Amino acid dipepetide frequency for Streptococcus phage Javan487

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.479AlaAla: 5.479 ± 1.095
0.1AlaCys: 0.1 ± 0.104
4.582AlaAsp: 4.582 ± 0.556
6.375AlaGlu: 6.375 ± 0.697
2.49AlaPhe: 2.49 ± 0.608
4.184AlaGly: 4.184 ± 1.086
0.996AlaHis: 0.996 ± 0.341
6.973AlaIle: 6.973 ± 1.285
7.969AlaLys: 7.969 ± 0.905
5.877AlaLeu: 5.877 ± 0.662
1.494AlaMet: 1.494 ± 0.323
4.483AlaAsn: 4.483 ± 0.94
1.195AlaPro: 1.195 ± 0.35
2.59AlaGln: 2.59 ± 0.518
2.49AlaArg: 2.49 ± 0.521
4.483AlaSer: 4.483 ± 0.755
4.084AlaThr: 4.084 ± 0.783
4.981AlaVal: 4.981 ± 0.574
0.996AlaTrp: 0.996 ± 0.384
2.092AlaTyr: 2.092 ± 0.427
0.0AlaXaa: 0.0 ± 0.0
Cys
0.299CysAla: 0.299 ± 0.197
0.199CysCys: 0.199 ± 0.135
0.398CysAsp: 0.398 ± 0.207
0.697CysGlu: 0.697 ± 0.27
0.299CysPhe: 0.299 ± 0.161
0.598CysGly: 0.598 ± 0.289
0.199CysHis: 0.199 ± 0.136
0.0CysIle: 0.0 ± 0.0
0.1CysLys: 0.1 ± 0.089
0.797CysLeu: 0.797 ± 0.265
0.1CysMet: 0.1 ± 0.098
0.199CysAsn: 0.199 ± 0.145
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.498CysArg: 0.498 ± 0.214
0.299CysSer: 0.299 ± 0.175
0.199CysThr: 0.199 ± 0.124
0.299CysVal: 0.299 ± 0.202
0.1CysTrp: 0.1 ± 0.104
0.398CysTyr: 0.398 ± 0.233
0.0CysXaa: 0.0 ± 0.0
Asp
4.283AspAla: 4.283 ± 0.723
0.697AspCys: 0.697 ± 0.279
4.383AspAsp: 4.383 ± 0.691
5.18AspGlu: 5.18 ± 0.881
2.49AspPhe: 2.49 ± 0.411
5.279AspGly: 5.279 ± 0.929
0.498AspHis: 0.498 ± 0.217
4.981AspIle: 4.981 ± 0.591
5.18AspLys: 5.18 ± 0.736
6.475AspLeu: 6.475 ± 0.817
1.295AspMet: 1.295 ± 0.303
3.785AspAsn: 3.785 ± 0.557
1.992AspPro: 1.992 ± 0.405
1.295AspGln: 1.295 ± 0.375
2.092AspArg: 2.092 ± 0.346
4.483AspSer: 4.483 ± 0.778
4.184AspThr: 4.184 ± 0.96
4.483AspVal: 4.483 ± 0.674
0.797AspTrp: 0.797 ± 0.3
2.988AspTyr: 2.988 ± 0.677
0.0AspXaa: 0.0 ± 0.0
Glu
6.375GluAla: 6.375 ± 0.939
0.299GluCys: 0.299 ± 0.167
3.785GluAsp: 3.785 ± 0.669
5.578GluGlu: 5.578 ± 0.925
3.188GluPhe: 3.188 ± 0.522
2.889GluGly: 2.889 ± 0.552
1.594GluHis: 1.594 ± 0.378
5.279GluIle: 5.279 ± 0.788
5.777GluLys: 5.777 ± 0.743
7.072GluLeu: 7.072 ± 0.983
1.893GluMet: 1.893 ± 0.472
3.785GluAsn: 3.785 ± 0.723
2.49GluPro: 2.49 ± 0.506
3.486GluGln: 3.486 ± 0.731
2.69GluArg: 2.69 ± 0.571
3.586GluSer: 3.586 ± 0.639
4.483GluThr: 4.483 ± 0.578
3.686GluVal: 3.686 ± 0.801
1.195GluTrp: 1.195 ± 0.326
2.092GluTyr: 2.092 ± 0.525
0.0GluXaa: 0.0 ± 0.0
Phe
3.785PheAla: 3.785 ± 0.62
0.1PheCys: 0.1 ± 0.109
3.586PheAsp: 3.586 ± 0.55
3.586PheGlu: 3.586 ± 0.738
1.494PhePhe: 1.494 ± 0.346
2.59PheGly: 2.59 ± 0.49
0.199PheHis: 0.199 ± 0.116
1.992PheIle: 1.992 ± 0.401
3.088PheLys: 3.088 ± 0.439
2.69PheLeu: 2.69 ± 0.575
0.996PheMet: 0.996 ± 0.362
2.49PheAsn: 2.49 ± 0.625
0.797PhePro: 0.797 ± 0.329
0.897PheGln: 0.897 ± 0.268
1.693PheArg: 1.693 ± 0.377
2.789PheSer: 2.789 ± 0.734
2.391PheThr: 2.391 ± 0.521
2.69PheVal: 2.69 ± 0.535
0.598PheTrp: 0.598 ± 0.233
0.797PheTyr: 0.797 ± 0.245
0.0PheXaa: 0.0 ± 0.0
Gly
3.984GlyAla: 3.984 ± 0.974
0.398GlyCys: 0.398 ± 0.183
4.383GlyAsp: 4.383 ± 0.626
4.184GlyGlu: 4.184 ± 0.793
2.69GlyPhe: 2.69 ± 0.562
4.184GlyGly: 4.184 ± 0.744
0.897GlyHis: 0.897 ± 0.215
6.574GlyIle: 6.574 ± 0.885
5.379GlyLys: 5.379 ± 0.824
5.977GlyLeu: 5.977 ± 0.972
2.191GlyMet: 2.191 ± 0.497
3.287GlyAsn: 3.287 ± 0.537
1.195GlyPro: 1.195 ± 0.553
1.992GlyGln: 1.992 ± 0.423
1.395GlyArg: 1.395 ± 0.364
3.486GlySer: 3.486 ± 0.639
3.984GlyThr: 3.984 ± 0.752
4.283GlyVal: 4.283 ± 0.912
1.096GlyTrp: 1.096 ± 0.572
4.184GlyTyr: 4.184 ± 0.605
0.0GlyXaa: 0.0 ± 0.0
His
0.897HisAla: 0.897 ± 0.353
0.0HisCys: 0.0 ± 0.0
0.598HisAsp: 0.598 ± 0.236
1.395HisGlu: 1.395 ± 0.328
0.398HisPhe: 0.398 ± 0.175
0.996HisGly: 0.996 ± 0.37
0.0HisHis: 0.0 ± 0.0
0.797HisIle: 0.797 ± 0.256
0.498HisLys: 0.498 ± 0.191
1.395HisLeu: 1.395 ± 0.357
0.299HisMet: 0.299 ± 0.164
0.697HisAsn: 0.697 ± 0.228
0.697HisPro: 0.697 ± 0.277
0.598HisGln: 0.598 ± 0.225
1.096HisArg: 1.096 ± 0.308
0.697HisSer: 0.697 ± 0.249
0.697HisThr: 0.697 ± 0.31
0.598HisVal: 0.598 ± 0.257
0.299HisTrp: 0.299 ± 0.151
0.299HisTyr: 0.299 ± 0.153
0.0HisXaa: 0.0 ± 0.0
Ile
4.483IleAla: 4.483 ± 0.775
0.299IleCys: 0.299 ± 0.216
6.276IleAsp: 6.276 ± 0.862
4.881IleGlu: 4.881 ± 0.917
3.188IlePhe: 3.188 ± 0.591
4.084IleGly: 4.084 ± 1.138
0.697IleHis: 0.697 ± 0.244
3.984IleIle: 3.984 ± 0.511
8.268IleLys: 8.268 ± 0.814
5.578IleLeu: 5.578 ± 0.797
2.191IleMet: 2.191 ± 0.533
3.885IleAsn: 3.885 ± 0.626
1.992IlePro: 1.992 ± 0.508
2.49IleGln: 2.49 ± 0.464
2.391IleArg: 2.391 ± 0.447
5.977IleSer: 5.977 ± 1.328
3.984IleThr: 3.984 ± 0.831
4.383IleVal: 4.383 ± 0.743
0.398IleTrp: 0.398 ± 0.199
1.992IleTyr: 1.992 ± 0.598
0.0IleXaa: 0.0 ± 0.0
Lys
6.276LysAla: 6.276 ± 0.776
0.199LysCys: 0.199 ± 0.135
7.471LysAsp: 7.471 ± 0.998
5.18LysGlu: 5.18 ± 0.662
2.69LysPhe: 2.69 ± 0.48
4.981LysGly: 4.981 ± 0.774
1.195LysHis: 1.195 ± 0.377
5.479LysIle: 5.479 ± 0.882
9.264LysLys: 9.264 ± 1.4
6.574LysLeu: 6.574 ± 0.957
2.291LysMet: 2.291 ± 0.385
4.483LysAsn: 4.483 ± 0.682
2.988LysPro: 2.988 ± 0.577
3.785LysGln: 3.785 ± 0.668
4.184LysArg: 4.184 ± 0.78
6.276LysSer: 6.276 ± 0.792
5.877LysThr: 5.877 ± 0.734
6.873LysVal: 6.873 ± 0.943
0.897LysTrp: 0.897 ± 0.291
3.387LysTyr: 3.387 ± 0.509
0.0LysXaa: 0.0 ± 0.0
Leu
7.272LeuAla: 7.272 ± 0.987
0.299LeuCys: 0.299 ± 0.158
6.176LeuAsp: 6.176 ± 0.869
5.877LeuGlu: 5.877 ± 1.026
2.889LeuPhe: 2.889 ± 0.437
5.18LeuGly: 5.18 ± 0.957
1.096LeuHis: 1.096 ± 0.354
4.981LeuIle: 4.981 ± 0.777
8.666LeuLys: 8.666 ± 1.04
6.873LeuLeu: 6.873 ± 0.895
1.295LeuMet: 1.295 ± 0.374
4.981LeuAsn: 4.981 ± 0.63
2.59LeuPro: 2.59 ± 0.494
3.785LeuGln: 3.785 ± 0.692
3.586LeuArg: 3.586 ± 0.549
5.977LeuSer: 5.977 ± 1.078
4.881LeuThr: 4.881 ± 0.728
4.781LeuVal: 4.781 ± 0.893
0.598LeuTrp: 0.598 ± 0.296
2.092LeuTyr: 2.092 ± 0.43
0.0LeuXaa: 0.0 ± 0.0
Met
2.49MetAla: 2.49 ± 0.721
0.1MetCys: 0.1 ± 0.098
1.494MetAsp: 1.494 ± 0.465
1.594MetGlu: 1.594 ± 0.502
0.398MetPhe: 0.398 ± 0.173
2.092MetGly: 2.092 ± 0.657
0.199MetHis: 0.199 ± 0.14
1.893MetIle: 1.893 ± 0.381
1.295MetLys: 1.295 ± 0.327
1.793MetLeu: 1.793 ± 0.376
0.398MetMet: 0.398 ± 0.182
1.295MetAsn: 1.295 ± 0.384
0.797MetPro: 0.797 ± 0.339
1.195MetGln: 1.195 ± 0.32
0.697MetArg: 0.697 ± 0.318
1.793MetSer: 1.793 ± 0.388
2.092MetThr: 2.092 ± 0.348
1.395MetVal: 1.395 ± 0.405
0.398MetTrp: 0.398 ± 0.184
0.697MetTyr: 0.697 ± 0.309
0.0MetXaa: 0.0 ± 0.0
Asn
4.084AsnAla: 4.084 ± 0.918
0.398AsnCys: 0.398 ± 0.198
1.992AsnAsp: 1.992 ± 0.422
2.988AsnGlu: 2.988 ± 0.669
2.988AsnPhe: 2.988 ± 0.616
4.383AsnGly: 4.383 ± 0.722
0.697AsnHis: 0.697 ± 0.28
3.586AsnIle: 3.586 ± 0.539
4.981AsnLys: 4.981 ± 0.96
4.881AsnLeu: 4.881 ± 0.623
1.594AsnMet: 1.594 ± 0.364
1.992AsnAsn: 1.992 ± 0.535
2.291AsnPro: 2.291 ± 0.561
2.191AsnGln: 2.191 ± 0.479
2.391AsnArg: 2.391 ± 0.605
2.889AsnSer: 2.889 ± 0.584
2.69AsnThr: 2.69 ± 0.443
2.889AsnVal: 2.889 ± 0.436
0.498AsnTrp: 0.498 ± 0.223
2.49AsnTyr: 2.49 ± 0.517
0.0AsnXaa: 0.0 ± 0.0
Pro
1.992ProAla: 1.992 ± 0.426
0.299ProCys: 0.299 ± 0.152
2.391ProAsp: 2.391 ± 0.571
1.693ProGlu: 1.693 ± 0.453
1.295ProPhe: 1.295 ± 0.415
1.096ProGly: 1.096 ± 0.32
0.299ProHis: 0.299 ± 0.148
2.291ProIle: 2.291 ± 0.471
4.184ProLys: 4.184 ± 0.675
2.092ProLeu: 2.092 ± 0.444
0.697ProMet: 0.697 ± 0.205
1.195ProAsn: 1.195 ± 0.375
0.598ProPro: 0.598 ± 0.203
1.096ProGln: 1.096 ± 0.322
0.797ProArg: 0.797 ± 0.26
2.59ProSer: 2.59 ± 0.572
1.594ProThr: 1.594 ± 0.504
1.096ProVal: 1.096 ± 0.434
0.199ProTrp: 0.199 ± 0.132
1.096ProTyr: 1.096 ± 0.321
0.0ProXaa: 0.0 ± 0.0
Gln
1.893GlnAla: 1.893 ± 0.41
0.398GlnCys: 0.398 ± 0.222
1.893GlnAsp: 1.893 ± 0.379
2.69GlnGlu: 2.69 ± 0.682
1.594GlnPhe: 1.594 ± 0.469
2.391GlnGly: 2.391 ± 0.454
0.398GlnHis: 0.398 ± 0.204
3.088GlnIle: 3.088 ± 0.674
2.49GlnLys: 2.49 ± 0.549
3.984GlnLeu: 3.984 ± 0.579
0.797GlnMet: 0.797 ± 0.307
2.49GlnAsn: 2.49 ± 0.52
1.195GlnPro: 1.195 ± 0.426
0.996GlnGln: 0.996 ± 0.317
1.893GlnArg: 1.893 ± 0.493
2.59GlnSer: 2.59 ± 0.552
2.49GlnThr: 2.49 ± 0.911
2.191GlnVal: 2.191 ± 0.479
0.797GlnTrp: 0.797 ± 0.394
0.797GlnTyr: 0.797 ± 0.319
0.0GlnXaa: 0.0 ± 0.0
Arg
2.49ArgAla: 2.49 ± 0.601
0.398ArgCys: 0.398 ± 0.245
1.992ArgAsp: 1.992 ± 0.447
3.686ArgGlu: 3.686 ± 0.592
1.096ArgPhe: 1.096 ± 0.339
2.59ArgGly: 2.59 ± 0.456
0.498ArgHis: 0.498 ± 0.223
2.69ArgIle: 2.69 ± 0.457
2.69ArgLys: 2.69 ± 0.573
4.184ArgLeu: 4.184 ± 0.655
0.897ArgMet: 0.897 ± 0.315
2.391ArgAsn: 2.391 ± 0.478
1.096ArgPro: 1.096 ± 0.263
1.594ArgGln: 1.594 ± 0.429
0.996ArgArg: 0.996 ± 0.336
1.793ArgSer: 1.793 ± 0.441
2.191ArgThr: 2.191 ± 0.438
2.291ArgVal: 2.291 ± 0.44
0.598ArgTrp: 0.598 ± 0.227
1.793ArgTyr: 1.793 ± 0.446
0.0ArgXaa: 0.0 ± 0.0
Ser
4.682SerAla: 4.682 ± 1.636
0.697SerCys: 0.697 ± 0.282
4.184SerAsp: 4.184 ± 0.753
3.984SerGlu: 3.984 ± 0.59
3.586SerPhe: 3.586 ± 0.723
5.578SerGly: 5.578 ± 0.8
0.498SerHis: 0.498 ± 0.216
4.582SerIle: 4.582 ± 0.576
5.379SerLys: 5.379 ± 0.791
5.977SerLeu: 5.977 ± 1.04
1.295SerMet: 1.295 ± 0.333
3.885SerAsn: 3.885 ± 0.705
1.295SerPro: 1.295 ± 0.347
2.391SerGln: 2.391 ± 0.635
2.49SerArg: 2.49 ± 0.844
4.981SerSer: 4.981 ± 0.945
3.785SerThr: 3.785 ± 0.506
4.184SerVal: 4.184 ± 0.458
0.797SerTrp: 0.797 ± 0.355
2.391SerTyr: 2.391 ± 0.43
0.0SerXaa: 0.0 ± 0.0
Thr
5.379ThrAla: 5.379 ± 0.916
0.199ThrCys: 0.199 ± 0.141
3.586ThrAsp: 3.586 ± 0.82
3.885ThrGlu: 3.885 ± 0.644
2.49ThrPhe: 2.49 ± 0.431
5.578ThrGly: 5.578 ± 1.001
1.096ThrHis: 1.096 ± 0.344
4.582ThrIle: 4.582 ± 0.714
5.08ThrLys: 5.08 ± 0.591
4.881ThrLeu: 4.881 ± 0.753
1.395ThrMet: 1.395 ± 0.315
2.59ThrAsn: 2.59 ± 0.419
1.693ThrPro: 1.693 ± 0.369
2.092ThrGln: 2.092 ± 0.433
1.494ThrArg: 1.494 ± 0.363
4.682ThrSer: 4.682 ± 0.652
3.785ThrThr: 3.785 ± 0.665
3.984ThrVal: 3.984 ± 0.538
0.797ThrTrp: 0.797 ± 0.32
1.992ThrTyr: 1.992 ± 0.354
0.0ThrXaa: 0.0 ± 0.0
Val
3.785ValAla: 3.785 ± 0.708
0.299ValCys: 0.299 ± 0.176
4.383ValAsp: 4.383 ± 0.717
4.881ValGlu: 4.881 ± 0.619
1.693ValPhe: 1.693 ± 0.376
4.383ValGly: 4.383 ± 0.577
0.797ValHis: 0.797 ± 0.256
4.383ValIle: 4.383 ± 0.681
4.881ValLys: 4.881 ± 0.561
4.084ValLeu: 4.084 ± 0.503
2.092ValMet: 2.092 ± 0.438
3.287ValAsn: 3.287 ± 0.562
2.191ValPro: 2.191 ± 0.466
2.49ValGln: 2.49 ± 0.454
2.191ValArg: 2.191 ± 0.474
4.781ValSer: 4.781 ± 0.669
5.678ValThr: 5.678 ± 0.742
5.18ValVal: 5.18 ± 0.727
0.199ValTrp: 0.199 ± 0.147
1.395ValTyr: 1.395 ± 0.321
0.0ValXaa: 0.0 ± 0.0
Trp
0.996TrpAla: 0.996 ± 0.38
0.1TrpCys: 0.1 ± 0.104
0.398TrpAsp: 0.398 ± 0.195
1.096TrpGlu: 1.096 ± 0.382
0.498TrpPhe: 0.498 ± 0.264
1.195TrpGly: 1.195 ± 0.464
0.299TrpHis: 0.299 ± 0.194
1.096TrpIle: 1.096 ± 0.367
0.897TrpLys: 0.897 ± 0.306
0.398TrpLeu: 0.398 ± 0.298
0.1TrpMet: 0.1 ± 0.09
0.398TrpAsn: 0.398 ± 0.167
0.299TrpPro: 0.299 ± 0.161
0.598TrpGln: 0.598 ± 0.22
0.797TrpArg: 0.797 ± 0.346
1.096TrpSer: 1.096 ± 0.302
0.697TrpThr: 0.697 ± 0.362
0.199TrpVal: 0.199 ± 0.136
0.1TrpTrp: 0.1 ± 0.096
0.697TrpTyr: 0.697 ± 0.229
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.988TyrAla: 2.988 ± 0.626
0.199TyrCys: 0.199 ± 0.133
2.889TyrAsp: 2.889 ± 0.61
1.793TyrGlu: 1.793 ± 0.436
1.793TyrPhe: 1.793 ± 0.478
1.494TyrGly: 1.494 ± 0.384
0.797TyrHis: 0.797 ± 0.308
2.291TyrIle: 2.291 ± 0.349
4.283TyrLys: 4.283 ± 0.653
2.291TyrLeu: 2.291 ± 0.544
0.697TyrMet: 0.697 ± 0.288
1.295TyrAsn: 1.295 ± 0.331
1.195TyrPro: 1.195 ± 0.304
1.494TyrGln: 1.494 ± 0.492
2.092TyrArg: 2.092 ± 0.558
1.395TyrSer: 1.395 ± 0.484
1.494TyrThr: 1.494 ± 0.416
2.59TyrVal: 2.59 ± 0.474
0.598TyrTrp: 0.598 ± 0.22
1.594TyrTyr: 1.594 ± 0.424
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 50 proteins (10040 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski