Amino acid dipepetide frequency for Streptococcus phage P9902

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.858AlaAla: 2.858 ± 0.891
0.179AlaCys: 0.179 ± 0.123
4.287AlaAsp: 4.287 ± 0.805
4.465AlaGlu: 4.465 ± 0.887
3.037AlaPhe: 3.037 ± 0.716
3.572AlaGly: 3.572 ± 0.596
0.893AlaHis: 0.893 ± 0.29
4.198AlaIle: 4.198 ± 0.831
6.252AlaLys: 6.252 ± 0.983
6.073AlaLeu: 6.073 ± 0.664
0.982AlaMet: 0.982 ± 0.303
4.465AlaAsn: 4.465 ± 0.797
1.518AlaPro: 1.518 ± 0.361
3.126AlaGln: 3.126 ± 0.474
2.411AlaArg: 2.411 ± 0.497
4.465AlaSer: 4.465 ± 0.766
4.376AlaThr: 4.376 ± 0.791
4.465AlaVal: 4.465 ± 0.522
0.893AlaTrp: 0.893 ± 0.23
2.322AlaTyr: 2.322 ± 0.515
0.0AlaXaa: 0.0 ± 0.0
Cys
0.179CysAla: 0.179 ± 0.116
0.0CysCys: 0.0 ± 0.0
0.714CysAsp: 0.714 ± 0.313
0.625CysGlu: 0.625 ± 0.278
0.536CysPhe: 0.536 ± 0.251
0.089CysGly: 0.089 ± 0.09
0.089CysHis: 0.089 ± 0.106
0.089CysIle: 0.089 ± 0.094
0.536CysLys: 0.536 ± 0.248
0.536CysLeu: 0.536 ± 0.258
0.089CysMet: 0.089 ± 0.087
0.179CysAsn: 0.179 ± 0.134
0.089CysPro: 0.089 ± 0.087
0.089CysGln: 0.089 ± 0.088
0.268CysArg: 0.268 ± 0.209
0.268CysSer: 0.268 ± 0.21
0.357CysThr: 0.357 ± 0.166
0.357CysVal: 0.357 ± 0.162
0.268CysTrp: 0.268 ± 0.154
0.268CysTyr: 0.268 ± 0.144
0.0CysXaa: 0.0 ± 0.0
Asp
3.572AspAla: 3.572 ± 0.537
0.536AspCys: 0.536 ± 0.225
4.019AspAsp: 4.019 ± 0.658
4.376AspGlu: 4.376 ± 0.618
3.662AspPhe: 3.662 ± 0.598
5.269AspGly: 5.269 ± 0.796
0.982AspHis: 0.982 ± 0.354
5.448AspIle: 5.448 ± 0.601
5.359AspLys: 5.359 ± 0.808
4.019AspLeu: 4.019 ± 0.812
2.59AspMet: 2.59 ± 0.433
4.733AspAsn: 4.733 ± 1.101
2.054AspPro: 2.054 ± 0.449
1.072AspGln: 1.072 ± 0.223
2.769AspArg: 2.769 ± 0.516
2.947AspSer: 2.947 ± 0.464
3.84AspThr: 3.84 ± 0.581
2.947AspVal: 2.947 ± 0.567
0.625AspTrp: 0.625 ± 0.227
2.322AspTyr: 2.322 ± 0.395
0.0AspXaa: 0.0 ± 0.0
Glu
4.733GluAla: 4.733 ± 0.583
0.268GluCys: 0.268 ± 0.127
3.93GluAsp: 3.93 ± 0.676
5.18GluGlu: 5.18 ± 1.175
2.143GluPhe: 2.143 ± 0.435
2.322GluGly: 2.322 ± 0.45
1.25GluHis: 1.25 ± 0.361
6.43GluIle: 6.43 ± 0.733
4.465GluLys: 4.465 ± 1.055
7.234GluLeu: 7.234 ± 1.091
2.411GluMet: 2.411 ± 0.547
4.376GluAsn: 4.376 ± 0.684
1.786GluPro: 1.786 ± 0.387
3.572GluGln: 3.572 ± 0.66
3.126GluArg: 3.126 ± 0.52
3.215GluSer: 3.215 ± 0.523
3.662GluThr: 3.662 ± 0.556
5.18GluVal: 5.18 ± 0.893
1.161GluTrp: 1.161 ± 0.232
3.483GluTyr: 3.483 ± 0.596
0.0GluXaa: 0.0 ± 0.0
Phe
2.858PheAla: 2.858 ± 0.486
0.089PheCys: 0.089 ± 0.104
3.572PheAsp: 3.572 ± 0.468
2.858PheGlu: 2.858 ± 0.759
1.518PhePhe: 1.518 ± 0.261
3.215PheGly: 3.215 ± 0.754
0.447PheHis: 0.447 ± 0.165
3.304PheIle: 3.304 ± 0.665
4.287PheLys: 4.287 ± 0.644
3.037PheLeu: 3.037 ± 0.407
0.536PheMet: 0.536 ± 0.254
2.947PheAsn: 2.947 ± 0.552
0.714PhePro: 0.714 ± 0.275
1.25PheGln: 1.25 ± 0.273
1.876PheArg: 1.876 ± 0.438
2.59PheSer: 2.59 ± 0.469
2.947PheThr: 2.947 ± 0.487
2.59PheVal: 2.59 ± 0.363
0.625PheTrp: 0.625 ± 0.288
2.233PheTyr: 2.233 ± 0.52
0.0PheXaa: 0.0 ± 0.0
Gly
2.858GlyAla: 2.858 ± 0.564
0.536GlyCys: 0.536 ± 0.226
3.84GlyAsp: 3.84 ± 0.607
4.198GlyGlu: 4.198 ± 0.594
3.037GlyPhe: 3.037 ± 0.579
4.198GlyGly: 4.198 ± 0.68
0.625GlyHis: 0.625 ± 0.249
4.733GlyIle: 4.733 ± 0.691
5.805GlyLys: 5.805 ± 0.793
5.894GlyLeu: 5.894 ± 0.802
1.608GlyMet: 1.608 ± 0.342
3.751GlyAsn: 3.751 ± 0.682
1.429GlyPro: 1.429 ± 0.364
2.947GlyGln: 2.947 ± 0.564
2.947GlyArg: 2.947 ± 0.441
4.108GlySer: 4.108 ± 0.537
4.376GlyThr: 4.376 ± 0.672
3.572GlyVal: 3.572 ± 0.737
0.982GlyTrp: 0.982 ± 0.333
2.947GlyTyr: 2.947 ± 0.625
0.0GlyXaa: 0.0 ± 0.0
His
0.625HisAla: 0.625 ± 0.259
0.089HisCys: 0.089 ± 0.092
0.804HisAsp: 0.804 ± 0.297
0.536HisGlu: 0.536 ± 0.27
0.714HisPhe: 0.714 ± 0.263
0.893HisGly: 0.893 ± 0.237
0.268HisHis: 0.268 ± 0.139
0.893HisIle: 0.893 ± 0.274
0.804HisLys: 0.804 ± 0.227
1.25HisLeu: 1.25 ± 0.272
0.536HisMet: 0.536 ± 0.244
1.072HisAsn: 1.072 ± 0.365
0.536HisPro: 0.536 ± 0.209
0.804HisGln: 0.804 ± 0.326
0.625HisArg: 0.625 ± 0.25
0.893HisSer: 0.893 ± 0.209
0.714HisThr: 0.714 ± 0.265
1.25HisVal: 1.25 ± 0.306
0.089HisTrp: 0.089 ± 0.098
0.982HisTyr: 0.982 ± 0.386
0.0HisXaa: 0.0 ± 0.0
Ile
4.555IleAla: 4.555 ± 1.022
0.357IleCys: 0.357 ± 0.158
4.376IleAsp: 4.376 ± 0.705
4.465IleGlu: 4.465 ± 0.892
1.876IlePhe: 1.876 ± 0.294
4.555IleGly: 4.555 ± 0.486
0.893IleHis: 0.893 ± 0.252
2.947IleIle: 2.947 ± 0.518
7.502IleLys: 7.502 ± 0.734
4.555IleLeu: 4.555 ± 0.838
1.786IleMet: 1.786 ± 0.511
4.376IleAsn: 4.376 ± 0.622
3.037IlePro: 3.037 ± 0.558
3.037IleGln: 3.037 ± 0.542
2.322IleArg: 2.322 ± 0.475
3.751IleSer: 3.751 ± 0.444
3.751IleThr: 3.751 ± 0.593
3.215IleVal: 3.215 ± 0.615
0.804IleTrp: 0.804 ± 0.231
2.411IleTyr: 2.411 ± 0.473
0.0IleXaa: 0.0 ± 0.0
Lys
6.341LysAla: 6.341 ± 0.793
0.268LysCys: 0.268 ± 0.164
4.912LysAsp: 4.912 ± 0.843
6.698LysGlu: 6.698 ± 1.025
3.662LysPhe: 3.662 ± 0.869
5.627LysGly: 5.627 ± 0.669
1.429LysHis: 1.429 ± 0.415
5.537LysIle: 5.537 ± 0.706
7.413LysLys: 7.413 ± 1.624
7.234LysLeu: 7.234 ± 0.775
2.233LysMet: 2.233 ± 0.48
5.537LysAsn: 5.537 ± 0.733
3.126LysPro: 3.126 ± 0.553
4.465LysGln: 4.465 ± 0.612
3.84LysArg: 3.84 ± 0.7
4.287LysSer: 4.287 ± 0.504
4.644LysThr: 4.644 ± 0.644
4.555LysVal: 4.555 ± 0.777
1.25LysTrp: 1.25 ± 0.328
3.215LysTyr: 3.215 ± 0.652
0.0LysXaa: 0.0 ± 0.0
Leu
6.966LeuAla: 6.966 ± 0.667
0.536LeuCys: 0.536 ± 0.308
5.269LeuAsp: 5.269 ± 0.697
7.77LeuGlu: 7.77 ± 1.019
2.947LeuPhe: 2.947 ± 0.302
5.627LeuGly: 5.627 ± 0.817
0.714LeuHis: 0.714 ± 0.32
3.662LeuIle: 3.662 ± 0.492
7.323LeuLys: 7.323 ± 0.862
5.716LeuLeu: 5.716 ± 0.755
2.411LeuMet: 2.411 ± 0.654
5.359LeuAsn: 5.359 ± 0.673
2.59LeuPro: 2.59 ± 0.396
2.233LeuGln: 2.233 ± 0.438
3.304LeuArg: 3.304 ± 0.634
5.448LeuSer: 5.448 ± 0.619
5.091LeuThr: 5.091 ± 0.7
4.555LeuVal: 4.555 ± 0.681
0.625LeuTrp: 0.625 ± 0.223
2.769LeuTyr: 2.769 ± 0.467
0.0LeuXaa: 0.0 ± 0.0
Met
1.429MetAla: 1.429 ± 0.324
0.0MetCys: 0.0 ± 0.0
1.161MetAsp: 1.161 ± 0.314
1.34MetGlu: 1.34 ± 0.358
1.518MetPhe: 1.518 ± 0.429
1.161MetGly: 1.161 ± 0.346
0.447MetHis: 0.447 ± 0.212
1.518MetIle: 1.518 ± 0.299
2.769MetLys: 2.769 ± 0.66
2.143MetLeu: 2.143 ± 0.341
0.804MetMet: 0.804 ± 0.343
1.25MetAsn: 1.25 ± 0.304
0.714MetPro: 0.714 ± 0.217
0.982MetGln: 0.982 ± 0.424
0.893MetArg: 0.893 ± 0.201
1.697MetSer: 1.697 ± 0.444
1.697MetThr: 1.697 ± 0.307
1.965MetVal: 1.965 ± 0.406
0.089MetTrp: 0.089 ± 0.074
1.25MetTyr: 1.25 ± 0.423
0.0MetXaa: 0.0 ± 0.0
Asn
4.555AsnAla: 4.555 ± 1.035
0.268AsnCys: 0.268 ± 0.153
3.483AsnAsp: 3.483 ± 0.547
4.019AsnGlu: 4.019 ± 0.818
2.858AsnPhe: 2.858 ± 0.446
6.877AsnGly: 6.877 ± 1.235
0.982AsnHis: 0.982 ± 0.247
4.198AsnIle: 4.198 ± 0.551
5.001AsnLys: 5.001 ± 0.687
5.716AsnLeu: 5.716 ± 0.674
0.893AsnMet: 0.893 ± 0.253
4.198AsnAsn: 4.198 ± 0.797
2.858AsnPro: 2.858 ± 0.659
3.126AsnGln: 3.126 ± 0.744
2.143AsnArg: 2.143 ± 0.558
4.733AsnSer: 4.733 ± 0.781
3.126AsnThr: 3.126 ± 0.439
3.483AsnVal: 3.483 ± 0.584
1.161AsnTrp: 1.161 ± 0.321
2.59AsnTyr: 2.59 ± 0.535
0.0AsnXaa: 0.0 ± 0.0
Pro
1.518ProAla: 1.518 ± 0.288
0.268ProCys: 0.268 ± 0.201
1.25ProAsp: 1.25 ± 0.373
1.876ProGlu: 1.876 ± 0.459
1.25ProPhe: 1.25 ± 0.337
0.982ProGly: 0.982 ± 0.344
0.536ProHis: 0.536 ± 0.217
1.518ProIle: 1.518 ± 0.314
3.215ProLys: 3.215 ± 0.474
2.322ProLeu: 2.322 ± 0.445
0.179ProMet: 0.179 ± 0.136
2.947ProAsn: 2.947 ± 0.43
0.536ProPro: 0.536 ± 0.223
1.965ProGln: 1.965 ± 0.3
1.161ProArg: 1.161 ± 0.357
2.501ProSer: 2.501 ± 0.366
1.876ProThr: 1.876 ± 0.396
1.25ProVal: 1.25 ± 0.381
0.447ProTrp: 0.447 ± 0.16
1.518ProTyr: 1.518 ± 0.498
0.0ProXaa: 0.0 ± 0.0
Gln
4.198GlnAla: 4.198 ± 0.571
0.268GlnCys: 0.268 ± 0.149
2.233GlnAsp: 2.233 ± 0.363
2.947GlnGlu: 2.947 ± 0.8
1.608GlnPhe: 1.608 ± 0.406
2.858GlnGly: 2.858 ± 0.511
0.536GlnHis: 0.536 ± 0.227
2.143GlnIle: 2.143 ± 0.487
3.394GlnLys: 3.394 ± 0.626
3.394GlnLeu: 3.394 ± 0.481
1.876GlnMet: 1.876 ± 0.322
2.679GlnAsn: 2.679 ± 0.406
0.357GlnPro: 0.357 ± 0.172
3.572GlnGln: 3.572 ± 0.803
1.697GlnArg: 1.697 ± 0.406
2.769GlnSer: 2.769 ± 0.564
2.858GlnThr: 2.858 ± 0.51
1.786GlnVal: 1.786 ± 0.467
0.893GlnTrp: 0.893 ± 0.262
1.786GlnTyr: 1.786 ± 0.331
0.0GlnXaa: 0.0 ± 0.0
Arg
2.322ArgAla: 2.322 ± 0.481
0.179ArgCys: 0.179 ± 0.135
2.322ArgAsp: 2.322 ± 0.554
2.501ArgGlu: 2.501 ± 0.591
1.965ArgPhe: 1.965 ± 0.369
2.054ArgGly: 2.054 ± 0.565
0.714ArgHis: 0.714 ± 0.241
2.947ArgIle: 2.947 ± 0.478
2.947ArgLys: 2.947 ± 0.636
3.572ArgLeu: 3.572 ± 0.495
1.072ArgMet: 1.072 ± 0.34
2.233ArgAsn: 2.233 ± 0.375
0.804ArgPro: 0.804 ± 0.216
2.858ArgGln: 2.858 ± 0.521
1.25ArgArg: 1.25 ± 0.304
1.876ArgSer: 1.876 ± 0.397
2.59ArgThr: 2.59 ± 0.626
3.126ArgVal: 3.126 ± 0.504
0.893ArgTrp: 0.893 ± 0.276
2.411ArgTyr: 2.411 ± 0.543
0.0ArgXaa: 0.0 ± 0.0
Ser
3.84SerAla: 3.84 ± 0.461
0.536SerCys: 0.536 ± 0.258
4.376SerAsp: 4.376 ± 0.496
3.572SerGlu: 3.572 ± 0.594
2.947SerPhe: 2.947 ± 0.506
4.465SerGly: 4.465 ± 0.57
0.625SerHis: 0.625 ± 0.272
4.108SerIle: 4.108 ± 0.576
5.359SerLys: 5.359 ± 0.835
4.465SerLeu: 4.465 ± 0.678
1.697SerMet: 1.697 ± 0.35
4.465SerAsn: 4.465 ± 0.677
2.143SerPro: 2.143 ± 0.396
2.143SerGln: 2.143 ± 0.395
3.304SerArg: 3.304 ± 0.567
3.572SerSer: 3.572 ± 0.59
3.572SerThr: 3.572 ± 0.642
4.644SerVal: 4.644 ± 0.604
0.447SerTrp: 0.447 ± 0.224
2.054SerTyr: 2.054 ± 0.407
0.0SerXaa: 0.0 ± 0.0
Thr
4.644ThrAla: 4.644 ± 0.73
0.268ThrCys: 0.268 ± 0.155
4.108ThrAsp: 4.108 ± 0.737
4.108ThrGlu: 4.108 ± 0.535
2.679ThrPhe: 2.679 ± 0.558
3.394ThrGly: 3.394 ± 0.501
0.893ThrHis: 0.893 ± 0.303
4.198ThrIle: 4.198 ± 0.609
4.912ThrLys: 4.912 ± 0.653
6.252ThrLeu: 6.252 ± 0.742
0.625ThrMet: 0.625 ± 0.248
4.376ThrAsn: 4.376 ± 0.69
1.608ThrPro: 1.608 ± 0.457
1.965ThrGln: 1.965 ± 0.477
2.233ThrArg: 2.233 ± 0.393
4.019ThrSer: 4.019 ± 0.467
2.679ThrThr: 2.679 ± 0.407
3.483ThrVal: 3.483 ± 0.577
0.625ThrTrp: 0.625 ± 0.27
2.947ThrTyr: 2.947 ± 0.601
0.0ThrXaa: 0.0 ± 0.0
Val
3.662ValAla: 3.662 ± 0.685
0.357ValCys: 0.357 ± 0.179
4.644ValAsp: 4.644 ± 0.577
4.912ValGlu: 4.912 ± 0.739
2.233ValPhe: 2.233 ± 0.4
4.019ValGly: 4.019 ± 0.63
0.982ValHis: 0.982 ± 0.347
3.394ValIle: 3.394 ± 0.374
5.269ValLys: 5.269 ± 0.589
2.769ValLeu: 2.769 ± 0.64
1.161ValMet: 1.161 ± 0.351
4.376ValAsn: 4.376 ± 0.677
1.786ValPro: 1.786 ± 0.347
1.876ValGln: 1.876 ± 0.527
2.054ValArg: 2.054 ± 0.496
4.733ValSer: 4.733 ± 0.681
5.001ValThr: 5.001 ± 0.817
3.483ValVal: 3.483 ± 0.62
1.072ValTrp: 1.072 ± 0.306
2.054ValTyr: 2.054 ± 0.483
0.0ValXaa: 0.0 ± 0.0
Trp
0.447TrpAla: 0.447 ± 0.187
0.0TrpCys: 0.0 ± 0.0
0.893TrpAsp: 0.893 ± 0.421
0.714TrpGlu: 0.714 ± 0.226
0.625TrpPhe: 0.625 ± 0.208
0.982TrpGly: 0.982 ± 0.39
0.357TrpHis: 0.357 ± 0.162
0.714TrpIle: 0.714 ± 0.237
0.625TrpLys: 0.625 ± 0.305
1.25TrpLeu: 1.25 ± 0.316
0.089TrpMet: 0.089 ± 0.098
0.804TrpAsn: 0.804 ± 0.325
0.179TrpPro: 0.179 ± 0.123
0.625TrpGln: 0.625 ± 0.213
0.714TrpArg: 0.714 ± 0.221
1.608TrpSer: 1.608 ± 0.498
0.714TrpThr: 0.714 ± 0.242
1.34TrpVal: 1.34 ± 0.252
0.357TrpTrp: 0.357 ± 0.192
0.447TrpTyr: 0.447 ± 0.188
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.679TyrAla: 2.679 ± 0.529
0.625TyrCys: 0.625 ± 0.3
2.947TyrAsp: 2.947 ± 0.524
2.858TyrGlu: 2.858 ± 0.553
2.679TyrPhe: 2.679 ± 0.555
2.233TyrGly: 2.233 ± 0.481
0.714TyrHis: 0.714 ± 0.228
2.59TyrIle: 2.59 ± 0.497
3.037TyrLys: 3.037 ± 0.516
3.483TyrLeu: 3.483 ± 0.445
1.161TyrMet: 1.161 ± 0.413
2.143TyrAsn: 2.143 ± 0.406
1.25TyrPro: 1.25 ± 0.325
2.143TyrGln: 2.143 ± 0.395
1.697TyrArg: 1.697 ± 0.293
2.858TyrSer: 2.858 ± 0.632
2.143TyrThr: 2.143 ± 0.462
2.59TyrVal: 2.59 ± 0.417
0.179TyrTrp: 0.179 ± 0.114
2.054TyrTyr: 2.054 ± 0.661
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 50 proteins (11198 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski