Amino acid dipepetide frequency for Campylobacter virus CPX

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.201AlaAla: 1.201 ± 0.206
0.434AlaCys: 0.434 ± 0.092
2.019AlaAsp: 2.019 ± 0.22
1.942AlaGlu: 1.942 ± 0.261
1.661AlaPhe: 1.661 ± 0.22
1.687AlaGly: 1.687 ± 0.265
0.409AlaHis: 0.409 ± 0.087
3.22AlaIle: 3.22 ± 0.267
3.169AlaLys: 3.169 ± 0.327
3.373AlaLeu: 3.373 ± 0.348
0.869AlaMet: 0.869 ± 0.181
2.632AlaAsn: 2.632 ± 0.297
0.869AlaPro: 0.869 ± 0.144
0.869AlaGln: 0.869 ± 0.17
1.252AlaArg: 1.252 ± 0.167
2.3AlaSer: 2.3 ± 0.241
1.942AlaThr: 1.942 ± 0.329
1.968AlaVal: 1.968 ± 0.285
0.23AlaTrp: 0.23 ± 0.077
1.61AlaTyr: 1.61 ± 0.175
0.0AlaXaa: 0.0 ± 0.0
Cys
0.486CysAla: 0.486 ± 0.105
0.204CysCys: 0.204 ± 0.083
1.124CysAsp: 1.124 ± 0.184
1.099CysGlu: 1.099 ± 0.218
0.486CysPhe: 0.486 ± 0.109
1.099CysGly: 1.099 ± 0.164
0.077CysHis: 0.077 ± 0.044
1.431CysIle: 1.431 ± 0.184
1.993CysLys: 1.993 ± 0.265
1.227CysLeu: 1.227 ± 0.198
0.256CysMet: 0.256 ± 0.078
1.917CysAsn: 1.917 ± 0.294
1.201CysPro: 1.201 ± 0.302
0.307CysGln: 0.307 ± 0.11
0.46CysArg: 0.46 ± 0.101
0.945CysSer: 0.945 ± 0.155
0.69CysThr: 0.69 ± 0.145
0.997CysVal: 0.997 ± 0.179
0.026CysTrp: 0.026 ± 0.025
1.124CysTyr: 1.124 ± 0.207
0.0CysXaa: 0.0 ± 0.0
Asp
2.019AspAla: 2.019 ± 0.268
0.767AspCys: 0.767 ± 0.123
5.494AspAsp: 5.494 ± 0.608
5.392AspGlu: 5.392 ± 0.408
4.063AspPhe: 4.063 ± 0.332
2.913AspGly: 2.913 ± 0.282
0.511AspHis: 0.511 ± 0.13
7.411AspIle: 7.411 ± 0.446
6.133AspLys: 6.133 ± 0.477
5.545AspLeu: 5.545 ± 0.49
1.227AspMet: 1.227 ± 0.177
5.826AspAsn: 5.826 ± 0.44
1.559AspPro: 1.559 ± 0.231
1.048AspGln: 1.048 ± 0.189
1.712AspArg: 1.712 ± 0.198
3.424AspSer: 3.424 ± 0.325
2.479AspThr: 2.479 ± 0.241
3.066AspVal: 3.066 ± 0.32
0.562AspTrp: 0.562 ± 0.115
3.578AspTyr: 3.578 ± 0.296
0.0AspXaa: 0.0 ± 0.0
Glu
2.325GluAla: 2.325 ± 0.254
1.329GluCys: 1.329 ± 0.235
3.194GluAsp: 3.194 ± 0.36
3.629GluGlu: 3.629 ± 0.36
3.782GluPhe: 3.782 ± 0.328
2.223GluGly: 2.223 ± 0.282
0.971GluHis: 0.971 ± 0.151
6.772GluIle: 6.772 ± 0.472
7.283GluLys: 7.283 ± 0.491
7.641GluLeu: 7.641 ± 0.484
1.227GluMet: 1.227 ± 0.174
6.235GluAsn: 6.235 ± 0.448
1.329GluPro: 1.329 ± 0.256
1.457GluGln: 1.457 ± 0.186
1.687GluArg: 1.687 ± 0.236
4.702GluSer: 4.702 ± 0.342
3.169GluThr: 3.169 ± 0.321
4.165GluVal: 4.165 ± 0.371
0.639GluTrp: 0.639 ± 0.116
4.446GluTyr: 4.446 ± 0.355
0.0GluXaa: 0.0 ± 0.0
Phe
1.712PheAla: 1.712 ± 0.213
0.818PheCys: 0.818 ± 0.169
4.063PheAsp: 4.063 ± 0.369
3.935PheGlu: 3.935 ± 0.329
1.814PhePhe: 1.814 ± 0.224
2.274PheGly: 2.274 ± 0.258
0.69PheHis: 0.69 ± 0.127
4.114PheIle: 4.114 ± 0.341
6.363PheLys: 6.363 ± 0.5
3.68PheLeu: 3.68 ± 0.335
1.227PheMet: 1.227 ± 0.196
3.961PheAsn: 3.961 ± 0.332
0.971PhePro: 0.971 ± 0.177
1.124PheGln: 1.124 ± 0.157
1.38PheArg: 1.38 ± 0.195
3.552PheSer: 3.552 ± 0.313
3.169PheThr: 3.169 ± 0.352
2.377PheVal: 2.377 ± 0.215
0.256PheTrp: 0.256 ± 0.084
2.377PheTyr: 2.377 ± 0.27
0.0PheXaa: 0.0 ± 0.0
Gly
2.095GlyAla: 2.095 ± 0.292
0.741GlyCys: 0.741 ± 0.129
3.348GlyAsp: 3.348 ± 0.319
2.147GlyGlu: 2.147 ± 0.259
2.913GlyPhe: 2.913 ± 0.306
2.249GlyGly: 2.249 ± 0.314
1.457GlyHis: 1.457 ± 0.377
4.574GlyIle: 4.574 ± 0.39
4.574GlyLys: 4.574 ± 0.333
3.603GlyLeu: 3.603 ± 0.327
1.022GlyMet: 1.022 ± 0.151
4.14GlyAsn: 4.14 ± 0.34
0.46GlyPro: 0.46 ± 0.101
1.278GlyGln: 1.278 ± 0.183
1.431GlyArg: 1.431 ± 0.214
4.242GlySer: 4.242 ± 0.384
2.734GlyThr: 2.734 ± 0.297
2.581GlyVal: 2.581 ± 0.216
0.204GlyTrp: 0.204 ± 0.074
3.296GlyTyr: 3.296 ± 0.401
0.0GlyXaa: 0.0 ± 0.0
His
0.434HisAla: 0.434 ± 0.119
0.179HisCys: 0.179 ± 0.068
0.869HisAsp: 0.869 ± 0.141
0.664HisGlu: 0.664 ± 0.152
0.843HisPhe: 0.843 ± 0.166
0.69HisGly: 0.69 ± 0.136
0.23HisHis: 0.23 ± 0.081
1.814HisIle: 1.814 ± 0.278
1.635HisLys: 1.635 ± 0.217
1.635HisLeu: 1.635 ± 0.232
0.281HisMet: 0.281 ± 0.08
1.175HisAsn: 1.175 ± 0.166
0.332HisPro: 0.332 ± 0.098
0.23HisGln: 0.23 ± 0.08
0.281HisArg: 0.281 ± 0.087
0.971HisSer: 0.971 ± 0.188
0.92HisThr: 0.92 ± 0.181
0.869HisVal: 0.869 ± 0.196
0.128HisTrp: 0.128 ± 0.056
0.945HisTyr: 0.945 ± 0.144
0.0HisXaa: 0.0 ± 0.0
Ile
2.53IleAla: 2.53 ± 0.233
1.687IleCys: 1.687 ± 0.264
6.746IleAsp: 6.746 ± 0.416
6.363IleGlu: 6.363 ± 0.341
3.935IlePhe: 3.935 ± 0.304
3.603IleGly: 3.603 ± 0.323
1.201IleHis: 1.201 ± 0.219
7.998IleIle: 7.998 ± 0.482
10.324IleLys: 10.324 ± 0.577
8.075IleLeu: 8.075 ± 0.485
2.095IleMet: 2.095 ± 0.195
8.637IleAsn: 8.637 ± 0.464
3.143IlePro: 3.143 ± 0.316
2.964IleGln: 2.964 ± 0.281
2.325IleArg: 2.325 ± 0.197
6.772IleSer: 6.772 ± 0.351
5.775IleThr: 5.775 ± 0.401
4.574IleVal: 4.574 ± 0.365
0.894IleTrp: 0.894 ± 0.156
3.731IleTyr: 3.731 ± 0.319
0.0IleXaa: 0.0 ± 0.0
Lys
3.015LysAla: 3.015 ± 0.334
2.351LysCys: 2.351 ± 0.532
6.951LysAsp: 6.951 ± 0.448
7.922LysGlu: 7.922 ± 0.591
4.6LysPhe: 4.6 ± 0.377
4.676LysGly: 4.676 ± 0.412
2.07LysHis: 2.07 ± 0.256
8.791LysIle: 8.791 ± 0.493
7.641LysLys: 7.641 ± 0.484
9.327LysLeu: 9.327 ± 0.415
2.198LysMet: 2.198 ± 0.25
9.506LysAsn: 9.506 ± 0.559
2.555LysPro: 2.555 ± 0.279
3.399LysGln: 3.399 ± 0.353
2.709LysArg: 2.709 ± 0.29
5.954LysSer: 5.954 ± 0.367
5.366LysThr: 5.366 ± 0.441
4.906LysVal: 4.906 ± 0.329
1.022LysTrp: 1.022 ± 0.185
6.133LysTyr: 6.133 ± 0.436
0.0LysXaa: 0.0 ± 0.0
Leu
3.092LeuAla: 3.092 ± 0.304
1.917LeuCys: 1.917 ± 0.242
5.903LeuAsp: 5.903 ± 0.42
7.002LeuGlu: 7.002 ± 0.568
3.143LeuPhe: 3.143 ± 0.32
5.06LeuGly: 5.06 ± 0.5
1.431LeuHis: 1.431 ± 0.194
6.388LeuIle: 6.388 ± 0.395
10.043LeuLys: 10.043 ± 0.581
7.871LeuLeu: 7.871 ± 0.602
2.223LeuMet: 2.223 ± 0.231
7.206LeuAsn: 7.206 ± 0.376
3.143LeuPro: 3.143 ± 0.271
2.888LeuGln: 2.888 ± 0.282
2.223LeuArg: 2.223 ± 0.212
6.133LeuSer: 6.133 ± 0.385
3.91LeuThr: 3.91 ± 0.369
3.526LeuVal: 3.526 ± 0.296
0.486LeuTrp: 0.486 ± 0.1
4.319LeuTyr: 4.319 ± 0.336
0.0LeuXaa: 0.0 ± 0.0
Met
1.354MetAla: 1.354 ± 0.171
0.613MetCys: 0.613 ± 0.122
1.175MetAsp: 1.175 ± 0.147
1.38MetGlu: 1.38 ± 0.185
1.431MetPhe: 1.431 ± 0.195
1.048MetGly: 1.048 ± 0.134
0.23MetHis: 0.23 ± 0.079
1.303MetIle: 1.303 ± 0.166
2.504MetLys: 2.504 ± 0.246
2.223MetLeu: 2.223 ± 0.265
0.256MetMet: 0.256 ± 0.082
1.635MetAsn: 1.635 ± 0.193
0.562MetPro: 0.562 ± 0.137
0.511MetGln: 0.511 ± 0.116
0.537MetArg: 0.537 ± 0.127
1.584MetSer: 1.584 ± 0.201
0.716MetThr: 0.716 ± 0.135
0.894MetVal: 0.894 ± 0.165
0.23MetTrp: 0.23 ± 0.076
1.048MetTyr: 1.048 ± 0.147
0.0MetXaa: 0.0 ± 0.0
Asn
2.325AsnAla: 2.325 ± 0.264
1.508AsnCys: 1.508 ± 0.205
4.395AsnAsp: 4.395 ± 0.395
5.596AsnGlu: 5.596 ± 0.45
4.165AsnPhe: 4.165 ± 0.315
5.494AsnGly: 5.494 ± 0.398
1.457AsnHis: 1.457 ± 0.197
11.065AsnIle: 11.065 ± 0.686
8.918AsnLys: 8.918 ± 0.432
7.181AsnLeu: 7.181 ± 0.437
2.019AsnMet: 2.019 ± 0.234
7.411AsnAsn: 7.411 ± 0.519
2.095AsnPro: 2.095 ± 0.276
2.172AsnGln: 2.172 ± 0.241
2.07AsnArg: 2.07 ± 0.3
5.315AsnSer: 5.315 ± 0.345
4.216AsnThr: 4.216 ± 0.42
4.242AsnVal: 4.242 ± 0.285
0.46AsnTrp: 0.46 ± 0.112
4.293AsnTyr: 4.293 ± 0.341
0.0AsnXaa: 0.0 ± 0.0
Pro
0.613ProAla: 0.613 ± 0.112
0.23ProCys: 0.23 ± 0.078
1.712ProAsp: 1.712 ± 0.238
1.942ProGlu: 1.942 ± 0.237
1.329ProPhe: 1.329 ± 0.202
1.38ProGly: 1.38 ± 0.184
0.383ProHis: 0.383 ± 0.103
2.734ProIle: 2.734 ± 0.252
2.709ProLys: 2.709 ± 0.295
2.07ProLeu: 2.07 ± 0.272
0.409ProMet: 0.409 ± 0.108
2.402ProAsn: 2.402 ± 0.323
0.69ProPro: 0.69 ± 0.162
0.716ProGln: 0.716 ± 0.151
0.639ProArg: 0.639 ± 0.13
2.555ProSer: 2.555 ± 0.328
1.533ProThr: 1.533 ± 0.207
1.227ProVal: 1.227 ± 0.195
0.179ProTrp: 0.179 ± 0.063
1.405ProTyr: 1.405 ± 0.196
0.0ProXaa: 0.0 ± 0.0
Gln
1.252GlnAla: 1.252 ± 0.215
0.434GlnCys: 0.434 ± 0.116
1.278GlnAsp: 1.278 ± 0.22
1.942GlnGlu: 1.942 ± 0.235
1.38GlnPhe: 1.38 ± 0.185
1.559GlnGly: 1.559 ± 0.234
0.307GlnHis: 0.307 ± 0.103
1.942GlnIle: 1.942 ± 0.241
2.325GlnLys: 2.325 ± 0.244
2.99GlnLeu: 2.99 ± 0.26
0.613GlnMet: 0.613 ± 0.112
2.095GlnAsn: 2.095 ± 0.202
0.69GlnPro: 0.69 ± 0.141
1.278GlnGln: 1.278 ± 0.201
0.767GlnArg: 0.767 ± 0.128
1.457GlnSer: 1.457 ± 0.175
1.278GlnThr: 1.278 ± 0.202
1.354GlnVal: 1.354 ± 0.192
0.179GlnTrp: 0.179 ± 0.055
1.508GlnTyr: 1.508 ± 0.207
0.0GlnXaa: 0.0 ± 0.0
Arg
1.022ArgAla: 1.022 ± 0.173
0.358ArgCys: 0.358 ± 0.108
1.559ArgAsp: 1.559 ± 0.18
1.84ArgGlu: 1.84 ± 0.208
1.38ArgPhe: 1.38 ± 0.166
1.252ArgGly: 1.252 ± 0.169
0.307ArgHis: 0.307 ± 0.092
2.095ArgIle: 2.095 ± 0.232
2.836ArgLys: 2.836 ± 0.293
2.428ArgLeu: 2.428 ± 0.269
0.46ArgMet: 0.46 ± 0.1
1.968ArgAsn: 1.968 ± 0.217
0.511ArgPro: 0.511 ± 0.143
0.997ArgGln: 0.997 ± 0.139
0.792ArgArg: 0.792 ± 0.165
1.559ArgSer: 1.559 ± 0.186
1.635ArgThr: 1.635 ± 0.219
1.508ArgVal: 1.508 ± 0.175
0.23ArgTrp: 0.23 ± 0.081
1.38ArgTyr: 1.38 ± 0.187
0.0ArgXaa: 0.0 ± 0.0
Ser
2.274SerAla: 2.274 ± 0.236
0.588SerCys: 0.588 ± 0.143
4.6SerAsp: 4.6 ± 0.361
4.165SerGlu: 4.165 ± 0.289
4.191SerPhe: 4.191 ± 0.34
3.654SerGly: 3.654 ± 0.403
1.099SerHis: 1.099 ± 0.165
6.772SerIle: 6.772 ± 0.391
6.797SerLys: 6.797 ± 0.373
6.695SerLeu: 6.695 ± 0.408
1.533SerMet: 1.533 ± 0.214
5.724SerAsn: 5.724 ± 0.379
1.482SerPro: 1.482 ± 0.206
1.61SerGln: 1.61 ± 0.204
1.687SerArg: 1.687 ± 0.255
4.906SerSer: 4.906 ± 0.49
3.348SerThr: 3.348 ± 0.309
3.45SerVal: 3.45 ± 0.373
0.664SerTrp: 0.664 ± 0.15
3.424SerTyr: 3.424 ± 0.318
0.0SerXaa: 0.0 ± 0.0
Thr
1.584ThrAla: 1.584 ± 0.201
0.869ThrCys: 0.869 ± 0.149
3.22ThrAsp: 3.22 ± 0.332
3.629ThrGlu: 3.629 ± 0.301
2.862ThrPhe: 2.862 ± 0.276
2.785ThrGly: 2.785 ± 0.303
0.613ThrHis: 0.613 ± 0.114
4.727ThrIle: 4.727 ± 0.433
4.293ThrLys: 4.293 ± 0.387
4.293ThrLeu: 4.293 ± 0.351
0.741ThrMet: 0.741 ± 0.141
4.293ThrAsn: 4.293 ± 0.33
2.453ThrPro: 2.453 ± 0.259
1.584ThrGln: 1.584 ± 0.27
1.354ThrArg: 1.354 ± 0.165
3.092ThrSer: 3.092 ± 0.277
2.683ThrThr: 2.683 ± 0.292
3.169ThrVal: 3.169 ± 0.341
0.46ThrTrp: 0.46 ± 0.1
2.836ThrTyr: 2.836 ± 0.313
0.0ThrXaa: 0.0 ± 0.0
Val
2.172ValAla: 2.172 ± 0.25
0.92ValCys: 0.92 ± 0.189
2.862ValAsp: 2.862 ± 0.357
3.629ValGlu: 3.629 ± 0.295
2.785ValPhe: 2.785 ± 0.289
2.606ValGly: 2.606 ± 0.263
0.486ValHis: 0.486 ± 0.115
4.651ValIle: 4.651 ± 0.346
5.699ValLys: 5.699 ± 0.357
3.68ValLeu: 3.68 ± 0.361
0.894ValMet: 0.894 ± 0.152
3.68ValAsn: 3.68 ± 0.344
1.303ValPro: 1.303 ± 0.182
0.843ValGln: 0.843 ± 0.129
1.252ValArg: 1.252 ± 0.16
4.191ValSer: 4.191 ± 0.379
2.913ValThr: 2.913 ± 0.297
3.169ValVal: 3.169 ± 0.279
0.562ValTrp: 0.562 ± 0.13
2.632ValTyr: 2.632 ± 0.264
0.0ValXaa: 0.0 ± 0.0
Trp
0.332TrpAla: 0.332 ± 0.097
0.204TrpCys: 0.204 ± 0.078
0.664TrpAsp: 0.664 ± 0.131
0.843TrpGlu: 0.843 ± 0.143
0.256TrpPhe: 0.256 ± 0.073
0.383TrpGly: 0.383 ± 0.087
0.332TrpHis: 0.332 ± 0.087
0.613TrpIle: 0.613 ± 0.138
0.511TrpLys: 0.511 ± 0.105
0.537TrpLeu: 0.537 ± 0.117
0.23TrpMet: 0.23 ± 0.079
0.716TrpAsn: 0.716 ± 0.147
0.026TrpPro: 0.026 ± 0.027
0.153TrpGln: 0.153 ± 0.062
0.204TrpArg: 0.204 ± 0.059
0.511TrpSer: 0.511 ± 0.107
0.358TrpThr: 0.358 ± 0.085
0.537TrpVal: 0.537 ± 0.117
0.051TrpTrp: 0.051 ± 0.037
0.486TrpTyr: 0.486 ± 0.114
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.814TyrAla: 1.814 ± 0.238
0.997TyrCys: 0.997 ± 0.148
3.552TyrAsp: 3.552 ± 0.311
3.143TyrGlu: 3.143 ± 0.338
2.836TyrPhe: 2.836 ± 0.271
2.453TyrGly: 2.453 ± 0.255
0.869TyrHis: 0.869 ± 0.174
4.957TyrIle: 4.957 ± 0.38
5.341TyrLys: 5.341 ± 0.269
3.859TyrLeu: 3.859 ± 0.294
1.431TyrMet: 1.431 ± 0.159
5.239TyrAsn: 5.239 ± 0.406
1.482TyrPro: 1.482 ± 0.196
1.201TyrGln: 1.201 ± 0.165
1.354TyrArg: 1.354 ± 0.145
4.497TyrSer: 4.497 ± 0.434
2.709TyrThr: 2.709 ± 0.297
2.351TyrVal: 2.351 ± 0.253
0.486TyrTrp: 0.486 ± 0.103
2.939TyrTyr: 2.939 ± 0.265
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 149 proteins (39134 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski