8.058LysLeu: 8.058 ± 0.568
2.451LysMet: 2.451 ± 0.254
8.333LysAsn: 8.333 ± 0.492
2.328LysPro: 2.328 ± 0.247
3.033LysGln: 3.033 ± 0.283
4.718LysArg: 4.718 ± 0.402
4.688LysSer: 4.688 ± 0.385
4.013LysThr: 4.013 ± 0.328
2.972LysVal: 2.972 ± 0.292
0.429LysTrp: 0.429 ± 0.108
4.197LysTyr: 4.197 ± 0.454
0.0LysXaa: 0.0 ± 0.0
Leu
2.972LeuAla: 2.972 ± 0.333
3.002LeuCys: 3.002 ± 0.32
3.922LeuAsp: 3.922 ± 0.309
3.86LeuGlu: 3.86 ± 0.375
5.515LeuPhe: 5.515 ± 0.422
2.328LeuGly: 2.328 ± 0.277
3.002LeuHis: 3.002 ± 0.282
7.567LeuIle: 7.567 ± 0.446
7.843LeuLys: 7.843 ± 0.497
9.436LeuLeu: 9.436 ± 0.595
2.757LeuMet: 2.757 ± 0.279
9.375LeuAsn: 9.375 ± 0.561
2.972LeuPro: 2.972 ± 0.312
4.412LeuGln: 4.412 ± 0.465
4.32LeuArg: 4.32 ± 0.422
6.618LeuSer: 6.618 ± 0.433
5.27LeuThr: 5.27 ± 0.429
4.657LeuVal: 4.657 ± 0.351
0.797LeuTrp: 0.797 ± 0.145
5.025LeuTyr: 5.025 ± 0.379
0.031LeuXaa: 0.031 ± 0.029
Met
1.072MetAla: 1.072 ± 0.191
1.134MetCys: 1.134 ± 0.185
1.317MetAsp: 1.317 ± 0.17
1.134MetGlu: 1.134 ± 0.165
1.869MetPhe: 1.869 ± 0.238
0.245MetGly: 0.245 ± 0.086
0.582MetHis: 0.582 ± 0.143
1.654MetIle: 1.654 ± 0.239
1.532MetLys: 1.532 ± 0.245
2.911MetLeu: 2.911 ± 0.272
0.551MetMet: 0.551 ± 0.149
2.237MetAsn: 2.237 ± 0.265
0.98MetPro: 0.98 ± 0.177
1.042MetGln: 1.042 ± 0.177
1.134MetArg: 1.134 ± 0.179
2.941MetSer: 2.941 ± 0.272
1.348MetThr: 1.348 ± 0.142
0.766MetVal: 0.766 ± 0.154
0.306MetTrp: 0.306 ± 0.093
1.532MetTyr: 1.532 ± 0.184
0.0MetXaa: 0.0 ± 0.0
Asn
4.442AsnAla: 4.442 ± 0.375
1.869AsnCys: 1.869 ± 0.255
6.373AsnAsp: 6.373 ± 0.438
6.587AsnGlu: 6.587 ± 0.435
5.331AsnPhe: 5.331 ± 0.399
3.094AsnGly: 3.094 ± 0.295
1.562AsnHis: 1.562 ± 0.184
6.863AsnIle: 6.863 ± 0.467
7.904AsnLys: 7.904 ± 0.531
7.659AsnLeu: 7.659 ± 0.493
1.93AsnMet: 1.93 ± 0.236
10.417AsnAsn: 10.417 ± 0.623
2.083AsnPro: 2.083 ± 0.315
3.002AsnGln: 3.002 ± 0.382
3.248AsnArg: 3.248 ± 0.311
5.882AsnSer: 5.882 ± 0.478
5.208AsnThr: 5.208 ± 0.571
7.966AsnVal: 7.966 ± 0.441
0.429AsnTrp: 0.429 ± 0.123
4.596AsnTyr: 4.596 ± 0.356
0.0AsnXaa: 0.0 ± 0.0
Pro
1.287ProAla: 1.287 ± 0.237
0.521ProCys: 0.521 ± 0.156
1.317ProAsp: 1.317 ± 0.218
1.317ProGlu: 1.317 ± 0.223
1.593ProPhe: 1.593 ± 0.218
0.797ProGly: 0.797 ± 0.17
0.613ProHis: 0.613 ± 0.126
2.237ProIle: 2.237 ± 0.328
1.961ProLys: 1.961 ± 0.217
2.696ProLeu: 2.696 ± 0.267
0.582ProMet: 0.582 ± 0.103
2.359ProAsn: 2.359 ± 0.286
1.961ProPro: 1.961 ± 0.423
1.072ProGln: 1.072 ± 0.21
1.042ProArg: 1.042 ± 0.186
1.991ProSer: 1.991 ± 0.266
1.746ProThr: 1.746 ± 0.214
1.624ProVal: 1.624 ± 0.246
0.092ProTrp: 0.092 ± 0.059
1.256ProTyr: 1.256 ± 0.168
0.0ProXaa: 0.0 ± 0.0
Gln
0.735GlnAla: 0.735 ± 0.181
1.256GlnCys: 1.256 ± 0.192
1.501GlnAsp: 1.501 ± 0.234
1.654GlnGlu: 1.654 ± 0.263
1.685GlnPhe: 1.685 ± 0.228
0.398GlnGly: 0.398 ± 0.124
1.348GlnHis: 1.348 ± 0.217
3.585GlnIle: 3.585 ± 0.337
3.278GlnLys: 3.278 ± 0.315
4.902GlnLeu: 4.902 ± 0.507
1.562GlnMet: 1.562 ± 0.184
3.983GlnAsn: 3.983 ± 0.326
1.011GlnPro: 1.011 ± 0.187
2.604GlnGln: 2.604 ± 0.416
1.317GlnArg: 1.317 ± 0.223
2.237GlnSer: 2.237 ± 0.292
2.328GlnThr: 2.328 ± 0.334
1.624GlnVal: 1.624 ± 0.208
0.429GlnTrp: 0.429 ± 0.124
1.777GlnTyr: 1.777 ± 0.173
0.0GlnXaa: 0.0 ± 0.0
Arg
1.9ArgAla: 1.9 ± 0.3
1.072ArgCys: 1.072 ± 0.163
2.39ArgAsp: 2.39 ± 0.312
1.777ArgGlu: 1.777 ± 0.242
2.145ArgPhe: 2.145 ± 0.268
0.888ArgGly: 0.888 ± 0.143
0.95ArgHis: 0.95 ± 0.173
2.911ArgIle: 2.911 ± 0.327
2.911ArgLys: 2.911 ± 0.279
3.738ArgLeu: 3.738 ± 0.366
1.195ArgMet: 1.195 ± 0.206
3.002ArgAsn: 3.002 ± 0.292
1.042ArgPro: 1.042 ± 0.162
1.838ArgGln: 1.838 ± 0.253
2.482ArgArg: 2.482 ± 0.663
2.665ArgSer: 2.665 ± 0.398
2.328ArgThr: 2.328 ± 0.312
1.808ArgVal: 1.808 ± 0.256
0.398ArgTrp: 0.398 ± 0.116
1.9ArgTyr: 1.9 ± 0.245
0.0ArgXaa: 0.0 ± 0.0
Ser
2.696SerAla: 2.696 ± 0.298
1.287SerCys: 1.287 ± 0.209
2.972SerAsp: 2.972 ± 0.364
3.217SerGlu: 3.217 ± 0.314
3.554SerPhe: 3.554 ± 0.295
1.9SerGly: 1.9 ± 0.241
1.195SerHis: 1.195 ± 0.149
4.136SerIle: 4.136 ± 0.302
4.565SerLys: 4.565 ± 0.436
6.373SerLeu: 6.373 ± 0.487
1.471SerMet: 1.471 ± 0.232
6.066SerAsn: 6.066 ± 0.393
1.716SerPro: 1.716 ± 0.262
2.298SerGln: 2.298 ± 0.318
2.053SerArg: 2.053 ± 0.318
4.902SerSer: 4.902 ± 0.496
4.197SerThr: 4.197 ± 0.299
4.626SerVal: 4.626 ± 0.333
0.429SerTrp: 0.429 ± 0.113
2.635SerTyr: 2.635 ± 0.27
0.0SerXaa: 0.0 ± 0.0
Thr
2.359ThrAla: 2.359 ± 0.258
1.256ThrCys: 1.256 ± 0.164
3.339ThrAsp: 3.339 ± 0.396
2.635ThrGlu: 2.635 ± 0.275
3.064ThrPhe: 3.064 ± 0.368
1.593ThrGly: 1.593 ± 0.183
1.501ThrHis: 1.501 ± 0.21
4.534ThrIle: 4.534 ± 0.347
4.504ThrLys: 4.504 ± 0.363
6.526ThrLeu: 6.526 ± 0.495
1.593ThrMet: 1.593 ± 0.206
5.362ThrAsn: 5.362 ± 0.481
1.838ThrPro: 1.838 ± 0.217
3.033ThrGln: 3.033 ± 0.315
2.298ThrArg: 2.298 ± 0.269
3.738ThrSer: 3.738 ± 0.316
3.523ThrThr: 3.523 ± 0.433
3.156ThrVal: 3.156 ± 0.339
0.214ThrTrp: 0.214 ± 0.091
2.237ThrTyr: 2.237 ± 0.247
0.0ThrXaa: 0.0 ± 0.0
Val
2.574ValAla: 2.574 ± 0.266
2.451ValCys: 2.451 ± 0.293
3.891ValAsp: 3.891 ± 0.287
3.339ValGlu: 3.339 ± 0.305
3.523ValPhe: 3.523 ± 0.348
1.746ValGly: 1.746 ± 0.238
2.114ValHis: 2.114 ± 0.242
3.983ValIle: 3.983 ± 0.291
4.044ValLys: 4.044 ± 0.431
6.863ValLeu: 6.863 ± 0.441
1.532ValMet: 1.532 ± 0.192
5.27ValAsn: 5.27 ± 0.385
2.114ValPro: 2.114 ± 0.302
2.512ValGln: 2.512 ± 0.313
2.237ValArg: 2.237 ± 0.234
4.136ValSer: 4.136 ± 0.322
3.309ValThr: 3.309 ± 0.317
3.83ValVal: 3.83 ± 0.332
0.398ValTrp: 0.398 ± 0.096
3.738ValTyr: 3.738 ± 0.457
0.0ValXaa: 0.0 ± 0.0
Trp
0.337TrpAla: 0.337 ± 0.093
0.184TrpCys: 0.184 ± 0.069
0.214TrpAsp: 0.214 ± 0.081
0.398TrpGlu: 0.398 ± 0.102
0.429TrpPhe: 0.429 ± 0.109
0.061TrpGly: 0.061 ± 0.065
0.306TrpHis: 0.306 ± 0.09
0.337TrpIle: 0.337 ± 0.089
0.429TrpLys: 0.429 ± 0.106
0.613TrpLeu: 0.613 ± 0.163
0.153TrpMet: 0.153 ± 0.094
0.705TrpAsn: 0.705 ± 0.132
0.245TrpPro: 0.245 ± 0.066
0.276TrpGln: 0.276 ± 0.085
0.306TrpArg: 0.306 ± 0.108
0.368TrpSer: 0.368 ± 0.103
0.306TrpThr: 0.306 ± 0.099
0.214TrpVal: 0.214 ± 0.086
0.092TrpTrp: 0.092 ± 0.05
0.337TrpTyr: 0.337 ± 0.107
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.206TyrAla: 2.206 ± 0.263
1.409TyrCys: 1.409 ± 0.256
2.911TyrAsp: 2.911 ± 0.309
2.482TyrGlu: 2.482 ± 0.284
2.819TyrPhe: 2.819 ± 0.317
1.409TyrGly: 1.409 ± 0.238
1.134TyrHis: 1.134 ± 0.222
3.83TyrIle: 3.83 ± 0.352
4.749TyrLys: 4.749 ± 0.377
3.891TyrLeu: 3.891 ± 0.392
1.593TyrMet: 1.593 ± 0.194
5.27TyrAsn: 5.27 ± 0.322
0.797TyrPro: 0.797 ± 0.144
1.225TyrGln: 1.225 ± 0.202
1.624TyrArg: 1.624 ± 0.244
2.604TyrSer: 2.604 ± 0.277
3.493TyrThr: 3.493 ± 0.41
4.259TyrVal: 4.259 ± 0.416
0.276TyrTrp: 0.276 ± 0.087
2.819TyrTyr: 2.819 ± 0.296
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.031XaaThr: 0.031 ± 0.029
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 119 proteins (32641 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski