Amino acid dipepetide frequency for Aggregatibacter segnis ATCC 33393

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.021AlaAla: 7.021 ± 0.156
0.915AlaCys: 0.915 ± 0.04
4.48AlaAsp: 4.48 ± 0.098
6.479AlaGlu: 6.479 ± 0.136
3.534AlaPhe: 3.534 ± 0.091
5.548AlaGly: 5.548 ± 0.121
1.512AlaHis: 1.512 ± 0.053
5.732AlaIle: 5.732 ± 0.107
5.814AlaLys: 5.814 ± 0.132
10.207AlaLeu: 10.207 ± 0.14
2.421AlaMet: 2.421 ± 0.07
3.737AlaAsn: 3.737 ± 0.1
2.652AlaPro: 2.652 ± 0.075
4.407AlaGln: 4.407 ± 0.087
3.582AlaArg: 3.582 ± 0.087
3.905AlaSer: 3.905 ± 0.093
4.232AlaThr: 4.232 ± 0.087
6.198AlaVal: 6.198 ± 0.101
0.921AlaTrp: 0.921 ± 0.041
2.485AlaTyr: 2.485 ± 0.06
0.0AlaXaa: 0.0 ± 0.0
Cys
0.836CysAla: 0.836 ± 0.036
0.151CysCys: 0.151 ± 0.016
0.582CysAsp: 0.582 ± 0.029
0.569CysGlu: 0.569 ± 0.028
0.487CysPhe: 0.487 ± 0.026
1.059CysGly: 1.059 ± 0.051
0.361CysHis: 0.361 ± 0.03
0.557CysIle: 0.557 ± 0.029
0.406CysLys: 0.406 ± 0.029
1.081CysLeu: 1.081 ± 0.041
0.18CysMet: 0.18 ± 0.019
0.379CysAsn: 0.379 ± 0.029
0.477CysPro: 0.477 ± 0.032
0.447CysGln: 0.447 ± 0.029
0.471CysArg: 0.471 ± 0.029
0.594CysSer: 0.594 ± 0.032
0.472CysThr: 0.472 ± 0.029
0.672CysVal: 0.672 ± 0.033
0.086CysTrp: 0.086 ± 0.012
0.351CysTyr: 0.351 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
3.737AspAla: 3.737 ± 0.089
0.545AspCys: 0.545 ± 0.034
2.526AspAsp: 2.526 ± 0.068
3.615AspGlu: 3.615 ± 0.08
2.689AspPhe: 2.689 ± 0.071
3.294AspGly: 3.294 ± 0.087
0.961AspHis: 0.961 ± 0.042
3.807AspIle: 3.807 ± 0.077
3.318AspLys: 3.318 ± 0.092
5.19AspLeu: 5.19 ± 0.091
1.167AspMet: 1.167 ± 0.044
2.385AspAsn: 2.385 ± 0.065
1.989AspPro: 1.989 ± 0.055
1.655AspGln: 1.655 ± 0.055
2.165AspArg: 2.165 ± 0.063
2.498AspSer: 2.498 ± 0.064
2.177AspThr: 2.177 ± 0.054
3.708AspVal: 3.708 ± 0.094
0.815AspTrp: 0.815 ± 0.038
2.062AspTyr: 2.062 ± 0.064
0.0AspXaa: 0.0 ± 0.0
Glu
4.745GluAla: 4.745 ± 0.116
0.452GluCys: 0.452 ± 0.029
2.656GluAsp: 2.656 ± 0.072
4.121GluGlu: 4.121 ± 0.105
2.41GluPhe: 2.41 ± 0.06
3.409GluGly: 3.409 ± 0.088
1.412GluHis: 1.412 ± 0.045
4.487GluIle: 4.487 ± 0.091
5.164GluLys: 5.164 ± 0.103
6.373GluLeu: 6.373 ± 0.122
1.705GluMet: 1.705 ± 0.055
3.898GluAsn: 3.898 ± 0.106
2.022GluPro: 2.022 ± 0.069
4.377GluGln: 4.377 ± 0.1
3.321GluArg: 3.321 ± 0.089
2.93GluSer: 2.93 ± 0.079
3.131GluThr: 3.131 ± 0.075
3.863GluVal: 3.863 ± 0.086
0.693GluTrp: 0.693 ± 0.033
1.736GluTyr: 1.736 ± 0.048
0.0GluXaa: 0.0 ± 0.0
Phe
3.783PheAla: 3.783 ± 0.083
0.602PheCys: 0.602 ± 0.03
2.761PheAsp: 2.761 ± 0.07
2.425PheGlu: 2.425 ± 0.06
2.145PhePhe: 2.145 ± 0.069
3.454PheGly: 3.454 ± 0.083
0.885PheHis: 0.885 ± 0.042
3.123PheIle: 3.123 ± 0.092
2.155PheLys: 2.155 ± 0.058
4.197PheLeu: 4.197 ± 0.103
1.091PheMet: 1.091 ± 0.044
2.385PheAsn: 2.385 ± 0.069
1.57PhePro: 1.57 ± 0.054
1.402PheGln: 1.402 ± 0.049
1.67PheArg: 1.67 ± 0.054
3.235PheSer: 3.235 ± 0.076
2.413PheThr: 2.413 ± 0.064
2.945PheVal: 2.945 ± 0.077
0.59PheTrp: 0.59 ± 0.037
1.623PheTyr: 1.623 ± 0.054
0.0PheXaa: 0.0 ± 0.0
Gly
5.31GlyAla: 5.31 ± 0.116
0.823GlyCys: 0.823 ± 0.045
3.261GlyAsp: 3.261 ± 0.092
4.327GlyGlu: 4.327 ± 0.1
3.196GlyPhe: 3.196 ± 0.082
4.695GlyGly: 4.695 ± 0.117
1.347GlyHis: 1.347 ± 0.045
4.997GlyIle: 4.997 ± 0.103
5.11GlyLys: 5.11 ± 0.105
6.857GlyLeu: 6.857 ± 0.122
1.804GlyMet: 1.804 ± 0.061
2.942GlyAsn: 2.942 ± 0.086
1.257GlyPro: 1.257 ± 0.047
2.493GlyGln: 2.493 ± 0.064
2.99GlyArg: 2.99 ± 0.067
3.527GlySer: 3.527 ± 0.088
3.326GlyThr: 3.326 ± 0.091
5.154GlyVal: 5.154 ± 0.098
0.88GlyTrp: 0.88 ± 0.043
2.471GlyTyr: 2.471 ± 0.07
0.0GlyXaa: 0.0 ± 0.0
His
1.492HisAla: 1.492 ± 0.047
0.374HisCys: 0.374 ± 0.027
0.984HisAsp: 0.984 ± 0.043
1.008HisGlu: 1.008 ± 0.042
1.335HisPhe: 1.335 ± 0.044
1.4HisGly: 1.4 ± 0.047
0.75HisHis: 0.75 ± 0.047
1.641HisIle: 1.641 ± 0.054
1.096HisLys: 1.096 ± 0.039
2.49HisLeu: 2.49 ± 0.074
0.437HisMet: 0.437 ± 0.028
0.955HisAsn: 0.955 ± 0.044
1.014HisPro: 1.014 ± 0.048
1.229HisGln: 1.229 ± 0.048
1.009HisArg: 1.009 ± 0.038
1.295HisSer: 1.295 ± 0.051
0.936HisThr: 0.936 ± 0.042
1.149HisVal: 1.149 ± 0.047
0.381HisTrp: 0.381 ± 0.027
0.923HisTyr: 0.923 ± 0.041
0.0HisXaa: 0.0 ± 0.0
Ile
6.477IleAla: 6.477 ± 0.125
0.767IleCys: 0.767 ± 0.039
3.77IleAsp: 3.77 ± 0.084
4.497IleGlu: 4.497 ± 0.098
2.794IlePhe: 2.794 ± 0.083
4.994IleGly: 4.994 ± 0.11
1.473IleHis: 1.473 ± 0.05
4.113IleIle: 4.113 ± 0.098
3.712IleLys: 3.712 ± 0.08
6.166IleLeu: 6.166 ± 0.111
1.309IleMet: 1.309 ± 0.047
3.1IleAsn: 3.1 ± 0.076
2.727IlePro: 2.727 ± 0.074
2.731IleGln: 2.731 ± 0.067
2.924IleArg: 2.924 ± 0.073
4.284IleSer: 4.284 ± 0.084
3.572IleThr: 3.572 ± 0.087
4.334IleVal: 4.334 ± 0.1
0.667IleTrp: 0.667 ± 0.035
2.022IleTyr: 2.022 ± 0.062
0.0IleXaa: 0.0 ± 0.0
Lys
5.366LysAla: 5.366 ± 0.128
0.457LysCys: 0.457 ± 0.028
3.038LysAsp: 3.038 ± 0.085
3.91LysGlu: 3.91 ± 0.11
2.1LysPhe: 2.1 ± 0.063
3.788LysGly: 3.788 ± 0.098
1.342LysHis: 1.342 ± 0.053
4.041LysIle: 4.041 ± 0.081
3.847LysLys: 3.847 ± 0.1
5.98LysLeu: 5.98 ± 0.105
1.899LysMet: 1.899 ± 0.054
3.369LysAsn: 3.369 ± 0.08
2.49LysPro: 2.49 ± 0.069
3.343LysGln: 3.343 ± 0.084
2.997LysArg: 2.997 ± 0.076
3.356LysSer: 3.356 ± 0.09
3.401LysThr: 3.401 ± 0.074
4.076LysVal: 4.076 ± 0.091
0.6LysTrp: 0.6 ± 0.037
1.744LysTyr: 1.744 ± 0.058
0.0LysXaa: 0.0 ± 0.0
Leu
9.935LeuAla: 9.935 ± 0.139
1.152LeuCys: 1.152 ± 0.048
5.511LeuAsp: 5.511 ± 0.104
5.875LeuGlu: 5.875 ± 0.113
4.919LeuPhe: 4.919 ± 0.113
7.076LeuGly: 7.076 ± 0.101
2.114LeuHis: 2.114 ± 0.063
6.599LeuIle: 6.599 ± 0.131
5.922LeuLys: 5.922 ± 0.105
11.343LeuLeu: 11.343 ± 0.194
2.398LeuMet: 2.398 ± 0.067
5.227LeuAsn: 5.227 ± 0.116
4.809LeuPro: 4.809 ± 0.104
4.7LeuGln: 4.7 ± 0.099
4.803LeuArg: 4.803 ± 0.098
7.304LeuSer: 7.304 ± 0.123
6.173LeuThr: 6.173 ± 0.101
6.595LeuVal: 6.595 ± 0.117
1.116LeuTrp: 1.116 ± 0.046
2.834LeuTyr: 2.834 ± 0.066
0.0LeuXaa: 0.0 ± 0.0
Met
2.335MetAla: 2.335 ± 0.067
0.196MetCys: 0.196 ± 0.02
0.996MetAsp: 0.996 ± 0.043
1.231MetGlu: 1.231 ± 0.047
0.89MetPhe: 0.89 ± 0.035
1.557MetGly: 1.557 ± 0.05
0.426MetHis: 0.426 ± 0.026
1.419MetIle: 1.419 ± 0.05
1.66MetLys: 1.66 ± 0.057
2.722MetLeu: 2.722 ± 0.074
0.71MetMet: 0.71 ± 0.037
1.161MetAsn: 1.161 ± 0.037
1.116MetPro: 1.116 ± 0.042
1.32MetGln: 1.32 ± 0.048
1.131MetArg: 1.131 ± 0.042
1.535MetSer: 1.535 ± 0.05
1.532MetThr: 1.532 ± 0.054
1.533MetVal: 1.533 ± 0.046
0.225MetTrp: 0.225 ± 0.02
0.477MetTyr: 0.477 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
4.041AsnAla: 4.041 ± 0.097
0.404AsnCys: 0.404 ± 0.027
2.247AsnAsp: 2.247 ± 0.061
2.787AsnGlu: 2.787 ± 0.071
1.839AsnPhe: 1.839 ± 0.057
3.436AsnGly: 3.436 ± 0.082
0.988AsnHis: 0.988 ± 0.039
3.371AsnIle: 3.371 ± 0.093
2.895AsnLys: 2.895 ± 0.074
4.796AsnLeu: 4.796 ± 0.092
1.137AsnMet: 1.137 ± 0.043
2.21AsnAsn: 2.21 ± 0.074
2.356AsnPro: 2.356 ± 0.058
2.385AsnGln: 2.385 ± 0.075
2.157AsnArg: 2.157 ± 0.07
2.521AsnSer: 2.521 ± 0.073
2.441AsnThr: 2.441 ± 0.07
3.153AsnVal: 3.153 ± 0.087
0.645AsnTrp: 0.645 ± 0.032
1.643AsnTyr: 1.643 ± 0.06
0.0AsnXaa: 0.0 ± 0.0
Pro
2.8ProAla: 2.8 ± 0.072
0.334ProCys: 0.334 ± 0.028
1.866ProAsp: 1.866 ± 0.056
2.935ProGlu: 2.935 ± 0.076
1.788ProPhe: 1.788 ± 0.071
1.635ProGly: 1.635 ± 0.057
1.101ProHis: 1.101 ± 0.046
2.531ProIle: 2.531 ± 0.055
2.275ProLys: 2.275 ± 0.069
4.058ProLeu: 4.058 ± 0.079
0.976ProMet: 0.976 ± 0.039
2.16ProAsn: 2.16 ± 0.07
1.194ProPro: 1.194 ± 0.056
2.139ProGln: 2.139 ± 0.073
1.34ProArg: 1.34 ± 0.047
2.187ProSer: 2.187 ± 0.062
2.31ProThr: 2.31 ± 0.058
2.704ProVal: 2.704 ± 0.077
0.421ProTrp: 0.421 ± 0.025
1.384ProTyr: 1.384 ± 0.056
0.0ProXaa: 0.0 ± 0.0
Gln
4.453GlnAla: 4.453 ± 0.113
0.389GlnCys: 0.389 ± 0.028
2.127GlnAsp: 2.127 ± 0.065
2.697GlnGlu: 2.697 ± 0.07
2.042GlnPhe: 2.042 ± 0.057
3.103GlnGly: 3.103 ± 0.078
1.349GlnHis: 1.349 ± 0.054
3.246GlnIle: 3.246 ± 0.081
2.942GlnLys: 2.942 ± 0.07
5.222GlnLeu: 5.222 ± 0.113
1.093GlnMet: 1.093 ± 0.041
2.189GlnAsn: 2.189 ± 0.057
1.946GlnPro: 1.946 ± 0.067
3.842GlnGln: 3.842 ± 0.112
2.618GlnArg: 2.618 ± 0.074
2.636GlnSer: 2.636 ± 0.077
2.428GlnThr: 2.428 ± 0.079
2.919GlnVal: 2.919 ± 0.068
0.674GlnTrp: 0.674 ± 0.035
1.52GlnTyr: 1.52 ± 0.047
0.0GlnXaa: 0.0 ± 0.0
Arg
3.261ArgAla: 3.261 ± 0.065
0.457ArgCys: 0.457 ± 0.026
2.21ArgAsp: 2.21 ± 0.07
3.018ArgGlu: 3.018 ± 0.076
2.361ArgPhe: 2.361 ± 0.061
2.714ArgGly: 2.714 ± 0.071
1.139ArgHis: 1.139 ± 0.044
3.18ArgIle: 3.18 ± 0.081
2.631ArgLys: 2.631 ± 0.063
5.13ArgLeu: 5.13 ± 0.1
1.019ArgMet: 1.019 ± 0.04
2.032ArgAsn: 2.032 ± 0.065
1.675ArgPro: 1.675 ± 0.055
2.283ArgGln: 2.283 ± 0.073
2.222ArgArg: 2.222 ± 0.071
2.351ArgSer: 2.351 ± 0.075
2.262ArgThr: 2.262 ± 0.058
2.882ArgVal: 2.882 ± 0.073
0.612ArgTrp: 0.612 ± 0.038
1.858ArgTyr: 1.858 ± 0.059
0.0ArgXaa: 0.0 ± 0.0
Ser
5.529SerAla: 5.529 ± 0.101
0.497SerCys: 0.497 ± 0.031
2.834SerAsp: 2.834 ± 0.075
3.289SerGlu: 3.289 ± 0.067
2.49SerPhe: 2.49 ± 0.066
4.375SerGly: 4.375 ± 0.092
1.342SerHis: 1.342 ± 0.047
3.441SerIle: 3.441 ± 0.08
3.01SerLys: 3.01 ± 0.08
6.135SerLeu: 6.135 ± 0.115
1.319SerMet: 1.319 ± 0.045
2.351SerAsn: 2.351 ± 0.06
2.115SerPro: 2.115 ± 0.061
2.608SerGln: 2.608 ± 0.068
2.534SerArg: 2.534 ± 0.068
3.198SerSer: 3.198 ± 0.091
2.887SerThr: 2.887 ± 0.074
4.043SerVal: 4.043 ± 0.096
0.635SerTrp: 0.635 ± 0.031
1.887SerTyr: 1.887 ± 0.07
0.0SerXaa: 0.0 ± 0.0
Thr
5.16ThrAla: 5.16 ± 0.105
0.431ThrCys: 0.431 ± 0.028
2.593ThrAsp: 2.593 ± 0.07
3.396ThrGlu: 3.396 ± 0.082
2.348ThrPhe: 2.348 ± 0.067
3.684ThrGly: 3.684 ± 0.073
1.099ThrHis: 1.099 ± 0.046
3.178ThrIle: 3.178 ± 0.07
2.704ThrLys: 2.704 ± 0.079
6.205ThrLeu: 6.205 ± 0.117
1.049ThrMet: 1.049 ± 0.043
2.039ThrAsn: 2.039 ± 0.054
2.593ThrPro: 2.593 ± 0.067
2.544ThrGln: 2.544 ± 0.07
1.974ThrArg: 1.974 ± 0.056
2.656ThrSer: 2.656 ± 0.067
2.752ThrThr: 2.752 ± 0.073
3.539ThrVal: 3.539 ± 0.082
0.539ThrTrp: 0.539 ± 0.033
1.483ThrTyr: 1.483 ± 0.059
0.0ThrXaa: 0.0 ± 0.0
Val
6.072ValAla: 6.072 ± 0.131
0.685ValCys: 0.685 ± 0.032
3.527ValAsp: 3.527 ± 0.09
4.552ValGlu: 4.552 ± 0.092
2.809ValPhe: 2.809 ± 0.076
4.611ValGly: 4.611 ± 0.097
1.171ValHis: 1.171 ± 0.048
4.565ValIle: 4.565 ± 0.089
4.432ValLys: 4.432 ± 0.103
6.911ValLeu: 6.911 ± 0.131
1.605ValMet: 1.605 ± 0.052
3.153ValAsn: 3.153 ± 0.077
2.491ValPro: 2.491 ± 0.062
2.541ValGln: 2.541 ± 0.074
2.937ValArg: 2.937 ± 0.082
4.124ValSer: 4.124 ± 0.088
3.635ValThr: 3.635 ± 0.089
4.898ValVal: 4.898 ± 0.102
0.695ValTrp: 0.695 ± 0.041
1.783ValTyr: 1.783 ± 0.057
0.0ValXaa: 0.0 ± 0.0
Trp
0.838TrpAla: 0.838 ± 0.038
0.146TrpCys: 0.146 ± 0.015
0.549TrpAsp: 0.549 ± 0.032
0.587TrpGlu: 0.587 ± 0.027
0.604TrpPhe: 0.604 ± 0.037
0.69TrpGly: 0.69 ± 0.036
0.324TrpHis: 0.324 ± 0.023
0.7TrpIle: 0.7 ± 0.034
0.629TrpLys: 0.629 ± 0.031
1.783TrpLeu: 1.783 ± 0.059
0.253TrpMet: 0.253 ± 0.021
0.511TrpAsn: 0.511 ± 0.031
0.19TrpPro: 0.19 ± 0.016
1.078TrpGln: 1.078 ± 0.046
0.64TrpArg: 0.64 ± 0.036
0.535TrpSer: 0.535 ± 0.032
0.471TrpThr: 0.471 ± 0.032
0.795TrpVal: 0.795 ± 0.039
0.173TrpTrp: 0.173 ± 0.018
0.341TrpTyr: 0.341 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.589TyrAla: 2.589 ± 0.074
0.439TyrCys: 0.439 ± 0.022
1.786TyrAsp: 1.786 ± 0.059
1.586TyrGlu: 1.586 ± 0.048
1.673TyrPhe: 1.673 ± 0.05
2.245TyrGly: 2.245 ± 0.064
0.807TyrHis: 0.807 ± 0.04
1.705TyrIle: 1.705 ± 0.059
1.425TyrLys: 1.425 ± 0.051
3.559TyrLeu: 3.559 ± 0.08
0.595TyrMet: 0.595 ± 0.033
1.272TyrAsn: 1.272 ± 0.057
1.453TyrPro: 1.453 ± 0.045
1.911TyrGln: 1.911 ± 0.065
1.814TyrArg: 1.814 ± 0.052
1.849TyrSer: 1.849 ± 0.063
1.414TyrThr: 1.414 ± 0.052
2.037TyrVal: 2.037 ± 0.068
0.467TyrTrp: 0.467 ± 0.031
1.051TyrTyr: 1.051 ± 0.048
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1956 proteins (601326 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski