Amino acid dipepetide frequency for Clostridium tagluense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.784AlaAla: 3.784 ± 0.089	0.786AlaCys: 0.786 ± 0.026	2.644AlaAsp: 2.644 ± 0.038	3.449AlaGlu: 3.449 ± 0.06	2.527AlaPhe: 2.527 ± 0.054	3.667AlaGly: 3.667 ± 0.07	0.856AlaHis: 0.856 ± 0.025	5.991AlaIle: 5.991 ± 0.092	4.743AlaLys: 4.743 ± 0.073	5.802AlaLeu: 5.802 ± 0.081	1.77AlaMet: 1.77 ± 0.033	2.673AlaAsn: 2.673 ± 0.045	1.346AlaPro: 1.346 ± 0.035	1.688AlaGln: 1.688 ± 0.036	1.964AlaArg: 1.964 ± 0.041	3.628AlaSer: 3.628 ± 0.055	3.197AlaThr: 3.197 ± 0.067	3.987AlaVal: 3.987 ± 0.06	0.351AlaTrp: 0.351 ± 0.018	2.144AlaTyr: 2.144 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.652CysAla: 0.652 ± 0.023	0.223CysCys: 0.223 ± 0.016	0.778CysAsp: 0.778 ± 0.025	0.866CysGlu: 0.866 ± 0.028	0.573CysPhe: 0.573 ± 0.021	1.171CysGly: 1.171 ± 0.035	0.233CysHis: 0.233 ± 0.013	1.251CysIle: 1.251 ± 0.031	1.028CysLys: 1.028 ± 0.031	0.962CysLeu: 0.962 ± 0.026	0.31CysMet: 0.31 ± 0.015	0.758CysAsn: 0.758 ± 0.026	0.477CysPro: 0.477 ± 0.022	0.216CysGln: 0.216 ± 0.014	0.419CysArg: 0.419 ± 0.018	0.893CysSer: 0.893 ± 0.029	0.647CysThr: 0.647 ± 0.023	0.717CysVal: 0.717 ± 0.024	0.08CysTrp: 0.08 ± 0.008	0.456CysTyr: 0.456 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	2.868AspAla: 2.868 ± 0.055	0.668AspCys: 0.668 ± 0.025	2.441AspAsp: 2.441 ± 0.05	4.227AspGlu: 4.227 ± 0.058	2.764AspPhe: 2.764 ± 0.046	3.225AspGly: 3.225 ± 0.049	0.535AspHis: 0.535 ± 0.019	6.265AspIle: 6.265 ± 0.074	5.334AspLys: 5.334 ± 0.076	4.891AspLeu: 4.891 ± 0.06	1.599AspMet: 1.599 ± 0.031	3.208AspAsn: 3.208 ± 0.047	1.185AspPro: 1.185 ± 0.03	0.776AspGln: 0.776 ± 0.023	1.688AspArg: 1.688 ± 0.032	3.2AspSer: 3.2 ± 0.05	2.624AspThr: 2.624 ± 0.044	3.439AspVal: 3.439 ± 0.053	0.374AspTrp: 0.374 ± 0.016	2.476AspTyr: 2.476 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	3.95GluAla: 3.95 ± 0.057	0.729GluCys: 0.729 ± 0.024	4.13GluAsp: 4.13 ± 0.07	5.991GluGlu: 5.991 ± 0.092	3.058GluPhe: 3.058 ± 0.046	3.949GluGly: 3.949 ± 0.056	0.975GluHis: 0.975 ± 0.027	7.296GluIle: 7.296 ± 0.086	7.516GluLys: 7.516 ± 0.087	6.637GluLeu: 6.637 ± 0.079	2.016GluMet: 2.016 ± 0.037	5.147GluAsn: 5.147 ± 0.07	1.372GluPro: 1.372 ± 0.032	1.903GluGln: 1.903 ± 0.04	2.36GluArg: 2.36 ± 0.039	3.491GluSer: 3.491 ± 0.053	3.016GluThr: 3.016 ± 0.045	4.69GluVal: 4.69 ± 0.061	0.488GluTrp: 0.488 ± 0.019	3.073GluTyr: 3.073 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	2.331PheAla: 2.331 ± 0.044	0.575PheCys: 0.575 ± 0.023	2.521PheAsp: 2.521 ± 0.04	2.878PheGlu: 2.878 ± 0.049	1.924PhePhe: 1.924 ± 0.047	2.741PheGly: 2.741 ± 0.051	0.603PheHis: 0.603 ± 0.02	4.651PheIle: 4.651 ± 0.063	4.052PheLys: 4.052 ± 0.057	3.782PheLeu: 3.782 ± 0.058	1.228PheMet: 1.228 ± 0.029	2.979PheAsn: 2.979 ± 0.048	1.111PhePro: 1.111 ± 0.031	1.025PheGln: 1.025 ± 0.026	1.237PheArg: 1.237 ± 0.032	3.2PheSer: 3.2 ± 0.053	2.375PheThr: 2.375 ± 0.043	2.687PheVal: 2.687 ± 0.048	0.358PheTrp: 0.358 ± 0.017	1.849PheTyr: 1.849 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	3.924GlyAla: 3.924 ± 0.068	0.883GlyCys: 0.883 ± 0.031	3.165GlyAsp: 3.165 ± 0.049	4.185GlyGlu: 4.185 ± 0.057	3.115GlyPhe: 3.115 ± 0.046	4.127GlyGly: 4.127 ± 0.071	0.949GlyHis: 0.949 ± 0.024	6.698GlyIle: 6.698 ± 0.077	5.631GlyLys: 5.631 ± 0.066	5.304GlyLeu: 5.304 ± 0.077	1.863GlyMet: 1.863 ± 0.032	3.295GlyAsn: 3.295 ± 0.051	1.153GlyPro: 1.153 ± 0.043	1.523GlyGln: 1.523 ± 0.034	2.132GlyArg: 2.132 ± 0.041	3.638GlySer: 3.638 ± 0.057	3.615GlyThr: 3.615 ± 0.064	4.473GlyVal: 4.473 ± 0.06	0.513GlyTrp: 0.513 ± 0.02	2.857GlyTyr: 2.857 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	0.71HisAla: 0.71 ± 0.025	0.218HisCys: 0.218 ± 0.012	0.7HisAsp: 0.7 ± 0.026	0.926HisGlu: 0.926 ± 0.027	0.651HisPhe: 0.651 ± 0.021	0.948HisGly: 0.948 ± 0.031	0.282HisHis: 0.282 ± 0.015	1.413HisIle: 1.413 ± 0.036	1.224HisLys: 1.224 ± 0.032	1.188HisLeu: 1.188 ± 0.031	0.409HisMet: 0.409 ± 0.018	0.833HisAsn: 0.833 ± 0.024	0.557HisPro: 0.557 ± 0.022	0.327HisGln: 0.327 ± 0.015	0.528HisArg: 0.528 ± 0.022	0.944HisSer: 0.944 ± 0.027	0.706HisThr: 0.706 ± 0.022	0.765HisVal: 0.765 ± 0.023	0.109HisTrp: 0.109 ± 0.008	0.597HisTyr: 0.597 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.019IleAla: 6.019 ± 0.079	1.315IleCys: 1.315 ± 0.034	5.762IleAsp: 5.762 ± 0.071	7.213IleGlu: 7.213 ± 0.084	4.283IlePhe: 4.283 ± 0.063	6.16IleGly: 6.16 ± 0.078	1.413IleHis: 1.413 ± 0.03	9.691IleIle: 9.691 ± 0.105	9.07IleLys: 9.07 ± 0.086	9.003IleLeu: 9.003 ± 0.088	2.627IleMet: 2.627 ± 0.044	6.316IleAsn: 6.316 ± 0.077	3.199IlePro: 3.199 ± 0.051	2.458IleGln: 2.458 ± 0.043	2.954IleArg: 2.954 ± 0.043	7.175IleSer: 7.175 ± 0.082	5.315IleThr: 5.315 ± 0.069	6.303IleVal: 6.303 ± 0.087	0.579IleTrp: 0.579 ± 0.02	3.583IleTyr: 3.583 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	4.983LysAla: 4.983 ± 0.065	0.971LysCys: 0.971 ± 0.032	5.596LysAsp: 5.596 ± 0.07	7.772LysGlu: 7.772 ± 0.101	3.452LysPhe: 3.452 ± 0.05	5.258LysGly: 5.258 ± 0.06	1.269LysHis: 1.269 ± 0.031	8.76LysIle: 8.76 ± 0.092	8.06LysLys: 8.06 ± 0.1	7.868LysLeu: 7.868 ± 0.077	2.628LysMet: 2.628 ± 0.046	6.441LysAsn: 6.441 ± 0.076	2.146LysPro: 2.146 ± 0.042	2.618LysGln: 2.618 ± 0.045	2.837LysArg: 2.837 ± 0.046	5.511LysSer: 5.511 ± 0.068	4.553LysThr: 4.553 ± 0.06	5.825LysVal: 5.825 ± 0.068	0.68LysTrp: 0.68 ± 0.023	4.184LysTyr: 4.184 ± 0.057	0.0LysXaa: 0.0 ± 0.0
Leu	5.115LeuAla: 5.115 ± 0.075	1.217LeuCys: 1.217 ± 0.028	4.877LeuAsp: 4.877 ± 0.059	6.217LeuGlu: 6.217 ± 0.076	3.678LeuPhe: 3.678 ± 0.064	5.906LeuGly: 5.906 ± 0.076	1.15LeuHis: 1.15 ± 0.031	8.253LeuIle: 8.253 ± 0.074	8.614LeuLys: 8.614 ± 0.083	7.938LeuLeu: 7.938 ± 0.102	2.513LeuMet: 2.513 ± 0.037	5.66LeuAsn: 5.66 ± 0.065	2.741LeuPro: 2.741 ± 0.047	2.477LeuGln: 2.477 ± 0.043	2.98LeuArg: 2.98 ± 0.048	6.625LeuSer: 6.625 ± 0.077	4.643LeuThr: 4.643 ± 0.067	5.324LeuVal: 5.324 ± 0.069	0.612LeuTrp: 0.612 ± 0.022	3.158LeuTyr: 3.158 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	1.841MetAla: 1.841 ± 0.037	0.313MetCys: 0.313 ± 0.017	1.722MetAsp: 1.722 ± 0.033	2.079MetGlu: 2.079 ± 0.034	1.078MetPhe: 1.078 ± 0.026	1.942MetGly: 1.942 ± 0.039	0.393MetHis: 0.393 ± 0.018	2.349MetIle: 2.349 ± 0.05	2.664MetLys: 2.664 ± 0.04	2.406MetLeu: 2.406 ± 0.041	0.667MetMet: 0.667 ± 0.027	1.794MetAsn: 1.794 ± 0.037	0.962MetPro: 0.962 ± 0.029	0.794MetGln: 0.794 ± 0.025	0.882MetArg: 0.882 ± 0.025	1.743MetSer: 1.743 ± 0.036	1.235MetThr: 1.235 ± 0.034	1.779MetVal: 1.779 ± 0.036	0.183MetTrp: 0.183 ± 0.011	0.957MetTyr: 0.957 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	2.994AsnAla: 2.994 ± 0.051	0.812AsnCys: 0.812 ± 0.026	2.881AsnAsp: 2.881 ± 0.043	4.304AsnGlu: 4.304 ± 0.064	2.639AsnPhe: 2.639 ± 0.043	3.551AsnGly: 3.551 ± 0.06	0.816AsnHis: 0.816 ± 0.022	7.246AsnIle: 7.246 ± 0.079	6.125AsnLys: 6.125 ± 0.085	5.585AsnLeu: 5.585 ± 0.067	1.761AsnMet: 1.761 ± 0.035	4.338AsnAsn: 4.338 ± 0.073	2.008AsnPro: 2.008 ± 0.043	1.422AsnGln: 1.422 ± 0.029	1.86AsnArg: 1.86 ± 0.039	4.072AsnSer: 4.072 ± 0.059	2.983AsnThr: 2.983 ± 0.056	3.669AsnVal: 3.669 ± 0.052	0.453AsnTrp: 0.453 ± 0.019	2.626AsnTyr: 2.626 ± 0.051	0.0AsnXaa: 0.0 ± 0.0
Pro	1.415ProAla: 1.415 ± 0.035	0.34ProCys: 0.34 ± 0.016	1.305ProAsp: 1.305 ± 0.033	1.982ProGlu: 1.982 ± 0.04	1.332ProPhe: 1.332 ± 0.037	1.565ProGly: 1.565 ± 0.033	0.455ProHis: 0.455 ± 0.018	2.726ProIle: 2.726 ± 0.046	2.255ProLys: 2.255 ± 0.045	2.404ProLeu: 2.404 ± 0.041	0.769ProMet: 0.769 ± 0.025	1.384ProAsn: 1.384 ± 0.033	0.582ProPro: 0.582 ± 0.024	0.801ProGln: 0.801 ± 0.022	0.831ProArg: 0.831 ± 0.023	1.809ProSer: 1.809 ± 0.041	1.608ProThr: 1.608 ± 0.042	2.017ProVal: 2.017 ± 0.044	0.209ProTrp: 0.209 ± 0.014	1.204ProTyr: 1.204 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	1.505GlnAla: 1.505 ± 0.036	0.333GlnCys: 0.333 ± 0.015	1.262GlnAsp: 1.262 ± 0.029	1.84GlnGlu: 1.84 ± 0.038	1.055GlnPhe: 1.055 ± 0.03	1.635GlnGly: 1.635 ± 0.035	0.396GlnHis: 0.396 ± 0.016	2.298GlnIle: 2.298 ± 0.044	2.289GlnLys: 2.289 ± 0.04	2.372GlnLeu: 2.372 ± 0.042	0.721GlnMet: 0.721 ± 0.027	1.563GlnAsn: 1.563 ± 0.033	0.6GlnPro: 0.6 ± 0.019	0.826GlnGln: 0.826 ± 0.024	0.985GlnArg: 0.985 ± 0.03	1.581GlnSer: 1.581 ± 0.037	1.183GlnThr: 1.183 ± 0.035	1.623GlnVal: 1.623 ± 0.034	0.244GlnTrp: 0.244 ± 0.014	1.13GlnTyr: 1.13 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	1.858ArgAla: 1.858 ± 0.04	0.375ArgCys: 0.375 ± 0.015	1.768ArgAsp: 1.768 ± 0.04	2.688ArgGlu: 2.688 ± 0.044	1.4ArgPhe: 1.4 ± 0.03	1.969ArgGly: 1.969 ± 0.044	0.464ArgHis: 0.464 ± 0.017	3.02ArgIle: 3.02 ± 0.047	2.85ArgLys: 2.85 ± 0.046	2.842ArgLeu: 2.842 ± 0.048	0.967ArgMet: 0.967 ± 0.025	1.921ArgAsn: 1.921 ± 0.035	0.799ArgPro: 0.799 ± 0.027	0.955ArgGln: 0.955 ± 0.028	1.277ArgArg: 1.277 ± 0.03	1.579ArgSer: 1.579 ± 0.034	1.523ArgThr: 1.523 ± 0.036	2.169ArgVal: 2.169 ± 0.04	0.237ArgTrp: 0.237 ± 0.013	1.337ArgTyr: 1.337 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	3.32SerAla: 3.32 ± 0.058	0.748SerCys: 0.748 ± 0.029	3.186SerAsp: 3.186 ± 0.057	4.357SerGlu: 4.357 ± 0.053	3.04SerPhe: 3.04 ± 0.05	4.378SerGly: 4.378 ± 0.062	0.929SerHis: 0.929 ± 0.027	6.698SerIle: 6.698 ± 0.075	6.095SerLys: 6.095 ± 0.076	5.857SerLeu: 5.857 ± 0.067	1.739SerMet: 1.739 ± 0.037	3.897SerAsn: 3.897 ± 0.065	1.732SerPro: 1.732 ± 0.031	1.706SerGln: 1.706 ± 0.032	2.049SerArg: 2.049 ± 0.042	4.311SerSer: 4.311 ± 0.066	3.322SerThr: 3.322 ± 0.054	3.902SerVal: 3.902 ± 0.053	0.448SerTrp: 0.448 ± 0.016	2.525SerTyr: 2.525 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	3.221ThrAla: 3.221 ± 0.063	0.564ThrCys: 0.564 ± 0.024	2.498ThrAsp: 2.498 ± 0.043	3.122ThrGlu: 3.122 ± 0.047	2.288ThrPhe: 2.288 ± 0.041	3.747ThrGly: 3.747 ± 0.077	0.778ThrHis: 0.778 ± 0.021	5.018ThrIle: 5.018 ± 0.06	4.142ThrLys: 4.142 ± 0.061	4.942ThrLeu: 4.942 ± 0.06	1.247ThrMet: 1.247 ± 0.031	2.915ThrAsn: 2.915 ± 0.057	1.801ThrPro: 1.801 ± 0.039	1.367ThrGln: 1.367 ± 0.039	1.53ThrArg: 1.53 ± 0.035	3.385ThrSer: 3.385 ± 0.053	2.928ThrThr: 2.928 ± 0.058	3.544ThrVal: 3.544 ± 0.065	0.398ThrTrp: 0.398 ± 0.019	1.969ThrTyr: 1.969 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	4.051ValAla: 4.051 ± 0.066	0.933ValCys: 0.933 ± 0.026	3.758ValAsp: 3.758 ± 0.048	4.412ValGlu: 4.412 ± 0.066	2.86ValPhe: 2.86 ± 0.046	4.094ValGly: 4.094 ± 0.062	0.858ValHis: 0.858 ± 0.025	6.203ValIle: 6.203 ± 0.063	5.359ValLys: 5.359 ± 0.063	5.719ValLeu: 5.719 ± 0.066	1.703ValMet: 1.703 ± 0.034	3.76ValAsn: 3.76 ± 0.058	1.921ValPro: 1.921 ± 0.039	1.57ValGln: 1.57 ± 0.033	1.86ValArg: 1.86 ± 0.038	4.296ValSer: 4.296 ± 0.067	3.5ValThr: 3.5 ± 0.067	4.618ValVal: 4.618 ± 0.059	0.407ValTrp: 0.407 ± 0.017	2.381ValTyr: 2.381 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.377TrpAla: 0.377 ± 0.015	0.107TrpCys: 0.107 ± 0.009	0.429TrpAsp: 0.429 ± 0.017	0.443TrpGlu: 0.443 ± 0.018	0.319TrpPhe: 0.319 ± 0.015	0.488TrpGly: 0.488 ± 0.02	0.123TrpHis: 0.123 ± 0.008	0.663TrpIle: 0.663 ± 0.022	0.589TrpLys: 0.589 ± 0.02	0.646TrpLeu: 0.646 ± 0.022	0.195TrpMet: 0.195 ± 0.012	0.515TrpAsn: 0.515 ± 0.021	0.155TrpPro: 0.155 ± 0.012	0.212TrpGln: 0.212 ± 0.012	0.25TrpArg: 0.25 ± 0.014	0.432TrpSer: 0.432 ± 0.019	0.332TrpThr: 0.332 ± 0.017	0.459TrpVal: 0.459 ± 0.018	0.084TrpTrp: 0.084 ± 0.009	0.294TrpTyr: 0.294 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.082TyrAla: 2.082 ± 0.044	0.601TyrCys: 0.601 ± 0.02	2.365TyrAsp: 2.365 ± 0.038	2.835TyrGlu: 2.835 ± 0.046	2.073TyrPhe: 2.073 ± 0.044	2.522TyrGly: 2.522 ± 0.034	0.557TyrHis: 0.557 ± 0.023	3.945TyrIle: 3.945 ± 0.055	3.77TyrLys: 3.77 ± 0.056	3.545TyrLeu: 3.545 ± 0.051	1.048TyrMet: 1.048 ± 0.027	2.749TyrAsn: 2.749 ± 0.044	1.146TyrPro: 1.146 ± 0.034	0.779TyrGln: 0.779 ± 0.026	1.376TyrArg: 1.376 ± 0.032	2.726TyrSer: 2.726 ± 0.045	2.099TyrThr: 2.099 ± 0.039	2.275TyrVal: 2.275 ± 0.038	0.307TyrTrp: 0.307 ± 0.014	1.809TyrTyr: 1.809 ± 0.044	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4934 proteins (1433567 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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