Amino acid dipepetide frequency for Streptococcus satellite phage Javan325

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.899AlaAla: 0.899 ± 0.487
0.599AlaCys: 0.599 ± 0.36
4.495AlaAsp: 4.495 ± 1.215
4.495AlaGlu: 4.495 ± 1.354
3.896AlaPhe: 3.896 ± 1.109
3.296AlaGly: 3.296 ± 0.854
0.3AlaHis: 0.3 ± 0.423
4.795AlaIle: 4.795 ± 1.072
5.694AlaLys: 5.694 ± 1.346
6.593AlaLeu: 6.593 ± 1.743
2.697AlaMet: 2.697 ± 0.934
3.296AlaAsn: 3.296 ± 1.107
0.599AlaPro: 0.599 ± 0.449
3.296AlaGln: 3.296 ± 1.212
3.296AlaArg: 3.296 ± 0.812
3.296AlaSer: 3.296 ± 0.944
2.697AlaThr: 2.697 ± 0.911
2.697AlaVal: 2.697 ± 0.814
0.899AlaTrp: 0.899 ± 0.455
3.896AlaTyr: 3.896 ± 1.422
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.3CysAsp: 0.3 ± 0.266
0.599CysGlu: 0.599 ± 0.383
0.0CysPhe: 0.0 ± 0.0
0.3CysGly: 0.3 ± 0.266
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
0.3CysLeu: 0.3 ± 0.289
0.0CysMet: 0.0 ± 0.0
0.599CysAsn: 0.599 ± 0.37
0.3CysPro: 0.3 ± 0.266
0.3CysGln: 0.3 ± 0.283
0.599CysArg: 0.599 ± 0.379
0.3CysSer: 0.3 ± 0.286
0.0CysThr: 0.0 ± 0.0
0.3CysVal: 0.3 ± 0.237
0.0CysTrp: 0.0 ± 0.0
0.599CysTyr: 0.599 ± 0.364
0.0CysXaa: 0.0 ± 0.0
Asp
1.498AspAla: 1.498 ± 0.665
0.0AspCys: 0.0 ± 0.0
5.094AspAsp: 5.094 ± 1.412
5.993AspGlu: 5.993 ± 1.296
2.397AspPhe: 2.397 ± 0.841
3.896AspGly: 3.896 ± 1.2
0.899AspHis: 0.899 ± 0.449
5.394AspIle: 5.394 ± 1.134
8.99AspLys: 8.99 ± 2.327
8.091AspLeu: 8.091 ± 1.629
1.498AspMet: 1.498 ± 0.598
2.397AspAsn: 2.397 ± 0.687
0.599AspPro: 0.599 ± 0.475
1.498AspGln: 1.498 ± 0.639
2.397AspArg: 2.397 ± 0.611
5.694AspSer: 5.694 ± 1.338
3.596AspThr: 3.596 ± 1.289
3.896AspVal: 3.896 ± 1.022
0.3AspTrp: 0.3 ± 0.266
3.296AspTyr: 3.296 ± 0.935
0.0AspXaa: 0.0 ± 0.0
Glu
4.495GluAla: 4.495 ± 1.241
0.3GluCys: 0.3 ± 0.289
5.094GluAsp: 5.094 ± 1.19
6.293GluGlu: 6.293 ± 1.646
4.195GluPhe: 4.195 ± 1.038
2.397GluGly: 2.397 ± 0.773
1.798GluHis: 1.798 ± 0.809
7.791GluIle: 7.791 ± 1.207
8.69GluLys: 8.69 ± 1.407
12.286GluLeu: 12.286 ± 2.147
2.697GluMet: 2.697 ± 0.748
6.892GluAsn: 6.892 ± 1.37
1.498GluPro: 1.498 ± 0.681
2.697GluGln: 2.697 ± 0.744
3.296GluArg: 3.296 ± 1.003
3.296GluSer: 3.296 ± 1.119
5.094GluThr: 5.094 ± 0.796
6.593GluVal: 6.593 ± 1.594
0.599GluTrp: 0.599 ± 0.433
3.296GluTyr: 3.296 ± 0.935
0.0GluXaa: 0.0 ± 0.0
Phe
2.098PheAla: 2.098 ± 0.724
0.0PheCys: 0.0 ± 0.0
2.997PheAsp: 2.997 ± 0.836
3.296PheGlu: 3.296 ± 0.959
1.498PhePhe: 1.498 ± 0.745
2.397PheGly: 2.397 ± 0.782
0.3PheHis: 0.3 ± 0.258
2.997PheIle: 2.997 ± 0.656
3.296PheLys: 3.296 ± 1.512
4.495PheLeu: 4.495 ± 1.021
0.599PheMet: 0.599 ± 0.407
1.798PheAsn: 1.798 ± 0.835
1.199PhePro: 1.199 ± 0.624
1.199PheGln: 1.199 ± 0.535
1.498PheArg: 1.498 ± 0.564
2.697PheSer: 2.697 ± 0.613
2.997PheThr: 2.997 ± 0.892
2.397PheVal: 2.397 ± 0.951
0.3PheTrp: 0.3 ± 0.237
0.599PheTyr: 0.599 ± 0.424
0.0PheXaa: 0.0 ± 0.0
Gly
2.397GlyAla: 2.397 ± 1.009
0.3GlyCys: 0.3 ± 0.258
2.098GlyAsp: 2.098 ± 0.733
3.896GlyGlu: 3.896 ± 1.101
2.697GlyPhe: 2.697 ± 0.917
1.798GlyGly: 1.798 ± 0.855
1.199GlyHis: 1.199 ± 0.553
2.997GlyIle: 2.997 ± 1.148
4.795GlyLys: 4.795 ± 1.455
5.694GlyLeu: 5.694 ± 1.376
0.3GlyMet: 0.3 ± 0.332
1.798GlyAsn: 1.798 ± 0.772
0.599GlyPro: 0.599 ± 0.374
1.498GlyGln: 1.498 ± 0.744
1.798GlyArg: 1.798 ± 0.725
1.199GlySer: 1.199 ± 0.49
3.296GlyThr: 3.296 ± 0.955
4.495GlyVal: 4.495 ± 0.937
1.498GlyTrp: 1.498 ± 0.753
2.397GlyTyr: 2.397 ± 0.694
0.0GlyXaa: 0.0 ± 0.0
His
0.599HisAla: 0.599 ± 0.347
0.0HisCys: 0.0 ± 0.0
2.098HisAsp: 2.098 ± 0.716
0.599HisGlu: 0.599 ± 0.457
0.899HisPhe: 0.899 ± 0.482
1.798HisGly: 1.798 ± 0.692
0.0HisHis: 0.0 ± 0.0
0.0HisIle: 0.0 ± 0.0
1.199HisLys: 1.199 ± 0.509
0.899HisLeu: 0.899 ± 0.41
0.599HisMet: 0.599 ± 0.329
1.498HisAsn: 1.498 ± 0.534
0.899HisPro: 0.899 ± 0.627
0.899HisGln: 0.899 ± 0.603
0.599HisArg: 0.599 ± 0.438
0.899HisSer: 0.899 ± 0.36
1.798HisThr: 1.798 ± 0.907
0.3HisVal: 0.3 ± 0.257
0.3HisTrp: 0.3 ± 0.257
1.498HisTyr: 1.498 ± 0.624
0.0HisXaa: 0.0 ± 0.0
Ile
4.195IleAla: 4.195 ± 1.252
1.199IleCys: 1.199 ± 0.637
5.094IleAsp: 5.094 ± 1.106
5.694IleGlu: 5.694 ± 1.092
1.498IlePhe: 1.498 ± 0.766
2.098IleGly: 2.098 ± 0.829
1.498IleHis: 1.498 ± 0.71
5.394IleIle: 5.394 ± 0.816
6.293IleLys: 6.293 ± 0.919
5.394IleLeu: 5.394 ± 1.325
0.599IleMet: 0.599 ± 0.401
3.896IleAsn: 3.896 ± 1.443
1.498IlePro: 1.498 ± 0.63
2.997IleGln: 2.997 ± 0.82
2.098IleArg: 2.098 ± 0.705
3.896IleSer: 3.896 ± 1.039
5.094IleThr: 5.094 ± 1.017
3.596IleVal: 3.596 ± 0.825
0.0IleTrp: 0.0 ± 0.0
1.498IleTyr: 1.498 ± 0.596
0.0IleXaa: 0.0 ± 0.0
Lys
7.492LysAla: 7.492 ± 1.684
0.0LysCys: 0.0 ± 0.0
6.593LysAsp: 6.593 ± 1.423
10.488LysGlu: 10.488 ± 1.629
2.997LysPhe: 2.997 ± 0.976
5.394LysGly: 5.394 ± 0.981
1.498LysHis: 1.498 ± 0.568
5.094LysIle: 5.094 ± 1.212
11.088LysLys: 11.088 ± 1.983
10.189LysLeu: 10.189 ± 1.005
2.397LysMet: 2.397 ± 0.483
5.094LysAsn: 5.094 ± 0.773
3.596LysPro: 3.596 ± 1.221
2.997LysGln: 2.997 ± 0.85
4.495LysArg: 4.495 ± 0.839
5.694LysSer: 5.694 ± 1.034
3.896LysThr: 3.896 ± 0.867
5.394LysVal: 5.394 ± 1.134
0.599LysTrp: 0.599 ± 0.298
4.195LysTyr: 4.195 ± 0.999
0.0LysXaa: 0.0 ± 0.0
Leu
5.993LeuAla: 5.993 ± 1.941
0.0LeuCys: 0.0 ± 0.0
10.488LeuAsp: 10.488 ± 1.322
10.488LeuGlu: 10.488 ± 1.763
3.896LeuPhe: 3.896 ± 1.326
4.495LeuGly: 4.495 ± 1.307
1.199LeuHis: 1.199 ± 0.553
4.795LeuIle: 4.795 ± 1.242
9.29LeuLys: 9.29 ± 1.527
10.189LeuLeu: 10.189 ± 2.306
0.599LeuMet: 0.599 ± 0.364
5.094LeuAsn: 5.094 ± 1.131
1.498LeuPro: 1.498 ± 0.5
1.199LeuGln: 1.199 ± 0.644
4.195LeuArg: 4.195 ± 1.159
3.896LeuSer: 3.896 ± 0.938
7.791LeuThr: 7.791 ± 1.623
5.993LeuVal: 5.993 ± 0.802
1.199LeuTrp: 1.199 ± 0.57
4.795LeuTyr: 4.795 ± 1.039
0.0LeuXaa: 0.0 ± 0.0
Met
2.397MetAla: 2.397 ± 0.842
0.0MetCys: 0.0 ± 0.0
1.498MetAsp: 1.498 ± 0.67
1.798MetGlu: 1.798 ± 0.75
0.3MetPhe: 0.3 ± 0.286
0.599MetGly: 0.599 ± 0.333
0.0MetHis: 0.0 ± 0.0
0.899MetIle: 0.899 ± 0.591
0.899MetLys: 0.899 ± 0.442
0.599MetLeu: 0.599 ± 0.403
0.899MetMet: 0.899 ± 0.404
3.896MetAsn: 3.896 ± 1.09
0.3MetPro: 0.3 ± 0.299
0.599MetGln: 0.599 ± 0.357
1.199MetArg: 1.199 ± 0.617
0.899MetSer: 0.899 ± 0.437
2.098MetThr: 2.098 ± 0.913
1.199MetVal: 1.199 ± 0.747
0.0MetTrp: 0.0 ± 0.0
0.3MetTyr: 0.3 ± 0.237
0.0MetXaa: 0.0 ± 0.0
Asn
4.795AsnAla: 4.795 ± 1.843
0.3AsnCys: 0.3 ± 0.266
3.596AsnAsp: 3.596 ± 0.732
5.394AsnGlu: 5.394 ± 1.319
2.098AsnPhe: 2.098 ± 0.871
4.195AsnGly: 4.195 ± 1.126
1.798AsnHis: 1.798 ± 0.601
2.697AsnIle: 2.697 ± 0.809
5.394AsnLys: 5.394 ± 1.16
4.195AsnLeu: 4.195 ± 1.028
1.199AsnMet: 1.199 ± 0.43
4.795AsnAsn: 4.795 ± 1.001
3.296AsnPro: 3.296 ± 0.657
2.397AsnGln: 2.397 ± 0.599
2.397AsnArg: 2.397 ± 0.74
3.296AsnSer: 3.296 ± 0.703
3.896AsnThr: 3.896 ± 1.121
3.296AsnVal: 3.296 ± 0.835
0.899AsnTrp: 0.899 ± 0.639
2.397AsnTyr: 2.397 ± 0.848
0.0AsnXaa: 0.0 ± 0.0
Pro
2.098ProAla: 2.098 ± 0.792
0.3ProCys: 0.3 ± 0.257
1.199ProAsp: 1.199 ± 0.579
1.199ProGlu: 1.199 ± 0.551
1.498ProPhe: 1.498 ± 0.531
0.899ProGly: 0.899 ± 0.591
0.0ProHis: 0.0 ± 0.0
1.498ProIle: 1.498 ± 0.858
3.596ProLys: 3.596 ± 0.852
1.798ProLeu: 1.798 ± 0.576
0.599ProMet: 0.599 ± 0.394
0.899ProAsn: 0.899 ± 0.368
1.199ProPro: 1.199 ± 0.554
0.899ProGln: 0.899 ± 0.683
0.899ProArg: 0.899 ± 0.425
2.098ProSer: 2.098 ± 0.782
0.599ProThr: 0.599 ± 0.365
2.397ProVal: 2.397 ± 0.643
0.0ProTrp: 0.0 ± 0.0
0.899ProTyr: 0.899 ± 0.522
0.0ProXaa: 0.0 ± 0.0
Gln
3.596GlnAla: 3.596 ± 1.313
0.0GlnCys: 0.0 ± 0.0
1.498GlnAsp: 1.498 ± 0.671
2.697GlnGlu: 2.697 ± 0.923
1.498GlnPhe: 1.498 ± 0.536
1.498GlnGly: 1.498 ± 0.584
0.0GlnHis: 0.0 ± 0.0
2.098GlnIle: 2.098 ± 0.792
3.596GlnLys: 3.596 ± 0.812
2.697GlnLeu: 2.697 ± 1.17
0.0GlnMet: 0.0 ± 0.0
2.397GlnAsn: 2.397 ± 0.757
0.3GlnPro: 0.3 ± 0.307
3.296GlnGln: 3.296 ± 1.005
2.397GlnArg: 2.397 ± 0.774
1.798GlnSer: 1.798 ± 0.84
1.798GlnThr: 1.798 ± 0.646
2.397GlnVal: 2.397 ± 0.832
0.3GlnTrp: 0.3 ± 0.289
2.397GlnTyr: 2.397 ± 0.98
0.0GlnXaa: 0.0 ± 0.0
Arg
4.795ArgAla: 4.795 ± 1.171
0.0ArgCys: 0.0 ± 0.0
2.098ArgAsp: 2.098 ± 0.594
4.795ArgGlu: 4.795 ± 1.395
1.498ArgPhe: 1.498 ± 0.698
1.498ArgGly: 1.498 ± 0.633
1.498ArgHis: 1.498 ± 0.555
3.896ArgIle: 3.896 ± 0.862
4.495ArgLys: 4.495 ± 0.996
2.997ArgLeu: 2.997 ± 0.769
1.498ArgMet: 1.498 ± 0.735
0.899ArgAsn: 0.899 ± 0.409
1.199ArgPro: 1.199 ± 0.552
2.697ArgGln: 2.697 ± 0.721
1.498ArgArg: 1.498 ± 0.723
1.498ArgSer: 1.498 ± 0.635
1.498ArgThr: 1.498 ± 0.736
1.498ArgVal: 1.498 ± 0.534
1.199ArgTrp: 1.199 ± 0.519
3.296ArgTyr: 3.296 ± 0.799
0.0ArgXaa: 0.0 ± 0.0
Ser
3.296SerAla: 3.296 ± 1.343
0.3SerCys: 0.3 ± 0.237
3.296SerAsp: 3.296 ± 0.77
5.694SerGlu: 5.694 ± 1.435
1.498SerPhe: 1.498 ± 0.53
2.697SerGly: 2.697 ± 0.724
0.3SerHis: 0.3 ± 0.257
2.697SerIle: 2.697 ± 1.257
4.195SerLys: 4.195 ± 1.16
3.596SerLeu: 3.596 ± 0.764
0.599SerMet: 0.599 ± 0.345
4.795SerAsn: 4.795 ± 1.57
2.098SerPro: 2.098 ± 0.658
0.899SerGln: 0.899 ± 0.558
2.397SerArg: 2.397 ± 0.893
2.697SerSer: 2.697 ± 0.801
2.098SerThr: 2.098 ± 0.741
3.896SerVal: 3.896 ± 0.867
0.599SerTrp: 0.599 ± 0.387
2.098SerTyr: 2.098 ± 0.51
0.0SerXaa: 0.0 ± 0.0
Thr
3.596ThrAla: 3.596 ± 0.649
0.0ThrCys: 0.0 ± 0.0
3.896ThrAsp: 3.896 ± 1.008
3.896ThrGlu: 3.896 ± 1.004
1.798ThrPhe: 1.798 ± 0.545
2.697ThrGly: 2.697 ± 0.635
1.199ThrHis: 1.199 ± 0.55
3.896ThrIle: 3.896 ± 1.559
4.195ThrLys: 4.195 ± 0.986
5.394ThrLeu: 5.394 ± 1.302
0.899ThrMet: 0.899 ± 0.478
4.195ThrAsn: 4.195 ± 1.372
1.798ThrPro: 1.798 ± 0.65
2.997ThrGln: 2.997 ± 1.042
2.697ThrArg: 2.697 ± 0.768
2.697ThrSer: 2.697 ± 0.8
4.495ThrThr: 4.495 ± 1.331
4.195ThrVal: 4.195 ± 1.126
0.599ThrTrp: 0.599 ± 0.405
2.697ThrTyr: 2.697 ± 0.716
0.0ThrXaa: 0.0 ± 0.0
Val
4.795ValAla: 4.795 ± 1.213
0.599ValCys: 0.599 ± 0.532
3.596ValAsp: 3.596 ± 1.17
5.094ValGlu: 5.094 ± 1.456
2.697ValPhe: 2.697 ± 0.858
1.798ValGly: 1.798 ± 0.772
2.098ValHis: 2.098 ± 0.544
2.697ValIle: 2.697 ± 0.83
3.896ValLys: 3.896 ± 0.897
5.094ValLeu: 5.094 ± 1.176
1.199ValMet: 1.199 ± 0.579
4.195ValAsn: 4.195 ± 1.022
2.098ValPro: 2.098 ± 0.753
1.199ValGln: 1.199 ± 0.607
3.596ValArg: 3.596 ± 0.837
1.798ValSer: 1.798 ± 0.63
2.997ValThr: 2.997 ± 0.846
4.195ValVal: 4.195 ± 1.257
0.899ValTrp: 0.899 ± 0.502
5.394ValTyr: 5.394 ± 1.173
0.0ValXaa: 0.0 ± 0.0
Trp
0.3TrpAla: 0.3 ± 0.258
0.3TrpCys: 0.3 ± 0.237
0.899TrpAsp: 0.899 ± 0.525
1.798TrpGlu: 1.798 ± 0.588
0.599TrpPhe: 0.599 ± 0.371
0.599TrpGly: 0.599 ± 0.365
0.3TrpHis: 0.3 ± 0.258
0.899TrpIle: 0.899 ± 0.482
1.199TrpLys: 1.199 ± 0.414
1.798TrpLeu: 1.798 ± 0.715
0.0TrpMet: 0.0 ± 0.0
0.599TrpAsn: 0.599 ± 0.364
0.0TrpPro: 0.0 ± 0.0
0.599TrpGln: 0.599 ± 0.378
0.3TrpArg: 0.3 ± 0.307
0.599TrpSer: 0.599 ± 0.433
0.3TrpThr: 0.3 ± 0.237
0.0TrpVal: 0.0 ± 0.0
0.3TrpTrp: 0.3 ± 0.258
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.397TyrAla: 2.397 ± 0.985
0.3TyrCys: 0.3 ± 0.289
1.498TyrAsp: 1.498 ± 0.658
5.094TyrGlu: 5.094 ± 0.91
1.199TyrPhe: 1.199 ± 0.661
2.397TyrGly: 2.397 ± 0.665
1.498TyrHis: 1.498 ± 0.486
2.997TyrIle: 2.997 ± 1.013
8.391TyrLys: 8.391 ± 1.568
4.795TyrLeu: 4.795 ± 1.152
1.199TyrMet: 1.199 ± 0.567
3.296TyrAsn: 3.296 ± 1.11
0.3TyrPro: 0.3 ± 0.237
2.098TyrGln: 2.098 ± 0.826
2.697TyrArg: 2.697 ± 1.035
1.498TyrSer: 1.498 ± 0.584
1.798TyrThr: 1.798 ± 0.595
1.199TyrVal: 1.199 ± 0.516
0.899TyrTrp: 0.899 ± 0.399
2.098TyrTyr: 2.098 ± 0.592
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 21 proteins (3338 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski