Amino acid dipepetide frequency for Nematocida parisii (strain ERTm3) (Nematode killer fungus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	2.999AlaAla: 2.999 ± 0.097	0.937AlaCys: 0.937 ± 0.033	2.382AlaAsp: 2.382 ± 0.052	3.692AlaGlu: 3.692 ± 0.065	1.841AlaPhe: 1.841 ± 0.044	2.447AlaGly: 2.447 ± 0.057	1.16AlaHis: 1.16 ± 0.042	4.089AlaIle: 4.089 ± 0.086	3.2AlaLys: 3.2 ± 0.061	5.104AlaLeu: 5.104 ± 0.08	1.297AlaMet: 1.297 ± 0.04	2.059AlaAsn: 2.059 ± 0.052	1.839AlaPro: 1.839 ± 0.053	1.911AlaGln: 1.911 ± 0.056	1.964AlaArg: 1.964 ± 0.046	3.612AlaSer: 3.612 ± 0.078	2.083AlaThr: 2.083 ± 0.056	3.388AlaVal: 3.388 ± 0.063	0.36AlaTrp: 0.36 ± 0.018	2.137AlaTyr: 2.137 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.998CysAla: 0.998 ± 0.031	0.367CysCys: 0.367 ± 0.027	0.762CysAsp: 0.762 ± 0.027	0.87CysGlu: 0.87 ± 0.032	0.819CysPhe: 0.819 ± 0.03	0.976CysGly: 0.976 ± 0.036	0.236CysHis: 0.236 ± 0.015	2.022CysIle: 2.022 ± 0.052	1.311CysLys: 1.311 ± 0.041	1.621CysLeu: 1.621 ± 0.045	0.514CysMet: 0.514 ± 0.022	0.997CysAsn: 0.997 ± 0.037	0.553CysPro: 0.553 ± 0.026	0.355CysGln: 0.355 ± 0.021	0.737CysArg: 0.737 ± 0.024	1.428CysSer: 1.428 ± 0.041	1.336CysThr: 1.336 ± 0.038	1.146CysVal: 1.146 ± 0.037	0.109CysTrp: 0.109 ± 0.01	0.563CysTyr: 0.563 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	2.304AspAla: 2.304 ± 0.056	0.714AspCys: 0.714 ± 0.025	1.99AspAsp: 1.99 ± 0.061	3.445AspGlu: 3.445 ± 0.071	1.72AspPhe: 1.72 ± 0.045	2.254AspGly: 2.254 ± 0.055	0.774AspHis: 0.774 ± 0.047	5.251AspIle: 5.251 ± 0.093	4.027AspLys: 4.027 ± 0.078	4.375AspLeu: 4.375 ± 0.082	1.353AspMet: 1.353 ± 0.038	2.382AspAsn: 2.382 ± 0.062	1.583AspPro: 1.583 ± 0.049	1.233AspGln: 1.233 ± 0.043	2.224AspArg: 2.224 ± 0.056	4.06AspSer: 4.06 ± 0.069	2.793AspThr: 2.793 ± 0.049	2.769AspVal: 2.769 ± 0.056	0.379AspTrp: 0.379 ± 0.017	1.77AspTyr: 1.77 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	3.157GluAla: 3.157 ± 0.062	1.381GluCys: 1.381 ± 0.04	3.942GluAsp: 3.942 ± 0.079	7.643GluGlu: 7.643 ± 0.139	2.657GluPhe: 2.657 ± 0.059	3.002GluGly: 3.002 ± 0.068	1.272GluHis: 1.272 ± 0.036	7.134GluIle: 7.134 ± 0.101	7.34GluLys: 7.34 ± 0.111	5.741GluLeu: 5.741 ± 0.079	2.151GluMet: 2.151 ± 0.051	4.625GluAsn: 4.625 ± 0.08	1.637GluPro: 1.637 ± 0.047	2.21GluGln: 2.21 ± 0.06	3.488GluArg: 3.488 ± 0.071	5.681GluSer: 5.681 ± 0.102	3.754GluThr: 3.754 ± 0.071	4.064GluVal: 4.064 ± 0.077	0.504GluTrp: 0.504 ± 0.022	3.941GluTyr: 3.941 ± 0.069	0.0GluXaa: 0.0 ± 0.0
Phe	1.54PheAla: 1.54 ± 0.045	0.827PheCys: 0.827 ± 0.032	1.71PheAsp: 1.71 ± 0.053	1.934PheGlu: 1.934 ± 0.042	2.228PhePhe: 2.228 ± 0.06	1.901PheGly: 1.901 ± 0.059	0.641PheHis: 0.641 ± 0.027	4.501PheIle: 4.501 ± 0.076	2.988PheLys: 2.988 ± 0.049	4.466PheLeu: 4.466 ± 0.085	1.198PheMet: 1.198 ± 0.034	2.409PheAsn: 2.409 ± 0.061	1.259PhePro: 1.259 ± 0.036	0.881PheGln: 0.881 ± 0.036	1.32PheArg: 1.32 ± 0.039	3.732PheSer: 3.732 ± 0.071	2.476PheThr: 2.476 ± 0.051	2.07PheVal: 2.07 ± 0.043	0.269PheTrp: 0.269 ± 0.017	2.013PheTyr: 2.013 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	2.236GlyAla: 2.236 ± 0.065	0.815GlyCys: 0.815 ± 0.036	1.912GlyAsp: 1.912 ± 0.044	2.669GlyGlu: 2.669 ± 0.063	1.829GlyPhe: 1.829 ± 0.048	2.34GlyGly: 2.34 ± 0.069	0.992GlyHis: 0.992 ± 0.037	4.661GlyIle: 4.661 ± 0.078	3.265GlyLys: 3.265 ± 0.063	4.009GlyLeu: 4.009 ± 0.081	1.408GlyMet: 1.408 ± 0.042	2.116GlyAsn: 2.116 ± 0.065	1.139GlyPro: 1.139 ± 0.046	1.165GlyGln: 1.165 ± 0.047	1.993GlyArg: 1.993 ± 0.05	3.418GlySer: 3.418 ± 0.074	2.34GlyThr: 2.34 ± 0.051	3.218GlyVal: 3.218 ± 0.067	0.376GlyTrp: 0.376 ± 0.023	2.027GlyTyr: 2.027 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	1.199HisAla: 1.199 ± 0.031	0.373HisCys: 0.373 ± 0.018	0.695HisAsp: 0.695 ± 0.042	1.035HisGlu: 1.035 ± 0.034	0.695HisPhe: 0.695 ± 0.029	0.984HisGly: 0.984 ± 0.039	0.348HisHis: 0.348 ± 0.019	1.983HisIle: 1.983 ± 0.049	1.613HisLys: 1.613 ± 0.04	1.931HisLeu: 1.931 ± 0.048	0.655HisMet: 0.655 ± 0.025	1.224HisAsn: 1.224 ± 0.041	0.863HisPro: 0.863 ± 0.033	0.498HisGln: 0.498 ± 0.026	1.006HisArg: 1.006 ± 0.038	1.973HisSer: 1.973 ± 0.064	1.482HisThr: 1.482 ± 0.038	0.991HisVal: 0.991 ± 0.032	0.142HisTrp: 0.142 ± 0.012	0.729HisTyr: 0.729 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	3.676IleAla: 3.676 ± 0.061	1.557IleCys: 1.557 ± 0.045	4.801IleAsp: 4.801 ± 0.076	6.925IleGlu: 6.925 ± 0.095	4.188IlePhe: 4.188 ± 0.083	3.667IleGly: 3.667 ± 0.067	1.9IleHis: 1.9 ± 0.049	8.203IleIle: 8.203 ± 0.122	8.191IleLys: 8.191 ± 0.107	9.331IleLeu: 9.331 ± 0.107	2.014IleMet: 2.014 ± 0.051	5.642IleAsn: 5.642 ± 0.112	3.342IlePro: 3.342 ± 0.071	3.182IleGln: 3.182 ± 0.057	3.969IleArg: 3.969 ± 0.068	8.318IleSer: 8.318 ± 0.098	5.132IleThr: 5.132 ± 0.079	4.556IleVal: 4.556 ± 0.07	0.587IleTrp: 0.587 ± 0.025	3.969IleTyr: 3.969 ± 0.069	0.0IleXaa: 0.0 ± 0.0
Lys	3.567LysAla: 3.567 ± 0.073	1.223LysCys: 1.223 ± 0.037	4.16LysAsp: 4.16 ± 0.081	8.954LysGlu: 8.954 ± 0.135	2.11LysPhe: 2.11 ± 0.049	3.081LysGly: 3.081 ± 0.07	1.736LysHis: 1.736 ± 0.053	7.03LysIle: 7.03 ± 0.101	9.166LysLys: 9.166 ± 0.139	5.906LysLeu: 5.906 ± 0.082	2.171LysMet: 2.171 ± 0.044	5.808LysAsn: 5.808 ± 0.099	2.437LysPro: 2.437 ± 0.064	2.731LysGln: 2.731 ± 0.066	4.051LysArg: 4.051 ± 0.075	6.026LysSer: 6.026 ± 0.095	4.954LysThr: 4.954 ± 0.08	4.048LysVal: 4.048 ± 0.078	0.497LysTrp: 0.497 ± 0.022	4.188LysTyr: 4.188 ± 0.083	0.0LysXaa: 0.0 ± 0.0
Leu	4.347LeuAla: 4.347 ± 0.077	2.16LeuCys: 2.16 ± 0.053	4.405LeuAsp: 4.405 ± 0.076	6.087LeuGlu: 6.087 ± 0.085	5.212LeuPhe: 5.212 ± 0.087	3.769LeuGly: 3.769 ± 0.082	1.894LeuHis: 1.894 ± 0.048	7.074LeuIle: 7.074 ± 0.096	7.116LeuLys: 7.116 ± 0.098	10.166LeuLeu: 10.166 ± 0.134	2.083LeuMet: 2.083 ± 0.049	5.377LeuAsn: 5.377 ± 0.089	3.348LeuPro: 3.348 ± 0.063	2.961LeuGln: 2.961 ± 0.055	3.37LeuArg: 3.37 ± 0.052	8.606LeuSer: 8.606 ± 0.114	4.173LeuThr: 4.173 ± 0.063	4.87LeuVal: 4.87 ± 0.084	0.618LeuTrp: 0.618 ± 0.024	4.186LeuTyr: 4.186 ± 0.081	0.0LeuXaa: 0.0 ± 0.0
Met	1.459MetAla: 1.459 ± 0.04	0.662MetCys: 0.662 ± 0.03	1.447MetAsp: 1.447 ± 0.04	1.841MetGlu: 1.841 ± 0.044	1.146MetPhe: 1.146 ± 0.038	1.332MetGly: 1.332 ± 0.041	1.095MetHis: 1.095 ± 0.036	1.636MetIle: 1.636 ± 0.04	2.18MetLys: 2.18 ± 0.048	2.273MetLeu: 2.273 ± 0.053	0.446MetMet: 0.446 ± 0.023	1.622MetAsn: 1.622 ± 0.041	1.12MetPro: 1.12 ± 0.051	1.187MetGln: 1.187 ± 0.034	1.1MetArg: 1.1 ± 0.036	1.714MetSer: 1.714 ± 0.041	0.965MetThr: 0.965 ± 0.032	1.329MetVal: 1.329 ± 0.038	0.206MetTrp: 0.206 ± 0.014	1.288MetTyr: 1.288 ± 0.039	0.0MetXaa: 0.0 ± 0.0
Asn	2.657AsnAla: 2.657 ± 0.065	0.783AsnCys: 0.783 ± 0.037	2.438AsnAsp: 2.438 ± 0.059	3.979AsnGlu: 3.979 ± 0.075	1.583AsnPhe: 1.583 ± 0.045	2.589AsnGly: 2.589 ± 0.065	1.009AsnHis: 1.009 ± 0.035	6.443AsnIle: 6.443 ± 0.115	5.374AsnLys: 5.374 ± 0.09	4.612AsnLeu: 4.612 ± 0.076	1.667AsnMet: 1.667 ± 0.042	4.75AsnAsn: 4.75 ± 0.125	2.404AsnPro: 2.404 ± 0.061	1.696AsnGln: 1.696 ± 0.051	2.646AsnArg: 2.646 ± 0.057	5.124AsnSer: 5.124 ± 0.111	4.499AsnThr: 4.499 ± 0.093	2.476AsnVal: 2.476 ± 0.062	0.382AsnTrp: 0.382 ± 0.019	2.406AsnTyr: 2.406 ± 0.057	0.0AsnXaa: 0.0 ± 0.0
Pro	1.89ProAla: 1.89 ± 0.06	0.553ProCys: 0.553 ± 0.026	1.633ProAsp: 1.633 ± 0.046	3.035ProGlu: 3.035 ± 0.059	1.421ProPhe: 1.421 ± 0.038	1.629ProGly: 1.629 ± 0.051	0.721ProHis: 0.721 ± 0.03	2.782ProIle: 2.782 ± 0.066	2.326ProLys: 2.326 ± 0.056	2.765ProLeu: 2.765 ± 0.057	0.833ProMet: 0.833 ± 0.034	1.775ProAsn: 1.775 ± 0.044	1.242ProPro: 1.242 ± 0.061	1.055ProGln: 1.055 ± 0.041	1.22ProArg: 1.22 ± 0.041	3.162ProSer: 3.162 ± 0.072	1.914ProThr: 1.914 ± 0.052	2.246ProVal: 2.246 ± 0.054	0.239ProTrp: 0.239 ± 0.015	1.313ProTyr: 1.313 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	1.669GlnAla: 1.669 ± 0.053	0.571GlnCys: 0.571 ± 0.027	1.365GlnAsp: 1.365 ± 0.041	2.82GlnGlu: 2.82 ± 0.081	1.017GlnPhe: 1.017 ± 0.036	1.115GlnGly: 1.115 ± 0.046	0.521GlnHis: 0.521 ± 0.025	2.639GlnIle: 2.639 ± 0.051	3.271GlnLys: 3.271 ± 0.068	2.382GlnLeu: 2.382 ± 0.053	1.034GlnMet: 1.034 ± 0.034	2.016GlnAsn: 2.016 ± 0.054	0.983GlnPro: 0.983 ± 0.042	1.05GlnGln: 1.05 ± 0.037	1.404GlnArg: 1.404 ± 0.039	2.413GlnSer: 2.413 ± 0.061	1.584GlnThr: 1.584 ± 0.047	1.458GlnVal: 1.458 ± 0.048	0.198GlnTrp: 0.198 ± 0.014	1.151GlnTyr: 1.151 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	2.199ArgAla: 2.199 ± 0.053	0.646ArgCys: 0.646 ± 0.032	1.811ArgAsp: 1.811 ± 0.047	3.238ArgGlu: 3.238 ± 0.057	1.526ArgPhe: 1.526 ± 0.042	1.64ArgGly: 1.64 ± 0.047	0.855ArgHis: 0.855 ± 0.034	4.391ArgIle: 4.391 ± 0.07	3.778ArgLys: 3.778 ± 0.073	3.642ArgLeu: 3.642 ± 0.063	1.344ArgMet: 1.344 ± 0.041	2.494ArgAsn: 2.494 ± 0.061	1.247ArgPro: 1.247 ± 0.044	1.262ArgGln: 1.262 ± 0.03	2.304ArgArg: 2.304 ± 0.062	2.674ArgSer: 2.674 ± 0.057	2.349ArgThr: 2.349 ± 0.051	2.868ArgVal: 2.868 ± 0.058	0.298ArgTrp: 0.298 ± 0.016	1.572ArgTyr: 1.572 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	4.516SerAla: 4.516 ± 0.083	1.099SerCys: 1.099 ± 0.033	4.096SerAsp: 4.096 ± 0.062	5.507SerGlu: 5.507 ± 0.093	3.159SerPhe: 3.159 ± 0.061	3.881SerGly: 3.881 ± 0.072	1.576SerHis: 1.576 ± 0.062	8.385SerIle: 8.385 ± 0.096	6.249SerLys: 6.249 ± 0.107	7.65SerLeu: 7.65 ± 0.101	2.055SerMet: 2.055 ± 0.053	4.815SerAsn: 4.815 ± 0.109	2.696SerPro: 2.696 ± 0.06	2.246SerGln: 2.246 ± 0.063	2.923SerArg: 2.923 ± 0.067	7.416SerSer: 7.416 ± 0.202	5.585SerThr: 5.585 ± 0.1	5.362SerVal: 5.362 ± 0.087	0.403SerTrp: 0.403 ± 0.02	2.766SerTyr: 2.766 ± 0.065	0.0SerXaa: 0.0 ± 0.0
Thr	3.28ThrAla: 3.28 ± 0.066	0.802ThrCys: 0.802 ± 0.029	2.91ThrAsp: 2.91 ± 0.052	5.042ThrGlu: 5.042 ± 0.088	1.848ThrPhe: 1.848 ± 0.045	3.019ThrGly: 3.019 ± 0.071	1.387ThrHis: 1.387 ± 0.046	4.71ThrIle: 4.71 ± 0.073	4.188ThrLys: 4.188 ± 0.076	5.05ThrLeu: 5.05 ± 0.073	1.17ThrMet: 1.17 ± 0.035	3.013ThrAsn: 3.013 ± 0.08	2.559ThrPro: 2.559 ± 0.068	1.937ThrGln: 1.937 ± 0.055	2.28ThrArg: 2.28 ± 0.047	4.084ThrSer: 4.084 ± 0.078	3.224ThrThr: 3.224 ± 0.07	3.864ThrVal: 3.864 ± 0.078	0.351ThrTrp: 0.351 ± 0.021	2.031ThrTyr: 2.031 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	2.262ValAla: 2.262 ± 0.056	1.392ValCys: 1.392 ± 0.039	2.883ValAsp: 2.883 ± 0.064	4.015ValGlu: 4.015 ± 0.074	3.097ValPhe: 3.097 ± 0.057	2.336ValGly: 2.336 ± 0.057	1.468ValHis: 1.468 ± 0.043	4.901ValIle: 4.901 ± 0.071	4.002ValLys: 4.002 ± 0.068	6.12ValLeu: 6.12 ± 0.091	1.231ValMet: 1.231 ± 0.037	2.83ValAsn: 2.83 ± 0.063	2.101ValPro: 2.101 ± 0.051	1.988ValGln: 1.988 ± 0.052	2.179ValArg: 2.179 ± 0.054	4.667ValSer: 4.667 ± 0.082	2.256ValThr: 2.256 ± 0.059	3.25ValVal: 3.25 ± 0.071	0.434ValTrp: 0.434 ± 0.024	2.996ValTyr: 2.996 ± 0.066	0.0ValXaa: 0.0 ± 0.0
Trp	0.359TrpAla: 0.359 ± 0.02	0.174TrpCys: 0.174 ± 0.012	0.315TrpAsp: 0.315 ± 0.017	0.396TrpGlu: 0.396 ± 0.02	0.266TrpPhe: 0.266 ± 0.016	0.33TrpGly: 0.33 ± 0.022	0.166TrpHis: 0.166 ± 0.012	0.634TrpIle: 0.634 ± 0.026	0.504TrpLys: 0.504 ± 0.023	0.613TrpLeu: 0.613 ± 0.025	0.216TrpMet: 0.216 ± 0.016	0.392TrpAsn: 0.392 ± 0.02	0.174TrpPro: 0.174 ± 0.014	0.167TrpGln: 0.167 ± 0.013	0.319TrpArg: 0.319 ± 0.016	0.568TrpSer: 0.568 ± 0.026	0.311TrpThr: 0.311 ± 0.019	0.396TrpVal: 0.396 ± 0.02	0.058TrpTrp: 0.058 ± 0.008	0.293TrpTyr: 0.293 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.186TyrAla: 2.186 ± 0.045	0.686TyrCys: 0.686 ± 0.025	1.742TyrAsp: 1.742 ± 0.048	2.199TyrGlu: 2.199 ± 0.055	2.0TyrPhe: 2.0 ± 0.049	1.636TyrGly: 1.636 ± 0.042	0.664TyrHis: 0.664 ± 0.029	4.685TyrIle: 4.685 ± 0.088	3.756TyrLys: 3.756 ± 0.074	4.066TyrLeu: 4.066 ± 0.076	1.204TyrMet: 1.204 ± 0.038	3.171TyrAsn: 3.171 ± 0.083	1.231TyrPro: 1.231 ± 0.038	0.947TyrGln: 0.947 ± 0.032	1.64TyrArg: 1.64 ± 0.048	3.708TyrSer: 3.708 ± 0.077	3.538TyrThr: 3.538 ± 0.068	2.039TyrVal: 2.039 ± 0.048	0.241TyrTrp: 0.241 ± 0.018	1.892TyrTyr: 1.892 ± 0.057	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2724 proteins (955631 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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