Amino acid dipepetide frequency for Prevotella dentalis (strain ATCC 49559 / DSM 3688 / JCM 13448 / NCTC 12043 / ES 2772) (Mitsuokella dentalis)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.527AlaAla: 8.527 ± 0.158
1.085AlaCys: 1.085 ± 0.036
5.689AlaAsp: 5.689 ± 0.08
5.076AlaGlu: 5.076 ± 0.086
3.321AlaPhe: 3.321 ± 0.066
6.416AlaGly: 6.416 ± 0.102
1.778AlaHis: 1.778 ± 0.05
4.29AlaIle: 4.29 ± 0.081
3.729AlaLys: 3.729 ± 0.08
7.949AlaLeu: 7.949 ± 0.116
2.341AlaMet: 2.341 ± 0.048
3.511AlaAsn: 3.511 ± 0.065
2.963AlaPro: 2.963 ± 0.066
3.504AlaGln: 3.504 ± 0.068
5.072AlaArg: 5.072 ± 0.084
4.677AlaSer: 4.677 ± 0.07
4.926AlaThr: 4.926 ± 0.091
5.909AlaVal: 5.909 ± 0.088
1.158AlaTrp: 1.158 ± 0.04
3.42AlaTyr: 3.42 ± 0.07
0.0AlaXaa: 0.0 ± 0.0
Cys
0.881CysAla: 0.881 ± 0.03
0.217CysCys: 0.217 ± 0.016
0.672CysAsp: 0.672 ± 0.025
0.608CysGlu: 0.608 ± 0.031
0.567CysPhe: 0.567 ± 0.026
1.079CysGly: 1.079 ± 0.042
0.356CysHis: 0.356 ± 0.023
0.719CysIle: 0.719 ± 0.029
0.512CysLys: 0.512 ± 0.026
1.146CysLeu: 1.146 ± 0.035
0.318CysMet: 0.318 ± 0.016
0.582CysAsn: 0.582 ± 0.024
0.573CysPro: 0.573 ± 0.028
0.419CysGln: 0.419 ± 0.022
0.879CysArg: 0.879 ± 0.034
0.717CysSer: 0.717 ± 0.03
0.78CysThr: 0.78 ± 0.03
0.831CysVal: 0.831 ± 0.031
0.199CysTrp: 0.199 ± 0.014
0.597CysTyr: 0.597 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
4.675AspAla: 4.675 ± 0.075
0.734AspCys: 0.734 ± 0.03
3.319AspAsp: 3.319 ± 0.065
3.886AspGlu: 3.886 ± 0.074
2.8AspPhe: 2.8 ± 0.053
5.098AspGly: 5.098 ± 0.102
1.161AspHis: 1.161 ± 0.038
3.582AspIle: 3.582 ± 0.06
3.302AspLys: 3.302 ± 0.066
4.577AspLeu: 4.577 ± 0.062
1.695AspMet: 1.695 ± 0.048
2.713AspAsn: 2.713 ± 0.063
2.038AspPro: 2.038 ± 0.043
1.447AspGln: 1.447 ± 0.034
3.423AspArg: 3.423 ± 0.065
3.197AspSer: 3.197 ± 0.067
3.075AspThr: 3.075 ± 0.067
3.868AspVal: 3.868 ± 0.076
0.947AspTrp: 0.947 ± 0.036
2.986AspTyr: 2.986 ± 0.057
0.0AspXaa: 0.0 ± 0.0
Glu
5.343GluAla: 5.343 ± 0.092
0.54GluCys: 0.54 ± 0.026
2.871GluAsp: 2.871 ± 0.059
3.664GluGlu: 3.664 ± 0.085
1.885GluPhe: 1.885 ± 0.046
3.917GluGly: 3.917 ± 0.078
1.268GluHis: 1.268 ± 0.04
3.104GluIle: 3.104 ± 0.063
3.314GluLys: 3.314 ± 0.081
5.252GluLeu: 5.252 ± 0.085
1.695GluMet: 1.695 ± 0.044
2.533GluAsn: 2.533 ± 0.051
1.986GluPro: 1.986 ± 0.053
2.678GluGln: 2.678 ± 0.057
3.462GluArg: 3.462 ± 0.071
2.656GluSer: 2.656 ± 0.052
3.17GluThr: 3.17 ± 0.057
3.757GluVal: 3.757 ± 0.069
0.696GluTrp: 0.696 ± 0.028
2.054GluTyr: 2.054 ± 0.052
0.0GluXaa: 0.0 ± 0.0
Phe
3.274PheAla: 3.274 ± 0.071
0.687PheCys: 0.687 ± 0.029
2.93PheAsp: 2.93 ± 0.053
2.031PheGlu: 2.031 ± 0.041
1.853PhePhe: 1.853 ± 0.048
3.262PheGly: 3.262 ± 0.066
0.929PheHis: 0.929 ± 0.033
2.176PheIle: 2.176 ± 0.05
1.972PheLys: 1.972 ± 0.051
3.364PheLeu: 3.364 ± 0.072
1.15PheMet: 1.15 ± 0.039
1.93PheAsn: 1.93 ± 0.045
1.488PhePro: 1.488 ± 0.038
1.198PheGln: 1.198 ± 0.042
2.371PheArg: 2.371 ± 0.05
2.986PheSer: 2.986 ± 0.056
2.546PheThr: 2.546 ± 0.06
2.947PheVal: 2.947 ± 0.059
0.57PheTrp: 0.57 ± 0.027
1.727PheTyr: 1.727 ± 0.048
0.0PheXaa: 0.0 ± 0.0
Gly
5.225GlyAla: 5.225 ± 0.093
1.02GlyCys: 1.02 ± 0.035
3.994GlyAsp: 3.994 ± 0.071
3.97GlyGlu: 3.97 ± 0.059
3.188GlyPhe: 3.188 ± 0.058
5.609GlyGly: 5.609 ± 0.096
1.717GlyHis: 1.717 ± 0.044
4.627GlyIle: 4.627 ± 0.07
4.466GlyLys: 4.466 ± 0.082
6.494GlyLeu: 6.494 ± 0.086
2.222GlyMet: 2.222 ± 0.057
3.492GlyAsn: 3.492 ± 0.076
1.722GlyPro: 1.722 ± 0.052
2.847GlyGln: 2.847 ± 0.056
5.018GlyArg: 5.018 ± 0.085
4.557GlySer: 4.557 ± 0.084
4.962GlyThr: 4.962 ± 0.089
5.156GlyVal: 5.156 ± 0.079
1.202GlyTrp: 1.202 ± 0.04
3.366GlyTyr: 3.366 ± 0.077
0.0GlyXaa: 0.0 ± 0.0
His
1.826HisAla: 1.826 ± 0.054
0.359HisCys: 0.359 ± 0.018
1.273HisAsp: 1.273 ± 0.037
1.174HisGlu: 1.174 ± 0.037
1.044HisPhe: 1.044 ± 0.035
1.679HisGly: 1.679 ± 0.047
0.661HisHis: 0.661 ± 0.03
1.409HisIle: 1.409 ± 0.039
0.842HisLys: 0.842 ± 0.036
2.028HisLeu: 2.028 ± 0.05
0.404HisMet: 0.404 ± 0.019
0.935HisAsn: 0.935 ± 0.031
1.14HisPro: 1.14 ± 0.036
0.828HisGln: 0.828 ± 0.03
1.384HisArg: 1.384 ± 0.047
1.159HisSer: 1.159 ± 0.035
1.24HisThr: 1.24 ± 0.038
1.566HisVal: 1.566 ± 0.041
0.309HisTrp: 0.309 ± 0.022
1.054HisTyr: 1.054 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
4.523IleAla: 4.523 ± 0.071
0.766IleCys: 0.766 ± 0.029
3.865IleAsp: 3.865 ± 0.074
3.179IleGlu: 3.179 ± 0.074
2.077IlePhe: 2.077 ± 0.057
4.117IleGly: 4.117 ± 0.072
1.193IleHis: 1.193 ± 0.036
3.057IleIle: 3.057 ± 0.07
2.69IleLys: 2.69 ± 0.059
4.276IleLeu: 4.276 ± 0.067
1.236IleMet: 1.236 ± 0.039
2.568IleAsn: 2.568 ± 0.051
2.541IlePro: 2.541 ± 0.049
1.732IleGln: 1.732 ± 0.045
3.17IleArg: 3.17 ± 0.066
3.301IleSer: 3.301 ± 0.071
3.199IleThr: 3.199 ± 0.06
3.944IleVal: 3.944 ± 0.067
0.557IleTrp: 0.557 ± 0.027
2.126IleTyr: 2.126 ± 0.046
0.0IleXaa: 0.0 ± 0.0
Lys
4.699LysAla: 4.699 ± 0.081
0.432LysCys: 0.432 ± 0.025
2.975LysAsp: 2.975 ± 0.064
3.361LysGlu: 3.361 ± 0.081
1.721LysPhe: 1.721 ± 0.045
3.684LysGly: 3.684 ± 0.072
1.027LysHis: 1.027 ± 0.028
2.822LysIle: 2.822 ± 0.066
3.164LysLys: 3.164 ± 0.067
4.153LysLeu: 4.153 ± 0.077
1.756LysMet: 1.756 ± 0.044
2.416LysAsn: 2.416 ± 0.053
1.968LysPro: 1.968 ± 0.04
2.051LysGln: 2.051 ± 0.051
2.677LysArg: 2.677 ± 0.059
2.63LysSer: 2.63 ± 0.058
3.387LysThr: 3.387 ± 0.063
3.449LysVal: 3.449 ± 0.063
0.69LysTrp: 0.69 ± 0.027
2.245LysTyr: 2.245 ± 0.044
0.0LysXaa: 0.0 ± 0.0
Leu
7.975LeuAla: 7.975 ± 0.109
1.411LeuCys: 1.411 ± 0.038
5.031LeuAsp: 5.031 ± 0.094
4.197LeuGlu: 4.197 ± 0.076
3.882LeuPhe: 3.882 ± 0.086
6.389LeuGly: 6.389 ± 0.101
2.079LeuHis: 2.079 ± 0.049
4.039LeuIle: 4.039 ± 0.086
4.697LeuLys: 4.697 ± 0.07
8.81LeuLeu: 8.81 ± 0.139
2.596LeuMet: 2.596 ± 0.063
3.948LeuAsn: 3.948 ± 0.081
4.191LeuPro: 4.191 ± 0.06
3.585LeuGln: 3.585 ± 0.065
5.667LeuArg: 5.667 ± 0.093
6.167LeuSer: 6.167 ± 0.098
5.551LeuThr: 5.551 ± 0.073
5.817LeuVal: 5.817 ± 0.089
1.204LeuTrp: 1.204 ± 0.046
3.413LeuTyr: 3.413 ± 0.055
0.0LeuXaa: 0.0 ± 0.0
Met
2.821MetAla: 2.821 ± 0.065
0.232MetCys: 0.232 ± 0.015
1.547MetAsp: 1.547 ± 0.044
1.647MetGlu: 1.647 ± 0.039
0.893MetPhe: 0.893 ± 0.04
2.076MetGly: 2.076 ± 0.056
0.517MetHis: 0.517 ± 0.021
1.205MetIle: 1.205 ± 0.035
2.052MetLys: 2.052 ± 0.05
2.626MetLeu: 2.626 ± 0.067
0.959MetMet: 0.959 ± 0.029
1.405MetAsn: 1.405 ± 0.042
1.343MetPro: 1.343 ± 0.042
1.189MetGln: 1.189 ± 0.034
1.659MetArg: 1.659 ± 0.044
1.541MetSer: 1.541 ± 0.044
1.698MetThr: 1.698 ± 0.047
1.721MetVal: 1.721 ± 0.043
0.24MetTrp: 0.24 ± 0.018
0.714MetTyr: 0.714 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
3.763AsnAla: 3.763 ± 0.07
0.51AsnCys: 0.51 ± 0.028
2.497AsnAsp: 2.497 ± 0.049
2.287AsnGlu: 2.287 ± 0.05
1.866AsnPhe: 1.866 ± 0.046
3.831AsnGly: 3.831 ± 0.081
1.032AsnHis: 1.032 ± 0.03
2.872AsnIle: 2.872 ± 0.06
2.226AsnLys: 2.226 ± 0.055
3.801AsnLeu: 3.801 ± 0.078
1.143AsnMet: 1.143 ± 0.036
2.115AsnAsn: 2.115 ± 0.062
2.265AsnPro: 2.265 ± 0.054
1.457AsnGln: 1.457 ± 0.037
2.543AsnArg: 2.543 ± 0.062
2.426AsnSer: 2.426 ± 0.061
2.58AsnThr: 2.58 ± 0.059
3.163AsnVal: 3.163 ± 0.058
0.657AsnTrp: 0.657 ± 0.03
2.145AsnTyr: 2.145 ± 0.051
0.0AsnXaa: 0.0 ± 0.0
Pro
3.857ProAla: 3.857 ± 0.079
0.43ProCys: 0.43 ± 0.022
2.704ProAsp: 2.704 ± 0.057
2.806ProGlu: 2.806 ± 0.057
1.718ProPhe: 1.718 ± 0.053
2.859ProGly: 2.859 ± 0.061
0.932ProHis: 0.932 ± 0.034
1.898ProIle: 1.898 ± 0.046
1.709ProLys: 1.709 ± 0.042
3.367ProLeu: 3.367 ± 0.071
1.168ProMet: 1.168 ± 0.035
1.665ProAsn: 1.665 ± 0.047
0.868ProPro: 0.868 ± 0.03
1.687ProGln: 1.687 ± 0.047
1.945ProArg: 1.945 ± 0.046
2.268ProSer: 2.268 ± 0.051
2.455ProThr: 2.455 ± 0.057
3.095ProVal: 3.095 ± 0.059
0.573ProTrp: 0.573 ± 0.027
1.72ProTyr: 1.72 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
3.127GlnAla: 3.127 ± 0.065
0.366GlnCys: 0.366 ± 0.02
1.754GlnAsp: 1.754 ± 0.042
2.085GlnGlu: 2.085 ± 0.054
1.403GlnPhe: 1.403 ± 0.039
2.785GlnGly: 2.785 ± 0.049
0.835GlnHis: 0.835 ± 0.029
2.054GlnIle: 2.054 ± 0.055
2.031GlnLys: 2.031 ± 0.049
3.946GlnLeu: 3.946 ± 0.075
1.192GlnMet: 1.192 ± 0.04
1.651GlnAsn: 1.651 ± 0.044
1.795GlnPro: 1.795 ± 0.051
2.015GlnGln: 2.015 ± 0.055
2.226GlnArg: 2.226 ± 0.054
2.003GlnSer: 2.003 ± 0.051
2.491GlnThr: 2.491 ± 0.06
2.417GlnVal: 2.417 ± 0.057
0.574GlnTrp: 0.574 ± 0.024
1.52GlnTyr: 1.52 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
4.274ArgAla: 4.274 ± 0.07
0.635ArgCys: 0.635 ± 0.027
2.865ArgAsp: 2.865 ± 0.053
3.439ArgGlu: 3.439 ± 0.067
2.545ArgPhe: 2.545 ± 0.056
3.638ArgGly: 3.638 ± 0.075
1.73ArgHis: 1.73 ± 0.054
3.381ArgIle: 3.381 ± 0.063
3.089ArgLys: 3.089 ± 0.072
6.329ArgLeu: 6.329 ± 0.109
1.944ArgMet: 1.944 ± 0.055
2.606ArgAsn: 2.606 ± 0.056
2.472ArgPro: 2.472 ± 0.065
3.076ArgGln: 3.076 ± 0.061
4.318ArgArg: 4.318 ± 0.104
2.885ArgSer: 2.885 ± 0.057
2.974ArgThr: 2.974 ± 0.064
3.718ArgVal: 3.718 ± 0.067
0.913ArgTrp: 0.913 ± 0.034
2.583ArgTyr: 2.583 ± 0.063
0.0ArgXaa: 0.0 ± 0.0
Ser
4.56SerAla: 4.56 ± 0.081
0.83SerCys: 0.83 ± 0.034
3.094SerAsp: 3.094 ± 0.059
2.785SerGlu: 2.785 ± 0.059
2.775SerPhe: 2.775 ± 0.061
4.506SerGly: 4.506 ± 0.074
1.283SerHis: 1.283 ± 0.036
3.257SerIle: 3.257 ± 0.064
2.545SerLys: 2.545 ± 0.061
5.739SerLeu: 5.739 ± 0.089
1.605SerMet: 1.605 ± 0.045
2.508SerAsn: 2.508 ± 0.064
2.403SerPro: 2.403 ± 0.057
2.027SerGln: 2.027 ± 0.049
3.335SerArg: 3.335 ± 0.062
3.539SerSer: 3.539 ± 0.072
3.269SerThr: 3.269 ± 0.07
4.133SerVal: 4.133 ± 0.074
0.892SerTrp: 0.892 ± 0.035
2.606SerTyr: 2.606 ± 0.058
0.0SerXaa: 0.0 ± 0.0
Thr
5.643ThrAla: 5.643 ± 0.087
0.61ThrCys: 0.61 ± 0.024
3.816ThrAsp: 3.816 ± 0.076
2.995ThrGlu: 2.995 ± 0.057
2.594ThrPhe: 2.594 ± 0.055
4.82ThrGly: 4.82 ± 0.083
1.248ThrHis: 1.248 ± 0.04
3.363ThrIle: 3.363 ± 0.069
2.416ThrLys: 2.416 ± 0.049
6.09ThrLeu: 6.09 ± 0.085
1.345ThrMet: 1.345 ± 0.037
2.323ThrAsn: 2.323 ± 0.054
3.002ThrPro: 3.002 ± 0.059
1.956ThrGln: 1.956 ± 0.045
2.918ThrArg: 2.918 ± 0.063
3.288ThrSer: 3.288 ± 0.065
3.745ThrThr: 3.745 ± 0.085
4.559ThrVal: 4.559 ± 0.081
0.753ThrTrp: 0.753 ± 0.032
2.368ThrTyr: 2.368 ± 0.058
0.0ThrXaa: 0.0 ± 0.0
Val
5.834ValAla: 5.834 ± 0.086
1.097ValCys: 1.097 ± 0.04
4.136ValAsp: 4.136 ± 0.082
3.908ValGlu: 3.908 ± 0.072
2.821ValPhe: 2.821 ± 0.062
4.925ValGly: 4.925 ± 0.074
1.249ValHis: 1.249 ± 0.037
3.458ValIle: 3.458 ± 0.073
3.78ValLys: 3.78 ± 0.061
5.737ValLeu: 5.737 ± 0.088
1.829ValMet: 1.829 ± 0.048
3.222ValAsn: 3.222 ± 0.053
2.912ValPro: 2.912 ± 0.064
2.27ValGln: 2.27 ± 0.048
3.858ValArg: 3.858 ± 0.073
4.591ValSer: 4.591 ± 0.071
4.22ValThr: 4.22 ± 0.083
5.292ValVal: 5.292 ± 0.083
0.86ValTrp: 0.86 ± 0.033
2.827ValTyr: 2.827 ± 0.058
0.0ValXaa: 0.0 ± 0.0
Trp
1.03TrpAla: 1.03 ± 0.036
0.203TrpCys: 0.203 ± 0.015
0.819TrpAsp: 0.819 ± 0.03
0.652TrpGlu: 0.652 ± 0.03
0.552TrpPhe: 0.552 ± 0.023
1.028TrpGly: 1.028 ± 0.043
0.365TrpHis: 0.365 ± 0.019
0.644TrpIle: 0.644 ± 0.026
0.767TrpLys: 0.767 ± 0.032
1.422TrpLeu: 1.422 ± 0.042
0.43TrpMet: 0.43 ± 0.02
0.829TrpAsn: 0.829 ± 0.03
0.429TrpPro: 0.429 ± 0.028
0.687TrpGln: 0.687 ± 0.027
0.822TrpArg: 0.822 ± 0.033
0.761TrpSer: 0.761 ± 0.033
0.846TrpThr: 0.846 ± 0.036
0.765TrpVal: 0.765 ± 0.029
0.251TrpTrp: 0.251 ± 0.018
0.543TrpTyr: 0.543 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.485TyrAla: 3.485 ± 0.067
0.49TyrCys: 0.49 ± 0.024
2.672TyrAsp: 2.672 ± 0.059
2.097TyrGlu: 2.097 ± 0.051
1.886TyrPhe: 1.886 ± 0.042
3.136TyrGly: 3.136 ± 0.068
0.951TyrHis: 0.951 ± 0.036
2.159TyrIle: 2.159 ± 0.045
2.007TyrLys: 2.007 ± 0.048
3.544TyrLeu: 3.544 ± 0.058
1.055TyrMet: 1.055 ± 0.037
2.224TyrAsn: 2.224 ± 0.06
1.627TyrPro: 1.627 ± 0.039
1.619TyrGln: 1.619 ± 0.046
2.665TyrArg: 2.665 ± 0.058
2.34TyrSer: 2.34 ± 0.052
2.736TyrThr: 2.736 ± 0.065
2.722TyrVal: 2.722 ± 0.058
0.6TyrTrp: 0.6 ± 0.027
2.109TyrTyr: 2.109 ± 0.067
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2494 proteins (957715 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski