Amino acid dipepetide frequency for Chlamydiales bacterium SCGC AG-110-M15

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.379AlaAla: 5.379 ± 0.221
0.883AlaCys: 0.883 ± 0.059
4.009AlaAsp: 4.009 ± 0.166
4.835AlaGlu: 4.835 ± 0.181
3.371AlaPhe: 3.371 ± 0.108
4.615AlaGly: 4.615 ± 0.169
1.594AlaHis: 1.594 ± 0.092
4.936AlaIle: 4.936 ± 0.151
4.738AlaLys: 4.738 ± 0.164
8.246AlaLeu: 8.246 ± 0.223
2.001AlaMet: 2.001 ± 0.079
2.809AlaAsn: 2.809 ± 0.106
2.372AlaPro: 2.372 ± 0.121
2.726AlaGln: 2.726 ± 0.093
3.14AlaArg: 3.14 ± 0.103
5.235AlaSer: 5.235 ± 0.171
3.112AlaThr: 3.112 ± 0.129
4.2AlaVal: 4.2 ± 0.141
0.775AlaTrp: 0.775 ± 0.054
2.463AlaTyr: 2.463 ± 0.09
0.0AlaXaa: 0.0 ± 0.0
Cys
0.782CysAla: 0.782 ± 0.059
0.191CysCys: 0.191 ± 0.026
0.617CysAsp: 0.617 ± 0.047
0.703CysGlu: 0.703 ± 0.056
0.606CysPhe: 0.606 ± 0.053
0.836CysGly: 0.836 ± 0.076
0.303CysHis: 0.303 ± 0.04
0.768CysIle: 0.768 ± 0.054
0.58CysLys: 0.58 ± 0.045
1.237CysLeu: 1.237 ± 0.075
0.332CysMet: 0.332 ± 0.064
0.418CysAsn: 0.418 ± 0.045
0.451CysPro: 0.451 ± 0.044
0.44CysGln: 0.44 ± 0.047
0.631CysArg: 0.631 ± 0.052
0.833CysSer: 0.833 ± 0.057
0.526CysThr: 0.526 ± 0.049
0.772CysVal: 0.772 ± 0.063
0.105CysTrp: 0.105 ± 0.02
0.357CysTyr: 0.357 ± 0.043
0.0CysXaa: 0.0 ± 0.0
Asp
3.98AspAla: 3.98 ± 0.163
0.717AspCys: 0.717 ± 0.067
3.22AspAsp: 3.22 ± 0.16
4.777AspGlu: 4.777 ± 0.16
2.884AspPhe: 2.884 ± 0.107
3.815AspGly: 3.815 ± 0.222
1.229AspHis: 1.229 ± 0.068
3.937AspIle: 3.937 ± 0.143
3.216AspLys: 3.216 ± 0.107
7.045AspLeu: 7.045 ± 0.186
1.219AspMet: 1.219 ± 0.078
1.954AspAsn: 1.954 ± 0.142
2.819AspPro: 2.819 ± 0.164
1.864AspGln: 1.864 ± 0.095
2.845AspArg: 2.845 ± 0.1
3.926AspSer: 3.926 ± 0.175
2.524AspThr: 2.524 ± 0.182
3.685AspVal: 3.685 ± 0.162
0.692AspTrp: 0.692 ± 0.052
2.012AspTyr: 2.012 ± 0.09
0.0AspXaa: 0.0 ± 0.0
Glu
5.679GluAla: 5.679 ± 0.205
0.584GluCys: 0.584 ± 0.053
4.193GluAsp: 4.193 ± 0.161
6.317GluGlu: 6.317 ± 0.319
2.686GluPhe: 2.686 ± 0.112
5.25GluGly: 5.25 ± 0.159
1.709GluHis: 1.709 ± 0.089
5.105GluIle: 5.105 ± 0.155
5.733GluLys: 5.733 ± 0.228
7.236GluLeu: 7.236 ± 0.205
1.914GluMet: 1.914 ± 0.094
3.4GluAsn: 3.4 ± 0.119
1.677GluPro: 1.677 ± 0.081
2.582GluGln: 2.582 ± 0.122
4.121GluArg: 4.121 ± 0.143
4.489GluSer: 4.489 ± 0.145
3.432GluThr: 3.432 ± 0.111
4.438GluVal: 4.438 ± 0.14
0.717GluTrp: 0.717 ± 0.057
2.185GluTyr: 2.185 ± 0.095
0.0GluXaa: 0.0 ± 0.0
Phe
3.18PheAla: 3.18 ± 0.12
0.584PheCys: 0.584 ± 0.045
2.827PheAsp: 2.827 ± 0.14
2.924PheGlu: 2.924 ± 0.097
2.279PhePhe: 2.279 ± 0.109
2.866PheGly: 2.866 ± 0.115
1.157PheHis: 1.157 ± 0.07
2.884PheIle: 2.884 ± 0.116
2.297PheLys: 2.297 ± 0.083
4.72PheLeu: 4.72 ± 0.168
0.988PheMet: 0.988 ± 0.059
1.904PheAsn: 1.904 ± 0.092
1.886PhePro: 1.886 ± 0.091
1.532PheGln: 1.532 ± 0.07
1.954PheArg: 1.954 ± 0.088
3.923PheSer: 3.923 ± 0.132
2.509PheThr: 2.509 ± 0.148
2.527PheVal: 2.527 ± 0.119
0.469PheTrp: 0.469 ± 0.049
1.554PheTyr: 1.554 ± 0.087
0.004PheXaa: 0.004 ± 0.004
Gly
4.572GlyAla: 4.572 ± 0.166
0.681GlyCys: 0.681 ± 0.064
3.623GlyAsp: 3.623 ± 0.129
4.276GlyGlu: 4.276 ± 0.149
3.155GlyPhe: 3.155 ± 0.131
4.64GlyGly: 4.64 ± 0.197
1.594GlyHis: 1.594 ± 0.073
4.388GlyIle: 4.388 ± 0.133
4.637GlyLys: 4.637 ± 0.158
6.425GlyLeu: 6.425 ± 0.154
1.929GlyMet: 1.929 ± 0.099
2.693GlyAsn: 2.693 ± 0.138
1.774GlyPro: 1.774 ± 0.087
2.005GlyGln: 2.005 ± 0.079
3.422GlyArg: 3.422 ± 0.159
4.409GlySer: 4.409 ± 0.166
3.378GlyThr: 3.378 ± 0.195
4.402GlyVal: 4.402 ± 0.157
0.649GlyTrp: 0.649 ± 0.047
1.994GlyTyr: 1.994 ± 0.097
0.0GlyXaa: 0.0 ± 0.0
His
1.666HisAla: 1.666 ± 0.086
0.382HisCys: 0.382 ± 0.038
1.327HisAsp: 1.327 ± 0.071
1.532HisGlu: 1.532 ± 0.082
1.413HisPhe: 1.413 ± 0.084
1.428HisGly: 1.428 ± 0.08
0.772HisHis: 0.772 ± 0.053
1.489HisIle: 1.489 ± 0.07
1.211HisLys: 1.211 ± 0.072
2.74HisLeu: 2.74 ± 0.107
0.541HisMet: 0.541 ± 0.048
0.909HisAsn: 0.909 ± 0.059
1.352HisPro: 1.352 ± 0.078
1.089HisGln: 1.089 ± 0.074
1.201HisArg: 1.201 ± 0.077
1.666HisSer: 1.666 ± 0.078
1.02HisThr: 1.02 ± 0.064
1.493HisVal: 1.493 ± 0.078
0.292HisTrp: 0.292 ± 0.034
0.919HisTyr: 0.919 ± 0.066
0.0HisXaa: 0.0 ± 0.0
Ile
5.358IleAla: 5.358 ± 0.164
0.847IleCys: 0.847 ± 0.064
4.226IleAsp: 4.226 ± 0.174
4.965IleGlu: 4.965 ± 0.148
2.755IlePhe: 2.755 ± 0.109
3.692IleGly: 3.692 ± 0.144
1.612IleHis: 1.612 ± 0.077
4.009IleIle: 4.009 ± 0.175
4.016IleLys: 4.016 ± 0.156
6.281IleLeu: 6.281 ± 0.163
1.172IleMet: 1.172 ± 0.066
3.003IleAsn: 3.003 ± 0.118
3.263IlePro: 3.263 ± 0.135
2.434IleGln: 2.434 ± 0.091
3.364IleArg: 3.364 ± 0.106
4.994IleSer: 4.994 ± 0.157
3.353IleThr: 3.353 ± 0.165
3.829IleVal: 3.829 ± 0.149
0.487IleTrp: 0.487 ± 0.045
2.03IleTyr: 2.03 ± 0.072
0.0IleXaa: 0.0 ± 0.0
Lys
5.242LysAla: 5.242 ± 0.176
0.62LysCys: 0.62 ± 0.065
3.732LysAsp: 3.732 ± 0.145
5.754LysGlu: 5.754 ± 0.229
1.889LysPhe: 1.889 ± 0.098
4.528LysGly: 4.528 ± 0.162
1.622LysHis: 1.622 ± 0.084
4.247LysIle: 4.247 ± 0.138
5.938LysLys: 5.938 ± 0.207
5.96LysLeu: 5.96 ± 0.187
1.568LysMet: 1.568 ± 0.074
3.021LysAsn: 3.021 ± 0.125
2.268LysPro: 2.268 ± 0.115
2.531LysGln: 2.531 ± 0.109
3.638LysArg: 3.638 ± 0.151
4.153LysSer: 4.153 ± 0.147
3.393LysThr: 3.393 ± 0.124
3.847LysVal: 3.847 ± 0.13
0.613LysTrp: 0.613 ± 0.044
1.969LysTyr: 1.969 ± 0.09
0.0LysXaa: 0.0 ± 0.0
Leu
7.723LeuAla: 7.723 ± 0.202
1.338LeuCys: 1.338 ± 0.077
6.23LeuAsp: 6.23 ± 0.166
7.874LeuGlu: 7.874 ± 0.201
4.81LeuPhe: 4.81 ± 0.16
6.223LeuGly: 6.223 ± 0.157
2.362LeuHis: 2.362 ± 0.098
6.605LeuIle: 6.605 ± 0.171
7.366LeuLys: 7.366 ± 0.213
10.467LeuLeu: 10.467 ± 0.231
2.499LeuMet: 2.499 ± 0.108
4.929LeuAsn: 4.929 ± 0.155
4.218LeuPro: 4.218 ± 0.131
4.024LeuGln: 4.024 ± 0.133
5.167LeuArg: 5.167 ± 0.17
8.451LeuSer: 8.451 ± 0.196
5.286LeuThr: 5.286 ± 0.157
5.185LeuVal: 5.185 ± 0.153
0.919LeuTrp: 0.919 ± 0.062
2.859LeuTyr: 2.859 ± 0.118
0.004LeuXaa: 0.004 ± 0.004
Met
1.702MetAla: 1.702 ± 0.077
0.209MetCys: 0.209 ± 0.029
1.431MetAsp: 1.431 ± 0.098
1.514MetGlu: 1.514 ± 0.088
0.757MetPhe: 0.757 ± 0.055
1.781MetGly: 1.781 ± 0.092
0.548MetHis: 0.548 ± 0.045
1.59MetIle: 1.59 ± 0.084
1.734MetLys: 1.734 ± 0.085
2.001MetLeu: 2.001 ± 0.081
0.631MetMet: 0.631 ± 0.052
1.121MetAsn: 1.121 ± 0.071
0.984MetPro: 0.984 ± 0.06
1.1MetGln: 1.1 ± 0.069
1.388MetArg: 1.388 ± 0.081
1.705MetSer: 1.705 ± 0.087
1.514MetThr: 1.514 ± 0.076
1.132MetVal: 1.132 ± 0.073
0.173MetTrp: 0.173 ± 0.024
0.425MetTyr: 0.425 ± 0.037
0.0MetXaa: 0.0 ± 0.0
Asn
3.05AsnAla: 3.05 ± 0.121
0.422AsnCys: 0.422 ± 0.047
2.495AsnAsp: 2.495 ± 0.13
2.87AsnGlu: 2.87 ± 0.105
1.763AsnPhe: 1.763 ± 0.082
2.888AsnGly: 2.888 ± 0.168
1.056AsnHis: 1.056 ± 0.067
3.032AsnIle: 3.032 ± 0.115
2.794AsnLys: 2.794 ± 0.117
4.5AsnLeu: 4.5 ± 0.132
0.782AsnMet: 0.782 ± 0.06
1.612AsnAsn: 1.612 ± 0.114
2.08AsnPro: 2.08 ± 0.088
1.796AsnGln: 1.796 ± 0.083
2.106AsnArg: 2.106 ± 0.092
2.657AsnSer: 2.657 ± 0.121
2.019AsnThr: 2.019 ± 0.107
2.463AsnVal: 2.463 ± 0.108
0.483AsnTrp: 0.483 ± 0.046
1.363AsnTyr: 1.363 ± 0.077
0.0AsnXaa: 0.0 ± 0.0
Pro
2.17ProAla: 2.17 ± 0.095
0.397ProCys: 0.397 ± 0.04
2.293ProAsp: 2.293 ± 0.109
3.252ProGlu: 3.252 ± 0.12
1.907ProPhe: 1.907 ± 0.088
2.394ProGly: 2.394 ± 0.133
0.959ProHis: 0.959 ± 0.063
2.444ProIle: 2.444 ± 0.116
2.509ProLys: 2.509 ± 0.111
4.117ProLeu: 4.117 ± 0.129
0.757ProMet: 0.757 ± 0.061
1.633ProAsn: 1.633 ± 0.088
1.485ProPro: 1.485 ± 0.1
1.467ProGln: 1.467 ± 0.076
1.568ProArg: 1.568 ± 0.067
3.299ProSer: 3.299 ± 0.121
1.943ProThr: 1.943 ± 0.113
2.419ProVal: 2.419 ± 0.103
0.422ProTrp: 0.422 ± 0.038
1.226ProTyr: 1.226 ± 0.082
0.004ProXaa: 0.004 ± 0.003
Gln
3.13GlnAla: 3.13 ± 0.124
0.332GlnCys: 0.332 ± 0.035
1.951GlnAsp: 1.951 ± 0.078
3.158GlnGlu: 3.158 ± 0.155
1.475GlnPhe: 1.475 ± 0.076
2.282GlnGly: 2.282 ± 0.086
0.981GlnHis: 0.981 ± 0.061
2.279GlnIle: 2.279 ± 0.084
2.816GlnLys: 2.816 ± 0.141
3.418GlnLeu: 3.418 ± 0.122
0.937GlnMet: 0.937 ± 0.063
1.835GlnAsn: 1.835 ± 0.081
0.999GlnPro: 0.999 ± 0.055
1.413GlnGln: 1.413 ± 0.09
2.091GlnArg: 2.091 ± 0.107
2.567GlnSer: 2.567 ± 0.097
1.759GlnThr: 1.759 ± 0.09
2.488GlnVal: 2.488 ± 0.099
0.4GlnTrp: 0.4 ± 0.041
1.219GlnTyr: 1.219 ± 0.076
0.0GlnXaa: 0.0 ± 0.0
Arg
3.216ArgAla: 3.216 ± 0.131
0.534ArgCys: 0.534 ± 0.041
2.816ArgAsp: 2.816 ± 0.112
3.724ArgGlu: 3.724 ± 0.165
2.315ArgPhe: 2.315 ± 0.093
2.974ArgGly: 2.974 ± 0.121
1.269ArgHis: 1.269 ± 0.069
3.404ArgIle: 3.404 ± 0.102
3.458ArgLys: 3.458 ± 0.147
5.552ArgLeu: 5.552 ± 0.167
1.276ArgMet: 1.276 ± 0.061
2.044ArgAsn: 2.044 ± 0.088
1.64ArgPro: 1.64 ± 0.106
1.914ArgGln: 1.914 ± 0.093
2.711ArgArg: 2.711 ± 0.133
3.407ArgSer: 3.407 ± 0.148
2.145ArgThr: 2.145 ± 0.083
3.295ArgVal: 3.295 ± 0.122
0.591ArgTrp: 0.591 ± 0.05
1.821ArgTyr: 1.821 ± 0.088
0.0ArgXaa: 0.0 ± 0.0
Ser
4.514SerAla: 4.514 ± 0.134
0.912SerCys: 0.912 ± 0.067
3.764SerAsp: 3.764 ± 0.195
4.817SerGlu: 4.817 ± 0.136
3.764SerPhe: 3.764 ± 0.115
4.424SerGly: 4.424 ± 0.141
1.846SerHis: 1.846 ± 0.089
4.777SerIle: 4.777 ± 0.133
4.424SerLys: 4.424 ± 0.162
7.95SerLeu: 7.95 ± 0.184
1.568SerMet: 1.568 ± 0.079
2.845SerAsn: 2.845 ± 0.128
3.176SerPro: 3.176 ± 0.143
2.928SerGln: 2.928 ± 0.109
3.371SerArg: 3.371 ± 0.135
6.227SerSer: 6.227 ± 0.285
3.753SerThr: 3.753 ± 0.176
3.887SerVal: 3.887 ± 0.132
0.793SerTrp: 0.793 ± 0.061
2.401SerTyr: 2.401 ± 0.114
0.004SerXaa: 0.004 ± 0.004
Thr
3.349ThrAla: 3.349 ± 0.147
0.584ThrCys: 0.584 ± 0.052
2.614ThrAsp: 2.614 ± 0.166
3.0ThrGlu: 3.0 ± 0.128
2.437ThrPhe: 2.437 ± 0.13
3.461ThrGly: 3.461 ± 0.159
1.201ThrHis: 1.201 ± 0.064
3.349ThrIle: 3.349 ± 0.149
2.769ThrLys: 2.769 ± 0.111
5.895ThrLeu: 5.895 ± 0.156
1.006ThrMet: 1.006 ± 0.063
1.705ThrAsn: 1.705 ± 0.096
2.437ThrPro: 2.437 ± 0.103
2.019ThrGln: 2.019 ± 0.093
2.116ThrArg: 2.116 ± 0.088
3.198ThrSer: 3.198 ± 0.162
2.365ThrThr: 2.365 ± 0.122
3.263ThrVal: 3.263 ± 0.16
0.526ThrTrp: 0.526 ± 0.048
1.788ThrTyr: 1.788 ± 0.128
0.0ThrXaa: 0.0 ± 0.0
Val
3.952ValAla: 3.952 ± 0.146
0.699ValCys: 0.699 ± 0.059
4.117ValAsp: 4.117 ± 0.176
4.395ValGlu: 4.395 ± 0.134
2.603ValPhe: 2.603 ± 0.108
3.847ValGly: 3.847 ± 0.14
1.446ValHis: 1.446 ± 0.078
4.089ValIle: 4.089 ± 0.136
3.818ValLys: 3.818 ± 0.134
6.115ValLeu: 6.115 ± 0.178
1.493ValMet: 1.493 ± 0.088
2.664ValAsn: 2.664 ± 0.132
2.199ValPro: 2.199 ± 0.098
1.954ValGln: 1.954 ± 0.088
2.956ValArg: 2.956 ± 0.117
4.193ValSer: 4.193 ± 0.133
2.899ValThr: 2.899 ± 0.143
3.551ValVal: 3.551 ± 0.161
0.458ValTrp: 0.458 ± 0.042
1.77ValTyr: 1.77 ± 0.087
0.0ValXaa: 0.0 ± 0.0
Trp
0.631TrpAla: 0.631 ± 0.052
0.112TrpCys: 0.112 ± 0.019
0.62TrpAsp: 0.62 ± 0.046
0.793TrpGlu: 0.793 ± 0.056
0.371TrpPhe: 0.371 ± 0.033
0.79TrpGly: 0.79 ± 0.055
0.231TrpHis: 0.231 ± 0.032
0.584TrpIle: 0.584 ± 0.052
0.847TrpLys: 0.847 ± 0.061
0.948TrpLeu: 0.948 ± 0.06
0.27TrpMet: 0.27 ± 0.031
0.461TrpAsn: 0.461 ± 0.039
0.288TrpPro: 0.288 ± 0.033
0.361TrpGln: 0.361 ± 0.035
0.505TrpArg: 0.505 ± 0.043
0.617TrpSer: 0.617 ± 0.049
0.508TrpThr: 0.508 ± 0.044
0.692TrpVal: 0.692 ± 0.049
0.101TrpTrp: 0.101 ± 0.021
0.306TrpTyr: 0.306 ± 0.039
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.16TyrAla: 2.16 ± 0.095
0.458TyrCys: 0.458 ± 0.037
2.257TyrAsp: 2.257 ± 0.174
1.961TyrGlu: 1.961 ± 0.097
1.727TyrPhe: 1.727 ± 0.096
1.911TyrGly: 1.911 ± 0.091
0.952TyrHis: 0.952 ± 0.063
1.77TyrIle: 1.77 ± 0.084
1.633TyrLys: 1.633 ± 0.083
3.685TyrLeu: 3.685 ± 0.121
0.555TyrMet: 0.555 ± 0.047
1.269TyrAsn: 1.269 ± 0.071
1.298TyrPro: 1.298 ± 0.068
1.352TyrGln: 1.352 ± 0.075
1.814TyrArg: 1.814 ± 0.086
2.196TyrSer: 2.196 ± 0.095
1.644TyrThr: 1.644 ± 0.106
1.651TyrVal: 1.651 ± 0.082
0.371TyrTrp: 0.371 ± 0.038
1.067TyrTyr: 1.067 ± 0.06
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.004XaaAla: 0.004 ± 0.004
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.004XaaGlu: 0.004 ± 0.004
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.004XaaPro: 0.004 ± 0.004
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.004XaaTyr: 0.004 ± 0.003
0.242XaaXaa: 0.242 ± 0.172
Statistics based on 847 proteins (277359 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski