Amino acid dipepetide frequency for Desulfoluna spongiiphila

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.139AlaAla: 9.139 ± 0.113	1.39AlaCys: 1.39 ± 0.034	4.981AlaAsp: 4.981 ± 0.06	5.977AlaGlu: 5.977 ± 0.064	4.157AlaPhe: 4.157 ± 0.05	8.012AlaGly: 8.012 ± 0.072	1.989AlaHis: 1.989 ± 0.029	4.964AlaIle: 4.964 ± 0.059	3.723AlaLys: 3.723 ± 0.058	10.465AlaLeu: 10.465 ± 0.098	3.325AlaMet: 3.325 ± 0.046	2.263AlaAsn: 2.263 ± 0.044	3.952AlaPro: 3.952 ± 0.059	2.378AlaGln: 2.378 ± 0.035	5.479AlaArg: 5.479 ± 0.065	5.511AlaSer: 5.511 ± 0.061	4.868AlaThr: 4.868 ± 0.055	7.361AlaVal: 7.361 ± 0.07	1.266AlaTrp: 1.266 ± 0.028	2.444AlaTyr: 2.444 ± 0.04	0.001AlaXaa: 0.001 ± 0.001
Cys	1.069CysAla: 1.069 ± 0.027	0.253CysCys: 0.253 ± 0.014	0.726CysAsp: 0.726 ± 0.019	0.669CysGlu: 0.669 ± 0.023	0.555CysPhe: 0.555 ± 0.019	1.454CysGly: 1.454 ± 0.035	0.386CysHis: 0.386 ± 0.02	0.677CysIle: 0.677 ± 0.018	0.428CysLys: 0.428 ± 0.015	1.319CysLeu: 1.319 ± 0.029	0.334CysMet: 0.334 ± 0.015	0.377CysAsn: 0.377 ± 0.016	0.733CysPro: 0.733 ± 0.024	0.301CysGln: 0.301 ± 0.012	0.924CysArg: 0.924 ± 0.025	0.801CysSer: 0.801 ± 0.024	0.718CysThr: 0.718 ± 0.021	0.875CysVal: 0.875 ± 0.021	0.137CysTrp: 0.137 ± 0.009	0.356CysTyr: 0.356 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	5.384AspAla: 5.384 ± 0.059	0.551AspCys: 0.551 ± 0.02	3.047AspAsp: 3.047 ± 0.055	3.973AspGlu: 3.973 ± 0.057	2.353AspPhe: 2.353 ± 0.042	4.501AspGly: 4.501 ± 0.068	1.337AspHis: 1.337 ± 0.029	3.584AspIle: 3.584 ± 0.047	2.41AspLys: 2.41 ± 0.04	5.674AspLeu: 5.674 ± 0.06	1.43AspMet: 1.43 ± 0.026	1.659AspAsn: 1.659 ± 0.033	2.87AspPro: 2.87 ± 0.045	1.372AspGln: 1.372 ± 0.026	3.317AspArg: 3.317 ± 0.043	2.683AspSer: 2.683 ± 0.039	3.407AspThr: 3.407 ± 0.044	3.583AspVal: 3.583 ± 0.055	0.634AspTrp: 0.634 ± 0.022	1.639AspTyr: 1.639 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	7.177GluAla: 7.177 ± 0.083	0.556GluCys: 0.556 ± 0.017	3.004GluAsp: 3.004 ± 0.05	5.093GluGlu: 5.093 ± 0.071	2.0GluPhe: 2.0 ± 0.034	5.087GluGly: 5.087 ± 0.059	1.196GluHis: 1.196 ± 0.028	4.1GluIle: 4.1 ± 0.051	4.584GluLys: 4.584 ± 0.054	5.932GluLeu: 5.932 ± 0.068	2.037GluMet: 2.037 ± 0.037	2.35GluAsn: 2.35 ± 0.039	2.339GluPro: 2.339 ± 0.036	1.801GluGln: 1.801 ± 0.034	3.618GluArg: 3.618 ± 0.05	3.585GluSer: 3.585 ± 0.053	4.3GluThr: 4.3 ± 0.054	4.802GluVal: 4.802 ± 0.058	0.561GluTrp: 0.561 ± 0.021	1.474GluTyr: 1.474 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	3.333PheAla: 3.333 ± 0.046	0.644PheCys: 0.644 ± 0.016	2.621PheAsp: 2.621 ± 0.039	2.307PheGlu: 2.307 ± 0.043	2.217PhePhe: 2.217 ± 0.044	3.408PheGly: 3.408 ± 0.047	0.943PheHis: 0.943 ± 0.023	2.234PheIle: 2.234 ± 0.036	1.875PheLys: 1.875 ± 0.035	4.121PheLeu: 4.121 ± 0.056	1.14PheMet: 1.14 ± 0.028	1.412PheAsn: 1.412 ± 0.029	1.742PhePro: 1.742 ± 0.031	1.158PheGln: 1.158 ± 0.024	2.124PheArg: 2.124 ± 0.035	3.221PheSer: 3.221 ± 0.049	2.634PheThr: 2.634 ± 0.041	2.785PheVal: 2.785 ± 0.044	0.488PheTrp: 0.488 ± 0.018	1.303PheTyr: 1.303 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	7.057GlyAla: 7.057 ± 0.07	1.285GlyCys: 1.285 ± 0.03	4.449GlyAsp: 4.449 ± 0.059	5.194GlyGlu: 5.194 ± 0.062	3.669GlyPhe: 3.669 ± 0.049	6.453GlyGly: 6.453 ± 0.082	1.82GlyHis: 1.82 ± 0.031	5.475GlyIle: 5.475 ± 0.06	4.403GlyLys: 4.403 ± 0.057	8.081GlyLeu: 8.081 ± 0.085	2.654GlyMet: 2.654 ± 0.041	2.589GlyAsn: 2.589 ± 0.043	2.723GlyPro: 2.723 ± 0.042	2.17GlyGln: 2.17 ± 0.035	4.548GlyArg: 4.548 ± 0.06	4.584GlySer: 4.584 ± 0.058	4.927GlyThr: 4.927 ± 0.064	6.196GlyVal: 6.196 ± 0.068	1.037GlyTrp: 1.037 ± 0.023	2.734GlyTyr: 2.734 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	1.952HisAla: 1.952 ± 0.035	0.333HisCys: 0.333 ± 0.014	1.11HisAsp: 1.11 ± 0.025	1.231HisGlu: 1.231 ± 0.027	0.987HisPhe: 0.987 ± 0.023	1.831HisGly: 1.831 ± 0.038	0.67HisHis: 0.67 ± 0.019	1.234HisIle: 1.234 ± 0.025	0.808HisLys: 0.808 ± 0.016	2.43HisLeu: 2.43 ± 0.036	0.595HisMet: 0.595 ± 0.018	0.619HisAsn: 0.619 ± 0.021	1.334HisPro: 1.334 ± 0.028	0.63HisGln: 0.63 ± 0.019	1.463HisArg: 1.463 ± 0.027	1.031HisSer: 1.031 ± 0.027	1.324HisThr: 1.324 ± 0.029	1.518HisVal: 1.518 ± 0.028	0.26HisTrp: 0.26 ± 0.014	0.68HisTyr: 0.68 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.115IleAla: 5.115 ± 0.064	0.724IleCys: 0.724 ± 0.021	3.443IleAsp: 3.443 ± 0.046	3.451IleGlu: 3.451 ± 0.052	2.164IlePhe: 2.164 ± 0.041	4.358IleGly: 4.358 ± 0.055	1.478IleHis: 1.478 ± 0.03	3.133IleIle: 3.133 ± 0.053	2.74IleLys: 2.74 ± 0.047	5.541IleLeu: 5.541 ± 0.06	1.345IleMet: 1.345 ± 0.031	2.099IleAsn: 2.099 ± 0.033	3.057IlePro: 3.057 ± 0.049	1.569IleGln: 1.569 ± 0.029	3.595IleArg: 3.595 ± 0.05	3.771IleSer: 3.771 ± 0.043	3.602IleThr: 3.602 ± 0.053	3.717IleVal: 3.717 ± 0.055	0.503IleTrp: 0.503 ± 0.02	1.53IleTyr: 1.53 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	5.132LysAla: 5.132 ± 0.067	0.398LysCys: 0.398 ± 0.015	2.458LysAsp: 2.458 ± 0.046	4.042LysGlu: 4.042 ± 0.057	1.133LysPhe: 1.133 ± 0.031	4.776LysGly: 4.776 ± 0.05	0.886LysHis: 0.886 ± 0.024	2.677LysIle: 2.677 ± 0.046	3.906LysLys: 3.906 ± 0.069	3.607LysLeu: 3.607 ± 0.048	1.369LysMet: 1.369 ± 0.028	1.934LysAsn: 1.934 ± 0.037	2.037LysPro: 2.037 ± 0.035	1.465LysGln: 1.465 ± 0.033	3.13LysArg: 3.13 ± 0.046	2.569LysSer: 2.569 ± 0.039	2.965LysThr: 2.965 ± 0.043	3.352LysVal: 3.352 ± 0.043	0.448LysTrp: 0.448 ± 0.016	1.107LysTyr: 1.107 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	10.043LeuAla: 10.043 ± 0.095	1.433LeuCys: 1.433 ± 0.032	5.317LeuAsp: 5.317 ± 0.061	5.883LeuGlu: 5.883 ± 0.059	4.861LeuPhe: 4.861 ± 0.071	7.24LeuGly: 7.24 ± 0.072	1.831LeuHis: 1.831 ± 0.042	5.248LeuIle: 5.248 ± 0.064	5.53LeuLys: 5.53 ± 0.057	9.398LeuLeu: 9.398 ± 0.092	2.765LeuMet: 2.765 ± 0.044	3.101LeuAsn: 3.101 ± 0.05	4.788LeuPro: 4.788 ± 0.057	2.317LeuGln: 2.317 ± 0.037	4.761LeuArg: 4.761 ± 0.057	7.457LeuSer: 7.457 ± 0.068	6.342LeuThr: 6.342 ± 0.073	6.864LeuVal: 6.864 ± 0.068	0.979LeuTrp: 0.979 ± 0.026	2.638LeuTyr: 2.638 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	3.474MetAla: 3.474 ± 0.046	0.253MetCys: 0.253 ± 0.013	1.933MetAsp: 1.933 ± 0.037	2.125MetGlu: 2.125 ± 0.034	0.765MetPhe: 0.765 ± 0.023	2.704MetGly: 2.704 ± 0.041	0.48MetHis: 0.48 ± 0.016	1.509MetIle: 1.509 ± 0.032	1.809MetLys: 1.809 ± 0.035	2.147MetLeu: 2.147 ± 0.039	0.847MetMet: 0.847 ± 0.024	1.128MetAsn: 1.128 ± 0.023	1.357MetPro: 1.357 ± 0.03	0.764MetGln: 0.764 ± 0.022	1.37MetArg: 1.37 ± 0.027	1.453MetSer: 1.453 ± 0.029	1.797MetThr: 1.797 ± 0.031	2.385MetVal: 2.385 ± 0.04	0.186MetTrp: 0.186 ± 0.011	0.498MetTyr: 0.498 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.741AsnAla: 2.741 ± 0.036	0.362AsnCys: 0.362 ± 0.016	1.572AsnAsp: 1.572 ± 0.034	1.675AsnGlu: 1.675 ± 0.026	1.071AsnPhe: 1.071 ± 0.026	2.606AsnGly: 2.606 ± 0.041	0.753AsnHis: 0.753 ± 0.022	2.032AsnIle: 2.032 ± 0.035	1.27AsnLys: 1.27 ± 0.033	3.238AsnLeu: 3.238 ± 0.043	0.836AsnMet: 0.836 ± 0.023	1.002AsnAsn: 1.002 ± 0.029	2.065AsnPro: 2.065 ± 0.036	0.948AsnGln: 0.948 ± 0.023	2.362AsnArg: 2.362 ± 0.038	1.576AsnSer: 1.576 ± 0.035	1.872AsnThr: 1.872 ± 0.033	2.024AsnVal: 2.024 ± 0.035	0.374AsnTrp: 0.374 ± 0.014	0.841AsnTyr: 0.841 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	4.022ProAla: 4.022 ± 0.059	0.579ProCys: 0.579 ± 0.019	3.17ProAsp: 3.17 ± 0.048	4.177ProGlu: 4.177 ± 0.055	2.159ProPhe: 2.159 ± 0.036	3.891ProGly: 3.891 ± 0.049	1.003ProHis: 1.003 ± 0.025	1.96ProIle: 1.96 ± 0.033	1.84ProLys: 1.84 ± 0.04	4.45ProLeu: 4.45 ± 0.051	1.427ProMet: 1.427 ± 0.029	1.138ProAsn: 1.138 ± 0.025	1.926ProPro: 1.926 ± 0.038	1.082ProGln: 1.082 ± 0.025	1.986ProArg: 1.986 ± 0.037	2.77ProSer: 2.77 ± 0.038	2.166ProThr: 2.166 ± 0.038	4.159ProVal: 4.159 ± 0.052	0.65ProTrp: 0.65 ± 0.02	1.266ProTyr: 1.266 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	2.863GlnAla: 2.863 ± 0.041	0.312GlnCys: 0.312 ± 0.014	1.287GlnAsp: 1.287 ± 0.026	1.818GlnGlu: 1.818 ± 0.033	0.914GlnPhe: 0.914 ± 0.025	2.405GlnGly: 2.405 ± 0.033	0.489GlnHis: 0.489 ± 0.019	1.508GlnIle: 1.508 ± 0.033	1.567GlnLys: 1.567 ± 0.035	2.352GlnLeu: 2.352 ± 0.04	0.761GlnMet: 0.761 ± 0.021	0.861GlnAsn: 0.861 ± 0.024	1.046GlnPro: 1.046 ± 0.026	0.818GlnGln: 0.818 ± 0.026	1.572GlnArg: 1.572 ± 0.034	1.467GlnSer: 1.467 ± 0.03	1.456GlnThr: 1.456 ± 0.027	2.267GlnVal: 2.267 ± 0.033	0.366GlnTrp: 0.366 ± 0.015	0.711GlnTyr: 0.711 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	4.476ArgAla: 4.476 ± 0.058	0.79ArgCys: 0.79 ± 0.022	3.148ArgAsp: 3.148 ± 0.048	4.172ArgGlu: 4.172 ± 0.055	2.864ArgPhe: 2.864 ± 0.045	3.53ArgGly: 3.53 ± 0.046	1.548ArgHis: 1.548 ± 0.032	3.781ArgIle: 3.781 ± 0.044	2.965ArgLys: 2.965 ± 0.045	6.143ArgLeu: 6.143 ± 0.065	1.749ArgMet: 1.749 ± 0.029	1.839ArgAsn: 1.839 ± 0.033	2.308ArgPro: 2.308 ± 0.039	1.972ArgGln: 1.972 ± 0.039	3.502ArgArg: 3.502 ± 0.06	3.03ArgSer: 3.03 ± 0.04	2.839ArgThr: 2.839 ± 0.039	4.311ArgVal: 4.311 ± 0.062	0.709ArgTrp: 0.709 ± 0.02	1.942ArgTyr: 1.942 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	5.03SerAla: 5.03 ± 0.054	0.824SerCys: 0.824 ± 0.023	3.265SerAsp: 3.265 ± 0.056	3.468SerGlu: 3.468 ± 0.05	2.692SerPhe: 2.692 ± 0.039	5.761SerGly: 5.761 ± 0.063	1.433SerHis: 1.433 ± 0.028	3.189SerIle: 3.189 ± 0.049	2.221SerLys: 2.221 ± 0.041	6.37SerLeu: 6.37 ± 0.067	1.771SerMet: 1.771 ± 0.033	1.511SerAsn: 1.511 ± 0.031	3.034SerPro: 3.034 ± 0.046	1.654SerGln: 1.654 ± 0.033	3.756SerArg: 3.756 ± 0.049	3.474SerSer: 3.474 ± 0.048	2.916SerThr: 2.916 ± 0.045	4.441SerVal: 4.441 ± 0.065	0.778SerTrp: 0.778 ± 0.022	1.651SerTyr: 1.651 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	5.226ThrAla: 5.226 ± 0.055	0.805ThrCys: 0.805 ± 0.022	3.347ThrAsp: 3.347 ± 0.048	3.4ThrGlu: 3.4 ± 0.042	2.391ThrPhe: 2.391 ± 0.036	5.593ThrGly: 5.593 ± 0.063	1.424ThrHis: 1.424 ± 0.026	3.222ThrIle: 3.222 ± 0.054	1.923ThrLys: 1.923 ± 0.036	6.784ThrLeu: 6.784 ± 0.072	1.438ThrMet: 1.438 ± 0.027	1.52ThrAsn: 1.52 ± 0.025	3.307ThrPro: 3.307 ± 0.047	1.523ThrGln: 1.523 ± 0.03	3.652ThrArg: 3.652 ± 0.045	3.053ThrSer: 3.053 ± 0.045	3.279ThrThr: 3.279 ± 0.048	4.544ThrVal: 4.544 ± 0.059	0.711ThrTrp: 0.711 ± 0.022	1.62ThrTyr: 1.62 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	7.083ValAla: 7.083 ± 0.075	1.065ValCys: 1.065 ± 0.022	4.26ValAsp: 4.26 ± 0.053	4.66ValGlu: 4.66 ± 0.058	2.984ValPhe: 2.984 ± 0.041	5.169ValGly: 5.169 ± 0.065	1.39ValHis: 1.39 ± 0.029	4.349ValIle: 4.349 ± 0.06	3.592ValLys: 3.592 ± 0.047	6.808ValLeu: 6.808 ± 0.065	2.193ValMet: 2.193 ± 0.038	2.409ValAsn: 2.409 ± 0.036	3.403ValPro: 3.403 ± 0.041	1.708ValGln: 1.708 ± 0.035	3.963ValArg: 3.963 ± 0.049	5.01ValSer: 5.01 ± 0.058	5.075ValThr: 5.075 ± 0.071	6.136ValVal: 6.136 ± 0.079	0.744ValTrp: 0.744 ± 0.021	1.912ValTyr: 1.912 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	0.933TrpAla: 0.933 ± 0.027	0.164TrpCys: 0.164 ± 0.009	0.618TrpAsp: 0.618 ± 0.018	0.676TrpGlu: 0.676 ± 0.02	0.556TrpPhe: 0.556 ± 0.02	0.934TrpGly: 0.934 ± 0.029	0.288TrpHis: 0.288 ± 0.012	0.619TrpIle: 0.619 ± 0.02	0.601TrpLys: 0.601 ± 0.017	1.112TrpLeu: 1.112 ± 0.024	0.339TrpMet: 0.339 ± 0.014	0.423TrpAsn: 0.423 ± 0.016	0.469TrpPro: 0.469 ± 0.019	0.42TrpGln: 0.42 ± 0.016	0.583TrpArg: 0.583 ± 0.021	0.631TrpSer: 0.631 ± 0.02	0.59TrpThr: 0.59 ± 0.018	0.878TrpVal: 0.878 ± 0.024	0.146TrpTrp: 0.146 ± 0.009	0.346TrpTyr: 0.346 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.396TyrAla: 2.396 ± 0.036	0.372TyrCys: 0.372 ± 0.015	1.652TyrAsp: 1.652 ± 0.039	1.604TyrGlu: 1.604 ± 0.032	1.218TyrPhe: 1.218 ± 0.025	2.335TyrGly: 2.335 ± 0.036	0.695TyrHis: 0.695 ± 0.019	1.439TyrIle: 1.439 ± 0.031	1.196TyrLys: 1.196 ± 0.03	2.825TyrLeu: 2.825 ± 0.041	0.626TyrMet: 0.626 ± 0.019	0.986TyrAsn: 0.986 ± 0.028	1.33TyrPro: 1.33 ± 0.031	0.792TyrGln: 0.792 ± 0.021	1.912TyrArg: 1.912 ± 0.033	1.561TyrSer: 1.561 ± 0.03	1.688TyrThr: 1.688 ± 0.034	1.717TyrVal: 1.717 ± 0.033	0.35TyrTrp: 0.35 ± 0.016	0.924TyrTyr: 0.924 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 5238 proteins (1765537 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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