Amino acid dipepetide frequency for Hymenobacter crusticola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.385AlaAla: 11.385 ± 0.12	0.755AlaCys: 0.755 ± 0.019	5.232AlaAsp: 5.232 ± 0.053	5.368AlaGlu: 5.368 ± 0.066	3.761AlaPhe: 3.761 ± 0.041	7.831AlaGly: 7.831 ± 0.079	1.924AlaHis: 1.924 ± 0.035	4.118AlaIle: 4.118 ± 0.046	3.9AlaLys: 3.9 ± 0.055	10.022AlaLeu: 10.022 ± 0.086	1.804AlaMet: 1.804 ± 0.035	3.677AlaAsn: 3.677 ± 0.054	4.753AlaPro: 4.753 ± 0.063	5.174AlaGln: 5.174 ± 0.055	5.013AlaArg: 5.013 ± 0.058	6.053AlaSer: 6.053 ± 0.073	6.871AlaThr: 6.871 ± 0.08	6.721AlaVal: 6.721 ± 0.071	1.216AlaTrp: 1.216 ± 0.028	3.279AlaTyr: 3.279 ± 0.039	0.001AlaXaa: 0.001 ± 0.001
Cys	0.599CysAla: 0.599 ± 0.019	0.1CysCys: 0.1 ± 0.007	0.357CysAsp: 0.357 ± 0.013	0.315CysGlu: 0.315 ± 0.014	0.299CysPhe: 0.299 ± 0.012	0.559CysGly: 0.559 ± 0.02	0.196CysHis: 0.196 ± 0.01	0.34CysIle: 0.34 ± 0.013	0.209CysLys: 0.209 ± 0.01	0.796CysLeu: 0.796 ± 0.02	0.113CysMet: 0.113 ± 0.008	0.254CysAsn: 0.254 ± 0.011	0.367CysPro: 0.367 ± 0.018	0.354CysGln: 0.354 ± 0.012	0.406CysArg: 0.406 ± 0.014	0.426CysSer: 0.426 ± 0.015	0.438CysThr: 0.438 ± 0.016	0.471CysVal: 0.471 ± 0.018	0.098CysTrp: 0.098 ± 0.006	0.274CysTyr: 0.274 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	4.642AspAla: 4.642 ± 0.053	0.335AspCys: 0.335 ± 0.012	2.23AspAsp: 2.23 ± 0.034	2.818AspGlu: 2.818 ± 0.041	2.498AspPhe: 2.498 ± 0.038	4.151AspGly: 4.151 ± 0.094	0.896AspHis: 0.896 ± 0.02	2.454AspIle: 2.454 ± 0.042	2.333AspLys: 2.333 ± 0.038	5.468AspLeu: 5.468 ± 0.087	0.876AspMet: 0.876 ± 0.024	2.067AspAsn: 2.067 ± 0.037	2.415AspPro: 2.415 ± 0.036	2.073AspGln: 2.073 ± 0.032	2.389AspArg: 2.389 ± 0.042	2.553AspSer: 2.553 ± 0.038	2.57AspThr: 2.57 ± 0.04	3.717AspVal: 3.717 ± 0.051	0.756AspTrp: 0.756 ± 0.022	2.19AspTyr: 2.19 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	5.393GluAla: 5.393 ± 0.059	0.289GluCys: 0.289 ± 0.013	2.125GluAsp: 2.125 ± 0.038	3.138GluGlu: 3.138 ± 0.057	1.941GluPhe: 1.941 ± 0.032	3.248GluGly: 3.248 ± 0.05	1.193GluHis: 1.193 ± 0.029	2.471GluIle: 2.471 ± 0.039	2.812GluLys: 2.812 ± 0.041	5.905GluLeu: 5.905 ± 0.068	1.122GluMet: 1.122 ± 0.025	2.025GluAsn: 2.025 ± 0.035	2.159GluPro: 2.159 ± 0.035	3.137GluGln: 3.137 ± 0.053	3.106GluArg: 3.106 ± 0.042	2.316GluSer: 2.316 ± 0.033	2.687GluThr: 2.687 ± 0.039	3.996GluVal: 3.996 ± 0.051	0.631GluTrp: 0.631 ± 0.019	1.772GluTyr: 1.772 ± 0.035	0.0GluXaa: 0.0 ± 0.001
Phe	3.669PheAla: 3.669 ± 0.04	0.357PheCys: 0.357 ± 0.016	2.421PheAsp: 2.421 ± 0.041	2.097PheGlu: 2.097 ± 0.035	1.869PhePhe: 1.869 ± 0.035	3.224PheGly: 3.224 ± 0.042	0.782PheHis: 0.782 ± 0.019	1.805PheIle: 1.805 ± 0.037	1.578PheLys: 1.578 ± 0.028	3.928PheLeu: 3.928 ± 0.054	0.767PheMet: 0.767 ± 0.018	1.932PheAsn: 1.932 ± 0.034	1.781PhePro: 1.781 ± 0.034	1.629PheGln: 1.629 ± 0.027	2.33PheArg: 2.33 ± 0.035	2.901PheSer: 2.901 ± 0.046	3.075PheThr: 3.075 ± 0.045	2.94PheVal: 2.94 ± 0.045	0.593PheTrp: 0.593 ± 0.018	1.681PheTyr: 1.681 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	6.415GlyAla: 6.415 ± 0.065	0.591GlyCys: 0.591 ± 0.017	3.625GlyAsp: 3.625 ± 0.107	3.416GlyGlu: 3.416 ± 0.046	3.208GlyPhe: 3.208 ± 0.041	5.664GlyGly: 5.664 ± 0.088	1.497GlyHis: 1.497 ± 0.032	3.932GlyIle: 3.932 ± 0.051	3.868GlyLys: 3.868 ± 0.057	7.665GlyLeu: 7.665 ± 0.079	1.438GlyMet: 1.438 ± 0.029	3.179GlyAsn: 3.179 ± 0.06	2.693GlyPro: 2.693 ± 0.04	3.704GlyGln: 3.704 ± 0.043	4.08GlyArg: 4.08 ± 0.047	4.766GlySer: 4.766 ± 0.069	5.472GlyThr: 5.472 ± 0.089	5.168GlyVal: 5.168 ± 0.064	1.113GlyTrp: 1.113 ± 0.026	3.073GlyTyr: 3.073 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	1.709HisAla: 1.709 ± 0.029	0.18HisCys: 0.18 ± 0.01	1.028HisAsp: 1.028 ± 0.026	1.083HisGlu: 1.083 ± 0.027	1.023HisPhe: 1.023 ± 0.023	1.421HisGly: 1.421 ± 0.03	0.595HisHis: 0.595 ± 0.019	0.908HisIle: 0.908 ± 0.02	0.682HisLys: 0.682 ± 0.018	2.468HisLeu: 2.468 ± 0.046	0.362HisMet: 0.362 ± 0.015	0.742HisAsn: 0.742 ± 0.022	1.24HisPro: 1.24 ± 0.026	0.999HisGln: 0.999 ± 0.024	1.12HisArg: 1.12 ± 0.025	1.013HisSer: 1.013 ± 0.025	1.214HisThr: 1.214 ± 0.025	1.345HisVal: 1.345 ± 0.027	0.334HisTrp: 0.334 ± 0.012	0.994HisTyr: 0.994 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	4.205IleAla: 4.205 ± 0.046	0.397IleCys: 0.397 ± 0.014	2.594IleAsp: 2.594 ± 0.037	2.545IleGlu: 2.545 ± 0.037	1.752IlePhe: 1.752 ± 0.032	3.678IleGly: 3.678 ± 0.048	0.868IleHis: 0.868 ± 0.023	2.343IleIle: 2.343 ± 0.046	2.063IleLys: 2.063 ± 0.036	3.877IleLeu: 3.877 ± 0.05	0.785IleMet: 0.785 ± 0.021	2.068IleAsn: 2.068 ± 0.035	2.24IlePro: 2.24 ± 0.035	1.791IleGln: 1.791 ± 0.032	2.775IleArg: 2.775 ± 0.042	3.013IleSer: 3.013 ± 0.046	3.345IleThr: 3.345 ± 0.042	3.101IleVal: 3.101 ± 0.043	0.524IleTrp: 0.524 ± 0.015	1.517IleTyr: 1.517 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	4.201LysAla: 4.201 ± 0.056	0.177LysCys: 0.177 ± 0.01	2.203LysAsp: 2.203 ± 0.041	2.389LysGlu: 2.389 ± 0.041	1.426LysPhe: 1.426 ± 0.028	3.009LysGly: 3.009 ± 0.047	0.82LysHis: 0.82 ± 0.024	2.055LysIle: 2.055 ± 0.036	2.361LysLys: 2.361 ± 0.045	4.569LysLeu: 4.569 ± 0.051	0.989LysMet: 0.989 ± 0.026	1.83LysAsn: 1.83 ± 0.032	2.376LysPro: 2.376 ± 0.044	2.216LysGln: 2.216 ± 0.033	2.241LysArg: 2.241 ± 0.036	2.217LysSer: 2.217 ± 0.036	2.6LysThr: 2.6 ± 0.046	3.06LysVal: 3.06 ± 0.046	0.533LysTrp: 0.533 ± 0.017	1.523LysTyr: 1.523 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	11.44LeuAla: 11.44 ± 0.091	0.758LeuCys: 0.758 ± 0.022	5.443LeuAsp: 5.443 ± 0.057	4.935LeuGlu: 4.935 ± 0.064	4.117LeuPhe: 4.117 ± 0.052	8.063LeuGly: 8.063 ± 0.076	2.317LeuHis: 2.317 ± 0.037	4.259LeuIle: 4.259 ± 0.053	4.337LeuLys: 4.337 ± 0.053	12.795LeuLeu: 12.795 ± 0.125	1.816LeuMet: 1.816 ± 0.034	4.458LeuAsn: 4.458 ± 0.067	5.91LeuPro: 5.91 ± 0.065	4.719LeuGln: 4.719 ± 0.055	6.768LeuArg: 6.768 ± 0.077	6.282LeuSer: 6.282 ± 0.065	7.292LeuThr: 7.292 ± 0.061	7.318LeuVal: 7.318 ± 0.07	1.109LeuTrp: 1.109 ± 0.027	3.349LeuTyr: 3.349 ± 0.049	0.001LeuXaa: 0.001 ± 0.001
Met	1.77MetAla: 1.77 ± 0.031	0.106MetCys: 0.106 ± 0.007	0.735MetAsp: 0.735 ± 0.02	0.868MetGlu: 0.868 ± 0.021	0.543MetPhe: 0.543 ± 0.018	1.234MetGly: 1.234 ± 0.027	0.434MetHis: 0.434 ± 0.016	0.768MetIle: 0.768 ± 0.022	1.074MetLys: 1.074 ± 0.021	2.07MetLeu: 2.07 ± 0.032	0.387MetMet: 0.387 ± 0.015	0.774MetAsn: 0.774 ± 0.018	1.173MetPro: 1.173 ± 0.024	1.001MetGln: 1.001 ± 0.025	1.183MetArg: 1.183 ± 0.023	1.146MetSer: 1.146 ± 0.027	1.065MetThr: 1.065 ± 0.024	1.199MetVal: 1.199 ± 0.027	0.191MetTrp: 0.191 ± 0.009	0.487MetTyr: 0.487 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.668AsnAla: 3.668 ± 0.046	0.278AsnCys: 0.278 ± 0.014	2.014AsnAsp: 2.014 ± 0.039	1.899AsnGlu: 1.899 ± 0.033	1.771AsnPhe: 1.771 ± 0.035	3.634AsnGly: 3.634 ± 0.069	0.737AsnHis: 0.737 ± 0.02	2.03AsnIle: 2.03 ± 0.038	1.658AsnLys: 1.658 ± 0.033	4.142AsnLeu: 4.142 ± 0.055	0.694AsnMet: 0.694 ± 0.018	2.067AsnAsn: 2.067 ± 0.058	2.622AsnPro: 2.622 ± 0.039	1.957AsnGln: 1.957 ± 0.032	2.225AsnArg: 2.225 ± 0.038	2.464AsnSer: 2.464 ± 0.052	2.722AsnThr: 2.722 ± 0.056	2.779AsnVal: 2.779 ± 0.04	0.578AsnTrp: 0.578 ± 0.016	1.731AsnTyr: 1.731 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	5.973ProAla: 5.973 ± 0.067	0.254ProCys: 0.254 ± 0.013	2.929ProAsp: 2.929 ± 0.045	3.254ProGlu: 3.254 ± 0.048	1.899ProPhe: 1.899 ± 0.036	3.605ProGly: 3.605 ± 0.044	0.967ProHis: 0.967 ± 0.021	2.159ProIle: 2.159 ± 0.034	1.87ProLys: 1.87 ± 0.035	4.87ProLeu: 4.87 ± 0.06	0.831ProMet: 0.831 ± 0.018	2.186ProAsn: 2.186 ± 0.032	1.876ProPro: 1.876 ± 0.04	2.046ProGln: 2.046 ± 0.033	2.202ProArg: 2.202 ± 0.036	3.077ProSer: 3.077 ± 0.038	3.662ProThr: 3.662 ± 0.045	4.03ProVal: 4.03 ± 0.05	0.587ProTrp: 0.587 ± 0.019	1.684ProTyr: 1.684 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	5.221GlnAla: 5.221 ± 0.062	0.238GlnCys: 0.238 ± 0.011	1.982GlnAsp: 1.982 ± 0.031	2.689GlnGlu: 2.689 ± 0.04	1.827GlnPhe: 1.827 ± 0.03	3.006GlnGly: 3.006 ± 0.042	1.241GlnHis: 1.241 ± 0.03	1.949GlnIle: 1.949 ± 0.034	1.982GlnLys: 1.982 ± 0.033	5.717GlnLeu: 5.717 ± 0.06	0.909GlnMet: 0.909 ± 0.023	1.88GlnAsn: 1.88 ± 0.033	2.929GlnPro: 2.929 ± 0.042	3.62GlnGln: 3.62 ± 0.058	3.117GlnArg: 3.117 ± 0.046	2.177GlnSer: 2.177 ± 0.031	2.658GlnThr: 2.658 ± 0.037	3.66GlnVal: 3.66 ± 0.047	0.618GlnTrp: 0.618 ± 0.019	1.626GlnTyr: 1.626 ± 0.031	0.001GlnXaa: 0.001 ± 0.001
Arg	4.689ArgAla: 4.689 ± 0.054	0.332ArgCys: 0.332 ± 0.013	2.527ArgAsp: 2.527 ± 0.032	2.997ArgGlu: 2.997 ± 0.051	2.565ArgPhe: 2.565 ± 0.036	3.315ArgGly: 3.315 ± 0.043	1.28ArgHis: 1.28 ± 0.028	2.851ArgIle: 2.851 ± 0.041	2.316ArgLys: 2.316 ± 0.038	6.528ArgLeu: 6.528 ± 0.063	1.164ArgMet: 1.164 ± 0.027	2.344ArgAsn: 2.344 ± 0.037	2.65ArgPro: 2.65 ± 0.041	3.235ArgGln: 3.235 ± 0.047	3.68ArgArg: 3.68 ± 0.057	2.824ArgSer: 2.824 ± 0.035	3.476ArgThr: 3.476 ± 0.044	4.005ArgVal: 4.005 ± 0.045	0.852ArgTrp: 0.852 ± 0.024	2.497ArgTyr: 2.497 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	5.41SerAla: 5.41 ± 0.059	0.489SerCys: 0.489 ± 0.017	2.592SerAsp: 2.592 ± 0.036	2.595SerGlu: 2.595 ± 0.042	2.998SerPhe: 2.998 ± 0.041	4.849SerGly: 4.849 ± 0.067	0.993SerHis: 0.993 ± 0.023	2.915SerIle: 2.915 ± 0.039	2.321SerLys: 2.321 ± 0.038	6.297SerLeu: 6.297 ± 0.061	1.109SerMet: 1.109 ± 0.028	2.391SerAsn: 2.391 ± 0.047	2.971SerPro: 2.971 ± 0.037	2.295SerGln: 2.295 ± 0.033	2.959SerArg: 2.959 ± 0.042	3.887SerSer: 3.887 ± 0.056	4.038SerThr: 4.038 ± 0.063	4.212SerVal: 4.212 ± 0.069	0.789SerTrp: 0.789 ± 0.019	2.412SerTyr: 2.412 ± 0.035	0.001SerXaa: 0.001 ± 0.001
Thr	6.634ThrAla: 6.634 ± 0.078	0.37ThrCys: 0.37 ± 0.014	3.352ThrAsp: 3.352 ± 0.046	2.947ThrGlu: 2.947 ± 0.042	2.789ThrPhe: 2.789 ± 0.041	5.444ThrGly: 5.444 ± 0.074	1.199ThrHis: 1.199 ± 0.029	3.237ThrIle: 3.237 ± 0.041	2.483ThrLys: 2.483 ± 0.039	6.913ThrLeu: 6.913 ± 0.066	0.969ThrMet: 0.969 ± 0.02	2.71ThrAsn: 2.71 ± 0.049	3.908ThrPro: 3.908 ± 0.048	2.71ThrGln: 2.71 ± 0.041	3.019ThrArg: 3.019 ± 0.041	4.018ThrSer: 4.018 ± 0.061	4.863ThrThr: 4.863 ± 0.088	4.846ThrVal: 4.846 ± 0.077	0.834ThrTrp: 0.834 ± 0.025	2.557ThrTyr: 2.557 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	7.471ValAla: 7.471 ± 0.075	0.524ValCys: 0.524 ± 0.016	3.42ValAsp: 3.42 ± 0.045	3.691ValGlu: 3.691 ± 0.047	2.825ValPhe: 2.825 ± 0.038	5.089ValGly: 5.089 ± 0.07	1.335ValHis: 1.335 ± 0.03	2.998ValIle: 2.998 ± 0.044	2.88ValLys: 2.88 ± 0.046	7.812ValLeu: 7.812 ± 0.074	1.246ValMet: 1.246 ± 0.028	2.794ValAsn: 2.794 ± 0.048	3.664ValPro: 3.664 ± 0.044	3.422ValGln: 3.422 ± 0.048	4.342ValArg: 4.342 ± 0.047	4.433ValSer: 4.433 ± 0.066	4.67ValThr: 4.67 ± 0.071	5.898ValVal: 5.898 ± 0.069	0.815ValTrp: 0.815 ± 0.022	2.366ValTyr: 2.366 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.062TrpAla: 1.062 ± 0.025	0.112TrpCys: 0.112 ± 0.007	0.597TrpAsp: 0.597 ± 0.021	0.624TrpGlu: 0.624 ± 0.02	0.526TrpPhe: 0.526 ± 0.019	0.844TrpGly: 0.844 ± 0.025	0.342TrpHis: 0.342 ± 0.013	0.485TrpIle: 0.485 ± 0.017	0.564TrpLys: 0.564 ± 0.02	1.676TrpLeu: 1.676 ± 0.032	0.298TrpMet: 0.298 ± 0.013	0.567TrpAsn: 0.567 ± 0.019	0.537TrpPro: 0.537 ± 0.019	0.889TrpGln: 0.889 ± 0.022	0.843TrpArg: 0.843 ± 0.024	0.753TrpSer: 0.753 ± 0.021	0.701TrpThr: 0.701 ± 0.019	0.882TrpVal: 0.882 ± 0.023	0.235TrpTrp: 0.235 ± 0.012	0.424TrpTyr: 0.424 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.304TyrAla: 3.304 ± 0.045	0.328TyrCys: 0.328 ± 0.013	2.027TyrAsp: 2.027 ± 0.032	1.798TyrGlu: 1.798 ± 0.034	1.721TyrPhe: 1.721 ± 0.033	2.699TyrGly: 2.699 ± 0.043	0.844TyrHis: 0.844 ± 0.02	1.404TyrIle: 1.404 ± 0.026	1.502TyrLys: 1.502 ± 0.033	3.966TyrLeu: 3.966 ± 0.049	0.531TyrMet: 0.531 ± 0.016	1.727TyrAsn: 1.727 ± 0.04	1.695TyrPro: 1.695 ± 0.027	2.075TyrGln: 2.075 ± 0.035	2.328TyrArg: 2.328 ± 0.037	2.205TyrSer: 2.205 ± 0.037	2.384TyrThr: 2.384 ± 0.04	2.346TyrVal: 2.346 ± 0.038	0.554TyrTrp: 0.554 ± 0.015	1.689TyrTyr: 1.689 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.001	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.001	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.001	0.0XaaThr: 0.0 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5735 proteins (2016218 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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