Amino acid dipepetide frequency for Acinetobacter phage ABPH49

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.355AlaAla: 7.355 ± 0.507
0.609AlaCys: 0.609 ± 0.128
4.438AlaAsp: 4.438 ± 0.372
5.301AlaGlu: 5.301 ± 0.426
2.714AlaPhe: 2.714 ± 0.255
6.188AlaGly: 6.188 ± 0.427
1.522AlaHis: 1.522 ± 0.202
3.906AlaIle: 3.906 ± 0.383
5.047AlaLys: 5.047 ± 0.414
5.63AlaLeu: 5.63 ± 0.43
2.359AlaMet: 2.359 ± 0.307
2.638AlaAsn: 2.638 ± 0.256
2.79AlaPro: 2.79 ± 0.292
2.638AlaGln: 2.638 ± 0.291
4.083AlaArg: 4.083 ± 0.367
3.982AlaSer: 3.982 ± 0.364
4.337AlaThr: 4.337 ± 0.352
5.351AlaVal: 5.351 ± 0.418
1.167AlaTrp: 1.167 ± 0.188
2.739AlaTyr: 2.739 ± 0.256
0.0AlaXaa: 0.0 ± 0.0
Cys
0.71CysAla: 0.71 ± 0.133
0.254CysCys: 0.254 ± 0.082
0.71CysAsp: 0.71 ± 0.151
0.761CysGlu: 0.761 ± 0.146
0.507CysPhe: 0.507 ± 0.107
0.964CysGly: 0.964 ± 0.163
0.279CysHis: 0.279 ± 0.089
0.406CysIle: 0.406 ± 0.101
0.938CysLys: 0.938 ± 0.148
0.938CysLeu: 0.938 ± 0.17
0.203CysMet: 0.203 ± 0.058
0.558CysAsn: 0.558 ± 0.124
0.761CysPro: 0.761 ± 0.147
0.457CysGln: 0.457 ± 0.109
0.71CysArg: 0.71 ± 0.144
0.609CysSer: 0.609 ± 0.137
0.533CysThr: 0.533 ± 0.124
0.786CysVal: 0.786 ± 0.151
0.127CysTrp: 0.127 ± 0.06
0.38CysTyr: 0.38 ± 0.101
0.0CysXaa: 0.0 ± 0.0
Asp
4.869AspAla: 4.869 ± 0.328
0.913AspCys: 0.913 ± 0.151
4.21AspAsp: 4.21 ± 0.364
4.438AspGlu: 4.438 ± 0.334
2.764AspPhe: 2.764 ± 0.263
5.909AspGly: 5.909 ± 0.546
1.293AspHis: 1.293 ± 0.184
3.931AspIle: 3.931 ± 0.341
4.844AspLys: 4.844 ± 0.381
6.137AspLeu: 6.137 ± 0.408
1.902AspMet: 1.902 ± 0.201
2.714AspAsn: 2.714 ± 0.243
2.815AspPro: 2.815 ± 0.367
2.384AspGln: 2.384 ± 0.259
3.449AspArg: 3.449 ± 0.287
3.094AspSer: 3.094 ± 0.29
3.246AspThr: 3.246 ± 0.338
4.21AspVal: 4.21 ± 0.383
1.547AspTrp: 1.547 ± 0.192
2.13AspTyr: 2.13 ± 0.221
0.0AspXaa: 0.0 ± 0.0
Glu
5.148GluAla: 5.148 ± 0.322
0.862GluCys: 0.862 ± 0.16
5.224GluAsp: 5.224 ± 0.36
7.101GluGlu: 7.101 ± 0.641
3.221GluPhe: 3.221 ± 0.288
5.123GluGly: 5.123 ± 0.41
1.293GluHis: 1.293 ± 0.227
4.945GluIle: 4.945 ± 0.402
4.895GluLys: 4.895 ± 0.388
6.061GluLeu: 6.061 ± 0.453
2.46GluMet: 2.46 ± 0.233
2.79GluAsn: 2.79 ± 0.259
1.851GluPro: 1.851 ± 0.377
2.46GluGln: 2.46 ± 0.255
3.906GluArg: 3.906 ± 0.279
3.906GluSer: 3.906 ± 0.32
2.79GluThr: 2.79 ± 0.253
5.656GluVal: 5.656 ± 0.435
1.04GluTrp: 1.04 ± 0.176
3.018GluTyr: 3.018 ± 0.299
0.0GluXaa: 0.0 ± 0.0
Phe
2.359PheAla: 2.359 ± 0.276
0.558PheCys: 0.558 ± 0.123
3.018PheAsp: 3.018 ± 0.225
2.688PheGlu: 2.688 ± 0.283
1.547PhePhe: 1.547 ± 0.22
3.246PheGly: 3.246 ± 0.357
0.634PheHis: 0.634 ± 0.123
2.308PheIle: 2.308 ± 0.217
2.942PheLys: 2.942 ± 0.325
2.283PheLeu: 2.283 ± 0.268
1.344PheMet: 1.344 ± 0.202
2.156PheAsn: 2.156 ± 0.245
1.395PhePro: 1.395 ± 0.209
0.989PheGln: 0.989 ± 0.143
1.674PheArg: 1.674 ± 0.197
2.79PheSer: 2.79 ± 0.282
2.232PheThr: 2.232 ± 0.217
3.17PheVal: 3.17 ± 0.316
0.685PheTrp: 0.685 ± 0.175
1.674PheTyr: 1.674 ± 0.228
0.0PheXaa: 0.0 ± 0.0
Gly
4.464GlyAla: 4.464 ± 0.507
0.786GlyCys: 0.786 ± 0.124
5.072GlyAsp: 5.072 ± 0.922
5.833GlyGlu: 5.833 ± 0.398
3.17GlyPhe: 3.17 ± 0.332
5.453GlyGly: 5.453 ± 0.481
1.598GlyHis: 1.598 ± 0.193
3.956GlyIle: 3.956 ± 0.31
6.112GlyLys: 6.112 ± 0.434
5.402GlyLeu: 5.402 ± 0.409
1.978GlyMet: 1.978 ± 0.237
3.677GlyAsn: 3.677 ± 0.361
2.485GlyPro: 2.485 ± 0.63
2.13GlyGln: 2.13 ± 0.235
3.373GlyArg: 3.373 ± 0.257
4.996GlySer: 4.996 ± 0.473
4.413GlyThr: 4.413 ± 0.424
5.351GlyVal: 5.351 ± 0.373
1.522GlyTrp: 1.522 ± 0.21
3.322GlyTyr: 3.322 ± 0.261
0.0GlyXaa: 0.0 ± 0.0
His
1.395HisAla: 1.395 ± 0.183
0.33HisCys: 0.33 ± 0.098
1.217HisAsp: 1.217 ± 0.156
1.141HisGlu: 1.141 ± 0.166
0.786HisPhe: 0.786 ± 0.165
1.598HisGly: 1.598 ± 0.213
0.634HisHis: 0.634 ± 0.149
1.268HisIle: 1.268 ± 0.181
1.116HisLys: 1.116 ± 0.169
1.572HisLeu: 1.572 ± 0.196
0.71HisMet: 0.71 ± 0.115
0.735HisAsn: 0.735 ± 0.15
1.192HisPro: 1.192 ± 0.169
0.786HisGln: 0.786 ± 0.129
1.091HisArg: 1.091 ± 0.182
1.04HisSer: 1.04 ± 0.159
0.862HisThr: 0.862 ± 0.15
1.268HisVal: 1.268 ± 0.204
0.457HisTrp: 0.457 ± 0.102
0.812HisTyr: 0.812 ± 0.15
0.0HisXaa: 0.0 ± 0.0
Ile
4.54IleAla: 4.54 ± 0.364
0.583IleCys: 0.583 ± 0.131
4.032IleAsp: 4.032 ± 0.259
4.134IleGlu: 4.134 ± 0.345
2.257IlePhe: 2.257 ± 0.262
3.677IleGly: 3.677 ± 0.368
1.167IleHis: 1.167 ± 0.19
2.714IleIle: 2.714 ± 0.27
3.652IleLys: 3.652 ± 0.3
3.5IleLeu: 3.5 ± 0.302
1.37IleMet: 1.37 ± 0.184
2.638IleAsn: 2.638 ± 0.269
2.232IlePro: 2.232 ± 0.29
1.699IleGln: 1.699 ± 0.196
4.134IleArg: 4.134 ± 0.341
3.906IleSer: 3.906 ± 0.336
3.703IleThr: 3.703 ± 0.284
3.956IleVal: 3.956 ± 0.35
0.609IleTrp: 0.609 ± 0.133
2.08IleTyr: 2.08 ± 0.198
0.0IleXaa: 0.0 ± 0.0
Lys
5.453LysAla: 5.453 ± 0.396
0.583LysCys: 0.583 ± 0.124
5.478LysAsp: 5.478 ± 0.416
5.808LysGlu: 5.808 ± 0.428
2.967LysPhe: 2.967 ± 0.301
5.199LysGly: 5.199 ± 0.9
1.496LysHis: 1.496 ± 0.172
4.134LysIle: 4.134 ± 0.286
5.072LysLys: 5.072 ± 0.419
4.54LysLeu: 4.54 ± 0.362
2.536LysMet: 2.536 ± 0.282
2.815LysAsn: 2.815 ± 0.291
2.359LysPro: 2.359 ± 0.251
2.257LysGln: 2.257 ± 0.258
3.145LysArg: 3.145 ± 0.284
3.627LysSer: 3.627 ± 0.351
3.398LysThr: 3.398 ± 0.299
5.351LysVal: 5.351 ± 0.468
0.913LysTrp: 0.913 ± 0.144
2.232LysTyr: 2.232 ± 0.218
0.0LysXaa: 0.0 ± 0.0
Leu
5.63LeuAla: 5.63 ± 0.428
0.888LeuCys: 0.888 ± 0.136
4.996LeuAsp: 4.996 ± 0.367
6.011LeuGlu: 6.011 ± 0.383
3.246LeuPhe: 3.246 ± 0.324
4.337LeuGly: 4.337 ± 0.373
1.42LeuHis: 1.42 ± 0.185
4.717LeuIle: 4.717 ± 0.405
5.25LeuLys: 5.25 ± 0.363
5.275LeuLeu: 5.275 ± 0.396
2.359LeuMet: 2.359 ± 0.231
4.032LeuAsn: 4.032 ± 0.342
3.322LeuPro: 3.322 ± 0.292
2.156LeuGln: 2.156 ± 0.22
4.565LeuArg: 4.565 ± 0.372
5.224LeuSer: 5.224 ± 0.378
4.489LeuThr: 4.489 ± 0.366
4.869LeuVal: 4.869 ± 0.297
0.964LeuTrp: 0.964 ± 0.166
2.232LeuTyr: 2.232 ± 0.227
0.0LeuXaa: 0.0 ± 0.0
Met
2.688MetAla: 2.688 ± 0.291
0.228MetCys: 0.228 ± 0.079
1.775MetAsp: 1.775 ± 0.229
2.054MetGlu: 2.054 ± 0.191
1.37MetPhe: 1.37 ± 0.221
1.572MetGly: 1.572 ± 0.195
0.457MetHis: 0.457 ± 0.106
1.927MetIle: 1.927 ± 0.236
2.714MetLys: 2.714 ± 0.341
2.308MetLeu: 2.308 ± 0.223
1.167MetMet: 1.167 ± 0.204
1.37MetAsn: 1.37 ± 0.196
1.217MetPro: 1.217 ± 0.167
0.913MetGln: 0.913 ± 0.156
1.598MetArg: 1.598 ± 0.223
2.156MetSer: 2.156 ± 0.254
1.75MetThr: 1.75 ± 0.204
2.206MetVal: 2.206 ± 0.239
0.761MetTrp: 0.761 ± 0.158
1.141MetTyr: 1.141 ± 0.164
0.0MetXaa: 0.0 ± 0.0
Asn
3.043AsnAla: 3.043 ± 0.283
0.609AsnCys: 0.609 ± 0.141
2.232AsnAsp: 2.232 ± 0.249
2.739AsnGlu: 2.739 ± 0.282
1.598AsnPhe: 1.598 ± 0.216
3.931AsnGly: 3.931 ± 0.317
0.989AsnHis: 0.989 ± 0.196
2.79AsnIle: 2.79 ± 0.284
3.043AsnLys: 3.043 ± 0.272
3.5AsnLeu: 3.5 ± 0.306
1.319AsnMet: 1.319 ± 0.198
2.333AsnAsn: 2.333 ± 0.278
2.029AsnPro: 2.029 ± 0.223
1.623AsnGln: 1.623 ± 0.227
2.08AsnArg: 2.08 ± 0.242
2.105AsnSer: 2.105 ± 0.261
2.714AsnThr: 2.714 ± 0.305
2.638AsnVal: 2.638 ± 0.315
0.812AsnTrp: 0.812 ± 0.123
1.75AsnTyr: 1.75 ± 0.192
0.0AsnXaa: 0.0 ± 0.0
Pro
3.551ProAla: 3.551 ± 0.29
0.457ProCys: 0.457 ± 0.109
2.79ProAsp: 2.79 ± 0.301
3.398ProGlu: 3.398 ± 0.398
1.395ProPhe: 1.395 ± 0.182
2.004ProGly: 2.004 ± 0.228
0.735ProHis: 0.735 ± 0.13
1.37ProIle: 1.37 ± 0.219
2.891ProLys: 2.891 ± 0.368
2.308ProLeu: 2.308 ± 0.218
1.04ProMet: 1.04 ± 0.163
1.522ProAsn: 1.522 ± 0.191
1.471ProPro: 1.471 ± 0.207
1.623ProGln: 1.623 ± 0.23
1.572ProArg: 1.572 ± 0.181
2.409ProSer: 2.409 ± 0.244
2.511ProThr: 2.511 ± 0.275
3.348ProVal: 3.348 ± 0.362
0.634ProTrp: 0.634 ± 0.138
1.091ProTyr: 1.091 ± 0.181
0.0ProXaa: 0.0 ± 0.0
Gln
2.485GlnAla: 2.485 ± 0.264
0.457GlnCys: 0.457 ± 0.121
1.877GlnAsp: 1.877 ± 0.237
2.156GlnGlu: 2.156 ± 0.218
1.37GlnPhe: 1.37 ± 0.208
2.562GlnGly: 2.562 ± 0.607
0.558GlnHis: 0.558 ± 0.117
2.054GlnIle: 2.054 ± 0.239
1.927GlnLys: 1.927 ± 0.209
3.601GlnLeu: 3.601 ± 0.289
1.319GlnMet: 1.319 ± 0.159
1.648GlnAsn: 1.648 ± 0.183
1.065GlnPro: 1.065 ± 0.162
1.395GlnGln: 1.395 ± 0.269
1.725GlnArg: 1.725 ± 0.239
1.547GlnSer: 1.547 ± 0.184
1.851GlnThr: 1.851 ± 0.201
2.181GlnVal: 2.181 ± 0.228
0.659GlnTrp: 0.659 ± 0.15
1.446GlnTyr: 1.446 ± 0.203
0.0GlnXaa: 0.0 ± 0.0
Arg
3.551ArgAla: 3.551 ± 0.29
0.659ArgCys: 0.659 ± 0.147
3.525ArgAsp: 3.525 ± 0.341
3.931ArgGlu: 3.931 ± 0.345
1.902ArgPhe: 1.902 ± 0.203
3.753ArgGly: 3.753 ± 0.349
1.293ArgHis: 1.293 ± 0.177
3.043ArgIle: 3.043 ± 0.28
3.5ArgLys: 3.5 ± 0.244
3.982ArgLeu: 3.982 ± 0.339
1.953ArgMet: 1.953 ± 0.221
2.359ArgAsn: 2.359 ± 0.273
1.877ArgPro: 1.877 ± 0.193
1.978ArgGln: 1.978 ± 0.242
3.221ArgArg: 3.221 ± 0.363
3.196ArgSer: 3.196 ± 0.279
2.536ArgThr: 2.536 ± 0.285
3.627ArgVal: 3.627 ± 0.338
0.634ArgTrp: 0.634 ± 0.142
1.598ArgTyr: 1.598 ± 0.238
0.0ArgXaa: 0.0 ± 0.0
Ser
4.743SerAla: 4.743 ± 0.38
0.659SerCys: 0.659 ± 0.131
4.21SerAsp: 4.21 ± 0.303
3.475SerGlu: 3.475 ± 0.357
2.156SerPhe: 2.156 ± 0.23
5.605SerGly: 5.605 ± 0.473
0.964SerHis: 0.964 ± 0.167
2.612SerIle: 2.612 ± 0.257
4.032SerLys: 4.032 ± 0.308
4.945SerLeu: 4.945 ± 0.371
1.725SerMet: 1.725 ± 0.206
2.333SerAsn: 2.333 ± 0.278
2.359SerPro: 2.359 ± 0.21
1.877SerGln: 1.877 ± 0.216
3.373SerArg: 3.373 ± 0.368
3.221SerSer: 3.221 ± 0.348
2.967SerThr: 2.967 ± 0.313
4.311SerVal: 4.311 ± 0.342
0.888SerTrp: 0.888 ± 0.146
2.054SerTyr: 2.054 ± 0.211
0.0SerXaa: 0.0 ± 0.0
Thr
3.652ThrAla: 3.652 ± 0.296
0.609ThrCys: 0.609 ± 0.114
3.322ThrAsp: 3.322 ± 0.277
3.627ThrGlu: 3.627 ± 0.27
2.257ThrPhe: 2.257 ± 0.218
5.326ThrGly: 5.326 ± 0.516
0.888ThrHis: 0.888 ± 0.173
3.551ThrIle: 3.551 ± 0.29
3.677ThrLys: 3.677 ± 0.299
4.109ThrLeu: 4.109 ± 0.288
1.471ThrMet: 1.471 ± 0.203
2.105ThrAsn: 2.105 ± 0.202
2.967ThrPro: 2.967 ± 0.255
1.978ThrGln: 1.978 ± 0.242
2.435ThrArg: 2.435 ± 0.203
3.373ThrSer: 3.373 ± 0.324
3.043ThrThr: 3.043 ± 0.38
4.159ThrVal: 4.159 ± 0.362
0.634ThrTrp: 0.634 ± 0.136
1.674ThrTyr: 1.674 ± 0.2
0.0ThrXaa: 0.0 ± 0.0
Val
5.529ValAla: 5.529 ± 0.367
0.812ValCys: 0.812 ± 0.15
4.869ValAsp: 4.869 ± 0.418
5.529ValGlu: 5.529 ± 0.43
2.638ValPhe: 2.638 ± 0.255
5.224ValGly: 5.224 ± 0.422
1.217ValHis: 1.217 ± 0.193
4.235ValIle: 4.235 ± 0.308
4.819ValLys: 4.819 ± 0.335
5.123ValLeu: 5.123 ± 0.347
2.359ValMet: 2.359 ± 0.265
3.043ValAsn: 3.043 ± 0.305
2.08ValPro: 2.08 ± 0.239
2.688ValGln: 2.688 ± 0.268
3.196ValArg: 3.196 ± 0.369
4.311ValSer: 4.311 ± 0.341
4.337ValThr: 4.337 ± 0.371
5.529ValVal: 5.529 ± 0.428
1.471ValTrp: 1.471 ± 0.198
2.562ValTyr: 2.562 ± 0.265
0.0ValXaa: 0.0 ± 0.0
Trp
0.989TrpAla: 0.989 ± 0.171
0.203TrpCys: 0.203 ± 0.074
0.989TrpAsp: 0.989 ± 0.158
1.42TrpGlu: 1.42 ± 0.195
0.862TrpPhe: 0.862 ± 0.157
0.938TrpGly: 0.938 ± 0.153
0.304TrpHis: 0.304 ± 0.096
0.761TrpIle: 0.761 ± 0.143
0.964TrpLys: 0.964 ± 0.204
1.471TrpLeu: 1.471 ± 0.191
0.634TrpMet: 0.634 ± 0.132
0.634TrpAsn: 0.634 ± 0.149
0.533TrpPro: 0.533 ± 0.112
0.634TrpGln: 0.634 ± 0.129
0.862TrpArg: 0.862 ± 0.119
1.065TrpSer: 1.065 ± 0.166
0.862TrpThr: 0.862 ± 0.166
1.243TrpVal: 1.243 ± 0.188
0.203TrpTrp: 0.203 ± 0.067
0.634TrpTyr: 0.634 ± 0.124
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.638TyrAla: 2.638 ± 0.301
0.533TyrCys: 0.533 ± 0.123
2.815TyrAsp: 2.815 ± 0.265
2.206TyrGlu: 2.206 ± 0.234
0.964TyrPhe: 0.964 ± 0.157
2.485TyrGly: 2.485 ± 0.251
1.268TyrHis: 1.268 ± 0.181
1.953TyrIle: 1.953 ± 0.222
1.927TyrLys: 1.927 ± 0.229
3.297TyrLeu: 3.297 ± 0.274
1.141TyrMet: 1.141 ± 0.192
1.801TyrAsn: 1.801 ± 0.217
1.319TyrPro: 1.319 ± 0.209
1.217TyrGln: 1.217 ± 0.161
1.927TyrArg: 1.927 ± 0.223
1.953TyrSer: 1.953 ± 0.227
2.283TyrThr: 2.283 ± 0.231
2.359TyrVal: 2.359 ± 0.221
0.482TyrTrp: 0.482 ± 0.132
1.268TyrTyr: 1.268 ± 0.195
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 243 proteins (39431 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski