Amino acid dipepetide frequency for Morganella phage MmP1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.579AlaAla: 8.579 ± 1.077
0.505AlaCys: 0.505 ± 0.227
5.467AlaAsp: 5.467 ± 0.715
5.971AlaGlu: 5.971 ± 0.649
3.196AlaPhe: 3.196 ± 0.425
6.644AlaGly: 6.644 ± 0.812
1.262AlaHis: 1.262 ± 0.268
4.71AlaIle: 4.71 ± 0.554
7.233AlaLys: 7.233 ± 0.764
7.906AlaLeu: 7.906 ± 0.91
3.532AlaMet: 3.532 ± 0.596
3.701AlaAsn: 3.701 ± 0.574
2.775AlaPro: 2.775 ± 0.672
4.542AlaGln: 4.542 ± 0.824
5.467AlaArg: 5.467 ± 0.694
4.289AlaSer: 4.289 ± 0.576
3.364AlaThr: 3.364 ± 0.469
5.383AlaVal: 5.383 ± 0.528
1.177AlaTrp: 1.177 ± 0.284
3.448AlaTyr: 3.448 ± 0.589
0.0AlaXaa: 0.0 ± 0.0
Cys
0.673CysAla: 0.673 ± 0.33
0.0CysCys: 0.0 ± 0.0
0.841CysAsp: 0.841 ± 0.395
1.009CysGlu: 1.009 ± 0.323
0.421CysPhe: 0.421 ± 0.216
0.673CysGly: 0.673 ± 0.225
0.336CysHis: 0.336 ± 0.14
0.336CysIle: 0.336 ± 0.191
0.336CysLys: 0.336 ± 0.197
0.841CysLeu: 0.841 ± 0.286
0.084CysMet: 0.084 ± 0.106
0.252CysAsn: 0.252 ± 0.146
0.589CysPro: 0.589 ± 0.232
0.336CysGln: 0.336 ± 0.143
0.505CysArg: 0.505 ± 0.209
0.589CysSer: 0.589 ± 0.277
0.168CysThr: 0.168 ± 0.154
0.757CysVal: 0.757 ± 0.257
0.084CysTrp: 0.084 ± 0.087
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
4.037AspAla: 4.037 ± 0.502
0.841AspCys: 0.841 ± 0.279
5.383AspAsp: 5.383 ± 0.723
4.878AspGlu: 4.878 ± 0.611
2.271AspPhe: 2.271 ± 0.355
6.224AspGly: 6.224 ± 0.645
1.093AspHis: 1.093 ± 0.271
3.28AspIle: 3.28 ± 0.371
4.037AspLys: 4.037 ± 0.56
4.373AspLeu: 4.373 ± 0.541
2.019AspMet: 2.019 ± 0.332
3.532AspAsn: 3.532 ± 0.494
3.112AspPro: 3.112 ± 0.633
1.682AspGln: 1.682 ± 0.381
2.944AspArg: 2.944 ± 0.436
3.448AspSer: 3.448 ± 0.615
3.616AspThr: 3.616 ± 0.607
3.953AspVal: 3.953 ± 0.503
0.841AspTrp: 0.841 ± 0.289
2.691AspTyr: 2.691 ± 0.443
0.0AspXaa: 0.0 ± 0.0
Glu
7.99GluAla: 7.99 ± 0.791
0.505GluCys: 0.505 ± 0.222
4.626GluAsp: 4.626 ± 0.641
6.14GluGlu: 6.14 ± 1.165
2.439GluPhe: 2.439 ± 0.347
4.794GluGly: 4.794 ± 0.597
1.514GluHis: 1.514 ± 0.382
3.869GluIle: 3.869 ± 0.584
3.364GluLys: 3.364 ± 0.512
6.728GluLeu: 6.728 ± 0.635
2.019GluMet: 2.019 ± 0.381
3.869GluAsn: 3.869 ± 0.752
1.514GluPro: 1.514 ± 0.367
2.523GluGln: 2.523 ± 0.537
3.869GluArg: 3.869 ± 0.604
4.458GluSer: 4.458 ± 0.744
4.373GluThr: 4.373 ± 0.65
4.71GluVal: 4.71 ± 0.811
1.177GluTrp: 1.177 ± 0.367
3.196GluTyr: 3.196 ± 0.481
0.0GluXaa: 0.0 ± 0.0
Phe
3.28PheAla: 3.28 ± 0.509
0.421PheCys: 0.421 ± 0.217
1.934PheAsp: 1.934 ± 0.476
2.355PheGlu: 2.355 ± 0.295
0.925PhePhe: 0.925 ± 0.337
2.691PheGly: 2.691 ± 0.448
1.093PheHis: 1.093 ± 0.324
2.523PheIle: 2.523 ± 0.596
2.355PheLys: 2.355 ± 0.607
2.523PheLeu: 2.523 ± 0.336
0.925PheMet: 0.925 ± 0.242
2.019PheAsn: 2.019 ± 0.385
1.514PhePro: 1.514 ± 0.374
0.757PheGln: 0.757 ± 0.302
1.682PheArg: 1.682 ± 0.257
2.103PheSer: 2.103 ± 0.428
3.112PheThr: 3.112 ± 0.619
2.187PheVal: 2.187 ± 0.482
0.421PheTrp: 0.421 ± 0.167
0.757PheTyr: 0.757 ± 0.284
0.0PheXaa: 0.0 ± 0.0
Gly
6.308GlyAla: 6.308 ± 0.745
0.505GlyCys: 0.505 ± 0.194
4.794GlyAsp: 4.794 ± 0.819
5.214GlyGlu: 5.214 ± 0.574
3.448GlyPhe: 3.448 ± 0.565
6.056GlyGly: 6.056 ± 0.684
0.673GlyHis: 0.673 ± 0.177
4.542GlyIle: 4.542 ± 0.848
6.308GlyLys: 6.308 ± 0.678
5.887GlyLeu: 5.887 ± 0.71
2.271GlyMet: 2.271 ± 0.465
2.86GlyAsn: 2.86 ± 0.405
0.0GlyPro: 0.0 ± 0.0
2.355GlyGln: 2.355 ± 0.495
4.205GlyArg: 4.205 ± 0.645
5.971GlySer: 5.971 ± 1.107
3.701GlyThr: 3.701 ± 0.487
3.364GlyVal: 3.364 ± 0.572
1.346GlyTrp: 1.346 ± 0.415
3.112GlyTyr: 3.112 ± 0.573
0.0GlyXaa: 0.0 ± 0.0
His
0.841HisAla: 0.841 ± 0.287
0.421HisCys: 0.421 ± 0.221
1.262HisAsp: 1.262 ± 0.276
1.514HisGlu: 1.514 ± 0.355
0.757HisPhe: 0.757 ± 0.285
0.925HisGly: 0.925 ± 0.241
0.336HisHis: 0.336 ± 0.197
1.177HisIle: 1.177 ± 0.318
1.093HisLys: 1.093 ± 0.306
1.934HisLeu: 1.934 ± 0.391
0.589HisMet: 0.589 ± 0.189
0.757HisAsn: 0.757 ± 0.294
0.673HisPro: 0.673 ± 0.201
0.252HisGln: 0.252 ± 0.156
0.589HisArg: 0.589 ± 0.215
0.757HisSer: 0.757 ± 0.242
1.43HisThr: 1.43 ± 0.274
1.009HisVal: 1.009 ± 0.352
0.421HisTrp: 0.421 ± 0.143
1.093HisTyr: 1.093 ± 0.287
0.0HisXaa: 0.0 ± 0.0
Ile
4.878IleAla: 4.878 ± 0.707
0.505IleCys: 0.505 ± 0.22
4.121IleAsp: 4.121 ± 0.524
3.364IleGlu: 3.364 ± 0.462
1.43IlePhe: 1.43 ± 0.371
3.869IleGly: 3.869 ± 0.386
1.009IleHis: 1.009 ± 0.291
3.028IleIle: 3.028 ± 0.588
3.364IleLys: 3.364 ± 0.477
3.869IleLeu: 3.869 ± 0.637
1.598IleMet: 1.598 ± 0.396
2.607IleAsn: 2.607 ± 0.425
2.523IlePro: 2.523 ± 0.414
1.682IleGln: 1.682 ± 0.383
3.28IleArg: 3.28 ± 0.348
2.86IleSer: 2.86 ± 0.41
3.28IleThr: 3.28 ± 0.606
3.112IleVal: 3.112 ± 0.375
0.505IleTrp: 0.505 ± 0.264
2.187IleTyr: 2.187 ± 0.409
0.0IleXaa: 0.0 ± 0.0
Lys
7.906LysAla: 7.906 ± 0.829
0.252LysCys: 0.252 ± 0.148
4.205LysAsp: 4.205 ± 0.574
5.13LysGlu: 5.13 ± 0.7
3.028LysPhe: 3.028 ± 0.499
6.224LysGly: 6.224 ± 0.652
1.766LysHis: 1.766 ± 0.436
1.43LysIle: 1.43 ± 0.37
3.532LysLys: 3.532 ± 0.576
5.299LysLeu: 5.299 ± 0.707
2.439LysMet: 2.439 ± 0.447
2.355LysAsn: 2.355 ± 0.425
2.775LysPro: 2.775 ± 0.558
2.691LysGln: 2.691 ± 0.529
4.373LysArg: 4.373 ± 0.687
4.121LysSer: 4.121 ± 0.467
3.364LysThr: 3.364 ± 0.477
5.803LysVal: 5.803 ± 0.615
0.841LysTrp: 0.841 ± 0.237
2.019LysTyr: 2.019 ± 0.38
0.0LysXaa: 0.0 ± 0.0
Leu
7.149LeuAla: 7.149 ± 1.059
0.673LeuCys: 0.673 ± 0.298
5.635LeuAsp: 5.635 ± 0.62
6.728LeuGlu: 6.728 ± 0.782
2.607LeuPhe: 2.607 ± 0.516
4.542LeuGly: 4.542 ± 0.75
1.43LeuHis: 1.43 ± 0.308
3.869LeuIle: 3.869 ± 0.499
6.56LeuLys: 6.56 ± 0.699
5.467LeuLeu: 5.467 ± 0.813
1.514LeuMet: 1.514 ± 0.289
4.037LeuAsn: 4.037 ± 0.625
3.196LeuPro: 3.196 ± 0.605
3.616LeuGln: 3.616 ± 0.471
5.214LeuArg: 5.214 ± 0.496
4.373LeuSer: 4.373 ± 0.527
5.214LeuThr: 5.214 ± 1.01
4.205LeuVal: 4.205 ± 0.526
1.346LeuTrp: 1.346 ± 0.418
2.271LeuTyr: 2.271 ± 0.443
0.0LeuXaa: 0.0 ± 0.0
Met
3.112MetAla: 3.112 ± 0.449
0.252MetCys: 0.252 ± 0.173
1.262MetAsp: 1.262 ± 0.281
2.019MetGlu: 2.019 ± 0.484
1.009MetPhe: 1.009 ± 0.249
1.43MetGly: 1.43 ± 0.352
0.421MetHis: 0.421 ± 0.263
1.093MetIle: 1.093 ± 0.298
1.934MetLys: 1.934 ± 0.27
2.86MetLeu: 2.86 ± 0.502
1.009MetMet: 1.009 ± 0.303
1.009MetAsn: 1.009 ± 0.255
1.682MetPro: 1.682 ± 0.371
1.43MetGln: 1.43 ± 0.33
1.346MetArg: 1.346 ± 0.342
2.355MetSer: 2.355 ± 0.422
2.187MetThr: 2.187 ± 0.327
2.103MetVal: 2.103 ± 0.401
0.336MetTrp: 0.336 ± 0.194
0.841MetTyr: 0.841 ± 0.285
0.0MetXaa: 0.0 ± 0.0
Asn
3.869AsnAla: 3.869 ± 0.559
0.505AsnCys: 0.505 ± 0.179
2.271AsnAsp: 2.271 ± 0.646
3.532AsnGlu: 3.532 ± 0.584
1.514AsnPhe: 1.514 ± 0.267
3.953AsnGly: 3.953 ± 0.687
0.673AsnHis: 0.673 ± 0.263
2.775AsnIle: 2.775 ± 0.492
3.28AsnLys: 3.28 ± 0.58
2.944AsnLeu: 2.944 ± 0.566
1.514AsnMet: 1.514 ± 0.315
1.934AsnAsn: 1.934 ± 0.425
3.28AsnPro: 3.28 ± 0.48
1.682AsnGln: 1.682 ± 0.395
2.355AsnArg: 2.355 ± 0.554
2.019AsnSer: 2.019 ± 0.462
2.607AsnThr: 2.607 ± 0.433
3.28AsnVal: 3.28 ± 0.471
0.336AsnTrp: 0.336 ± 0.163
2.439AsnTyr: 2.439 ± 0.541
0.0AsnXaa: 0.0 ± 0.0
Pro
3.28ProAla: 3.28 ± 0.543
0.336ProCys: 0.336 ± 0.144
2.944ProAsp: 2.944 ± 0.548
3.953ProGlu: 3.953 ± 0.76
1.177ProPhe: 1.177 ± 0.258
0.252ProGly: 0.252 ± 0.123
0.673ProHis: 0.673 ± 0.228
1.346ProIle: 1.346 ± 0.327
4.037ProLys: 4.037 ± 0.591
2.691ProLeu: 2.691 ± 0.575
1.009ProMet: 1.009 ± 0.336
2.187ProAsn: 2.187 ± 0.458
0.841ProPro: 0.841 ± 0.239
1.262ProGln: 1.262 ± 0.333
1.009ProArg: 1.009 ± 0.286
2.355ProSer: 2.355 ± 0.416
1.766ProThr: 1.766 ± 0.394
3.112ProVal: 3.112 ± 0.485
0.757ProTrp: 0.757 ± 0.244
1.934ProTyr: 1.934 ± 0.407
0.0ProXaa: 0.0 ± 0.0
Gln
3.785GlnAla: 3.785 ± 0.782
0.168GlnCys: 0.168 ± 0.11
2.271GlnAsp: 2.271 ± 0.435
2.187GlnGlu: 2.187 ± 0.401
1.514GlnPhe: 1.514 ± 0.348
2.691GlnGly: 2.691 ± 0.462
0.505GlnHis: 0.505 ± 0.185
2.187GlnIle: 2.187 ± 0.428
2.019GlnLys: 2.019 ± 0.384
3.364GlnLeu: 3.364 ± 0.555
0.925GlnMet: 0.925 ± 0.325
1.262GlnAsn: 1.262 ± 0.389
1.093GlnPro: 1.093 ± 0.355
2.019GlnGln: 2.019 ± 0.438
2.103GlnArg: 2.103 ± 0.427
2.439GlnSer: 2.439 ± 0.38
1.514GlnThr: 1.514 ± 0.318
2.187GlnVal: 2.187 ± 0.514
1.009GlnTrp: 1.009 ± 0.266
1.43GlnTyr: 1.43 ± 0.388
0.0GlnXaa: 0.0 ± 0.0
Arg
4.289ArgAla: 4.289 ± 0.801
0.589ArgCys: 0.589 ± 0.259
3.028ArgAsp: 3.028 ± 0.567
4.458ArgGlu: 4.458 ± 0.612
1.766ArgPhe: 1.766 ± 0.485
3.28ArgGly: 3.28 ± 0.544
1.177ArgHis: 1.177 ± 0.338
3.364ArgIle: 3.364 ± 0.864
4.794ArgLys: 4.794 ± 1.206
4.373ArgLeu: 4.373 ± 0.653
1.514ArgMet: 1.514 ± 0.242
3.112ArgAsn: 3.112 ± 0.549
1.682ArgPro: 1.682 ± 0.281
2.187ArgGln: 2.187 ± 0.43
2.523ArgArg: 2.523 ± 0.418
3.785ArgSer: 3.785 ± 0.793
2.86ArgThr: 2.86 ± 0.511
2.607ArgVal: 2.607 ± 0.431
0.589ArgTrp: 0.589 ± 0.229
1.934ArgTyr: 1.934 ± 0.446
0.0ArgXaa: 0.0 ± 0.0
Ser
5.299SerAla: 5.299 ± 1.183
0.757SerCys: 0.757 ± 0.341
4.542SerAsp: 4.542 ± 0.832
3.196SerGlu: 3.196 ± 0.681
2.187SerPhe: 2.187 ± 0.409
4.794SerGly: 4.794 ± 0.614
0.757SerHis: 0.757 ± 0.224
2.944SerIle: 2.944 ± 0.566
4.373SerLys: 4.373 ± 0.624
3.953SerLeu: 3.953 ± 0.632
1.934SerMet: 1.934 ± 0.393
2.439SerAsn: 2.439 ± 0.578
2.691SerPro: 2.691 ± 0.345
2.523SerGln: 2.523 ± 0.529
2.607SerArg: 2.607 ± 0.425
3.364SerSer: 3.364 ± 0.556
2.86SerThr: 2.86 ± 0.613
3.953SerVal: 3.953 ± 0.457
1.177SerTrp: 1.177 ± 0.314
2.691SerTyr: 2.691 ± 0.44
0.0SerXaa: 0.0 ± 0.0
Thr
4.121ThrAla: 4.121 ± 0.606
0.336ThrCys: 0.336 ± 0.165
3.869ThrAsp: 3.869 ± 0.685
4.458ThrGlu: 4.458 ± 0.479
2.355ThrPhe: 2.355 ± 0.381
5.551ThrGly: 5.551 ± 0.917
0.841ThrHis: 0.841 ± 0.277
4.542ThrIle: 4.542 ± 0.729
3.701ThrLys: 3.701 ± 0.675
4.878ThrLeu: 4.878 ± 0.758
1.43ThrMet: 1.43 ± 0.345
2.355ThrAsn: 2.355 ± 0.474
3.196ThrPro: 3.196 ± 0.481
1.514ThrGln: 1.514 ± 0.459
2.523ThrArg: 2.523 ± 0.397
2.944ThrSer: 2.944 ± 0.831
3.364ThrThr: 3.364 ± 0.806
3.616ThrVal: 3.616 ± 0.76
0.336ThrTrp: 0.336 ± 0.142
1.43ThrTyr: 1.43 ± 0.327
0.0ThrXaa: 0.0 ± 0.0
Val
4.878ValAla: 4.878 ± 0.676
0.589ValCys: 0.589 ± 0.216
2.523ValAsp: 2.523 ± 0.486
4.121ValGlu: 4.121 ± 0.719
2.523ValPhe: 2.523 ± 0.504
4.458ValGly: 4.458 ± 0.769
1.262ValHis: 1.262 ± 0.413
3.953ValIle: 3.953 ± 0.737
4.289ValLys: 4.289 ± 0.657
4.794ValLeu: 4.794 ± 0.593
1.766ValMet: 1.766 ± 0.42
3.532ValAsn: 3.532 ± 0.562
2.355ValPro: 2.355 ± 0.405
1.934ValGln: 1.934 ± 0.329
4.037ValArg: 4.037 ± 0.65
3.953ValSer: 3.953 ± 0.511
4.962ValThr: 4.962 ± 0.854
4.373ValVal: 4.373 ± 0.705
0.589ValTrp: 0.589 ± 0.206
2.691ValTyr: 2.691 ± 0.478
0.0ValXaa: 0.0 ± 0.0
Trp
1.093TrpAla: 1.093 ± 0.304
0.252TrpCys: 0.252 ± 0.137
0.925TrpAsp: 0.925 ± 0.232
0.841TrpGlu: 0.841 ± 0.247
0.336TrpPhe: 0.336 ± 0.171
1.009TrpGly: 1.009 ± 0.269
0.336TrpHis: 0.336 ± 0.194
0.252TrpIle: 0.252 ± 0.146
0.925TrpLys: 0.925 ± 0.246
1.598TrpLeu: 1.598 ± 0.405
0.168TrpMet: 0.168 ± 0.111
0.673TrpAsn: 0.673 ± 0.25
0.252TrpPro: 0.252 ± 0.131
0.421TrpGln: 0.421 ± 0.186
0.925TrpArg: 0.925 ± 0.337
0.757TrpSer: 0.757 ± 0.26
1.346TrpThr: 1.346 ± 0.361
1.346TrpVal: 1.346 ± 0.479
0.336TrpTrp: 0.336 ± 0.176
0.336TrpTyr: 0.336 ± 0.203
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.869TyrAla: 3.869 ± 0.653
0.421TyrCys: 0.421 ± 0.173
2.355TyrAsp: 2.355 ± 0.356
2.607TyrGlu: 2.607 ± 0.435
0.673TyrPhe: 0.673 ± 0.227
2.86TyrGly: 2.86 ± 0.453
0.673TyrHis: 0.673 ± 0.206
1.85TyrIle: 1.85 ± 0.485
2.019TyrLys: 2.019 ± 0.327
3.364TyrLeu: 3.364 ± 0.586
1.346TyrMet: 1.346 ± 0.302
2.271TyrAsn: 2.271 ± 0.408
1.177TyrPro: 1.177 ± 0.332
1.262TyrGln: 1.262 ± 0.38
2.355TyrArg: 2.355 ± 0.457
2.103TyrSer: 2.103 ± 0.406
2.271TyrThr: 2.271 ± 0.459
2.523TyrVal: 2.523 ± 0.33
0.505TyrTrp: 0.505 ± 0.205
0.925TyrTyr: 0.925 ± 0.318
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 49 proteins (11891 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski