Amino acid dipepetide frequency for Vibrio phage henriette 12B8

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.806AlaAla: 4.806 ± 0.587
0.974AlaCys: 0.974 ± 0.195
3.455AlaAsp: 3.455 ± 0.349
4.492AlaGlu: 4.492 ± 0.348
2.293AlaPhe: 2.293 ± 0.264
3.487AlaGly: 3.487 ± 0.313
1.728AlaHis: 1.728 ± 0.245
4.743AlaIle: 4.743 ± 0.342
4.711AlaLys: 4.711 ± 0.42
5.497AlaLeu: 5.497 ± 0.419
2.104AlaMet: 2.104 ± 0.323
3.549AlaAsn: 3.549 ± 0.384
1.885AlaPro: 1.885 ± 0.293
2.167AlaGln: 2.167 ± 0.38
2.701AlaArg: 2.701 ± 0.32
3.518AlaSer: 3.518 ± 0.372
4.178AlaThr: 4.178 ± 0.551
4.02AlaVal: 4.02 ± 0.357
0.597AlaTrp: 0.597 ± 0.156
2.513AlaTyr: 2.513 ± 0.269
0.0AlaXaa: 0.0 ± 0.0
Cys
1.099CysAla: 1.099 ± 0.191
0.314CysCys: 0.314 ± 0.11
1.351CysAsp: 1.351 ± 0.21
0.817CysGlu: 0.817 ± 0.212
0.534CysPhe: 0.534 ± 0.144
1.508CysGly: 1.508 ± 0.243
0.597CysHis: 0.597 ± 0.165
0.848CysIle: 0.848 ± 0.16
1.633CysLys: 1.633 ± 0.22
0.754CysLeu: 0.754 ± 0.153
0.628CysMet: 0.628 ± 0.125
0.879CysAsn: 0.879 ± 0.151
0.565CysPro: 0.565 ± 0.152
0.471CysGln: 0.471 ± 0.102
0.879CysArg: 0.879 ± 0.241
0.879CysSer: 0.879 ± 0.162
0.942CysThr: 0.942 ± 0.153
1.194CysVal: 1.194 ± 0.262
0.22CysTrp: 0.22 ± 0.082
0.722CysTyr: 0.722 ± 0.158
0.0CysXaa: 0.0 ± 0.0
Asp
3.958AspAla: 3.958 ± 0.348
0.817AspCys: 0.817 ± 0.149
5.057AspAsp: 5.057 ± 0.386
5.245AspGlu: 5.245 ± 0.378
3.015AspPhe: 3.015 ± 0.294
6.156AspGly: 6.156 ± 0.423
1.131AspHis: 1.131 ± 0.222
4.963AspIle: 4.963 ± 0.433
4.146AspLys: 4.146 ± 0.389
5.622AspLeu: 5.622 ± 0.341
2.576AspMet: 2.576 ± 0.232
3.801AspAsn: 3.801 ± 0.317
2.733AspPro: 2.733 ± 0.34
1.633AspGln: 1.633 ± 0.216
2.387AspArg: 2.387 ± 0.242
3.644AspSer: 3.644 ± 0.314
3.769AspThr: 3.769 ± 0.32
5.528AspVal: 5.528 ± 0.44
1.413AspTrp: 1.413 ± 0.24
3.361AspTyr: 3.361 ± 0.403
0.0AspXaa: 0.0 ± 0.0
Glu
4.554GluAla: 4.554 ± 0.312
1.131GluCys: 1.131 ± 0.193
3.706GluAsp: 3.706 ± 0.306
4.586GluGlu: 4.586 ± 0.488
3.172GluPhe: 3.172 ± 0.34
3.895GluGly: 3.895 ± 0.393
1.79GluHis: 1.79 ± 0.27
4.209GluIle: 4.209 ± 0.37
3.706GluLys: 3.706 ± 0.374
6.659GluLeu: 6.659 ± 0.415
2.199GluMet: 2.199 ± 0.288
3.078GluAsn: 3.078 ± 0.322
2.23GluPro: 2.23 ± 0.283
2.387GluGln: 2.387 ± 0.275
3.235GluArg: 3.235 ± 0.356
3.738GluSer: 3.738 ± 0.303
3.518GluThr: 3.518 ± 0.321
5.183GluVal: 5.183 ± 0.437
1.665GluTrp: 1.665 ± 0.221
3.078GluTyr: 3.078 ± 0.293
0.0GluXaa: 0.0 ± 0.0
Phe
2.45PheAla: 2.45 ± 0.334
1.005PheCys: 1.005 ± 0.163
3.801PheAsp: 3.801 ± 0.328
2.638PheGlu: 2.638 ± 0.339
1.351PhePhe: 1.351 ± 0.215
2.953PheGly: 2.953 ± 0.36
0.817PheHis: 0.817 ± 0.155
2.262PheIle: 2.262 ± 0.276
2.858PheLys: 2.858 ± 0.413
2.073PheLeu: 2.073 ± 0.247
1.068PheMet: 1.068 ± 0.186
2.324PheAsn: 2.324 ± 0.327
1.131PhePro: 1.131 ± 0.178
1.037PheGln: 1.037 ± 0.172
1.728PheArg: 1.728 ± 0.233
2.607PheSer: 2.607 ± 0.264
2.701PheThr: 2.701 ± 0.26
2.89PheVal: 2.89 ± 0.298
0.503PheTrp: 0.503 ± 0.111
1.382PheTyr: 1.382 ± 0.206
0.0PheXaa: 0.0 ± 0.0
Gly
4.052GlyAla: 4.052 ± 0.393
1.099GlyCys: 1.099 ± 0.181
5.685GlyAsp: 5.685 ± 0.391
4.397GlyGlu: 4.397 ± 0.377
2.953GlyPhe: 2.953 ± 0.288
5.026GlyGly: 5.026 ± 0.501
1.319GlyHis: 1.319 ± 0.225
4.46GlyIle: 4.46 ± 0.379
4.68GlyLys: 4.68 ± 0.402
4.68GlyLeu: 4.68 ± 0.396
2.167GlyMet: 2.167 ± 0.266
3.424GlyAsn: 3.424 ± 0.306
0.754GlyPro: 0.754 ± 0.255
1.696GlyGln: 1.696 ± 0.207
3.141GlyArg: 3.141 ± 0.296
3.958GlySer: 3.958 ± 0.502
4.774GlyThr: 4.774 ± 0.429
4.492GlyVal: 4.492 ± 0.394
0.848GlyTrp: 0.848 ± 0.122
2.733GlyTyr: 2.733 ± 0.253
0.0GlyXaa: 0.0 ± 0.0
His
1.319HisAla: 1.319 ± 0.158
0.503HisCys: 0.503 ± 0.133
1.696HisAsp: 1.696 ± 0.233
1.413HisGlu: 1.413 ± 0.2
0.974HisPhe: 0.974 ± 0.167
1.256HisGly: 1.256 ± 0.21
0.597HisHis: 0.597 ± 0.154
1.759HisIle: 1.759 ± 0.276
2.136HisLys: 2.136 ± 0.306
1.445HisLeu: 1.445 ± 0.231
0.597HisMet: 0.597 ± 0.128
1.319HisAsn: 1.319 ± 0.197
0.722HisPro: 0.722 ± 0.151
0.722HisGln: 0.722 ± 0.13
1.068HisArg: 1.068 ± 0.186
1.256HisSer: 1.256 ± 0.22
1.413HisThr: 1.413 ± 0.235
0.974HisVal: 0.974 ± 0.159
0.377HisTrp: 0.377 ± 0.114
1.068HisTyr: 1.068 ± 0.155
0.0HisXaa: 0.0 ± 0.0
Ile
4.178IleAla: 4.178 ± 0.433
0.785IleCys: 0.785 ± 0.163
5.528IleAsp: 5.528 ± 0.522
4.46IleGlu: 4.46 ± 0.368
2.104IlePhe: 2.104 ± 0.307
4.272IleGly: 4.272 ± 0.422
1.319IleHis: 1.319 ± 0.214
4.429IleIle: 4.429 ± 0.402
4.963IleLys: 4.963 ± 0.4
3.863IleLeu: 3.863 ± 0.345
2.23IleMet: 2.23 ± 0.23
4.806IleAsn: 4.806 ± 0.403
2.199IlePro: 2.199 ± 0.277
2.199IleGln: 2.199 ± 0.243
2.795IleArg: 2.795 ± 0.257
4.649IleSer: 4.649 ± 0.397
4.115IleThr: 4.115 ± 0.355
3.487IleVal: 3.487 ± 0.336
0.754IleTrp: 0.754 ± 0.156
2.387IleTyr: 2.387 ± 0.267
0.0IleXaa: 0.0 ± 0.0
Lys
4.46LysAla: 4.46 ± 0.51
1.162LysCys: 1.162 ± 0.217
3.675LysAsp: 3.675 ± 0.402
4.649LysGlu: 4.649 ± 0.457
2.827LysPhe: 2.827 ± 0.297
3.832LysGly: 3.832 ± 0.333
2.104LysHis: 2.104 ± 0.277
3.612LysIle: 3.612 ± 0.289
4.617LysLys: 4.617 ± 0.605
6.188LysLeu: 6.188 ± 0.527
2.356LysMet: 2.356 ± 0.312
3.612LysAsn: 3.612 ± 0.288
2.544LysPro: 2.544 ± 0.312
2.921LysGln: 2.921 ± 0.343
3.392LysArg: 3.392 ± 0.306
4.429LysSer: 4.429 ± 0.354
4.146LysThr: 4.146 ± 0.42
3.989LysVal: 3.989 ± 0.354
0.754LysTrp: 0.754 ± 0.138
3.015LysTyr: 3.015 ± 0.388
0.0LysXaa: 0.0 ± 0.0
Leu
4.806LeuAla: 4.806 ± 0.468
1.602LeuCys: 1.602 ± 0.235
5.403LeuAsp: 5.403 ± 0.43
4.711LeuGlu: 4.711 ± 0.359
3.11LeuPhe: 3.11 ± 0.244
4.617LeuGly: 4.617 ± 0.389
1.539LeuHis: 1.539 ± 0.197
4.366LeuIle: 4.366 ± 0.378
4.649LeuLys: 4.649 ± 0.29
5.654LeuLeu: 5.654 ± 0.432
2.701LeuMet: 2.701 ± 0.285
4.397LeuAsn: 4.397 ± 0.343
3.235LeuPro: 3.235 ± 0.241
1.319LeuGln: 1.319 ± 0.2
3.769LeuArg: 3.769 ± 0.383
5.497LeuSer: 5.497 ± 0.388
4.586LeuThr: 4.586 ± 0.329
4.9LeuVal: 4.9 ± 0.387
0.911LeuTrp: 0.911 ± 0.152
3.361LeuTyr: 3.361 ± 0.333
0.0LeuXaa: 0.0 ± 0.0
Met
2.293MetAla: 2.293 ± 0.291
0.722MetCys: 0.722 ± 0.184
2.104MetAsp: 2.104 ± 0.219
2.042MetGlu: 2.042 ± 0.269
1.194MetPhe: 1.194 ± 0.16
1.916MetGly: 1.916 ± 0.229
0.848MetHis: 0.848 ± 0.167
1.885MetIle: 1.885 ± 0.264
2.042MetLys: 2.042 ± 0.229
2.45MetLeu: 2.45 ± 0.242
1.005MetMet: 1.005 ± 0.181
1.79MetAsn: 1.79 ± 0.218
1.068MetPro: 1.068 ± 0.19
1.225MetGln: 1.225 ± 0.146
1.665MetArg: 1.665 ± 0.252
2.293MetSer: 2.293 ± 0.23
1.508MetThr: 1.508 ± 0.204
2.042MetVal: 2.042 ± 0.235
0.408MetTrp: 0.408 ± 0.098
1.194MetTyr: 1.194 ± 0.234
0.0MetXaa: 0.0 ± 0.0
Asn
3.141AsnAla: 3.141 ± 0.325
0.628AsnCys: 0.628 ± 0.149
3.958AsnAsp: 3.958 ± 0.443
3.958AsnGlu: 3.958 ± 0.371
1.853AsnPhe: 1.853 ± 0.243
5.403AsnGly: 5.403 ± 0.397
1.382AsnHis: 1.382 ± 0.203
4.209AsnIle: 4.209 ± 0.318
3.895AsnLys: 3.895 ± 0.341
4.397AsnLeu: 4.397 ± 0.326
1.57AsnMet: 1.57 ± 0.243
2.764AsnAsn: 2.764 ± 0.373
1.979AsnPro: 1.979 ± 0.214
2.293AsnGln: 2.293 ± 0.226
2.199AsnArg: 2.199 ± 0.302
2.89AsnSer: 2.89 ± 0.366
2.858AsnThr: 2.858 ± 0.348
4.146AsnVal: 4.146 ± 0.355
0.879AsnTrp: 0.879 ± 0.157
1.728AsnTyr: 1.728 ± 0.242
0.0AsnXaa: 0.0 ± 0.0
Pro
2.073ProAla: 2.073 ± 0.251
0.408ProCys: 0.408 ± 0.113
2.701ProAsp: 2.701 ± 0.268
2.67ProGlu: 2.67 ± 0.284
1.508ProPhe: 1.508 ± 0.319
0.722ProGly: 0.722 ± 0.153
1.005ProHis: 1.005 ± 0.16
2.073ProIle: 2.073 ± 0.284
2.01ProLys: 2.01 ± 0.278
2.481ProLeu: 2.481 ± 0.301
1.068ProMet: 1.068 ± 0.193
2.073ProAsn: 2.073 ± 0.236
1.445ProPro: 1.445 ± 0.247
1.351ProGln: 1.351 ± 0.212
1.068ProArg: 1.068 ± 0.193
2.45ProSer: 2.45 ± 0.277
2.513ProThr: 2.513 ± 0.301
2.136ProVal: 2.136 ± 0.242
0.534ProTrp: 0.534 ± 0.135
1.225ProTyr: 1.225 ± 0.205
0.0ProXaa: 0.0 ± 0.0
Gln
2.167GlnAla: 2.167 ± 0.502
0.66GlnCys: 0.66 ± 0.132
1.539GlnAsp: 1.539 ± 0.203
2.199GlnGlu: 2.199 ± 0.273
1.476GlnPhe: 1.476 ± 0.191
1.759GlnGly: 1.759 ± 0.251
0.691GlnHis: 0.691 ± 0.144
1.947GlnIle: 1.947 ± 0.246
2.167GlnLys: 2.167 ± 0.329
2.67GlnLeu: 2.67 ± 0.331
0.785GlnMet: 0.785 ± 0.161
1.476GlnAsn: 1.476 ± 0.264
0.974GlnPro: 0.974 ± 0.179
1.947GlnGln: 1.947 ± 0.66
1.288GlnArg: 1.288 ± 0.207
2.293GlnSer: 2.293 ± 0.25
1.979GlnThr: 1.979 ± 0.264
1.916GlnVal: 1.916 ± 0.249
0.346GlnTrp: 0.346 ± 0.097
1.445GlnTyr: 1.445 ± 0.206
0.0GlnXaa: 0.0 ± 0.0
Arg
2.607ArgAla: 2.607 ± 0.255
1.005ArgCys: 1.005 ± 0.207
2.481ArgAsp: 2.481 ± 0.266
3.738ArgGlu: 3.738 ± 0.4
1.822ArgPhe: 1.822 ± 0.251
2.953ArgGly: 2.953 ± 0.311
0.628ArgHis: 0.628 ± 0.136
3.455ArgIle: 3.455 ± 0.319
3.361ArgLys: 3.361 ± 0.328
3.581ArgLeu: 3.581 ± 0.288
1.382ArgMet: 1.382 ± 0.207
2.199ArgAsn: 2.199 ± 0.289
1.131ArgPro: 1.131 ± 0.15
1.099ArgGln: 1.099 ± 0.152
1.885ArgArg: 1.885 ± 0.249
2.576ArgSer: 2.576 ± 0.277
2.544ArgThr: 2.544 ± 0.275
3.141ArgVal: 3.141 ± 0.31
0.534ArgTrp: 0.534 ± 0.137
2.167ArgTyr: 2.167 ± 0.259
0.0ArgXaa: 0.0 ± 0.0
Ser
3.204SerAla: 3.204 ± 0.308
0.911SerCys: 0.911 ± 0.177
5.026SerAsp: 5.026 ± 0.43
3.895SerGlu: 3.895 ± 0.301
2.073SerPhe: 2.073 ± 0.303
4.743SerGly: 4.743 ± 0.554
1.194SerHis: 1.194 ± 0.2
4.397SerIle: 4.397 ± 0.397
4.24SerLys: 4.24 ± 0.386
4.68SerLeu: 4.68 ± 0.353
1.79SerMet: 1.79 ± 0.221
3.738SerAsn: 3.738 ± 0.413
2.262SerPro: 2.262 ± 0.211
1.822SerGln: 1.822 ± 0.235
2.67SerArg: 2.67 ± 0.343
4.397SerSer: 4.397 ± 0.479
3.706SerThr: 3.706 ± 0.513
3.895SerVal: 3.895 ± 0.342
0.754SerTrp: 0.754 ± 0.147
2.984SerTyr: 2.984 ± 0.348
0.0SerXaa: 0.0 ± 0.0
Thr
3.581ThrAla: 3.581 ± 0.405
0.66ThrCys: 0.66 ± 0.143
4.303ThrAsp: 4.303 ± 0.378
4.429ThrGlu: 4.429 ± 0.403
2.45ThrPhe: 2.45 ± 0.288
3.801ThrGly: 3.801 ± 0.42
1.382ThrHis: 1.382 ± 0.207
4.272ThrIle: 4.272 ± 0.452
4.743ThrLys: 4.743 ± 0.429
4.083ThrLeu: 4.083 ± 0.312
1.728ThrMet: 1.728 ± 0.195
3.895ThrAsn: 3.895 ± 0.41
2.67ThrPro: 2.67 ± 0.299
2.23ThrGln: 2.23 ± 0.299
2.67ThrArg: 2.67 ± 0.343
3.298ThrSer: 3.298 ± 0.387
4.083ThrThr: 4.083 ± 0.509
3.926ThrVal: 3.926 ± 0.351
0.848ThrTrp: 0.848 ± 0.251
2.544ThrTyr: 2.544 ± 0.274
0.0ThrXaa: 0.0 ± 0.0
Val
4.492ValAla: 4.492 ± 0.358
1.256ValCys: 1.256 ± 0.212
4.963ValAsp: 4.963 ± 0.408
3.738ValGlu: 3.738 ± 0.433
3.015ValPhe: 3.015 ± 0.348
4.46ValGly: 4.46 ± 0.403
1.288ValHis: 1.288 ± 0.212
4.083ValIle: 4.083 ± 0.353
4.335ValLys: 4.335 ± 0.422
4.272ValLeu: 4.272 ± 0.348
2.387ValMet: 2.387 ± 0.268
3.738ValAsn: 3.738 ± 0.325
2.199ValPro: 2.199 ± 0.223
1.288ValGln: 1.288 ± 0.199
3.141ValArg: 3.141 ± 0.427
4.617ValSer: 4.617 ± 0.39
4.335ValThr: 4.335 ± 0.477
5.183ValVal: 5.183 ± 0.489
1.099ValTrp: 1.099 ± 0.234
2.544ValTyr: 2.544 ± 0.272
0.0ValXaa: 0.0 ± 0.0
Trp
1.131TrpAla: 1.131 ± 0.158
0.534TrpCys: 0.534 ± 0.122
0.879TrpAsp: 0.879 ± 0.213
1.037TrpGlu: 1.037 ± 0.194
0.597TrpPhe: 0.597 ± 0.141
0.974TrpGly: 0.974 ± 0.172
0.251TrpHis: 0.251 ± 0.087
0.785TrpIle: 0.785 ± 0.16
0.722TrpLys: 0.722 ± 0.141
1.319TrpLeu: 1.319 ± 0.214
0.283TrpMet: 0.283 ± 0.099
0.754TrpAsn: 0.754 ± 0.15
0.157TrpPro: 0.157 ± 0.074
0.314TrpGln: 0.314 ± 0.104
0.879TrpArg: 0.879 ± 0.19
0.942TrpSer: 0.942 ± 0.207
0.879TrpThr: 0.879 ± 0.15
1.037TrpVal: 1.037 ± 0.199
0.22TrpTrp: 0.22 ± 0.084
0.565TrpTyr: 0.565 ± 0.145
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.047TyrAla: 3.047 ± 0.234
0.66TyrCys: 0.66 ± 0.144
3.644TyrAsp: 3.644 ± 0.294
2.607TyrGlu: 2.607 ± 0.274
1.256TyrPhe: 1.256 ± 0.206
2.638TyrGly: 2.638 ± 0.266
1.005TyrHis: 1.005 ± 0.169
2.764TyrIle: 2.764 ± 0.335
2.67TyrLys: 2.67 ± 0.279
2.764TyrLeu: 2.764 ± 0.26
1.037TyrMet: 1.037 ± 0.177
2.513TyrAsn: 2.513 ± 0.217
1.633TyrPro: 1.633 ± 0.275
1.602TyrGln: 1.602 ± 0.194
1.728TyrArg: 1.728 ± 0.222
2.45TyrSer: 2.45 ± 0.308
3.047TyrThr: 3.047 ± 0.302
2.356TyrVal: 2.356 ± 0.302
0.597TyrTrp: 0.597 ± 0.13
1.57TyrTyr: 1.57 ± 0.227
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 154 proteins (31838 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski