Amino acid dipepetide frequency for Candidatus Gracilibacteria bacterium GN02-872

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.575AlaAla: 1.575 ± 0.099
0.322AlaCys: 0.322 ± 0.037
2.09AlaAsp: 2.09 ± 0.1
3.248AlaGlu: 3.248 ± 0.128
2.477AlaPhe: 2.477 ± 0.107
3.242AlaGly: 3.242 ± 0.13
0.527AlaHis: 0.527 ± 0.048
4.446AlaIle: 4.446 ± 0.133
4.645AlaLys: 4.645 ± 0.128
3.932AlaLeu: 3.932 ± 0.151
1.133AlaMet: 1.133 ± 0.071
2.382AlaAsn: 2.382 ± 0.099
1.058AlaPro: 1.058 ± 0.064
1.038AlaGln: 1.038 ± 0.052
1.666AlaArg: 1.666 ± 0.075
2.874AlaSer: 2.874 ± 0.12
2.246AlaThr: 2.246 ± 0.101
2.321AlaVal: 2.321 ± 0.1
0.286AlaTrp: 0.286 ± 0.03
1.852AlaTyr: 1.852 ± 0.087
0.0AlaXaa: 0.0 ± 0.0
Cys
0.251CysAla: 0.251 ± 0.026
0.052CysCys: 0.052 ± 0.013
0.469CysAsp: 0.469 ± 0.043
0.589CysGlu: 0.589 ± 0.048
0.436CysPhe: 0.436 ± 0.039
0.599CysGly: 0.599 ± 0.051
0.098CysHis: 0.098 ± 0.019
0.498CysIle: 0.498 ± 0.038
0.674CysLys: 0.674 ± 0.06
0.547CysLeu: 0.547 ± 0.042
0.111CysMet: 0.111 ± 0.019
0.413CysAsn: 0.413 ± 0.038
0.319CysPro: 0.319 ± 0.039
0.159CysGln: 0.159 ± 0.022
0.189CysArg: 0.189 ± 0.023
0.504CysSer: 0.504 ± 0.04
0.254CysThr: 0.254 ± 0.028
0.335CysVal: 0.335 ± 0.037
0.052CysTrp: 0.052 ± 0.014
0.296CysTyr: 0.296 ± 0.032
0.0CysXaa: 0.0 ± 0.0
Asp
2.122AspAla: 2.122 ± 0.095
0.361AspCys: 0.361 ± 0.038
2.744AspAsp: 2.744 ± 0.12
4.586AspGlu: 4.586 ± 0.132
5.172AspPhe: 5.172 ± 0.149
3.444AspGly: 3.444 ± 0.128
0.381AspHis: 0.381 ± 0.035
4.928AspIle: 4.928 ± 0.13
5.732AspLys: 5.732 ± 0.148
6.327AspLeu: 6.327 ± 0.154
0.957AspMet: 0.957 ± 0.058
3.001AspAsn: 3.001 ± 0.09
1.331AspPro: 1.331 ± 0.079
0.895AspGln: 0.895 ± 0.049
1.536AspArg: 1.536 ± 0.069
3.486AspSer: 3.486 ± 0.104
2.008AspThr: 2.008 ± 0.082
2.64AspVal: 2.64 ± 0.097
0.335AspTrp: 0.335 ± 0.038
2.877AspTyr: 2.877 ± 0.115
0.0AspXaa: 0.0 ± 0.0
Glu
3.795GluAla: 3.795 ± 0.128
0.283GluCys: 0.283 ± 0.037
3.639GluAsp: 3.639 ± 0.132
7.108GluGlu: 7.108 ± 0.193
3.642GluPhe: 3.642 ± 0.116
3.535GluGly: 3.535 ± 0.119
0.739GluHis: 0.739 ± 0.055
9.377GluIle: 9.377 ± 0.197
13.12GluLys: 13.12 ± 0.282
7.05GluLeu: 7.05 ± 0.183
1.364GluMet: 1.364 ± 0.086
7.844GluAsn: 7.844 ± 0.199
1.188GluPro: 1.188 ± 0.081
2.216GluGln: 2.216 ± 0.09
2.389GluArg: 2.389 ± 0.11
3.805GluSer: 3.805 ± 0.095
3.665GluThr: 3.665 ± 0.112
4.215GluVal: 4.215 ± 0.114
0.325GluTrp: 0.325 ± 0.039
2.906GluTyr: 2.906 ± 0.101
0.0GluXaa: 0.0 ± 0.0
Phe
2.675PheAla: 2.675 ± 0.105
0.618PheCys: 0.618 ± 0.044
3.857PheAsp: 3.857 ± 0.107
4.963PheGlu: 4.963 ± 0.137
4.4PhePhe: 4.4 ± 0.185
4.453PheGly: 4.453 ± 0.16
0.576PheHis: 0.576 ± 0.041
5.764PheIle: 5.764 ± 0.197
4.85PheLys: 4.85 ± 0.142
7.037PheLeu: 7.037 ± 0.233
1.097PheMet: 1.097 ± 0.065
2.578PheAsn: 2.578 ± 0.11
1.732PhePro: 1.732 ± 0.074
1.364PheGln: 1.364 ± 0.064
1.715PheArg: 1.715 ± 0.08
5.341PheSer: 5.341 ± 0.143
2.591PheThr: 2.591 ± 0.084
3.704PheVal: 3.704 ± 0.127
0.531PheTrp: 0.531 ± 0.043
2.741PheTyr: 2.741 ± 0.105
0.0PheXaa: 0.0 ± 0.0
Gly
3.31GlyAla: 3.31 ± 0.122
0.459GlyCys: 0.459 ± 0.037
3.642GlyAsp: 3.642 ± 0.126
5.211GlyGlu: 5.211 ± 0.136
3.694GlyPhe: 3.694 ± 0.123
4.052GlyGly: 4.052 ± 0.208
0.791GlyHis: 0.791 ± 0.049
6.353GlyIle: 6.353 ± 0.164
7.3GlyLys: 7.3 ± 0.17
5.016GlyLeu: 5.016 ± 0.175
1.103GlyMet: 1.103 ± 0.063
4.231GlyAsn: 4.231 ± 0.136
1.064GlyPro: 1.064 ± 0.065
1.673GlyGln: 1.673 ± 0.072
1.953GlyArg: 1.953 ± 0.083
3.349GlySer: 3.349 ± 0.136
3.144GlyThr: 3.144 ± 0.107
4.114GlyVal: 4.114 ± 0.125
0.312GlyTrp: 0.312 ± 0.028
2.454GlyTyr: 2.454 ± 0.079
0.0GlyXaa: 0.0 ± 0.0
His
0.352HisAla: 0.352 ± 0.033
0.133HisCys: 0.133 ± 0.02
0.397HisAsp: 0.397 ± 0.032
0.518HisGlu: 0.518 ± 0.043
0.797HisPhe: 0.797 ± 0.055
0.609HisGly: 0.609 ± 0.046
0.195HisHis: 0.195 ± 0.021
1.155HisIle: 1.155 ± 0.063
1.015HisLys: 1.015 ± 0.052
1.084HisLeu: 1.084 ± 0.055
0.163HisMet: 0.163 ± 0.024
0.605HisAsn: 0.605 ± 0.048
0.43HisPro: 0.43 ± 0.039
0.277HisGln: 0.277 ± 0.031
0.417HisArg: 0.417 ± 0.041
0.788HisSer: 0.788 ± 0.057
0.557HisThr: 0.557 ± 0.05
0.365HisVal: 0.365 ± 0.031
0.068HisTrp: 0.068 ± 0.016
0.491HisTyr: 0.491 ± 0.044
0.0HisXaa: 0.0 ± 0.0
Ile
4.189IleAla: 4.189 ± 0.138
0.788IleCys: 0.788 ± 0.051
5.647IleAsp: 5.647 ± 0.152
7.538IleGlu: 7.538 ± 0.172
7.795IlePhe: 7.795 ± 0.27
6.483IleGly: 6.483 ± 0.174
0.934IleHis: 0.934 ± 0.068
9.92IleIle: 9.92 ± 0.243
9.237IleLys: 9.237 ± 0.189
10.314IleLeu: 10.314 ± 0.211
1.644IleMet: 1.644 ± 0.088
5.556IleAsn: 5.556 ± 0.167
2.819IlePro: 2.819 ± 0.093
1.898IleGln: 1.898 ± 0.087
2.343IleArg: 2.343 ± 0.099
7.603IleSer: 7.603 ± 0.154
3.968IleThr: 3.968 ± 0.118
5.188IleVal: 5.188 ± 0.145
0.514IleTrp: 0.514 ± 0.039
3.756IleTyr: 3.756 ± 0.112
0.0IleXaa: 0.0 ± 0.0
Lys
4.518LysAla: 4.518 ± 0.157
0.42LysCys: 0.42 ± 0.044
6.767LysAsp: 6.767 ± 0.155
10.135LysGlu: 10.135 ± 0.225
5.003LysPhe: 5.003 ± 0.151
5.409LysGly: 5.409 ± 0.152
0.928LysHis: 0.928 ± 0.051
12.277LysIle: 12.277 ± 0.233
13.013LysLys: 13.013 ± 0.286
8.296LysLeu: 8.296 ± 0.165
2.597LysMet: 2.597 ± 0.097
10.734LysAsn: 10.734 ± 0.236
1.917LysPro: 1.917 ± 0.074
2.975LysGln: 2.975 ± 0.09
3.196LysArg: 3.196 ± 0.103
5.907LysSer: 5.907 ± 0.175
5.881LysThr: 5.881 ± 0.147
5.719LysVal: 5.719 ± 0.152
0.43LysTrp: 0.43 ± 0.038
5.172LysTyr: 5.172 ± 0.113
0.0LysXaa: 0.0 ± 0.0
Leu
4.518LeuAla: 4.518 ± 0.146
0.501LeuCys: 0.501 ± 0.036
5.344LeuAsp: 5.344 ± 0.132
9.182LeuGlu: 9.182 ± 0.197
5.24LeuPhe: 5.24 ± 0.176
5.839LeuGly: 5.839 ± 0.16
0.963LeuHis: 0.963 ± 0.057
7.229LeuIle: 7.229 ± 0.205
11.2LeuLys: 11.2 ± 0.185
7.444LeuLeu: 7.444 ± 0.168
1.445LeuMet: 1.445 ± 0.078
5.865LeuAsn: 5.865 ± 0.146
2.565LeuPro: 2.565 ± 0.115
2.389LeuGln: 2.389 ± 0.095
2.789LeuArg: 2.789 ± 0.099
6.431LeuSer: 6.431 ± 0.167
4.433LeuThr: 4.433 ± 0.126
4.824LeuVal: 4.824 ± 0.156
0.54LeuTrp: 0.54 ± 0.044
2.959LeuTyr: 2.959 ± 0.108
0.0LeuXaa: 0.0 ± 0.0
Met
0.999MetAla: 0.999 ± 0.069
0.117MetCys: 0.117 ± 0.023
0.892MetAsp: 0.892 ± 0.056
1.214MetGlu: 1.214 ± 0.072
0.866MetPhe: 0.866 ± 0.056
1.214MetGly: 1.214 ± 0.077
0.202MetHis: 0.202 ± 0.027
1.751MetIle: 1.751 ± 0.075
2.483MetLys: 2.483 ± 0.111
1.569MetLeu: 1.569 ± 0.077
0.387MetMet: 0.387 ± 0.038
1.081MetAsn: 1.081 ± 0.066
0.518MetPro: 0.518 ± 0.037
0.605MetGln: 0.605 ± 0.054
0.648MetArg: 0.648 ± 0.049
1.051MetSer: 1.051 ± 0.069
0.967MetThr: 0.967 ± 0.058
0.937MetVal: 0.937 ± 0.055
0.081MetTrp: 0.081 ± 0.014
0.501MetTyr: 0.501 ± 0.042
0.0MetXaa: 0.0 ± 0.0
Asn
2.311AsnAla: 2.311 ± 0.088
0.508AsnCys: 0.508 ± 0.038
3.017AsnAsp: 3.017 ± 0.123
3.932AsnGlu: 3.932 ± 0.121
4.749AsnPhe: 4.749 ± 0.138
4.189AsnGly: 4.189 ± 0.142
0.765AsnHis: 0.765 ± 0.055
8.039AsnIle: 8.039 ± 0.17
6.77AsnLys: 6.77 ± 0.182
7.232AsnLeu: 7.232 ± 0.201
1.194AsnMet: 1.194 ± 0.066
4.046AsnAsn: 4.046 ± 0.178
2.285AsnPro: 2.285 ± 0.096
1.937AsnGln: 1.937 ± 0.084
1.722AsnArg: 1.722 ± 0.085
5.055AsnSer: 5.055 ± 0.153
3.069AsnThr: 3.069 ± 0.104
2.741AsnVal: 2.741 ± 0.093
0.449AsnTrp: 0.449 ± 0.042
3.489AsnTyr: 3.489 ± 0.108
0.0AsnXaa: 0.0 ± 0.0
Pro
1.042ProAla: 1.042 ± 0.072
0.179ProCys: 0.179 ± 0.023
1.426ProAsp: 1.426 ± 0.067
2.522ProGlu: 2.522 ± 0.104
1.481ProPhe: 1.481 ± 0.062
1.549ProGly: 1.549 ± 0.079
0.381ProHis: 0.381 ± 0.043
2.298ProIle: 2.298 ± 0.105
2.633ProLys: 2.633 ± 0.089
1.774ProLeu: 1.774 ± 0.082
0.381ProMet: 0.381 ± 0.032
1.686ProAsn: 1.686 ± 0.082
0.579ProPro: 0.579 ± 0.082
0.583ProGln: 0.583 ± 0.042
0.667ProArg: 0.667 ± 0.048
1.429ProSer: 1.429 ± 0.065
1.383ProThr: 1.383 ± 0.075
1.445ProVal: 1.445 ± 0.066
0.202ProTrp: 0.202 ± 0.023
0.96ProTyr: 0.96 ± 0.058
0.0ProXaa: 0.0 ± 0.0
Gln
1.39GlnAla: 1.39 ± 0.066
0.114GlnCys: 0.114 ± 0.02
1.344GlnAsp: 1.344 ± 0.062
2.252GlnGlu: 2.252 ± 0.098
0.957GlnPhe: 0.957 ± 0.054
1.103GlnGly: 1.103 ± 0.059
0.221GlnHis: 0.221 ± 0.03
2.643GlnIle: 2.643 ± 0.101
3.681GlnLys: 3.681 ± 0.112
1.66GlnLeu: 1.66 ± 0.086
0.449GlnMet: 0.449 ± 0.036
2.343GlnAsn: 2.343 ± 0.106
0.407GlnPro: 0.407 ± 0.04
0.501GlnGln: 0.501 ± 0.043
0.849GlnArg: 0.849 ± 0.051
1.292GlnSer: 1.292 ± 0.06
1.364GlnThr: 1.364 ± 0.065
1.393GlnVal: 1.393 ± 0.075
0.114GlnTrp: 0.114 ± 0.018
0.648GlnTyr: 0.648 ± 0.047
0.0GlnXaa: 0.0 ± 0.0
Arg
1.471ArgAla: 1.471 ± 0.067
0.205ArgCys: 0.205 ± 0.025
1.595ArgAsp: 1.595 ± 0.067
2.695ArgGlu: 2.695 ± 0.119
1.621ArgPhe: 1.621 ± 0.077
1.79ArgGly: 1.79 ± 0.092
0.348ArgHis: 0.348 ± 0.032
2.845ArgIle: 2.845 ± 0.09
3.356ArgLys: 3.356 ± 0.102
2.347ArgLeu: 2.347 ± 0.11
0.579ArgMet: 0.579 ± 0.04
2.295ArgAsn: 2.295 ± 0.106
0.618ArgPro: 0.618 ± 0.047
0.921ArgGln: 0.921 ± 0.061
0.993ArgArg: 0.993 ± 0.063
1.279ArgSer: 1.279 ± 0.071
1.374ArgThr: 1.374 ± 0.072
1.66ArgVal: 1.66 ± 0.069
0.156ArgTrp: 0.156 ± 0.022
1.107ArgTyr: 1.107 ± 0.052
0.0ArgXaa: 0.0 ± 0.0
Ser
2.747SerAla: 2.747 ± 0.102
0.531SerCys: 0.531 ± 0.044
3.593SerAsp: 3.593 ± 0.107
5.344SerGlu: 5.344 ± 0.149
4.042SerPhe: 4.042 ± 0.131
5.055SerGly: 5.055 ± 0.164
0.697SerHis: 0.697 ± 0.047
5.868SerIle: 5.868 ± 0.149
6.493SerLys: 6.493 ± 0.167
6.256SerLeu: 6.256 ± 0.137
1.107SerMet: 1.107 ± 0.052
3.684SerAsn: 3.684 ± 0.144
1.647SerPro: 1.647 ± 0.083
1.858SerGln: 1.858 ± 0.082
1.888SerArg: 1.888 ± 0.087
4.716SerSer: 4.716 ± 0.168
2.923SerThr: 2.923 ± 0.108
3.492SerVal: 3.492 ± 0.108
0.534SerTrp: 0.534 ± 0.04
2.545SerTyr: 2.545 ± 0.087
0.0SerXaa: 0.0 ± 0.0
Thr
2.06ThrAla: 2.06 ± 0.109
0.404ThrCys: 0.404 ± 0.044
2.604ThrAsp: 2.604 ± 0.087
3.541ThrGlu: 3.541 ± 0.115
2.659ThrPhe: 2.659 ± 0.097
3.85ThrGly: 3.85 ± 0.132
0.586ThrHis: 0.586 ± 0.042
4.28ThrIle: 4.28 ± 0.116
4.768ThrLys: 4.768 ± 0.128
3.935ThrLeu: 3.935 ± 0.122
0.765ThrMet: 0.765 ± 0.055
2.978ThrAsn: 2.978 ± 0.115
1.653ThrPro: 1.653 ± 0.096
1.204ThrGln: 1.204 ± 0.063
1.299ThrArg: 1.299 ± 0.066
2.923ThrSer: 2.923 ± 0.098
2.496ThrThr: 2.496 ± 0.112
2.513ThrVal: 2.513 ± 0.098
0.306ThrTrp: 0.306 ± 0.041
1.839ThrTyr: 1.839 ± 0.074
0.0ThrXaa: 0.0 ± 0.0
Val
2.402ValAla: 2.402 ± 0.096
0.452ValCys: 0.452 ± 0.042
3.066ValAsp: 3.066 ± 0.109
4.316ValGlu: 4.316 ± 0.135
3.639ValPhe: 3.639 ± 0.126
4.013ValGly: 4.013 ± 0.134
0.537ValHis: 0.537 ± 0.046
4.41ValIle: 4.41 ± 0.15
5.178ValLys: 5.178 ± 0.118
4.944ValLeu: 4.944 ± 0.132
0.849ValMet: 0.849 ± 0.055
3.079ValAsn: 3.079 ± 0.115
1.38ValPro: 1.38 ± 0.072
1.038ValGln: 1.038 ± 0.053
1.631ValArg: 1.631 ± 0.081
3.828ValSer: 3.828 ± 0.121
2.412ValThr: 2.412 ± 0.114
3.053ValVal: 3.053 ± 0.108
0.361ValTrp: 0.361 ± 0.039
2.184ValTyr: 2.184 ± 0.085
0.0ValXaa: 0.0 ± 0.0
Trp
0.273TrpAla: 0.273 ± 0.027
0.033TrpCys: 0.033 ± 0.01
0.355TrpAsp: 0.355 ± 0.039
0.504TrpGlu: 0.504 ± 0.041
0.296TrpPhe: 0.296 ± 0.038
0.491TrpGly: 0.491 ± 0.035
0.111TrpHis: 0.111 ± 0.021
0.553TrpIle: 0.553 ± 0.045
0.622TrpLys: 0.622 ± 0.05
0.475TrpLeu: 0.475 ± 0.039
0.12TrpMet: 0.12 ± 0.018
0.365TrpAsn: 0.365 ± 0.036
0.114TrpPro: 0.114 ± 0.02
0.218TrpGln: 0.218 ± 0.026
0.186TrpArg: 0.186 ± 0.023
0.358TrpSer: 0.358 ± 0.033
0.244TrpThr: 0.244 ± 0.029
0.27TrpVal: 0.27 ± 0.035
0.078TrpTrp: 0.078 ± 0.016
0.238TrpTyr: 0.238 ± 0.031
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.36TyrAla: 1.36 ± 0.072
0.365TyrCys: 0.365 ± 0.038
2.376TyrAsp: 2.376 ± 0.098
2.806TyrGlu: 2.806 ± 0.104
3.619TyrPhe: 3.619 ± 0.128
2.308TyrGly: 2.308 ± 0.088
0.436TyrHis: 0.436 ± 0.042
3.499TyrIle: 3.499 ± 0.108
4.527TyrLys: 4.527 ± 0.13
4.462TyrLeu: 4.462 ± 0.135
0.635TyrMet: 0.635 ± 0.04
2.731TyrAsn: 2.731 ± 0.113
0.976TyrPro: 0.976 ± 0.055
0.976TyrGln: 0.976 ± 0.059
1.178TyrArg: 1.178 ± 0.06
3.001TyrSer: 3.001 ± 0.098
1.686TyrThr: 1.686 ± 0.079
1.845TyrVal: 1.845 ± 0.084
0.228TyrTrp: 0.228 ± 0.027
1.839TyrTyr: 1.839 ± 0.089
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 972 proteins (307244 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski