Amino acid dipepetide frequency for Cohnella lupini

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.927AlaAla: 7.927 ± 0.091
0.701AlaCys: 0.701 ± 0.023
4.502AlaAsp: 4.502 ± 0.063
5.466AlaGlu: 5.466 ± 0.066
3.4AlaPhe: 3.4 ± 0.048
6.668AlaGly: 6.668 ± 0.073
1.317AlaHis: 1.317 ± 0.027
5.836AlaIle: 5.836 ± 0.063
4.115AlaLys: 4.115 ± 0.05
8.233AlaLeu: 8.233 ± 0.081
2.286AlaMet: 2.286 ± 0.034
3.063AlaAsn: 3.063 ± 0.048
2.714AlaPro: 2.714 ± 0.053
2.527AlaGln: 2.527 ± 0.036
3.757AlaArg: 3.757 ± 0.051
5.594AlaSer: 5.594 ± 0.053
4.211AlaThr: 4.211 ± 0.064
6.251AlaVal: 6.251 ± 0.059
1.008AlaTrp: 1.008 ± 0.025
2.677AlaTyr: 2.677 ± 0.04
0.0AlaXaa: 0.0 ± 0.0
Cys
0.493CysAla: 0.493 ± 0.018
0.098CysCys: 0.098 ± 0.008
0.348CysAsp: 0.348 ± 0.016
0.411CysGlu: 0.411 ± 0.014
0.266CysPhe: 0.266 ± 0.014
0.732CysGly: 0.732 ± 0.02
0.171CysHis: 0.171 ± 0.01
0.461CysIle: 0.461 ± 0.015
0.281CysLys: 0.281 ± 0.013
0.688CysLeu: 0.688 ± 0.018
0.182CysMet: 0.182 ± 0.01
0.236CysAsn: 0.236 ± 0.012
0.303CysPro: 0.303 ± 0.013
0.175CysGln: 0.175 ± 0.01
0.412CysArg: 0.412 ± 0.018
0.519CysSer: 0.519 ± 0.017
0.34CysThr: 0.34 ± 0.015
0.416CysVal: 0.416 ± 0.016
0.078CysTrp: 0.078 ± 0.006
0.236CysTyr: 0.236 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
4.152AspAla: 4.152 ± 0.056
0.349AspCys: 0.349 ± 0.015
2.663AspAsp: 2.663 ± 0.045
3.828AspGlu: 3.828 ± 0.05
2.255AspPhe: 2.255 ± 0.039
4.467AspGly: 4.467 ± 0.058
1.032AspHis: 1.032 ± 0.023
3.567AspIle: 3.567 ± 0.053
2.888AspLys: 2.888 ± 0.047
4.907AspLeu: 4.907 ± 0.049
1.382AspMet: 1.382 ± 0.031
2.229AspAsn: 2.229 ± 0.039
2.522AspPro: 2.522 ± 0.042
1.745AspGln: 1.745 ± 0.032
3.139AspArg: 3.139 ± 0.052
3.267AspSer: 3.267 ± 0.048
2.516AspThr: 2.516 ± 0.039
3.675AspVal: 3.675 ± 0.046
0.942AspTrp: 0.942 ± 0.023
2.137AspTyr: 2.137 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
5.821GluAla: 5.821 ± 0.066
0.349GluCys: 0.349 ± 0.015
3.132GluAsp: 3.132 ± 0.045
5.032GluGlu: 5.032 ± 0.068
2.271GluPhe: 2.271 ± 0.036
4.33GluGly: 4.33 ± 0.054
1.333GluHis: 1.333 ± 0.027
4.376GluIle: 4.376 ± 0.058
3.605GluLys: 3.605 ± 0.056
6.864GluLeu: 6.864 ± 0.073
1.932GluMet: 1.932 ± 0.033
2.447GluAsn: 2.447 ± 0.037
2.233GluPro: 2.233 ± 0.032
3.054GluGln: 3.054 ± 0.042
4.087GluArg: 4.087 ± 0.06
3.935GluSer: 3.935 ± 0.052
3.47GluThr: 3.47 ± 0.043
4.256GluVal: 4.256 ± 0.051
0.983GluTrp: 0.983 ± 0.024
1.976GluTyr: 1.976 ± 0.034
0.0GluXaa: 0.0 ± 0.0
Phe
3.452PheAla: 3.452 ± 0.046
0.305PheCys: 0.305 ± 0.015
2.465PheAsp: 2.465 ± 0.035
2.41PheGlu: 2.41 ± 0.042
1.789PhePhe: 1.789 ± 0.035
3.466PheGly: 3.466 ± 0.055
0.852PheHis: 0.852 ± 0.025
2.766PheIle: 2.766 ± 0.046
1.994PheLys: 1.994 ± 0.035
3.943PheLeu: 3.943 ± 0.058
1.096PheMet: 1.096 ± 0.026
1.689PheAsn: 1.689 ± 0.031
1.723PhePro: 1.723 ± 0.033
1.325PheGln: 1.325 ± 0.029
2.216PheArg: 2.216 ± 0.032
2.84PheSer: 2.84 ± 0.04
2.309PheThr: 2.309 ± 0.043
3.189PheVal: 3.189 ± 0.041
0.53PheTrp: 0.53 ± 0.016
1.422PheTyr: 1.422 ± 0.029
0.0PheXaa: 0.0 ± 0.0
Gly
5.644GlyAla: 5.644 ± 0.075
0.651GlyCys: 0.651 ± 0.019
3.775GlyAsp: 3.775 ± 0.051
4.571GlyGlu: 4.571 ± 0.052
3.399GlyPhe: 3.399 ± 0.049
5.691GlyGly: 5.691 ± 0.086
1.411GlyHis: 1.411 ± 0.03
5.872GlyIle: 5.872 ± 0.065
4.59GlyLys: 4.59 ± 0.052
7.343GlyLeu: 7.343 ± 0.067
2.358GlyMet: 2.358 ± 0.043
3.242GlyAsn: 3.242 ± 0.056
1.94GlyPro: 1.94 ± 0.04
2.521GlyGln: 2.521 ± 0.038
3.636GlyArg: 3.636 ± 0.053
5.037GlySer: 5.037 ± 0.062
4.593GlyThr: 4.593 ± 0.071
5.234GlyVal: 5.234 ± 0.057
1.146GlyTrp: 1.146 ± 0.028
2.981GlyTyr: 2.981 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
1.444HisAla: 1.444 ± 0.026
0.163HisCys: 0.163 ± 0.01
0.975HisAsp: 0.975 ± 0.022
1.169HisGlu: 1.169 ± 0.026
0.941HisPhe: 0.941 ± 0.023
1.462HisGly: 1.462 ± 0.03
0.522HisHis: 0.522 ± 0.021
1.165HisIle: 1.165 ± 0.023
0.72HisLys: 0.72 ± 0.021
1.962HisLeu: 1.962 ± 0.043
0.509HisMet: 0.509 ± 0.017
0.658HisAsn: 0.658 ± 0.021
1.153HisPro: 1.153 ± 0.026
0.639HisGln: 0.639 ± 0.019
1.12HisArg: 1.12 ± 0.03
1.234HisSer: 1.234 ± 0.027
0.89HisThr: 0.89 ± 0.02
1.274HisVal: 1.274 ± 0.025
0.331HisTrp: 0.331 ± 0.014
0.803HisTyr: 0.803 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
6.136IleAla: 6.136 ± 0.068
0.526IleCys: 0.526 ± 0.017
3.897IleAsp: 3.897 ± 0.047
4.253IleGlu: 4.253 ± 0.048
2.383IlePhe: 2.383 ± 0.047
5.594IleGly: 5.594 ± 0.063
1.314IleHis: 1.314 ± 0.027
4.047IleIle: 4.047 ± 0.063
2.978IleLys: 2.978 ± 0.044
5.868IleLeu: 5.868 ± 0.076
1.567IleMet: 1.567 ± 0.032
2.389IleAsn: 2.389 ± 0.038
3.222IlePro: 3.222 ± 0.047
2.348IleGln: 2.348 ± 0.036
4.129IleArg: 4.129 ± 0.055
4.616IleSer: 4.616 ± 0.051
3.697IleThr: 3.697 ± 0.052
5.694IleVal: 5.694 ± 0.067
0.751IleTrp: 0.751 ± 0.021
2.032IleTyr: 2.032 ± 0.034
0.0IleXaa: 0.0 ± 0.0
Lys
4.17LysAla: 4.17 ± 0.057
0.207LysCys: 0.207 ± 0.011
2.843LysAsp: 2.843 ± 0.045
3.899LysGlu: 3.899 ± 0.052
1.687LysPhe: 1.687 ± 0.033
3.453LysGly: 3.453 ± 0.044
1.026LysHis: 1.026 ± 0.026
3.152LysIle: 3.152 ± 0.045
2.937LysLys: 2.937 ± 0.047
5.486LysLeu: 5.486 ± 0.066
1.486LysMet: 1.486 ± 0.026
1.954LysAsn: 1.954 ± 0.034
2.394LysPro: 2.394 ± 0.041
2.166LysGln: 2.166 ± 0.041
2.747LysArg: 2.747 ± 0.04
3.113LysSer: 3.113 ± 0.049
2.76LysThr: 2.76 ± 0.04
3.5LysVal: 3.5 ± 0.047
0.758LysTrp: 0.758 ± 0.021
1.738LysTyr: 1.738 ± 0.033
0.0LysXaa: 0.0 ± 0.0
Leu
8.288LeuAla: 8.288 ± 0.091
0.727LeuCys: 0.727 ± 0.023
5.212LeuAsp: 5.212 ± 0.056
6.055LeuGlu: 6.055 ± 0.066
4.603LeuPhe: 4.603 ± 0.064
6.615LeuGly: 6.615 ± 0.074
1.937LeuHis: 1.937 ± 0.034
6.533LeuIle: 6.533 ± 0.075
5.139LeuLys: 5.139 ± 0.069
10.708LeuLeu: 10.708 ± 0.117
2.49LeuMet: 2.49 ± 0.037
4.091LeuAsn: 4.091 ± 0.048
4.5LeuPro: 4.5 ± 0.056
3.609LeuGln: 3.609 ± 0.049
5.224LeuArg: 5.224 ± 0.069
7.476LeuSer: 7.476 ± 0.072
5.862LeuThr: 5.862 ± 0.063
6.466LeuVal: 6.466 ± 0.074
1.07LeuTrp: 1.07 ± 0.028
3.075LeuTyr: 3.075 ± 0.046
0.0LeuXaa: 0.0 ± 0.0
Met
2.219MetAla: 2.219 ± 0.039
0.137MetCys: 0.137 ± 0.009
1.552MetAsp: 1.552 ± 0.035
1.772MetGlu: 1.772 ± 0.032
0.983MetPhe: 0.983 ± 0.025
1.764MetGly: 1.764 ± 0.035
0.435MetHis: 0.435 ± 0.016
1.845MetIle: 1.845 ± 0.035
1.897MetLys: 1.897 ± 0.034
2.732MetLeu: 2.732 ± 0.043
0.809MetMet: 0.809 ± 0.022
1.471MetAsn: 1.471 ± 0.028
1.175MetPro: 1.175 ± 0.031
0.904MetGln: 0.904 ± 0.021
1.391MetArg: 1.391 ± 0.029
1.812MetSer: 1.812 ± 0.03
1.683MetThr: 1.683 ± 0.028
1.668MetVal: 1.668 ± 0.031
0.231MetTrp: 0.231 ± 0.01
0.704MetTyr: 0.704 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
3.289AsnAla: 3.289 ± 0.049
0.226AsnCys: 0.226 ± 0.01
2.193AsnAsp: 2.193 ± 0.041
2.777AsnGlu: 2.777 ± 0.046
1.4AsnPhe: 1.4 ± 0.031
3.704AsnGly: 3.704 ± 0.053
0.799AsnHis: 0.799 ± 0.021
2.355AsnIle: 2.355 ± 0.035
2.062AsnLys: 2.062 ± 0.035
3.476AsnLeu: 3.476 ± 0.048
0.971AsnMet: 0.971 ± 0.024
1.717AsnAsn: 1.717 ± 0.035
2.199AsnPro: 2.199 ± 0.038
1.368AsnGln: 1.368 ± 0.029
2.341AsnArg: 2.341 ± 0.033
2.374AsnSer: 2.374 ± 0.047
2.025AsnThr: 2.025 ± 0.038
2.924AsnVal: 2.924 ± 0.045
0.605AsnTrp: 0.605 ± 0.019
1.422AsnTyr: 1.422 ± 0.032
0.0AsnXaa: 0.0 ± 0.0
Pro
3.289ProAla: 3.289 ± 0.042
0.211ProCys: 0.211 ± 0.011
2.704ProAsp: 2.704 ± 0.048
3.289ProGlu: 3.289 ± 0.044
1.884ProPhe: 1.884 ± 0.031
3.021ProGly: 3.021 ± 0.053
0.866ProHis: 0.866 ± 0.021
2.769ProIle: 2.769 ± 0.037
1.772ProLys: 1.772 ± 0.03
3.884ProLeu: 3.884 ± 0.048
1.049ProMet: 1.049 ± 0.027
1.694ProAsn: 1.694 ± 0.033
1.307ProPro: 1.307 ± 0.034
1.306ProGln: 1.306 ± 0.031
1.562ProArg: 1.562 ± 0.033
2.91ProSer: 2.91 ± 0.047
2.282ProThr: 2.282 ± 0.043
3.173ProVal: 3.173 ± 0.044
0.512ProTrp: 0.512 ± 0.017
1.517ProTyr: 1.517 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
3.268GlnAla: 3.268 ± 0.043
0.179GlnCys: 0.179 ± 0.01
1.557GlnAsp: 1.557 ± 0.03
2.147GlnGlu: 2.147 ± 0.04
1.454GlnPhe: 1.454 ± 0.027
2.454GlnGly: 2.454 ± 0.047
0.611GlnHis: 0.611 ± 0.019
2.273GlnIle: 2.273 ± 0.032
1.576GlnLys: 1.576 ± 0.03
3.785GlnLeu: 3.785 ± 0.047
1.027GlnMet: 1.027 ± 0.023
1.152GlnAsn: 1.152 ± 0.028
1.449GlnPro: 1.449 ± 0.029
1.498GlnGln: 1.498 ± 0.033
1.767GlnArg: 1.767 ± 0.033
2.415GlnSer: 2.415 ± 0.035
1.876GlnThr: 1.876 ± 0.032
2.325GlnVal: 2.325 ± 0.039
0.565GlnTrp: 0.565 ± 0.021
1.241GlnTyr: 1.241 ± 0.027
0.0GlnXaa: 0.0 ± 0.0
Arg
3.381ArgAla: 3.381 ± 0.045
0.329ArgCys: 0.329 ± 0.013
2.737ArgAsp: 2.737 ± 0.037
3.818ArgGlu: 3.818 ± 0.051
2.457ArgPhe: 2.457 ± 0.035
3.115ArgGly: 3.115 ± 0.046
1.054ArgHis: 1.054 ± 0.025
4.051ArgIle: 4.051 ± 0.052
3.169ArgLys: 3.169 ± 0.047
5.641ArgLeu: 5.641 ± 0.067
1.766ArgMet: 1.766 ± 0.031
2.343ArgAsn: 2.343 ± 0.036
1.723ArgPro: 1.723 ± 0.033
1.993ArgGln: 1.993 ± 0.033
2.986ArgArg: 2.986 ± 0.058
3.368ArgSer: 3.368 ± 0.044
2.875ArgThr: 2.875 ± 0.039
3.333ArgVal: 3.333 ± 0.044
0.729ArgTrp: 0.729 ± 0.022
1.889ArgTyr: 1.889 ± 0.032
0.0ArgXaa: 0.0 ± 0.0
Ser
5.345SerAla: 5.345 ± 0.063
0.416SerCys: 0.416 ± 0.017
3.613SerAsp: 3.613 ± 0.046
4.11SerGlu: 4.11 ± 0.047
3.147SerPhe: 3.147 ± 0.037
5.858SerGly: 5.858 ± 0.066
1.228SerHis: 1.228 ± 0.026
4.53SerIle: 4.53 ± 0.059
3.236SerLys: 3.236 ± 0.051
6.763SerLeu: 6.763 ± 0.061
1.821SerMet: 1.821 ± 0.034
2.61SerAsn: 2.61 ± 0.046
2.761SerPro: 2.761 ± 0.044
1.975SerGln: 1.975 ± 0.034
3.372SerArg: 3.372 ± 0.044
4.853SerSer: 4.853 ± 0.057
3.319SerThr: 3.319 ± 0.052
4.965SerVal: 4.965 ± 0.064
0.915SerTrp: 0.915 ± 0.02
2.321SerTyr: 2.321 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
4.74ThrAla: 4.74 ± 0.072
0.302ThrCys: 0.302 ± 0.012
3.075ThrAsp: 3.075 ± 0.043
3.285ThrGlu: 3.285 ± 0.044
2.325ThrPhe: 2.325 ± 0.037
4.623ThrGly: 4.623 ± 0.059
0.93ThrHis: 0.93 ± 0.023
4.043ThrIle: 4.043 ± 0.051
2.402ThrLys: 2.402 ± 0.039
5.561ThrLeu: 5.561 ± 0.059
1.355ThrMet: 1.355 ± 0.028
2.128ThrAsn: 2.128 ± 0.045
2.644ThrPro: 2.644 ± 0.053
1.493ThrGln: 1.493 ± 0.03
2.382ThrArg: 2.382 ± 0.039
3.465ThrSer: 3.465 ± 0.053
2.988ThrThr: 2.988 ± 0.068
4.49ThrVal: 4.49 ± 0.067
0.669ThrTrp: 0.669 ± 0.021
1.873ThrTyr: 1.873 ± 0.037
0.0ThrXaa: 0.0 ± 0.0
Val
5.714ValAla: 5.714 ± 0.062
0.589ValCys: 0.589 ± 0.018
3.749ValAsp: 3.749 ± 0.052
4.209ValGlu: 4.209 ± 0.049
2.92ValPhe: 2.92 ± 0.041
4.855ValGly: 4.855 ± 0.064
1.373ValHis: 1.373 ± 0.028
4.857ValIle: 4.857 ± 0.057
3.783ValLys: 3.783 ± 0.05
7.031ValLeu: 7.031 ± 0.065
1.866ValMet: 1.866 ± 0.037
2.961ValAsn: 2.961 ± 0.046
3.111ValPro: 3.111 ± 0.042
2.414ValGln: 2.414 ± 0.038
3.66ValArg: 3.66 ± 0.045
5.097ValSer: 5.097 ± 0.061
4.576ValThr: 4.576 ± 0.065
5.214ValVal: 5.214 ± 0.062
0.895ValTrp: 0.895 ± 0.02
2.384ValTyr: 2.384 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
0.848TrpAla: 0.848 ± 0.023
0.111TrpCys: 0.111 ± 0.008
0.742TrpAsp: 0.742 ± 0.02
0.786TrpGlu: 0.786 ± 0.023
0.597TrpPhe: 0.597 ± 0.02
0.927TrpGly: 0.927 ± 0.024
0.28TrpHis: 0.28 ± 0.012
0.954TrpIle: 0.954 ± 0.025
0.791TrpLys: 0.791 ± 0.02
1.449TrpLeu: 1.449 ± 0.035
0.405TrpMet: 0.405 ± 0.015
0.782TrpAsn: 0.782 ± 0.02
0.423TrpPro: 0.423 ± 0.014
0.494TrpGln: 0.494 ± 0.016
0.645TrpArg: 0.645 ± 0.019
0.916TrpSer: 0.916 ± 0.024
0.808TrpThr: 0.808 ± 0.021
0.838TrpVal: 0.838 ± 0.02
0.208TrpTrp: 0.208 ± 0.011
0.413TrpTyr: 0.413 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.633TyrAla: 2.633 ± 0.041
0.268TyrCys: 0.268 ± 0.012
1.928TyrAsp: 1.928 ± 0.038
2.201TyrGlu: 2.201 ± 0.037
1.618TyrPhe: 1.618 ± 0.03
2.837TyrGly: 2.837 ± 0.042
0.643TyrHis: 0.643 ± 0.017
1.99TyrIle: 1.99 ± 0.033
1.539TyrLys: 1.539 ± 0.03
3.357TyrLeu: 3.357 ± 0.046
0.827TyrMet: 0.827 ± 0.023
1.37TyrAsn: 1.37 ± 0.03
1.505TyrPro: 1.505 ± 0.03
1.065TyrGln: 1.065 ± 0.027
2.184TyrArg: 2.184 ± 0.039
2.316TyrSer: 2.316 ± 0.041
1.694TyrThr: 1.694 ± 0.037
2.375TyrVal: 2.375 ± 0.036
0.49TyrTrp: 0.49 ± 0.017
1.378TyrTyr: 1.378 ± 0.029
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5622 proteins (1863763 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski