Amino acid dipepetide frequency for Alcanivorax borkumensis (strain ATCC 700651 / DSM 11573 / NCIMB 13689 / SK2)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.276AlaAla: 10.276 ± 0.136	1.101AlaCys: 1.101 ± 0.036	5.861AlaAsp: 5.861 ± 0.095	5.932AlaGlu: 5.932 ± 0.096	3.602AlaPhe: 3.602 ± 0.071	8.227AlaGly: 8.227 ± 0.105	2.062AlaHis: 2.062 ± 0.042	5.156AlaIle: 5.156 ± 0.08	3.556AlaLys: 3.556 ± 0.094	12.644AlaLeu: 12.644 ± 0.154	3.107AlaMet: 3.107 ± 0.061	3.055AlaAsn: 3.055 ± 0.062	4.145AlaPro: 4.145 ± 0.069	4.38AlaGln: 4.38 ± 0.078	6.306AlaArg: 6.306 ± 0.097	5.662AlaSer: 5.662 ± 0.095	4.891AlaThr: 4.891 ± 0.079	7.072AlaVal: 7.072 ± 0.096	1.376AlaTrp: 1.376 ± 0.037	2.125AlaTyr: 2.125 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.921CysAla: 0.921 ± 0.031	0.139CysCys: 0.139 ± 0.014	0.61CysAsp: 0.61 ± 0.031	0.635CysGlu: 0.635 ± 0.024	0.362CysPhe: 0.362 ± 0.019	0.93CysGly: 0.93 ± 0.037	0.35CysHis: 0.35 ± 0.02	0.415CysIle: 0.415 ± 0.022	0.302CysLys: 0.302 ± 0.016	1.008CysLeu: 1.008 ± 0.033	0.236CysMet: 0.236 ± 0.017	0.285CysAsn: 0.285 ± 0.017	0.545CysPro: 0.545 ± 0.031	0.463CysGln: 0.463 ± 0.025	0.597CysArg: 0.597 ± 0.028	0.571CysSer: 0.571 ± 0.023	0.434CysThr: 0.434 ± 0.023	0.694CysVal: 0.694 ± 0.025	0.164CysTrp: 0.164 ± 0.015	0.299CysTyr: 0.299 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	5.798AspAla: 5.798 ± 0.09	0.546AspCys: 0.546 ± 0.024	3.645AspAsp: 3.645 ± 0.073	3.803AspGlu: 3.803 ± 0.072	2.208AspPhe: 2.208 ± 0.05	4.485AspGly: 4.485 ± 0.086	1.34AspHis: 1.34 ± 0.044	3.07AspIle: 3.07 ± 0.059	2.211AspLys: 2.211 ± 0.06	5.611AspLeu: 5.611 ± 0.081	1.535AspMet: 1.535 ± 0.044	2.263AspAsn: 2.263 ± 0.057	2.663AspPro: 2.663 ± 0.055	2.473AspGln: 2.473 ± 0.052	3.346AspArg: 3.346 ± 0.066	3.274AspSer: 3.274 ± 0.064	3.097AspThr: 3.097 ± 0.059	3.972AspVal: 3.972 ± 0.065	0.967AspTrp: 0.967 ± 0.037	1.902AspTyr: 1.902 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	6.09GluAla: 6.09 ± 0.09	0.444GluCys: 0.444 ± 0.022	3.121GluAsp: 3.121 ± 0.064	3.828GluGlu: 3.828 ± 0.087	1.742GluPhe: 1.742 ± 0.053	4.269GluGly: 4.269 ± 0.075	1.622GluHis: 1.622 ± 0.048	3.023GluIle: 3.023 ± 0.062	3.201GluLys: 3.201 ± 0.067	6.364GluLeu: 6.364 ± 0.099	1.592GluMet: 1.592 ± 0.043	2.093GluAsn: 2.093 ± 0.052	2.404GluPro: 2.404 ± 0.051	4.013GluGln: 4.013 ± 0.069	4.248GluArg: 4.248 ± 0.08	3.121GluSer: 3.121 ± 0.065	3.038GluThr: 3.038 ± 0.066	4.057GluVal: 4.057 ± 0.078	0.734GluTrp: 0.734 ± 0.029	1.466GluTyr: 1.466 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.336PheAla: 3.336 ± 0.056	0.412PheCys: 0.412 ± 0.023	2.461PheAsp: 2.461 ± 0.05	2.079PheGlu: 2.079 ± 0.043	1.627PhePhe: 1.627 ± 0.047	3.056PheGly: 3.056 ± 0.062	0.802PheHis: 0.802 ± 0.032	1.844PheIle: 1.844 ± 0.053	1.192PheLys: 1.192 ± 0.032	3.344PheLeu: 3.344 ± 0.069	0.991PheMet: 0.991 ± 0.039	1.394PheAsn: 1.394 ± 0.038	1.537PhePro: 1.537 ± 0.045	1.332PheGln: 1.332 ± 0.039	1.955PheArg: 1.955 ± 0.05	2.769PheSer: 2.769 ± 0.058	2.066PheThr: 2.066 ± 0.047	2.501PheVal: 2.501 ± 0.056	0.584PheTrp: 0.584 ± 0.03	1.123PheTyr: 1.123 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	6.92GlyAla: 6.92 ± 0.101	0.991GlyCys: 0.991 ± 0.036	4.517GlyAsp: 4.517 ± 0.098	5.061GlyGlu: 5.061 ± 0.082	3.173GlyPhe: 3.173 ± 0.064	6.124GlyGly: 6.124 ± 0.094	1.891GlyHis: 1.891 ± 0.041	4.333GlyIle: 4.333 ± 0.066	3.685GlyLys: 3.685 ± 0.07	8.394GlyLeu: 8.394 ± 0.114	2.357GlyMet: 2.357 ± 0.054	2.617GlyAsn: 2.617 ± 0.052	2.532GlyPro: 2.532 ± 0.058	3.256GlyGln: 3.256 ± 0.069	4.38GlyArg: 4.38 ± 0.076	4.294GlySer: 4.294 ± 0.068	3.695GlyThr: 3.695 ± 0.059	5.863GlyVal: 5.863 ± 0.09	1.337GlyTrp: 1.337 ± 0.04	2.403GlyTyr: 2.403 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	1.99HisAla: 1.99 ± 0.055	0.355HisCys: 0.355 ± 0.017	1.222HisAsp: 1.222 ± 0.037	1.156HisGlu: 1.156 ± 0.04	1.038HisPhe: 1.038 ± 0.035	2.013HisGly: 2.013 ± 0.056	0.765HisHis: 0.765 ± 0.037	1.109HisIle: 1.109 ± 0.036	0.757HisLys: 0.757 ± 0.032	2.396HisLeu: 2.396 ± 0.057	0.587HisMet: 0.587 ± 0.027	0.756HisAsn: 0.756 ± 0.03	1.43HisPro: 1.43 ± 0.041	1.07HisGln: 1.07 ± 0.039	1.623HisArg: 1.623 ± 0.049	1.358HisSer: 1.358 ± 0.037	1.14HisThr: 1.14 ± 0.037	1.388HisVal: 1.388 ± 0.045	0.487HisTrp: 0.487 ± 0.025	0.794HisTyr: 0.794 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.187IleAla: 5.187 ± 0.082	0.497IleCys: 0.497 ± 0.024	3.136IleAsp: 3.136 ± 0.055	3.305IleGlu: 3.305 ± 0.065	1.582IlePhe: 1.582 ± 0.042	4.023IleGly: 4.023 ± 0.065	1.157IleHis: 1.157 ± 0.038	2.485IleIle: 2.485 ± 0.061	1.907IleLys: 1.907 ± 0.049	4.317IleLeu: 4.317 ± 0.075	1.197IleMet: 1.197 ± 0.043	2.026IleAsn: 2.026 ± 0.051	2.363IlePro: 2.363 ± 0.052	1.815IleGln: 1.815 ± 0.047	3.159IleArg: 3.159 ± 0.058	3.178IleSer: 3.178 ± 0.057	3.051IleThr: 3.051 ± 0.061	3.291IleVal: 3.291 ± 0.063	0.529IleTrp: 0.529 ± 0.027	1.246IleTyr: 1.246 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	4.306LysAla: 4.306 ± 0.094	0.226LysCys: 0.226 ± 0.019	2.108LysAsp: 2.108 ± 0.058	2.342LysGlu: 2.342 ± 0.066	0.898LysPhe: 0.898 ± 0.032	2.996LysGly: 2.996 ± 0.063	0.835LysHis: 0.835 ± 0.029	1.752LysIle: 1.752 ± 0.05	2.013LysLys: 2.013 ± 0.073	3.7LysLeu: 3.7 ± 0.07	0.987LysMet: 0.987 ± 0.039	1.24LysAsn: 1.24 ± 0.039	2.177LysPro: 2.177 ± 0.056	1.913LysGln: 1.913 ± 0.056	2.502LysArg: 2.502 ± 0.06	1.998LysSer: 1.998 ± 0.058	2.085LysThr: 2.085 ± 0.055	3.065LysVal: 3.065 ± 0.067	0.375LysTrp: 0.375 ± 0.021	0.825LysTyr: 0.825 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	12.45LeuAla: 12.45 ± 0.15	1.125LeuCys: 1.125 ± 0.041	6.505LeuAsp: 6.505 ± 0.093	6.529LeuGlu: 6.529 ± 0.105	4.078LeuPhe: 4.078 ± 0.074	8.199LeuGly: 8.199 ± 0.106	2.335LeuHis: 2.335 ± 0.057	5.328LeuIle: 5.328 ± 0.091	4.285LeuLys: 4.285 ± 0.077	12.112LeuLeu: 12.112 ± 0.182	2.777LeuMet: 2.777 ± 0.055	3.761LeuAsn: 3.761 ± 0.068	6.018LeuPro: 6.018 ± 0.093	4.202LeuGln: 4.202 ± 0.076	6.451LeuArg: 6.451 ± 0.103	7.157LeuSer: 7.157 ± 0.116	5.796LeuThr: 5.796 ± 0.096	7.722LeuVal: 7.722 ± 0.103	1.454LeuTrp: 1.454 ± 0.048	2.638LeuTyr: 2.638 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	3.078MetAla: 3.078 ± 0.053	0.189MetCys: 0.189 ± 0.015	1.495MetAsp: 1.495 ± 0.045	1.477MetGlu: 1.477 ± 0.041	0.686MetPhe: 0.686 ± 0.025	2.041MetGly: 2.041 ± 0.052	0.531MetHis: 0.531 ± 0.023	1.204MetIle: 1.204 ± 0.036	1.207MetLys: 1.207 ± 0.039	3.011MetLeu: 3.011 ± 0.064	0.785MetMet: 0.785 ± 0.035	0.955MetAsn: 0.955 ± 0.031	1.413MetPro: 1.413 ± 0.042	1.065MetGln: 1.065 ± 0.036	1.5MetArg: 1.5 ± 0.043	1.65MetSer: 1.65 ± 0.036	1.605MetThr: 1.605 ± 0.048	1.961MetVal: 1.961 ± 0.051	0.2MetTrp: 0.2 ± 0.014	0.382MetTyr: 0.382 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.347AsnAla: 3.347 ± 0.066	0.29AsnCys: 0.29 ± 0.019	2.086AsnAsp: 2.086 ± 0.051	1.877AsnGlu: 1.877 ± 0.05	1.102AsnPhe: 1.102 ± 0.035	2.936AsnGly: 2.936 ± 0.059	0.823AsnHis: 0.823 ± 0.029	1.689AsnIle: 1.689 ± 0.049	1.149AsnLys: 1.149 ± 0.038	3.267AsnLeu: 3.267 ± 0.061	0.744AsnMet: 0.744 ± 0.027	1.303AsnAsn: 1.303 ± 0.04	2.116AsnPro: 2.116 ± 0.051	1.431AsnGln: 1.431 ± 0.044	2.193AsnArg: 2.193 ± 0.05	1.749AsnSer: 1.749 ± 0.047	1.829AsnThr: 1.829 ± 0.05	2.127AsnVal: 2.127 ± 0.048	0.512AsnTrp: 0.512 ± 0.026	0.892AsnTyr: 0.892 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	4.848ProAla: 4.848 ± 0.087	0.401ProCys: 0.401 ± 0.022	3.039ProAsp: 3.039 ± 0.055	3.521ProGlu: 3.521 ± 0.055	1.819ProPhe: 1.819 ± 0.041	3.849ProGly: 3.849 ± 0.075	1.022ProHis: 1.022 ± 0.033	1.937ProIle: 1.937 ± 0.052	1.666ProLys: 1.666 ± 0.053	5.27ProLeu: 5.27 ± 0.1	1.318ProMet: 1.318 ± 0.038	1.465ProAsn: 1.465 ± 0.038	1.833ProPro: 1.833 ± 0.048	2.047ProGln: 2.047 ± 0.05	2.258ProArg: 2.258 ± 0.048	2.608ProSer: 2.608 ± 0.062	2.156ProThr: 2.156 ± 0.053	4.085ProVal: 4.085 ± 0.072	0.747ProTrp: 0.747 ± 0.031	1.138ProTyr: 1.138 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	5.283GlnAla: 5.283 ± 0.088	0.458GlnCys: 0.458 ± 0.025	1.949GlnAsp: 1.949 ± 0.044	2.35GlnGlu: 2.35 ± 0.052	1.391GlnPhe: 1.391 ± 0.039	3.418GlnGly: 3.418 ± 0.061	1.184GlnHis: 1.184 ± 0.035	1.964GlnIle: 1.964 ± 0.051	1.493GlnLys: 1.493 ± 0.042	5.137GlnLeu: 5.137 ± 0.103	1.086GlnMet: 1.086 ± 0.034	1.153GlnAsn: 1.153 ± 0.033	2.208GlnPro: 2.208 ± 0.051	3.222GlnGln: 3.222 ± 0.088	3.333GlnArg: 3.333 ± 0.077	2.314GlnSer: 2.314 ± 0.053	1.99GlnThr: 1.99 ± 0.048	3.489GlnVal: 3.489 ± 0.063	0.941GlnTrp: 0.941 ± 0.043	1.06GlnTyr: 1.06 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	5.261ArgAla: 5.261 ± 0.086	0.586ArgCys: 0.586 ± 0.026	3.677ArgAsp: 3.677 ± 0.069	4.193ArgGlu: 4.193 ± 0.075	2.765ArgPhe: 2.765 ± 0.055	3.711ArgGly: 3.711 ± 0.065	1.749ArgHis: 1.749 ± 0.045	3.25ArgIle: 3.25 ± 0.063	2.519ArgLys: 2.519 ± 0.051	7.175ArgLeu: 7.175 ± 0.121	1.562ArgMet: 1.562 ± 0.044	2.126ArgAsn: 2.126 ± 0.055	2.571ArgPro: 2.571 ± 0.06	3.243ArgGln: 3.243 ± 0.073	4.116ArgArg: 4.116 ± 0.097	3.13ArgSer: 3.13 ± 0.065	2.628ArgThr: 2.628 ± 0.062	4.178ArgVal: 4.178 ± 0.072	1.081ArgTrp: 1.081 ± 0.035	2.16ArgTyr: 2.16 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	5.628SerAla: 5.628 ± 0.087	0.503SerCys: 0.503 ± 0.025	3.318SerAsp: 3.318 ± 0.064	3.325SerGlu: 3.325 ± 0.072	2.112SerPhe: 2.112 ± 0.054	4.947SerGly: 4.947 ± 0.072	1.354SerHis: 1.354 ± 0.044	2.765SerIle: 2.765 ± 0.058	2.01SerLys: 2.01 ± 0.048	6.862SerLeu: 6.862 ± 0.1	1.473SerMet: 1.473 ± 0.036	1.905SerAsn: 1.905 ± 0.051	2.703SerPro: 2.703 ± 0.06	2.529SerGln: 2.529 ± 0.057	3.504SerArg: 3.504 ± 0.067	3.311SerSer: 3.311 ± 0.07	2.771SerThr: 2.771 ± 0.055	4.101SerVal: 4.101 ± 0.068	0.864SerTrp: 0.864 ± 0.031	1.451SerTyr: 1.451 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	4.837ThrAla: 4.837 ± 0.079	0.491ThrCys: 0.491 ± 0.025	2.929ThrAsp: 2.929 ± 0.061	2.725ThrGlu: 2.725 ± 0.05	1.955ThrPhe: 1.955 ± 0.051	4.571ThrGly: 4.571 ± 0.076	1.091ThrHis: 1.091 ± 0.035	2.359ThrIle: 2.359 ± 0.048	1.265ThrLys: 1.265 ± 0.04	7.11ThrLeu: 7.11 ± 0.112	1.105ThrMet: 1.105 ± 0.035	1.374ThrAsn: 1.374 ± 0.044	3.025ThrPro: 3.025 ± 0.061	1.851ThrGln: 1.851 ± 0.052	2.982ThrArg: 2.982 ± 0.062	2.534ThrSer: 2.534 ± 0.055	2.526ThrThr: 2.526 ± 0.062	4.225ThrVal: 4.225 ± 0.066	0.65ThrTrp: 0.65 ± 0.029	1.078ThrTyr: 1.078 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	7.628ValAla: 7.628 ± 0.1	0.709ValCys: 0.709 ± 0.026	4.507ValAsp: 4.507 ± 0.073	4.377ValGlu: 4.377 ± 0.074	2.601ValPhe: 2.601 ± 0.055	4.964ValGly: 4.964 ± 0.083	1.473ValHis: 1.473 ± 0.043	4.142ValIle: 4.142 ± 0.071	2.625ValLys: 2.625 ± 0.061	7.89ValLeu: 7.89 ± 0.104	2.017ValMet: 2.017 ± 0.051	2.486ValAsn: 2.486 ± 0.051	3.392ValPro: 3.392 ± 0.068	2.524ValGln: 2.524 ± 0.061	4.126ValArg: 4.126 ± 0.069	4.506ValSer: 4.506 ± 0.079	4.077ValThr: 4.077 ± 0.078	5.745ValVal: 5.745 ± 0.104	0.866ValTrp: 0.866 ± 0.033	1.555ValTyr: 1.555 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.125TrpAla: 1.125 ± 0.039	0.18TrpCys: 0.18 ± 0.016	0.639TrpAsp: 0.639 ± 0.029	0.666TrpGlu: 0.666 ± 0.023	0.578TrpPhe: 0.578 ± 0.025	0.895TrpGly: 0.895 ± 0.038	0.409TrpHis: 0.409 ± 0.02	0.646TrpIle: 0.646 ± 0.027	0.496TrpLys: 0.496 ± 0.024	2.3TrpLeu: 2.3 ± 0.059	0.387TrpMet: 0.387 ± 0.019	0.422TrpAsn: 0.422 ± 0.023	0.681TrpPro: 0.681 ± 0.03	1.12TrpGln: 1.12 ± 0.046	1.081TrpArg: 1.081 ± 0.041	0.746TrpSer: 0.746 ± 0.034	0.524TrpThr: 0.524 ± 0.021	1.056TrpVal: 1.056 ± 0.035	0.221TrpTrp: 0.221 ± 0.016	0.35TrpTyr: 0.35 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.226TyrAla: 2.226 ± 0.045	0.316TyrCys: 0.316 ± 0.019	1.381TyrAsp: 1.381 ± 0.044	1.289TyrGlu: 1.289 ± 0.039	1.085TyrPhe: 1.085 ± 0.038	2.17TyrGly: 2.17 ± 0.055	0.637TyrHis: 0.637 ± 0.027	0.983TyrIle: 0.983 ± 0.031	0.805TyrLys: 0.805 ± 0.031	3.013TyrLeu: 3.013 ± 0.056	0.595TyrMet: 0.595 ± 0.031	0.783TyrAsn: 0.783 ± 0.033	1.27TyrPro: 1.27 ± 0.035	1.474TyrGln: 1.474 ± 0.041	2.023TyrArg: 2.023 ± 0.05	1.506TyrSer: 1.506 ± 0.044	1.283TyrThr: 1.283 ± 0.04	1.616TyrVal: 1.616 ± 0.049	0.433TyrTrp: 0.433 ± 0.026	0.68TyrTyr: 0.68 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2752 proteins (907762 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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