Amino acid dipepetide frequency for Macellibacteroides sp. HH-ZS

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.542AlaAla: 5.542 ± 0.09	0.905AlaCys: 0.905 ± 0.028	4.168AlaAsp: 4.168 ± 0.067	4.335AlaGlu: 4.335 ± 0.065	3.315AlaPhe: 3.315 ± 0.054	5.357AlaGly: 5.357 ± 0.08	1.09AlaHis: 1.09 ± 0.03	4.925AlaIle: 4.925 ± 0.079	4.283AlaLys: 4.283 ± 0.07	6.659AlaLeu: 6.659 ± 0.085	1.819AlaMet: 1.819 ± 0.047	3.327AlaAsn: 3.327 ± 0.064	2.222AlaPro: 2.222 ± 0.049	2.446AlaGln: 2.446 ± 0.053	2.849AlaArg: 2.849 ± 0.051	4.714AlaSer: 4.714 ± 0.063	3.769AlaThr: 3.769 ± 0.056	4.581AlaVal: 4.581 ± 0.078	0.766AlaTrp: 0.766 ± 0.022	2.836AlaTyr: 2.836 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.653CysAla: 0.653 ± 0.025	0.168CysCys: 0.168 ± 0.011	0.556CysAsp: 0.556 ± 0.025	0.596CysGlu: 0.596 ± 0.026	0.611CysPhe: 0.611 ± 0.022	0.873CysGly: 0.873 ± 0.032	0.236CysHis: 0.236 ± 0.014	0.812CysIle: 0.812 ± 0.024	0.678CysLys: 0.678 ± 0.023	0.982CysLeu: 0.982 ± 0.031	0.323CysMet: 0.323 ± 0.016	0.613CysAsn: 0.613 ± 0.023	0.473CysPro: 0.473 ± 0.021	0.252CysGln: 0.252 ± 0.015	0.531CysArg: 0.531 ± 0.02	0.761CysSer: 0.761 ± 0.026	0.572CysThr: 0.572 ± 0.025	0.631CysVal: 0.631 ± 0.025	0.132CysTrp: 0.132 ± 0.011	0.434CysTyr: 0.434 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	3.787AspAla: 3.787 ± 0.059	0.563AspCys: 0.563 ± 0.023	2.422AspAsp: 2.422 ± 0.054	3.455AspGlu: 3.455 ± 0.059	2.951AspPhe: 2.951 ± 0.051	3.753AspGly: 3.753 ± 0.066	0.811AspHis: 0.811 ± 0.027	3.915AspIle: 3.915 ± 0.064	4.275AspLys: 4.275 ± 0.062	5.018AspLeu: 5.018 ± 0.064	1.405AspMet: 1.405 ± 0.034	2.854AspAsn: 2.854 ± 0.054	2.05AspPro: 2.05 ± 0.037	1.533AspGln: 1.533 ± 0.036	2.289AspArg: 2.289 ± 0.046	3.336AspSer: 3.336 ± 0.057	2.674AspThr: 2.674 ± 0.044	3.506AspVal: 3.506 ± 0.057	0.824AspTrp: 0.824 ± 0.031	2.716AspTyr: 2.716 ± 0.056	0.0AspXaa: 0.0 ± 0.0
Glu	4.867GluAla: 4.867 ± 0.078	0.513GluCys: 0.513 ± 0.024	3.043GluAsp: 3.043 ± 0.06	4.518GluGlu: 4.518 ± 0.079	2.562GluPhe: 2.562 ± 0.048	3.953GluGly: 3.953 ± 0.06	1.037GluHis: 1.037 ± 0.03	4.816GluIle: 4.816 ± 0.067	5.082GluLys: 5.082 ± 0.076	6.087GluLeu: 6.087 ± 0.071	1.949GluMet: 1.949 ± 0.048	3.499GluAsn: 3.499 ± 0.049	1.688GluPro: 1.688 ± 0.04	2.429GluGln: 2.429 ± 0.049	2.781GluArg: 2.781 ± 0.055	3.621GluSer: 3.621 ± 0.058	3.265GluThr: 3.265 ± 0.053	4.337GluVal: 4.337 ± 0.065	0.795GluTrp: 0.795 ± 0.031	2.429GluTyr: 2.429 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	3.19PheAla: 3.19 ± 0.047	0.596PheCys: 0.596 ± 0.024	2.89PheAsp: 2.89 ± 0.05	2.726PheGlu: 2.726 ± 0.045	2.366PhePhe: 2.366 ± 0.05	3.297PheGly: 3.297 ± 0.058	0.831PheHis: 0.831 ± 0.028	3.471PheIle: 3.471 ± 0.063	2.707PheLys: 2.707 ± 0.049	4.178PheLeu: 4.178 ± 0.064	1.31PheMet: 1.31 ± 0.032	2.721PheAsn: 2.721 ± 0.048	1.828PhePro: 1.828 ± 0.043	1.269PheGln: 1.269 ± 0.034	2.073PheArg: 2.073 ± 0.045	3.582PheSer: 3.582 ± 0.055	2.982PheThr: 2.982 ± 0.051	3.119PheVal: 3.119 ± 0.051	0.578PheTrp: 0.578 ± 0.024	2.015PheTyr: 2.015 ± 0.046	0.0PheXaa: 0.0 ± 0.0
Gly	4.463GlyAla: 4.463 ± 0.068	0.855GlyCys: 0.855 ± 0.031	3.455GlyAsp: 3.455 ± 0.064	3.84GlyGlu: 3.84 ± 0.054	3.338GlyPhe: 3.338 ± 0.048	4.739GlyGly: 4.739 ± 0.079	1.103GlyHis: 1.103 ± 0.031	5.461GlyIle: 5.461 ± 0.075	5.317GlyLys: 5.317 ± 0.07	5.864GlyLeu: 5.864 ± 0.08	2.078GlyMet: 2.078 ± 0.042	3.607GlyAsn: 3.607 ± 0.067	1.405GlyPro: 1.405 ± 0.036	1.978GlyGln: 1.978 ± 0.045	2.581GlyArg: 2.581 ± 0.047	4.358GlySer: 4.358 ± 0.075	4.151GlyThr: 4.151 ± 0.058	4.825GlyVal: 4.825 ± 0.061	1.015GlyTrp: 1.015 ± 0.031	3.376GlyTyr: 3.376 ± 0.057	0.001GlyXaa: 0.001 ± 0.001
His	1.136HisAla: 1.136 ± 0.031	0.251HisCys: 0.251 ± 0.015	0.819HisAsp: 0.819 ± 0.024	0.912HisGlu: 0.912 ± 0.028	0.991HisPhe: 0.991 ± 0.028	1.143HisGly: 1.143 ± 0.033	0.366HisHis: 0.366 ± 0.019	1.325HisIle: 1.325 ± 0.035	0.973HisLys: 0.973 ± 0.029	1.65HisLeu: 1.65 ± 0.039	0.351HisMet: 0.351 ± 0.017	0.856HisAsn: 0.856 ± 0.026	0.994HisPro: 0.994 ± 0.031	0.588HisGln: 0.588 ± 0.021	0.786HisArg: 0.786 ± 0.025	1.1HisSer: 1.1 ± 0.032	1.026HisThr: 1.026 ± 0.033	0.973HisVal: 0.973 ± 0.026	0.228HisTrp: 0.228 ± 0.014	0.78HisTyr: 0.78 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.381IleAla: 5.381 ± 0.077	0.87IleCys: 0.87 ± 0.027	4.096IleAsp: 4.096 ± 0.061	4.743IleGlu: 4.743 ± 0.068	2.837IlePhe: 2.837 ± 0.059	4.722IleGly: 4.722 ± 0.066	1.306IleHis: 1.306 ± 0.032	4.671IleIle: 4.671 ± 0.08	4.702IleLys: 4.702 ± 0.072	6.378IleLeu: 6.378 ± 0.077	1.48IleMet: 1.48 ± 0.039	3.741IleAsn: 3.741 ± 0.065	3.385IlePro: 3.385 ± 0.058	2.477IleGln: 2.477 ± 0.05	3.49IleArg: 3.49 ± 0.052	4.98IleSer: 4.98 ± 0.074	4.153IleThr: 4.153 ± 0.055	4.376IleVal: 4.376 ± 0.07	0.694IleTrp: 0.694 ± 0.023	2.698IleTyr: 2.698 ± 0.051	0.0IleXaa: 0.0 ± 0.0
Lys	4.951LysAla: 4.951 ± 0.077	0.497LysCys: 0.497 ± 0.021	4.026LysAsp: 4.026 ± 0.064	5.993LysGlu: 5.993 ± 0.081	2.251LysPhe: 2.251 ± 0.044	4.675LysGly: 4.675 ± 0.054	1.201LysHis: 1.201 ± 0.031	4.584LysIle: 4.584 ± 0.071	5.113LysLys: 5.113 ± 0.071	5.945LysLeu: 5.945 ± 0.069	2.028LysMet: 2.028 ± 0.036	3.717LysAsn: 3.717 ± 0.069	2.386LysPro: 2.386 ± 0.044	2.825LysGln: 2.825 ± 0.056	3.155LysArg: 3.155 ± 0.054	3.881LysSer: 3.881 ± 0.055	3.675LysThr: 3.675 ± 0.055	4.397LysVal: 4.397 ± 0.057	0.781LysTrp: 0.781 ± 0.027	2.799LysTyr: 2.799 ± 0.053	0.001LysXaa: 0.001 ± 0.001
Leu	6.38LeuAla: 6.38 ± 0.09	1.175LeuCys: 1.175 ± 0.035	4.707LeuAsp: 4.707 ± 0.069	5.031LeuGlu: 5.031 ± 0.079	5.016LeuPhe: 5.016 ± 0.074	5.703LeuGly: 5.703 ± 0.083	1.654LeuHis: 1.654 ± 0.04	6.268LeuIle: 6.268 ± 0.077	6.641LeuLys: 6.641 ± 0.075	9.469LeuLeu: 9.469 ± 0.122	2.398LeuMet: 2.398 ± 0.051	5.027LeuAsn: 5.027 ± 0.061	4.071LeuPro: 4.071 ± 0.063	3.346LeuGln: 3.346 ± 0.061	4.003LeuArg: 4.003 ± 0.053	7.17LeuSer: 7.17 ± 0.082	5.372LeuThr: 5.372 ± 0.056	5.368LeuVal: 5.368 ± 0.066	1.006LeuTrp: 1.006 ± 0.029	3.702LeuTyr: 3.702 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	1.998MetAla: 1.998 ± 0.046	0.216MetCys: 0.216 ± 0.014	1.492MetAsp: 1.492 ± 0.036	1.806MetGlu: 1.806 ± 0.035	0.988MetPhe: 0.988 ± 0.03	1.771MetGly: 1.771 ± 0.041	0.507MetHis: 0.507 ± 0.022	1.641MetIle: 1.641 ± 0.037	2.329MetLys: 2.329 ± 0.04	2.543MetLeu: 2.543 ± 0.054	0.651MetMet: 0.651 ± 0.027	1.524MetAsn: 1.524 ± 0.038	1.118MetPro: 1.118 ± 0.031	1.041MetGln: 1.041 ± 0.031	1.151MetArg: 1.151 ± 0.031	1.453MetSer: 1.453 ± 0.036	1.227MetThr: 1.227 ± 0.031	1.641MetVal: 1.641 ± 0.039	0.207MetTrp: 0.207 ± 0.015	0.874MetTyr: 0.874 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.404AsnAla: 3.404 ± 0.058	0.501AsnCys: 0.501 ± 0.024	2.659AsnAsp: 2.659 ± 0.041	3.46AsnGlu: 3.46 ± 0.056	2.37AsnPhe: 2.37 ± 0.055	3.87AsnGly: 3.87 ± 0.056	0.94AsnHis: 0.94 ± 0.027	3.673AsnIle: 3.673 ± 0.068	3.75AsnLys: 3.75 ± 0.059	4.677AsnLeu: 4.677 ± 0.068	1.253AsnMet: 1.253 ± 0.032	3.019AsnAsn: 3.019 ± 0.059	2.743AsnPro: 2.743 ± 0.052	1.923AsnGln: 1.923 ± 0.041	2.554AsnArg: 2.554 ± 0.046	3.154AsnSer: 3.154 ± 0.063	2.793AsnThr: 2.793 ± 0.057	3.258AsnVal: 3.258 ± 0.056	0.708AsnTrp: 0.708 ± 0.029	2.447AsnTyr: 2.447 ± 0.054	0.0AsnXaa: 0.0 ± 0.0
Pro	2.84ProAla: 2.84 ± 0.054	0.302ProCys: 0.302 ± 0.018	2.568ProAsp: 2.568 ± 0.04	3.25ProGlu: 3.25 ± 0.053	1.941ProPhe: 1.941 ± 0.04	2.507ProGly: 2.507 ± 0.047	0.666ProHis: 0.666 ± 0.027	2.305ProIle: 2.305 ± 0.046	1.975ProLys: 1.975 ± 0.042	3.394ProLeu: 3.394 ± 0.057	0.936ProMet: 0.936 ± 0.029	1.758ProAsn: 1.758 ± 0.04	0.848ProPro: 0.848 ± 0.031	1.42ProGln: 1.42 ± 0.038	1.28ProArg: 1.28 ± 0.03	2.462ProSer: 2.462 ± 0.046	1.81ProThr: 1.81 ± 0.038	3.338ProVal: 3.338 ± 0.049	0.45ProTrp: 0.45 ± 0.02	1.736ProTyr: 1.736 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	2.304GlnAla: 2.304 ± 0.05	0.299GlnCys: 0.299 ± 0.015	1.543GlnAsp: 1.543 ± 0.037	2.156GlnGlu: 2.156 ± 0.039	1.452GlnPhe: 1.452 ± 0.033	2.051GlnGly: 2.051 ± 0.043	0.587GlnHis: 0.587 ± 0.02	2.505GlnIle: 2.505 ± 0.051	2.388GlnLys: 2.388 ± 0.046	3.559GlnLeu: 3.559 ± 0.063	0.942GlnMet: 0.942 ± 0.027	1.806GlnAsn: 1.806 ± 0.039	1.19GlnPro: 1.19 ± 0.033	1.605GlnGln: 1.605 ± 0.04	1.443GlnArg: 1.443 ± 0.036	2.213GlnSer: 2.213 ± 0.041	2.066GlnThr: 2.066 ± 0.046	2.151GlnVal: 2.151 ± 0.047	0.454GlnTrp: 0.454 ± 0.02	1.417GlnTyr: 1.417 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	2.454ArgAla: 2.454 ± 0.04	0.422ArgCys: 0.422 ± 0.019	2.035ArgAsp: 2.035 ± 0.044	2.75ArgGlu: 2.75 ± 0.052	2.403ArgPhe: 2.403 ± 0.043	2.216ArgGly: 2.216 ± 0.047	0.741ArgHis: 0.741 ± 0.025	3.707ArgIle: 3.707 ± 0.06	3.304ArgLys: 3.304 ± 0.047	4.089ArgLeu: 4.089 ± 0.057	1.376ArgMet: 1.376 ± 0.037	2.356ArgAsn: 2.356 ± 0.047	1.466ArgPro: 1.466 ± 0.038	1.477ArgGln: 1.477 ± 0.034	1.836ArgArg: 1.836 ± 0.043	2.582ArgSer: 2.582 ± 0.056	2.299ArgThr: 2.299 ± 0.041	2.594ArgVal: 2.594 ± 0.048	0.602ArgTrp: 0.602 ± 0.022	2.02ArgTyr: 2.02 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	4.447SerAla: 4.447 ± 0.066	0.775SerCys: 0.775 ± 0.028	3.618SerAsp: 3.618 ± 0.064	3.691SerGlu: 3.691 ± 0.059	3.793SerPhe: 3.793 ± 0.058	4.907SerGly: 4.907 ± 0.072	1.112SerHis: 1.112 ± 0.032	4.826SerIle: 4.826 ± 0.069	4.032SerLys: 4.032 ± 0.063	6.479SerLeu: 6.479 ± 0.083	1.636SerMet: 1.636 ± 0.039	3.172SerAsn: 3.172 ± 0.055	2.408SerPro: 2.408 ± 0.05	1.972SerGln: 1.972 ± 0.042	2.661SerArg: 2.661 ± 0.049	4.406SerSer: 4.406 ± 0.092	3.212SerThr: 3.212 ± 0.053	4.695SerVal: 4.695 ± 0.06	0.866SerTrp: 0.866 ± 0.027	3.036SerTyr: 3.036 ± 0.061	0.0SerXaa: 0.0 ± 0.0
Thr	3.854ThrAla: 3.854 ± 0.061	0.526ThrCys: 0.526 ± 0.022	3.399ThrAsp: 3.399 ± 0.059	3.29ThrGlu: 3.29 ± 0.049	2.776ThrPhe: 2.776 ± 0.05	4.394ThrGly: 4.394 ± 0.068	1.026ThrHis: 1.026 ± 0.033	3.918ThrIle: 3.918 ± 0.058	3.043ThrLys: 3.043 ± 0.047	5.359ThrLeu: 5.359 ± 0.071	1.166ThrMet: 1.166 ± 0.032	2.682ThrAsn: 2.682 ± 0.053	2.699ThrPro: 2.699 ± 0.046	1.71ThrGln: 1.71 ± 0.039	2.045ThrArg: 2.045 ± 0.041	3.549ThrSer: 3.549 ± 0.056	3.117ThrThr: 3.117 ± 0.064	3.735ThrVal: 3.735 ± 0.061	0.579ThrTrp: 0.579 ± 0.023	2.366ThrTyr: 2.366 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	4.652ValAla: 4.652 ± 0.07	0.812ValCys: 0.812 ± 0.028	3.611ValAsp: 3.611 ± 0.057	3.78ValGlu: 3.78 ± 0.063	3.012ValPhe: 3.012 ± 0.049	4.018ValGly: 4.018 ± 0.067	1.007ValHis: 1.007 ± 0.027	4.613ValIle: 4.613 ± 0.073	4.492ValLys: 4.492 ± 0.061	6.16ValLeu: 6.16 ± 0.08	1.567ValMet: 1.567 ± 0.034	3.449ValAsn: 3.449 ± 0.054	2.582ValPro: 2.582 ± 0.047	1.948ValGln: 1.948 ± 0.036	2.703ValArg: 2.703 ± 0.042	4.845ValSer: 4.845 ± 0.069	3.875ValThr: 3.875 ± 0.056	4.703ValVal: 4.703 ± 0.076	0.775ValTrp: 0.775 ± 0.027	2.736ValTyr: 2.736 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.717TrpAla: 0.717 ± 0.023	0.163TrpCys: 0.163 ± 0.012	0.715TrpAsp: 0.715 ± 0.028	0.736TrpGlu: 0.736 ± 0.029	0.551TrpPhe: 0.551 ± 0.022	0.936TrpGly: 0.936 ± 0.032	0.235TrpHis: 0.235 ± 0.014	0.885TrpIle: 0.885 ± 0.029	0.896TrpLys: 0.896 ± 0.03	1.098TrpLeu: 1.098 ± 0.031	0.42TrpMet: 0.42 ± 0.02	0.798TrpAsn: 0.798 ± 0.03	0.274TrpPro: 0.274 ± 0.015	0.459TrpGln: 0.459 ± 0.021	0.547TrpArg: 0.547 ± 0.021	0.755TrpSer: 0.755 ± 0.027	0.629TrpThr: 0.629 ± 0.021	0.703TrpVal: 0.703 ± 0.025	0.185TrpTrp: 0.185 ± 0.013	0.504TrpTyr: 0.504 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.89TyrAla: 2.89 ± 0.051	0.478TyrCys: 0.478 ± 0.017	2.312TyrAsp: 2.312 ± 0.042	2.202TyrGlu: 2.202 ± 0.043	2.206TyrPhe: 2.206 ± 0.048	2.926TyrGly: 2.926 ± 0.052	0.795TyrHis: 0.795 ± 0.025	2.857TyrIle: 2.857 ± 0.048	2.899TyrLys: 2.899 ± 0.05	3.916TyrLeu: 3.916 ± 0.06	1.088TyrMet: 1.088 ± 0.033	2.629TyrAsn: 2.629 ± 0.055	1.959TyrPro: 1.959 ± 0.041	1.431TyrGln: 1.431 ± 0.033	1.969TyrArg: 1.969 ± 0.04	2.819TyrSer: 2.819 ± 0.057	2.568TyrThr: 2.568 ± 0.047	2.41TyrVal: 2.41 ± 0.05	0.564TyrTrp: 0.564 ± 0.022	2.022TyrTyr: 2.022 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3239 proteins (1208148 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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