Amino acid dipepetide frequency for Anopheles minimus irodovirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.735AlaAla: 2.735 ± 0.384
0.739AlaCys: 0.739 ± 0.121
1.996AlaAsp: 1.996 ± 0.186
3.228AlaGlu: 3.228 ± 0.356
2.119AlaPhe: 2.119 ± 0.221
2.07AlaGly: 2.07 ± 0.415
0.887AlaHis: 0.887 ± 0.126
3.425AlaIle: 3.425 ± 0.3
3.647AlaLys: 3.647 ± 0.272
4.559AlaLeu: 4.559 ± 0.319
0.887AlaMet: 0.887 ± 0.131
2.686AlaAsn: 2.686 ± 0.295
1.848AlaPro: 1.848 ± 0.243
1.897AlaGln: 1.897 ± 0.215
1.552AlaArg: 1.552 ± 0.171
2.957AlaSer: 2.957 ± 0.308
2.883AlaThr: 2.883 ± 0.412
2.982AlaVal: 2.982 ± 0.287
0.222AlaTrp: 0.222 ± 0.071
1.848AlaTyr: 1.848 ± 0.209
0.0AlaXaa: 0.0 ± 0.0
Cys
0.887CysAla: 0.887 ± 0.186
0.394CysCys: 0.394 ± 0.125
1.281CysAsp: 1.281 ± 0.172
1.232CysGlu: 1.232 ± 0.192
0.789CysPhe: 0.789 ± 0.139
1.454CysGly: 1.454 ± 0.235
0.345CysHis: 0.345 ± 0.082
1.035CysIle: 1.035 ± 0.145
1.331CysLys: 1.331 ± 0.156
1.429CysLeu: 1.429 ± 0.236
0.345CysMet: 0.345 ± 0.085
0.986CysAsn: 0.986 ± 0.139
0.665CysPro: 0.665 ± 0.123
0.715CysGln: 0.715 ± 0.143
0.567CysArg: 0.567 ± 0.124
1.429CysSer: 1.429 ± 0.259
0.887CysThr: 0.887 ± 0.15
1.281CysVal: 1.281 ± 0.213
0.148CysTrp: 0.148 ± 0.053
0.591CysTyr: 0.591 ± 0.119
0.0CysXaa: 0.0 ± 0.0
Asp
2.267AspAla: 2.267 ± 0.262
1.232AspCys: 1.232 ± 0.175
3.129AspAsp: 3.129 ± 0.324
3.893AspGlu: 3.893 ± 0.316
2.686AspPhe: 2.686 ± 0.254
2.587AspGly: 2.587 ± 0.24
1.134AspHis: 1.134 ± 0.179
4.435AspIle: 4.435 ± 0.333
4.534AspLys: 4.534 ± 0.368
6.407AspLeu: 6.407 ± 0.433
1.01AspMet: 1.01 ± 0.154
3.277AspAsn: 3.277 ± 0.274
2.341AspPro: 2.341 ± 0.245
1.922AspGln: 1.922 ± 0.225
1.922AspArg: 1.922 ± 0.225
3.524AspSer: 3.524 ± 0.371
2.735AspThr: 2.735 ± 0.307
3.45AspVal: 3.45 ± 0.337
0.616AspTrp: 0.616 ± 0.14
2.883AspTyr: 2.883 ± 0.273
0.0AspXaa: 0.0 ± 0.0
Glu
2.76GluAla: 2.76 ± 0.334
1.134GluCys: 1.134 ± 0.163
4.164GluAsp: 4.164 ± 0.333
6.111GluGlu: 6.111 ± 0.601
3.351GluPhe: 3.351 ± 0.282
2.661GluGly: 2.661 ± 0.251
0.986GluHis: 0.986 ± 0.152
4.657GluIle: 4.657 ± 0.381
6.185GluLys: 6.185 ± 0.47
6.111GluLeu: 6.111 ± 0.445
1.873GluMet: 1.873 ± 0.215
4.115GluAsn: 4.115 ± 0.321
1.873GluPro: 1.873 ± 0.196
3.228GluGln: 3.228 ± 0.416
2.76GluArg: 2.76 ± 0.297
4.09GluSer: 4.09 ± 0.355
3.672GluThr: 3.672 ± 0.29
3.006GluVal: 3.006 ± 0.314
0.789GluTrp: 0.789 ± 0.134
3.129GluTyr: 3.129 ± 0.261
0.0GluXaa: 0.0 ± 0.0
Phe
2.39PheAla: 2.39 ± 0.261
0.813PheCys: 0.813 ± 0.152
2.858PheAsp: 2.858 ± 0.245
3.746PheGlu: 3.746 ± 0.326
2.119PhePhe: 2.119 ± 0.234
2.76PheGly: 2.76 ± 0.271
0.887PheHis: 0.887 ± 0.141
3.302PheIle: 3.302 ± 0.324
5.175PheLys: 5.175 ± 0.376
4.559PheLeu: 4.559 ± 0.353
1.207PheMet: 1.207 ± 0.187
3.327PheAsn: 3.327 ± 0.254
1.577PhePro: 1.577 ± 0.205
2.095PheGln: 2.095 ± 0.241
2.021PheArg: 2.021 ± 0.207
3.302PheSer: 3.302 ± 0.251
2.612PheThr: 2.612 ± 0.274
3.573PheVal: 3.573 ± 0.267
0.394PheTrp: 0.394 ± 0.104
1.996PheTyr: 1.996 ± 0.268
0.0PheXaa: 0.0 ± 0.0
Gly
2.44GlyAla: 2.44 ± 0.281
0.912GlyCys: 0.912 ± 0.145
2.686GlyAsp: 2.686 ± 0.303
3.228GlyGlu: 3.228 ± 0.314
2.07GlyPhe: 2.07 ± 0.25
3.548GlyGly: 3.548 ± 0.513
0.739GlyHis: 0.739 ± 0.135
3.179GlyIle: 3.179 ± 0.329
3.351GlyLys: 3.351 ± 0.291
4.362GlyLeu: 4.362 ± 0.344
0.838GlyMet: 0.838 ± 0.143
2.489GlyAsn: 2.489 ± 0.307
1.429GlyPro: 1.429 ± 0.239
2.242GlyGln: 2.242 ± 0.206
1.725GlyArg: 1.725 ± 0.191
3.524GlySer: 3.524 ± 0.42
3.228GlyThr: 3.228 ± 0.45
3.992GlyVal: 3.992 ± 0.411
0.641GlyTrp: 0.641 ± 0.119
2.366GlyTyr: 2.366 ± 0.239
0.0GlyXaa: 0.0 ± 0.0
His
0.69HisAla: 0.69 ± 0.13
0.419HisCys: 0.419 ± 0.107
0.616HisAsp: 0.616 ± 0.152
1.207HisGlu: 1.207 ± 0.168
1.331HisPhe: 1.331 ± 0.138
0.591HisGly: 0.591 ± 0.106
0.493HisHis: 0.493 ± 0.124
1.602HisIle: 1.602 ± 0.207
1.823HisLys: 1.823 ± 0.21
1.996HisLeu: 1.996 ± 0.226
0.419HisMet: 0.419 ± 0.108
1.01HisAsn: 1.01 ± 0.18
1.38HisPro: 1.38 ± 0.157
0.665HisGln: 0.665 ± 0.139
0.665HisArg: 0.665 ± 0.127
1.06HisSer: 1.06 ± 0.171
1.232HisThr: 1.232 ± 0.161
1.207HisVal: 1.207 ± 0.19
0.172HisTrp: 0.172 ± 0.054
0.838HisTyr: 0.838 ± 0.176
0.0HisXaa: 0.0 ± 0.0
Ile
3.598IleAla: 3.598 ± 0.284
0.986IleCys: 0.986 ± 0.151
3.943IleAsp: 3.943 ± 0.301
4.09IleGlu: 4.09 ± 0.337
4.041IlePhe: 4.041 ± 0.304
3.228IleGly: 3.228 ± 0.253
1.552IleHis: 1.552 ± 0.173
4.386IleIle: 4.386 ± 0.349
6.998IleLys: 6.998 ± 0.528
5.791IleLeu: 5.791 ± 0.33
1.799IleMet: 1.799 ± 0.232
5.027IleAsn: 5.027 ± 0.408
2.415IlePro: 2.415 ± 0.259
2.784IleGln: 2.784 ± 0.239
2.366IleArg: 2.366 ± 0.271
4.682IleSer: 4.682 ± 0.343
3.746IleThr: 3.746 ± 0.314
4.435IleVal: 4.435 ± 0.417
0.542IleTrp: 0.542 ± 0.108
3.056IleTyr: 3.056 ± 0.229
0.0IleXaa: 0.0 ± 0.0
Lys
3.524LysAla: 3.524 ± 0.29
1.602LysCys: 1.602 ± 0.244
5.446LysAsp: 5.446 ± 0.429
7.491LysGlu: 7.491 ± 0.608
3.918LysPhe: 3.918 ± 0.349
3.203LysGly: 3.203 ± 0.302
2.045LysHis: 2.045 ± 0.225
7.368LysIle: 7.368 ± 0.368
9.413LysLys: 9.413 ± 0.653
8.353LysLeu: 8.353 ± 0.602
2.39LysMet: 2.39 ± 0.265
6.333LysAsn: 6.333 ± 0.485
3.598LysPro: 3.598 ± 0.436
3.228LysGln: 3.228 ± 0.303
3.672LysArg: 3.672 ± 0.383
5.273LysSer: 5.273 ± 0.389
5.692LysThr: 5.692 ± 0.424
5.175LysVal: 5.175 ± 0.293
0.986LysTrp: 0.986 ± 0.152
3.992LysTyr: 3.992 ± 0.349
0.0LysXaa: 0.0 ± 0.0
Leu
4.066LeuAla: 4.066 ± 0.306
1.75LeuCys: 1.75 ± 0.199
4.978LeuAsp: 4.978 ± 0.35
6.481LeuGlu: 6.481 ± 0.505
4.164LeuPhe: 4.164 ± 0.324
3.992LeuGly: 3.992 ± 0.346
1.947LeuHis: 1.947 ± 0.243
5.692LeuIle: 5.692 ± 0.39
10.99LeuLys: 10.99 ± 0.532
8.748LeuLeu: 8.748 ± 0.519
1.922LeuMet: 1.922 ± 0.181
6.505LeuAsn: 6.505 ± 0.416
3.548LeuPro: 3.548 ± 0.311
3.721LeuGln: 3.721 ± 0.343
3.622LeuArg: 3.622 ± 0.286
7.417LeuSer: 7.417 ± 0.382
5.446LeuThr: 5.446 ± 0.461
5.002LeuVal: 5.002 ± 0.34
0.887LeuTrp: 0.887 ± 0.133
3.425LeuTyr: 3.425 ± 0.344
0.0LeuXaa: 0.0 ± 0.0
Met
1.454MetAla: 1.454 ± 0.181
0.616MetCys: 0.616 ± 0.128
1.454MetAsp: 1.454 ± 0.213
1.281MetGlu: 1.281 ± 0.197
1.109MetPhe: 1.109 ± 0.135
1.281MetGly: 1.281 ± 0.18
0.222MetHis: 0.222 ± 0.081
1.257MetIle: 1.257 ± 0.16
1.577MetLys: 1.577 ± 0.181
1.454MetLeu: 1.454 ± 0.173
0.468MetMet: 0.468 ± 0.127
0.961MetAsn: 0.961 ± 0.152
0.542MetPro: 0.542 ± 0.127
0.764MetGln: 0.764 ± 0.13
0.887MetArg: 0.887 ± 0.129
1.873MetSer: 1.873 ± 0.215
1.183MetThr: 1.183 ± 0.178
1.873MetVal: 1.873 ± 0.229
0.222MetTrp: 0.222 ± 0.084
0.961MetTyr: 0.961 ± 0.137
0.0MetXaa: 0.0 ± 0.0
Asn
2.637AsnAla: 2.637 ± 0.345
1.183AsnCys: 1.183 ± 0.19
2.39AsnAsp: 2.39 ± 0.236
3.548AsnGlu: 3.548 ± 0.312
3.696AsnPhe: 3.696 ± 0.347
3.302AsnGly: 3.302 ± 0.272
1.207AsnHis: 1.207 ± 0.178
4.559AsnIle: 4.559 ± 0.36
5.865AsnLys: 5.865 ± 0.443
6.974AsnLeu: 6.974 ± 0.385
1.478AsnMet: 1.478 ± 0.18
3.721AsnAsn: 3.721 ± 0.241
2.168AsnPro: 2.168 ± 0.179
1.947AsnGln: 1.947 ± 0.238
2.341AsnArg: 2.341 ± 0.243
3.327AsnSer: 3.327 ± 0.313
3.302AsnThr: 3.302 ± 0.281
3.943AsnVal: 3.943 ± 0.322
0.493AsnTrp: 0.493 ± 0.134
2.661AsnTyr: 2.661 ± 0.239
0.0AsnXaa: 0.0 ± 0.0
Pro
1.528ProAla: 1.528 ± 0.237
0.616ProCys: 0.616 ± 0.146
2.513ProAsp: 2.513 ± 0.25
2.366ProGlu: 2.366 ± 0.295
2.193ProPhe: 2.193 ± 0.231
1.947ProGly: 1.947 ± 0.257
1.035ProHis: 1.035 ± 0.157
2.932ProIle: 2.932 ± 0.27
3.795ProLys: 3.795 ± 0.514
3.869ProLeu: 3.869 ± 0.329
0.444ProMet: 0.444 ± 0.15
2.193ProAsn: 2.193 ± 0.24
2.292ProPro: 2.292 ± 0.338
1.897ProGln: 1.897 ± 0.252
1.552ProArg: 1.552 ± 0.234
3.228ProSer: 3.228 ± 0.346
2.735ProThr: 2.735 ± 0.347
2.193ProVal: 2.193 ± 0.304
0.345ProTrp: 0.345 ± 0.098
1.109ProTyr: 1.109 ± 0.167
0.0ProXaa: 0.0 ± 0.0
Gln
1.281GlnAla: 1.281 ± 0.154
0.517GlnCys: 0.517 ± 0.11
2.07GlnAsp: 2.07 ± 0.199
2.415GlnGlu: 2.415 ± 0.325
2.168GlnPhe: 2.168 ± 0.256
1.429GlnGly: 1.429 ± 0.204
1.01GlnHis: 1.01 ± 0.164
3.056GlnIle: 3.056 ± 0.27
3.746GlnLys: 3.746 ± 0.343
3.893GlnLeu: 3.893 ± 0.34
0.715GlnMet: 0.715 ± 0.125
2.661GlnAsn: 2.661 ± 0.317
1.725GlnPro: 1.725 ± 0.261
1.873GlnGln: 1.873 ± 0.276
1.454GlnArg: 1.454 ± 0.185
2.44GlnSer: 2.44 ± 0.266
3.031GlnThr: 3.031 ± 0.294
1.7GlnVal: 1.7 ± 0.244
0.345GlnTrp: 0.345 ± 0.096
1.725GlnTyr: 1.725 ± 0.222
0.0GlnXaa: 0.0 ± 0.0
Arg
1.947ArgAla: 1.947 ± 0.288
0.69ArgCys: 0.69 ± 0.129
2.489ArgAsp: 2.489 ± 0.239
2.784ArgGlu: 2.784 ± 0.299
2.095ArgPhe: 2.095 ± 0.21
1.577ArgGly: 1.577 ± 0.224
0.493ArgHis: 0.493 ± 0.107
2.563ArgIle: 2.563 ± 0.21
3.647ArgLys: 3.647 ± 0.43
3.179ArgLeu: 3.179 ± 0.336
0.936ArgMet: 0.936 ± 0.17
2.242ArgAsn: 2.242 ± 0.226
1.947ArgPro: 1.947 ± 0.227
1.651ArgGln: 1.651 ± 0.21
1.626ArgArg: 1.626 ± 0.254
2.316ArgSer: 2.316 ± 0.424
1.725ArgThr: 1.725 ± 0.174
2.366ArgVal: 2.366 ± 0.262
0.32ArgTrp: 0.32 ± 0.092
1.651ArgTyr: 1.651 ± 0.205
0.0ArgXaa: 0.0 ± 0.0
Ser
3.721SerAla: 3.721 ± 0.304
1.183SerCys: 1.183 ± 0.205
3.696SerAsp: 3.696 ± 0.3
4.386SerGlu: 4.386 ± 0.463
3.967SerPhe: 3.967 ± 0.314
3.844SerGly: 3.844 ± 0.518
1.306SerHis: 1.306 ± 0.182
3.499SerIle: 3.499 ± 0.306
6.875SerLys: 6.875 ± 0.375
6.702SerLeu: 6.702 ± 0.394
1.281SerMet: 1.281 ± 0.185
3.401SerAsn: 3.401 ± 0.306
3.105SerPro: 3.105 ± 0.497
2.464SerGln: 2.464 ± 0.26
2.809SerArg: 2.809 ± 0.259
5.347SerSer: 5.347 ± 0.403
4.509SerThr: 4.509 ± 0.454
3.967SerVal: 3.967 ± 0.369
0.591SerTrp: 0.591 ± 0.108
2.021SerTyr: 2.021 ± 0.22
0.0SerXaa: 0.0 ± 0.0
Thr
2.267ThrAla: 2.267 ± 0.289
1.281ThrCys: 1.281 ± 0.264
2.637ThrAsp: 2.637 ± 0.276
2.858ThrGlu: 2.858 ± 0.243
3.08ThrPhe: 3.08 ± 0.278
3.721ThrGly: 3.721 ± 0.494
1.183ThrHis: 1.183 ± 0.147
4.83ThrIle: 4.83 ± 0.351
4.534ThrLys: 4.534 ± 0.394
5.347ThrLeu: 5.347 ± 0.438
0.838ThrMet: 0.838 ± 0.159
4.09ThrAsn: 4.09 ± 0.319
3.327ThrPro: 3.327 ± 0.429
1.996ThrGln: 1.996 ± 0.24
2.908ThrArg: 2.908 ± 0.293
4.411ThrSer: 4.411 ± 0.437
4.14ThrThr: 4.14 ± 0.418
2.784ThrVal: 2.784 ± 0.252
0.394ThrTrp: 0.394 ± 0.097
2.07ThrTyr: 2.07 ± 0.305
0.0ThrXaa: 0.0 ± 0.0
Val
2.858ValAla: 2.858 ± 0.28
0.986ValCys: 0.986 ± 0.179
4.657ValAsp: 4.657 ± 0.321
4.066ValGlu: 4.066 ± 0.35
3.129ValPhe: 3.129 ± 0.281
2.982ValGly: 2.982 ± 0.25
1.207ValHis: 1.207 ± 0.175
3.598ValIle: 3.598 ± 0.225
4.928ValLys: 4.928 ± 0.363
5.692ValLeu: 5.692 ± 0.37
1.429ValMet: 1.429 ± 0.186
2.834ValAsn: 2.834 ± 0.266
2.982ValPro: 2.982 ± 0.343
2.44ValGln: 2.44 ± 0.215
2.045ValArg: 2.045 ± 0.228
4.608ValSer: 4.608 ± 0.375
2.686ValThr: 2.686 ± 0.294
4.214ValVal: 4.214 ± 0.373
0.567ValTrp: 0.567 ± 0.108
2.44ValTyr: 2.44 ± 0.302
0.0ValXaa: 0.0 ± 0.0
Trp
0.32TrpAla: 0.32 ± 0.092
0.246TrpCys: 0.246 ± 0.071
0.32TrpAsp: 0.32 ± 0.087
0.468TrpGlu: 0.468 ± 0.092
0.468TrpPhe: 0.468 ± 0.105
0.37TrpGly: 0.37 ± 0.126
0.148TrpHis: 0.148 ± 0.053
0.764TrpIle: 0.764 ± 0.13
0.616TrpLys: 0.616 ± 0.115
0.961TrpLeu: 0.961 ± 0.155
0.296TrpMet: 0.296 ± 0.075
0.665TrpAsn: 0.665 ± 0.147
0.345TrpPro: 0.345 ± 0.108
0.172TrpGln: 0.172 ± 0.073
0.246TrpArg: 0.246 ± 0.089
0.789TrpSer: 0.789 ± 0.127
0.567TrpThr: 0.567 ± 0.133
0.517TrpVal: 0.517 ± 0.096
0.123TrpTrp: 0.123 ± 0.05
0.591TrpTyr: 0.591 ± 0.137
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.799TyrAla: 1.799 ± 0.209
0.517TyrCys: 0.517 ± 0.112
2.661TyrAsp: 2.661 ± 0.272
1.774TyrGlu: 1.774 ± 0.212
2.218TyrPhe: 2.218 ± 0.237
2.44TyrGly: 2.44 ± 0.288
0.591TyrHis: 0.591 ± 0.102
3.327TyrIle: 3.327 ± 0.304
3.672TyrLys: 3.672 ± 0.288
3.918TyrLeu: 3.918 ± 0.325
0.838TyrMet: 0.838 ± 0.126
2.218TyrAsn: 2.218 ± 0.214
1.676TyrPro: 1.676 ± 0.181
1.552TyrGln: 1.552 ± 0.218
1.503TyrArg: 1.503 ± 0.167
3.08TyrSer: 3.08 ± 0.283
2.686TyrThr: 2.686 ± 0.266
2.686TyrVal: 2.686 ± 0.276
0.197TyrTrp: 0.197 ± 0.063
2.292TyrTyr: 2.292 ± 0.244
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 131 proteins (40583 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski