Amino acid dipepetide frequency for Legionella lansingensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.941AlaAla: 6.941 ± 0.118	1.109AlaCys: 1.109 ± 0.036	3.556AlaAsp: 3.556 ± 0.064	4.512AlaGlu: 4.512 ± 0.085	3.43AlaPhe: 3.43 ± 0.063	5.266AlaGly: 5.266 ± 0.106	1.809AlaHis: 1.809 ± 0.053	6.56AlaIle: 6.56 ± 0.097	5.117AlaLys: 5.117 ± 0.091	9.673AlaLeu: 9.673 ± 0.123	2.229AlaMet: 2.229 ± 0.059	3.557AlaAsn: 3.557 ± 0.077	2.513AlaPro: 2.513 ± 0.065	3.555AlaGln: 3.555 ± 0.073	3.632AlaArg: 3.632 ± 0.073	4.834AlaSer: 4.834 ± 0.083	4.309AlaThr: 4.309 ± 0.075	5.018AlaVal: 5.018 ± 0.084	0.835AlaTrp: 0.835 ± 0.034	2.62AlaTyr: 2.62 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.827CysAla: 0.827 ± 0.03	0.2CysCys: 0.2 ± 0.016	0.584CysAsp: 0.584 ± 0.028	0.686CysGlu: 0.686 ± 0.026	0.659CysPhe: 0.659 ± 0.026	0.852CysGly: 0.852 ± 0.034	0.384CysHis: 0.384 ± 0.021	0.78CysIle: 0.78 ± 0.035	0.569CysLys: 0.569 ± 0.024	1.398CysLeu: 1.398 ± 0.04	0.255CysMet: 0.255 ± 0.018	0.433CysAsn: 0.433 ± 0.025	0.488CysPro: 0.488 ± 0.027	0.571CysGln: 0.571 ± 0.025	0.532CysArg: 0.532 ± 0.024	0.737CysSer: 0.737 ± 0.034	0.538CysThr: 0.538 ± 0.024	0.695CysVal: 0.695 ± 0.03	0.169CysTrp: 0.169 ± 0.013	0.45CysTyr: 0.45 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	3.652AspAla: 3.652 ± 0.07	0.613AspCys: 0.613 ± 0.025	2.442AspAsp: 2.442 ± 0.064	3.447AspGlu: 3.447 ± 0.068	2.43AspPhe: 2.43 ± 0.049	2.654AspGly: 2.654 ± 0.067	1.083AspHis: 1.083 ± 0.037	3.684AspIle: 3.684 ± 0.066	3.402AspLys: 3.402 ± 0.065	5.048AspLeu: 5.048 ± 0.085	1.026AspMet: 1.026 ± 0.037	2.14AspAsn: 2.14 ± 0.053	2.099AspPro: 2.099 ± 0.052	1.512AspGln: 1.512 ± 0.048	1.96AspArg: 1.96 ± 0.042	2.814AspSer: 2.814 ± 0.069	2.213AspThr: 2.213 ± 0.051	3.241AspVal: 3.241 ± 0.06	0.702AspTrp: 0.702 ± 0.029	2.085AspTyr: 2.085 ± 0.054	0.002AspXaa: 0.002 ± 0.002
Glu	4.865GluAla: 4.865 ± 0.088	0.524GluCys: 0.524 ± 0.027	2.689GluAsp: 2.689 ± 0.062	4.581GluGlu: 4.581 ± 0.094	2.376GluPhe: 2.376 ± 0.056	3.208GluGly: 3.208 ± 0.062	1.619GluHis: 1.619 ± 0.043	4.447GluIle: 4.447 ± 0.083	4.713GluLys: 4.713 ± 0.088	6.693GluLeu: 6.693 ± 0.099	1.503GluMet: 1.503 ± 0.042	2.845GluAsn: 2.845 ± 0.063	1.929GluPro: 1.929 ± 0.046	3.256GluGln: 3.256 ± 0.066	3.196GluArg: 3.196 ± 0.073	3.099GluSer: 3.099 ± 0.068	3.057GluThr: 3.057 ± 0.07	3.641GluVal: 3.641 ± 0.077	0.61GluTrp: 0.61 ± 0.024	1.753GluTyr: 1.753 ± 0.052	0.001GluXaa: 0.001 ± 0.001
Phe	3.832PheAla: 3.832 ± 0.077	0.633PheCys: 0.633 ± 0.032	2.42PheAsp: 2.42 ± 0.049	2.243PheGlu: 2.243 ± 0.047	2.53PhePhe: 2.53 ± 0.065	2.705PheGly: 2.705 ± 0.063	0.966PheHis: 0.966 ± 0.036	3.524PheIle: 3.524 ± 0.073	2.326PheLys: 2.326 ± 0.055	4.8PheLeu: 4.8 ± 0.091	1.013PheMet: 1.013 ± 0.032	2.144PheAsn: 2.144 ± 0.049	1.787PhePro: 1.787 ± 0.048	1.478PheGln: 1.478 ± 0.044	1.641PheArg: 1.641 ± 0.042	3.47PheSer: 3.47 ± 0.073	2.471PheThr: 2.471 ± 0.055	2.599PheVal: 2.599 ± 0.057	0.576PheTrp: 0.576 ± 0.027	1.724PheTyr: 1.724 ± 0.05	0.0PheXaa: 0.0 ± 0.0
Gly	4.506GlyAla: 4.506 ± 0.088	0.825GlyCys: 0.825 ± 0.037	2.812GlyAsp: 2.812 ± 0.062	3.561GlyGlu: 3.561 ± 0.069	3.236GlyPhe: 3.236 ± 0.073	4.109GlyGly: 4.109 ± 0.099	1.609GlyHis: 1.609 ± 0.045	4.862GlyIle: 4.862 ± 0.099	3.827GlyLys: 3.827 ± 0.071	6.692GlyLeu: 6.692 ± 0.097	1.622GlyMet: 1.622 ± 0.048	2.429GlyAsn: 2.429 ± 0.065	1.773GlyPro: 1.773 ± 0.051	2.496GlyGln: 2.496 ± 0.062	2.781GlyArg: 2.781 ± 0.06	3.54GlySer: 3.54 ± 0.078	3.031GlyThr: 3.031 ± 0.066	4.34GlyVal: 4.34 ± 0.074	0.896GlyTrp: 0.896 ± 0.039	2.426GlyTyr: 2.426 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	1.944HisAla: 1.944 ± 0.046	0.425HisCys: 0.425 ± 0.023	1.198HisAsp: 1.198 ± 0.041	1.38HisGlu: 1.38 ± 0.04	1.368HisPhe: 1.368 ± 0.039	1.682HisGly: 1.682 ± 0.049	0.973HisHis: 0.973 ± 0.043	1.583HisIle: 1.583 ± 0.045	1.138HisLys: 1.138 ± 0.041	3.01HisLeu: 3.01 ± 0.06	0.496HisMet: 0.496 ± 0.022	0.911HisAsn: 0.911 ± 0.033	1.414HisPro: 1.414 ± 0.039	1.194HisGln: 1.194 ± 0.042	1.245HisArg: 1.245 ± 0.041	1.475HisSer: 1.475 ± 0.047	1.111HisThr: 1.111 ± 0.034	1.486HisVal: 1.486 ± 0.041	0.435HisTrp: 0.435 ± 0.02	1.144HisTyr: 1.144 ± 0.036	0.0HisXaa: 0.0 ± 0.0
Ile	6.678IleAla: 6.678 ± 0.096	0.839IleCys: 0.839 ± 0.031	4.148IleAsp: 4.148 ± 0.068	4.467IleGlu: 4.467 ± 0.072	2.861IlePhe: 2.861 ± 0.062	4.617IleGly: 4.617 ± 0.089	1.845IleHis: 1.845 ± 0.047	5.05IleIle: 5.05 ± 0.089	4.495IleLys: 4.495 ± 0.083	7.194IleLeu: 7.194 ± 0.104	1.359IleMet: 1.359 ± 0.039	3.569IleAsn: 3.569 ± 0.071	3.345IlePro: 3.345 ± 0.061	2.531IleGln: 2.531 ± 0.054	3.156IleArg: 3.156 ± 0.061	4.671IleSer: 4.671 ± 0.082	4.172IleThr: 4.172 ± 0.078	4.349IleVal: 4.349 ± 0.081	0.633IleTrp: 0.633 ± 0.028	2.227IleTyr: 2.227 ± 0.046	0.0IleXaa: 0.0 ± 0.0
Lys	4.926LysAla: 4.926 ± 0.091	0.381LysCys: 0.381 ± 0.022	3.013LysAsp: 3.013 ± 0.076	4.601LysGlu: 4.601 ± 0.084	1.753LysPhe: 1.753 ± 0.047	3.122LysGly: 3.122 ± 0.06	1.496LysHis: 1.496 ± 0.043	4.423LysIle: 4.423 ± 0.078	4.573LysLys: 4.573 ± 0.074	6.173LysLeu: 6.173 ± 0.097	1.463LysMet: 1.463 ± 0.039	3.014LysAsn: 3.014 ± 0.074	2.651LysPro: 2.651 ± 0.052	3.325LysGln: 3.325 ± 0.063	3.168LysArg: 3.168 ± 0.056	3.371LysSer: 3.371 ± 0.063	3.549LysThr: 3.549 ± 0.082	3.121LysVal: 3.121 ± 0.06	0.58LysTrp: 0.58 ± 0.026	1.599LysTyr: 1.599 ± 0.043	0.0LysXaa: 0.0 ± 0.0
Leu	10.138LeuAla: 10.138 ± 0.127	1.384LeuCys: 1.384 ± 0.044	5.162LeuAsp: 5.162 ± 0.087	5.89LeuGlu: 5.89 ± 0.095	5.123LeuPhe: 5.123 ± 0.087	6.824LeuGly: 6.824 ± 0.1	2.631LeuHis: 2.631 ± 0.061	8.016LeuIle: 8.016 ± 0.103	6.419LeuLys: 6.419 ± 0.099	12.658LeuLeu: 12.658 ± 0.193	2.471LeuMet: 2.471 ± 0.059	4.939LeuAsn: 4.939 ± 0.088	5.315LeuPro: 5.315 ± 0.087	5.012LeuGln: 5.012 ± 0.097	5.089LeuArg: 5.089 ± 0.082	7.885LeuSer: 7.885 ± 0.106	6.219LeuThr: 6.219 ± 0.083	6.427LeuVal: 6.427 ± 0.098	1.136LeuTrp: 1.136 ± 0.043	3.108LeuTyr: 3.108 ± 0.071	0.0LeuXaa: 0.0 ± 0.0
Met	2.035MetAla: 2.035 ± 0.056	0.174MetCys: 0.174 ± 0.014	1.046MetAsp: 1.046 ± 0.038	1.242MetGlu: 1.242 ± 0.039	0.75MetPhe: 0.75 ± 0.029	1.445MetGly: 1.445 ± 0.045	0.588MetHis: 0.588 ± 0.024	1.597MetIle: 1.597 ± 0.042	1.505MetLys: 1.505 ± 0.043	2.608MetLeu: 2.608 ± 0.06	0.664MetMet: 0.664 ± 0.03	1.088MetAsn: 1.088 ± 0.032	1.114MetPro: 1.114 ± 0.034	1.158MetGln: 1.158 ± 0.037	1.239MetArg: 1.239 ± 0.042	1.557MetSer: 1.557 ± 0.039	1.452MetThr: 1.452 ± 0.038	1.481MetVal: 1.481 ± 0.047	0.179MetTrp: 0.179 ± 0.015	0.51MetTyr: 0.51 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	3.243AsnAla: 3.243 ± 0.061	0.502AsnCys: 0.502 ± 0.025	2.218AsnAsp: 2.218 ± 0.052	2.678AsnGlu: 2.678 ± 0.056	1.807AsnPhe: 1.807 ± 0.043	2.362AsnGly: 2.362 ± 0.062	1.325AsnHis: 1.325 ± 0.043	3.071AsnIle: 3.071 ± 0.06	2.737AsnLys: 2.737 ± 0.063	4.693AsnLeu: 4.693 ± 0.093	0.85AsnMet: 0.85 ± 0.035	2.187AsnAsn: 2.187 ± 0.064	2.558AsnPro: 2.558 ± 0.053	2.249AsnGln: 2.249 ± 0.053	2.02AsnArg: 2.02 ± 0.048	2.479AsnSer: 2.479 ± 0.059	2.251AsnThr: 2.251 ± 0.059	2.488AsnVal: 2.488 ± 0.058	0.578AsnTrp: 0.578 ± 0.026	1.748AsnTyr: 1.748 ± 0.048	0.0AsnXaa: 0.0 ± 0.0
Pro	3.012ProAla: 3.012 ± 0.067	0.447ProCys: 0.447 ± 0.026	2.152ProAsp: 2.152 ± 0.051	3.125ProGlu: 3.125 ± 0.061	1.989ProPhe: 1.989 ± 0.05	2.668ProGly: 2.668 ± 0.054	1.056ProHis: 1.056 ± 0.033	2.862ProIle: 2.862 ± 0.053	2.312ProLys: 2.312 ± 0.049	4.546ProLeu: 4.546 ± 0.076	0.941ProMet: 0.941 ± 0.033	1.766ProAsn: 1.766 ± 0.051	1.671ProPro: 1.671 ± 0.05	1.945ProGln: 1.945 ± 0.05	1.65ProArg: 1.65 ± 0.046	2.58ProSer: 2.58 ± 0.057	2.267ProThr: 2.267 ± 0.056	2.928ProVal: 2.928 ± 0.063	0.506ProTrp: 0.506 ± 0.026	1.479ProTyr: 1.479 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	4.231GlnAla: 4.231 ± 0.088	0.476GlnCys: 0.476 ± 0.025	1.962GlnAsp: 1.962 ± 0.052	2.815GlnGlu: 2.815 ± 0.067	1.98GlnPhe: 1.98 ± 0.045	2.667GlnGly: 2.667 ± 0.064	1.245GlnHis: 1.245 ± 0.04	2.908GlnIle: 2.908 ± 0.06	2.691GlnLys: 2.691 ± 0.057	5.214GlnLeu: 5.214 ± 0.092	1.051GlnMet: 1.051 ± 0.033	1.802GlnAsn: 1.802 ± 0.05	1.665GlnPro: 1.665 ± 0.044	2.911GlnGln: 2.911 ± 0.078	2.322GlnArg: 2.322 ± 0.051	2.467GlnSer: 2.467 ± 0.05	2.334GlnThr: 2.334 ± 0.06	2.637GlnVal: 2.637 ± 0.054	0.63GlnTrp: 0.63 ± 0.028	1.428GlnTyr: 1.428 ± 0.043	0.0GlnXaa: 0.0 ± 0.0
Arg	3.325ArgAla: 3.325 ± 0.065	0.503ArgCys: 0.503 ± 0.027	2.343ArgAsp: 2.343 ± 0.06	3.104ArgGlu: 3.104 ± 0.075	2.349ArgPhe: 2.349 ± 0.051	2.665ArgGly: 2.665 ± 0.061	1.256ArgHis: 1.256 ± 0.036	3.178ArgIle: 3.178 ± 0.06	2.57ArgLys: 2.57 ± 0.06	5.464ArgLeu: 5.464 ± 0.093	1.168ArgMet: 1.168 ± 0.039	1.935ArgAsn: 1.935 ± 0.044	1.56ArgPro: 1.56 ± 0.047	2.256ArgGln: 2.256 ± 0.06	2.293ArgArg: 2.293 ± 0.064	2.448ArgSer: 2.448 ± 0.045	2.07ArgThr: 2.07 ± 0.051	2.922ArgVal: 2.922 ± 0.064	0.627ArgTrp: 0.627 ± 0.028	1.877ArgTyr: 1.877 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	4.331SerAla: 4.331 ± 0.079	0.784SerCys: 0.784 ± 0.032	2.771SerAsp: 2.771 ± 0.062	3.577SerGlu: 3.577 ± 0.068	2.961SerPhe: 2.961 ± 0.069	4.105SerGly: 4.105 ± 0.071	1.643SerHis: 1.643 ± 0.04	4.162SerIle: 4.162 ± 0.071	3.544SerLys: 3.544 ± 0.068	7.564SerLeu: 7.564 ± 0.103	1.601SerMet: 1.601 ± 0.05	2.557SerAsn: 2.557 ± 0.056	2.735SerPro: 2.735 ± 0.057	2.788SerGln: 2.788 ± 0.059	2.633SerArg: 2.633 ± 0.06	4.434SerSer: 4.434 ± 0.074	3.205SerThr: 3.205 ± 0.077	3.546SerVal: 3.546 ± 0.057	0.836SerTrp: 0.836 ± 0.033	2.232SerTyr: 2.232 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	4.251ThrAla: 4.251 ± 0.069	0.565ThrCys: 0.565 ± 0.027	2.376ThrAsp: 2.376 ± 0.053	2.825ThrGlu: 2.825 ± 0.065	2.137ThrPhe: 2.137 ± 0.057	3.648ThrGly: 3.648 ± 0.07	1.384ThrHis: 1.384 ± 0.045	3.954ThrIle: 3.954 ± 0.067	2.745ThrLys: 2.745 ± 0.064	6.113ThrLeu: 6.113 ± 0.091	1.187ThrMet: 1.187 ± 0.036	2.18ThrAsn: 2.18 ± 0.049	2.808ThrPro: 2.808 ± 0.059	2.374ThrGln: 2.374 ± 0.058	2.234ThrArg: 2.234 ± 0.049	3.312ThrSer: 3.312 ± 0.071	3.22ThrThr: 3.22 ± 0.068	3.338ThrVal: 3.338 ± 0.076	0.597ThrTrp: 0.597 ± 0.028	1.605ThrTyr: 1.605 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	5.108ValAla: 5.108 ± 0.087	0.73ValCys: 0.73 ± 0.032	3.259ValAsp: 3.259 ± 0.063	3.434ValGlu: 3.434 ± 0.074	2.724ValPhe: 2.724 ± 0.062	3.885ValGly: 3.885 ± 0.087	1.305ValHis: 1.305 ± 0.042	4.895ValIle: 4.895 ± 0.086	3.494ValLys: 3.494 ± 0.073	6.485ValLeu: 6.485 ± 0.088	1.597ValMet: 1.597 ± 0.044	2.887ValAsn: 2.887 ± 0.061	2.472ValPro: 2.472 ± 0.058	2.049ValGln: 2.049 ± 0.051	2.647ValArg: 2.647 ± 0.063	4.1ValSer: 4.1 ± 0.067	3.338ValThr: 3.338 ± 0.066	4.239ValVal: 4.239 ± 0.088	0.582ValTrp: 0.582 ± 0.025	1.817ValTyr: 1.817 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.726TrpAla: 0.726 ± 0.031	0.154TrpCys: 0.154 ± 0.013	0.51TrpAsp: 0.51 ± 0.023	0.614TrpGlu: 0.614 ± 0.027	0.625TrpPhe: 0.625 ± 0.023	0.748TrpGly: 0.748 ± 0.031	0.365TrpHis: 0.365 ± 0.022	0.767TrpIle: 0.767 ± 0.032	0.49TrpLys: 0.49 ± 0.027	1.695TrpLeu: 1.695 ± 0.054	0.312TrpMet: 0.312 ± 0.019	0.439TrpAsn: 0.439 ± 0.022	0.494TrpPro: 0.494 ± 0.025	0.814TrpGln: 0.814 ± 0.031	0.627TrpArg: 0.627 ± 0.029	0.633TrpSer: 0.633 ± 0.026	0.468TrpThr: 0.468 ± 0.026	0.744TrpVal: 0.744 ± 0.028	0.182TrpTrp: 0.182 ± 0.014	0.409TrpTyr: 0.409 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.503TyrAla: 2.503 ± 0.059	0.539TyrCys: 0.539 ± 0.026	1.59TyrAsp: 1.59 ± 0.044	1.822TyrGlu: 1.822 ± 0.043	1.793TyrPhe: 1.793 ± 0.051	2.139TyrGly: 2.139 ± 0.054	1.03TyrHis: 1.03 ± 0.032	1.882TyrIle: 1.882 ± 0.052	1.632TyrLys: 1.632 ± 0.047	4.126TyrLeu: 4.126 ± 0.067	0.627TyrMet: 0.627 ± 0.031	1.224TyrAsn: 1.224 ± 0.037	1.512TyrPro: 1.512 ± 0.051	1.96TyrGln: 1.96 ± 0.057	1.848TyrArg: 1.848 ± 0.046	2.104TyrSer: 2.104 ± 0.045	1.577TyrThr: 1.577 ± 0.046	1.806TyrVal: 1.806 ± 0.055	0.525TyrTrp: 0.525 ± 0.023	1.336TyrTyr: 1.336 ± 0.047	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.001XaaCys: 0.001 ± 0.001	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.001	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.01XaaXaa: 0.01 ± 0.006

Statistics based on 2630 proteins (866165 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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