Amino acid dipepetide frequency for Tea plant necrotic ring blotch virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.642AlaAla: 2.642 ± 1.36
0.961AlaCys: 0.961 ± 0.391
3.122AlaAsp: 3.122 ± 0.731
1.681AlaGlu: 1.681 ± 0.65
2.402AlaPhe: 2.402 ± 0.639
3.362AlaGly: 3.362 ± 0.446
1.201AlaHis: 1.201 ± 0.376
2.642AlaIle: 2.642 ± 0.604
3.362AlaLys: 3.362 ± 1.046
6.004AlaLeu: 6.004 ± 1.223
0.961AlaMet: 0.961 ± 0.386
1.441AlaAsn: 1.441 ± 0.462
3.362AlaPro: 3.362 ± 1.845
1.681AlaGln: 1.681 ± 0.49
1.201AlaArg: 1.201 ± 0.603
2.642AlaSer: 2.642 ± 1.462
3.122AlaThr: 3.122 ± 1.448
5.283AlaVal: 5.283 ± 0.978
0.24AlaTrp: 0.24 ± 0.153
2.642AlaTyr: 2.642 ± 0.909
0.0AlaXaa: 0.0 ± 0.0
Cys
0.72CysAla: 0.72 ± 0.505
0.72CysCys: 0.72 ± 0.258
1.441CysAsp: 1.441 ± 0.531
0.961CysGlu: 0.961 ± 0.547
0.961CysPhe: 0.961 ± 0.305
1.201CysGly: 1.201 ± 0.413
0.24CysHis: 0.24 ± 0.153
0.48CysIle: 0.48 ± 0.176
0.961CysLys: 0.961 ± 0.547
0.72CysLeu: 0.72 ± 0.351
0.24CysMet: 0.24 ± 0.205
0.24CysAsn: 0.24 ± 0.153
2.402CysPro: 2.402 ± 0.619
0.24CysGln: 0.24 ± 0.205
1.681CysArg: 1.681 ± 0.635
2.402CysSer: 2.402 ± 0.965
0.48CysThr: 0.48 ± 0.176
2.402CysVal: 2.402 ± 0.79
0.0CysTrp: 0.0 ± 0.0
1.201CysTyr: 1.201 ± 0.85
0.0CysXaa: 0.0 ± 0.0
Asp
2.402AspAla: 2.402 ± 0.882
0.961AspCys: 0.961 ± 0.386
5.524AspAsp: 5.524 ± 1.69
5.043AspGlu: 5.043 ± 1.109
1.441AspPhe: 1.441 ± 0.841
1.921AspGly: 1.921 ± 0.935
1.921AspHis: 1.921 ± 0.471
3.122AspIle: 3.122 ± 0.568
6.724AspLys: 6.724 ± 1.484
5.524AspLeu: 5.524 ± 1.625
2.161AspMet: 2.161 ± 0.755
3.602AspAsn: 3.602 ± 0.995
2.882AspPro: 2.882 ± 0.881
1.921AspGln: 1.921 ± 0.669
3.122AspArg: 3.122 ± 0.715
4.803AspSer: 4.803 ± 0.786
4.083AspThr: 4.083 ± 1.237
8.165AspVal: 8.165 ± 1.137
0.48AspTrp: 0.48 ± 0.176
1.921AspTyr: 1.921 ± 0.865
0.0AspXaa: 0.0 ± 0.0
Glu
2.161GluAla: 2.161 ± 0.684
0.72GluCys: 0.72 ± 0.258
2.882GluAsp: 2.882 ± 1.632
3.122GluGlu: 3.122 ± 0.793
3.842GluPhe: 3.842 ± 1.224
1.681GluGly: 1.681 ± 0.49
1.921GluHis: 1.921 ± 0.633
4.323GluIle: 4.323 ± 0.789
2.402GluLys: 2.402 ± 0.982
6.484GluLeu: 6.484 ± 0.9
0.72GluMet: 0.72 ± 0.488
3.602GluAsn: 3.602 ± 0.822
2.882GluPro: 2.882 ± 0.472
0.961GluGln: 0.961 ± 0.489
2.642GluArg: 2.642 ± 0.905
4.083GluSer: 4.083 ± 0.836
1.921GluThr: 1.921 ± 1.091
4.803GluVal: 4.803 ± 1.175
0.0GluTrp: 0.0 ± 0.0
3.122GluTyr: 3.122 ± 1.153
0.0GluXaa: 0.0 ± 0.0
Phe
2.161PheAla: 2.161 ± 0.562
0.961PheCys: 0.961 ± 0.822
4.323PheAsp: 4.323 ± 1.373
3.842PheGlu: 3.842 ± 1.083
1.681PhePhe: 1.681 ± 0.585
3.122PheGly: 3.122 ± 0.915
0.961PheHis: 0.961 ± 0.662
3.842PheIle: 3.842 ± 1.635
1.441PheLys: 1.441 ± 0.9
3.602PheLeu: 3.602 ± 1.146
1.201PheMet: 1.201 ± 0.653
0.961PheAsn: 0.961 ± 0.378
2.402PhePro: 2.402 ± 0.592
0.72PheGln: 0.72 ± 0.547
3.602PheArg: 3.602 ± 1.218
3.842PheSer: 3.842 ± 0.342
3.122PheThr: 3.122 ± 1.015
4.083PheVal: 4.083 ± 1.032
0.0PheTrp: 0.0 ± 0.0
1.201PheTyr: 1.201 ± 0.415
0.0PheXaa: 0.0 ± 0.0
Gly
1.921GlyAla: 1.921 ± 0.769
0.961GlyCys: 0.961 ± 0.547
4.563GlyAsp: 4.563 ± 1.101
3.362GlyGlu: 3.362 ± 0.64
3.122GlyPhe: 3.122 ± 0.684
1.201GlyGly: 1.201 ± 0.376
0.961GlyHis: 0.961 ± 0.621
1.441GlyIle: 1.441 ± 0.683
2.402GlyLys: 2.402 ± 0.775
3.362GlyLeu: 3.362 ± 1.746
0.24GlyMet: 0.24 ± 0.153
3.362GlyAsn: 3.362 ± 0.509
3.122GlyPro: 3.122 ± 0.736
1.441GlyGln: 1.441 ± 0.522
3.122GlyArg: 3.122 ± 0.987
3.602GlySer: 3.602 ± 1.326
1.201GlyThr: 1.201 ± 0.695
2.161GlyVal: 2.161 ± 0.912
0.48GlyTrp: 0.48 ± 0.415
2.161GlyTyr: 2.161 ± 0.468
0.0GlyXaa: 0.0 ± 0.0
His
1.201HisAla: 1.201 ± 0.743
0.72HisCys: 0.72 ± 0.458
2.642HisAsp: 2.642 ± 0.444
1.441HisGlu: 1.441 ± 0.462
0.961HisPhe: 0.961 ± 0.386
0.48HisGly: 0.48 ± 0.176
0.24HisHis: 0.24 ± 0.205
1.681HisIle: 1.681 ± 0.648
1.681HisLys: 1.681 ± 0.667
1.921HisLeu: 1.921 ± 0.537
0.961HisMet: 0.961 ± 0.305
0.24HisAsn: 0.24 ± 0.438
2.161HisPro: 2.161 ± 1.404
0.0HisGln: 0.0 ± 0.0
1.201HisArg: 1.201 ± 0.695
3.122HisSer: 3.122 ± 0.543
0.961HisThr: 0.961 ± 0.378
1.921HisVal: 1.921 ± 0.674
0.24HisTrp: 0.24 ± 0.153
0.72HisTyr: 0.72 ± 0.351
0.0HisXaa: 0.0 ± 0.0
Ile
3.362IleAla: 3.362 ± 0.712
1.441IleCys: 1.441 ± 0.465
4.563IleAsp: 4.563 ± 1.292
3.122IleGlu: 3.122 ± 0.771
1.441IlePhe: 1.441 ± 0.687
3.122IleGly: 3.122 ± 0.798
1.921IleHis: 1.921 ± 0.521
1.921IleIle: 1.921 ± 0.777
2.161IleLys: 2.161 ± 0.654
6.004IleLeu: 6.004 ± 1.541
0.961IleMet: 0.961 ± 0.612
3.362IleAsn: 3.362 ± 1.395
2.882IlePro: 2.882 ± 1.095
1.681IleGln: 1.681 ± 0.639
1.681IleArg: 1.681 ± 0.467
4.803IleSer: 4.803 ± 0.863
2.882IleThr: 2.882 ± 1.196
5.764IleVal: 5.764 ± 1.388
0.24IleTrp: 0.24 ± 0.348
1.441IleTyr: 1.441 ± 0.49
0.0IleXaa: 0.0 ± 0.0
Lys
1.921LysAla: 1.921 ± 0.647
0.72LysCys: 0.72 ± 0.351
2.642LysAsp: 2.642 ± 0.863
4.083LysGlu: 4.083 ± 1.351
3.842LysPhe: 3.842 ± 1.278
1.921LysGly: 1.921 ± 0.71
1.201LysHis: 1.201 ± 0.353
1.441LysIle: 1.441 ± 0.446
4.083LysLys: 4.083 ± 1.388
6.964LysLeu: 6.964 ± 0.99
0.961LysMet: 0.961 ± 0.305
4.803LysAsn: 4.803 ± 1.247
2.402LysPro: 2.402 ± 0.994
0.48LysGln: 0.48 ± 0.411
4.803LysArg: 4.803 ± 1.183
7.205LysSer: 7.205 ± 1.422
1.921LysThr: 1.921 ± 0.544
5.043LysVal: 5.043 ± 1.33
0.24LysTrp: 0.24 ± 0.205
4.083LysTyr: 4.083 ± 1.051
0.0LysXaa: 0.0 ± 0.0
Leu
3.122LeuAla: 3.122 ± 0.771
1.921LeuCys: 1.921 ± 0.871
6.244LeuAsp: 6.244 ± 1.188
5.283LeuGlu: 5.283 ± 1.456
4.323LeuPhe: 4.323 ± 1.61
4.803LeuGly: 4.803 ± 0.486
0.961LeuHis: 0.961 ± 0.388
5.043LeuIle: 5.043 ± 0.864
5.283LeuLys: 5.283 ± 1.437
7.925LeuLeu: 7.925 ± 3.04
3.122LeuMet: 3.122 ± 0.656
4.563LeuAsn: 4.563 ± 1.494
4.323LeuPro: 4.323 ± 0.675
2.402LeuGln: 2.402 ± 0.78
5.043LeuArg: 5.043 ± 0.961
7.445LeuSer: 7.445 ± 1.363
6.004LeuThr: 6.004 ± 1.487
6.964LeuVal: 6.964 ± 1.942
0.961LeuTrp: 0.961 ± 0.547
2.642LeuTyr: 2.642 ± 0.664
0.0LeuXaa: 0.0 ± 0.0
Met
1.921MetAla: 1.921 ± 0.612
0.0MetCys: 0.0 ± 0.0
1.681MetAsp: 1.681 ± 0.471
0.961MetGlu: 0.961 ± 0.353
1.201MetPhe: 1.201 ± 0.628
0.72MetGly: 0.72 ± 0.547
0.961MetHis: 0.961 ± 0.547
0.961MetIle: 0.961 ± 0.512
1.441MetLys: 1.441 ± 0.49
2.161MetLeu: 2.161 ± 0.86
0.961MetMet: 0.961 ± 0.681
0.961MetAsn: 0.961 ± 0.305
1.681MetPro: 1.681 ± 0.355
0.72MetGln: 0.72 ± 0.351
0.72MetArg: 0.72 ± 0.351
1.441MetSer: 1.441 ± 1.089
1.201MetThr: 1.201 ± 0.353
2.882MetVal: 2.882 ± 1.72
0.0MetTrp: 0.0 ± 0.0
1.681MetTyr: 1.681 ± 0.446
0.0MetXaa: 0.0 ± 0.0
Asn
2.161AsnAla: 2.161 ± 0.622
1.441AsnCys: 1.441 ± 0.419
3.362AsnAsp: 3.362 ± 1.27
2.642AsnGlu: 2.642 ± 0.925
3.602AsnPhe: 3.602 ± 1.026
1.681AsnGly: 1.681 ± 0.866
0.48AsnHis: 0.48 ± 0.415
1.921AsnIle: 1.921 ± 0.669
3.842AsnLys: 3.842 ± 0.815
4.563AsnLeu: 4.563 ± 0.783
1.441AsnMet: 1.441 ± 0.413
1.201AsnAsn: 1.201 ± 0.457
2.161AsnPro: 2.161 ± 0.718
0.72AsnGln: 0.72 ± 0.351
3.122AsnArg: 3.122 ± 1.117
4.563AsnSer: 4.563 ± 1.439
1.921AsnThr: 1.921 ± 0.491
3.122AsnVal: 3.122 ± 1.23
0.24AsnTrp: 0.24 ± 0.205
3.602AsnTyr: 3.602 ± 0.587
0.0AsnXaa: 0.0 ± 0.0
Pro
4.323ProAla: 4.323 ± 0.895
0.72ProCys: 0.72 ± 0.258
1.921ProAsp: 1.921 ± 0.623
2.161ProGlu: 2.161 ± 0.693
2.161ProPhe: 2.161 ± 1.051
3.122ProGly: 3.122 ± 0.846
1.441ProHis: 1.441 ± 0.364
3.362ProIle: 3.362 ± 1.411
2.882ProLys: 2.882 ± 0.467
2.642ProLeu: 2.642 ± 0.856
1.441ProMet: 1.441 ± 0.369
2.161ProAsn: 2.161 ± 0.657
1.441ProPro: 1.441 ± 0.479
2.642ProGln: 2.642 ± 1.506
2.642ProArg: 2.642 ± 0.999
4.083ProSer: 4.083 ± 1.1
2.642ProThr: 2.642 ± 0.765
6.244ProVal: 6.244 ± 1.779
0.0ProTrp: 0.0 ± 0.0
1.681ProTyr: 1.681 ± 1.183
0.0ProXaa: 0.0 ± 0.0
Gln
1.201GlnAla: 1.201 ± 0.415
0.0GlnCys: 0.0 ± 0.0
0.961GlnAsp: 0.961 ± 0.822
0.961GlnGlu: 0.961 ± 0.386
0.48GlnPhe: 0.48 ± 0.306
1.921GlnGly: 1.921 ± 0.712
0.961GlnHis: 0.961 ± 0.323
2.402GlnIle: 2.402 ± 0.408
1.921GlnLys: 1.921 ± 0.647
2.882GlnLeu: 2.882 ± 0.803
0.48GlnMet: 0.48 ± 0.176
1.681GlnAsn: 1.681 ± 0.443
1.201GlnPro: 1.201 ± 0.485
0.48GlnGln: 0.48 ± 0.38
0.961GlnArg: 0.961 ± 0.305
1.681GlnSer: 1.681 ± 0.807
0.961GlnThr: 0.961 ± 0.356
3.362GlnVal: 3.362 ± 1.289
0.0GlnTrp: 0.0 ± 0.0
1.441GlnTyr: 1.441 ± 0.917
0.0GlnXaa: 0.0 ± 0.0
Arg
2.161ArgAla: 2.161 ± 0.389
1.201ArgCys: 1.201 ± 0.516
4.323ArgAsp: 4.323 ± 0.64
2.402ArgGlu: 2.402 ± 1.134
2.161ArgPhe: 2.161 ± 0.606
0.72ArgGly: 0.72 ± 0.258
1.921ArgHis: 1.921 ± 0.647
4.083ArgIle: 4.083 ± 0.92
3.602ArgLys: 3.602 ± 0.991
5.764ArgLeu: 5.764 ± 1.684
1.681ArgMet: 1.681 ± 0.823
2.882ArgAsn: 2.882 ± 0.864
1.921ArgPro: 1.921 ± 0.508
0.48ArgGln: 0.48 ± 0.394
4.563ArgArg: 4.563 ± 1.886
6.004ArgSer: 6.004 ± 1.009
1.921ArgThr: 1.921 ± 0.555
5.524ArgVal: 5.524 ± 1.421
0.24ArgTrp: 0.24 ± 0.153
3.362ArgTyr: 3.362 ± 0.605
0.0ArgXaa: 0.0 ± 0.0
Ser
4.803SerAla: 4.803 ± 1.278
1.441SerCys: 1.441 ± 1.202
4.803SerAsp: 4.803 ± 1.374
4.563SerGlu: 4.563 ± 1.423
4.083SerPhe: 4.083 ± 0.717
5.043SerGly: 5.043 ± 1.041
1.441SerHis: 1.441 ± 0.678
5.283SerIle: 5.283 ± 1.597
6.244SerLys: 6.244 ± 1.511
7.685SerLeu: 7.685 ± 1.484
2.161SerMet: 2.161 ± 0.794
4.083SerAsn: 4.083 ± 1.2
2.642SerPro: 2.642 ± 1.038
2.161SerGln: 2.161 ± 0.838
6.724SerArg: 6.724 ± 1.773
8.165SerSer: 8.165 ± 0.749
5.283SerThr: 5.283 ± 1.223
7.445SerVal: 7.445 ± 0.999
1.441SerTrp: 1.441 ± 0.419
3.602SerTyr: 3.602 ± 0.83
0.0SerXaa: 0.0 ± 0.0
Thr
1.921ThrAla: 1.921 ± 0.428
1.681ThrCys: 1.681 ± 0.733
3.122ThrAsp: 3.122 ± 1.154
1.921ThrGlu: 1.921 ± 0.458
1.201ThrPhe: 1.201 ± 0.483
2.161ThrGly: 2.161 ± 0.785
1.921ThrHis: 1.921 ± 1.089
3.362ThrIle: 3.362 ± 0.955
1.921ThrLys: 1.921 ± 0.721
4.323ThrLeu: 4.323 ± 0.8
1.921ThrMet: 1.921 ± 0.824
2.402ThrAsn: 2.402 ± 0.301
3.122ThrPro: 3.122 ± 1.936
2.642ThrGln: 2.642 ± 0.904
1.681ThrArg: 1.681 ± 0.49
4.083ThrSer: 4.083 ± 1.22
2.642ThrThr: 2.642 ± 1.464
5.764ThrVal: 5.764 ± 1.939
0.961ThrTrp: 0.961 ± 0.323
2.161ThrTyr: 2.161 ± 0.621
0.0ThrXaa: 0.0 ± 0.0
Val
6.244ValAla: 6.244 ± 3.476
2.161ValCys: 2.161 ± 1.004
5.764ValAsp: 5.764 ± 0.783
4.803ValGlu: 4.803 ± 1.239
5.043ValPhe: 5.043 ± 1.97
3.842ValGly: 3.842 ± 1.751
2.882ValHis: 2.882 ± 0.818
6.004ValIle: 6.004 ± 1.601
5.283ValLys: 5.283 ± 0.932
6.724ValLeu: 6.724 ± 1.554
1.201ValMet: 1.201 ± 1.087
2.642ValAsn: 2.642 ± 1.175
4.803ValPro: 4.803 ± 1.171
3.602ValGln: 3.602 ± 0.942
5.043ValArg: 5.043 ± 1.151
11.287ValSer: 11.287 ± 1.67
4.323ValThr: 4.323 ± 1.444
6.724ValVal: 6.724 ± 1.791
0.24ValTrp: 0.24 ± 0.348
3.842ValTyr: 3.842 ± 0.739
0.0ValXaa: 0.0 ± 0.0
Trp
0.72TrpAla: 0.72 ± 0.459
0.24TrpCys: 0.24 ± 0.205
0.0TrpAsp: 0.0 ± 0.0
0.0TrpGlu: 0.0 ± 0.0
0.961TrpPhe: 0.961 ± 0.323
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.48TrpIle: 0.48 ± 0.335
0.72TrpLys: 0.72 ± 0.339
0.48TrpLeu: 0.48 ± 0.411
0.0TrpMet: 0.0 ± 0.0
0.48TrpAsn: 0.48 ± 0.176
0.24TrpPro: 0.24 ± 0.205
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
0.0TrpSer: 0.0 ± 0.0
0.48TrpThr: 0.48 ± 0.364
1.201TrpVal: 1.201 ± 0.428
0.48TrpTrp: 0.48 ± 0.306
0.24TrpTyr: 0.24 ± 0.205
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.882TyrAla: 2.882 ± 1.213
0.72TyrCys: 0.72 ± 0.258
3.842TyrAsp: 3.842 ± 0.796
2.161TyrGlu: 2.161 ± 0.83
2.161TyrPhe: 2.161 ± 0.641
2.161TyrGly: 2.161 ± 0.9
0.961TyrHis: 0.961 ± 0.323
0.961TyrIle: 0.961 ± 0.353
2.402TyrLys: 2.402 ± 0.833
2.642TyrLeu: 2.642 ± 0.462
1.201TyrMet: 1.201 ± 0.372
3.122TyrAsn: 3.122 ± 0.859
1.681TyrPro: 1.681 ± 0.687
0.961TyrGln: 0.961 ± 0.412
3.362TyrArg: 3.362 ± 1.178
3.842TyrSer: 3.842 ± 0.95
3.842TyrThr: 3.842 ± 1.134
3.602TyrVal: 3.602 ± 1.174
0.24TyrTrp: 0.24 ± 0.153
2.161TyrTyr: 2.161 ± 0.657
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (4165 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski