Amino acid dipepetide frequency for Escherichia virus LS3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.072AlaAla: 9.072 ± 1.2
0.84AlaCys: 0.84 ± 0.324
5.292AlaAsp: 5.292 ± 0.773
5.628AlaGlu: 5.628 ± 0.872
2.856AlaPhe: 2.856 ± 0.389
7.392AlaGly: 7.392 ± 1.004
1.092AlaHis: 1.092 ± 0.308
5.544AlaIle: 5.544 ± 0.618
6.636AlaLys: 6.636 ± 0.727
7.14AlaLeu: 7.14 ± 0.956
2.184AlaMet: 2.184 ± 0.471
3.192AlaAsn: 3.192 ± 0.391
2.268AlaPro: 2.268 ± 0.579
2.52AlaGln: 2.52 ± 0.472
4.116AlaArg: 4.116 ± 0.549
5.376AlaSer: 5.376 ± 0.639
4.116AlaThr: 4.116 ± 0.668
5.796AlaVal: 5.796 ± 1.023
1.512AlaTrp: 1.512 ± 0.4
2.352AlaTyr: 2.352 ± 0.502
0.0AlaXaa: 0.0 ± 0.0
Cys
0.504CysAla: 0.504 ± 0.181
0.168CysCys: 0.168 ± 0.123
0.588CysAsp: 0.588 ± 0.306
0.504CysGlu: 0.504 ± 0.241
0.42CysPhe: 0.42 ± 0.184
0.504CysGly: 0.504 ± 0.226
0.42CysHis: 0.42 ± 0.172
0.336CysIle: 0.336 ± 0.201
0.672CysLys: 0.672 ± 0.281
1.092CysLeu: 1.092 ± 0.278
0.42CysMet: 0.42 ± 0.253
0.252CysAsn: 0.252 ± 0.153
0.504CysPro: 0.504 ± 0.198
0.336CysGln: 0.336 ± 0.151
0.504CysArg: 0.504 ± 0.21
0.42CysSer: 0.42 ± 0.229
0.252CysThr: 0.252 ± 0.136
0.756CysVal: 0.756 ± 0.251
0.168CysTrp: 0.168 ± 0.101
0.336CysTyr: 0.336 ± 0.213
0.0CysXaa: 0.0 ± 0.0
Asp
6.552AspAla: 6.552 ± 0.738
0.42AspCys: 0.42 ± 0.25
3.948AspAsp: 3.948 ± 0.75
4.2AspGlu: 4.2 ± 0.535
1.932AspPhe: 1.932 ± 0.371
6.636AspGly: 6.636 ± 0.579
1.26AspHis: 1.26 ± 0.363
3.276AspIle: 3.276 ± 0.505
3.024AspLys: 3.024 ± 0.601
5.796AspLeu: 5.796 ± 0.659
1.932AspMet: 1.932 ± 0.349
2.52AspAsn: 2.52 ± 0.456
2.52AspPro: 2.52 ± 0.529
2.268AspGln: 2.268 ± 0.452
2.016AspArg: 2.016 ± 0.384
3.612AspSer: 3.612 ± 0.327
3.696AspThr: 3.696 ± 0.659
4.284AspVal: 4.284 ± 0.626
1.092AspTrp: 1.092 ± 0.331
2.856AspTyr: 2.856 ± 0.771
0.0AspXaa: 0.0 ± 0.0
Glu
6.888GluAla: 6.888 ± 0.947
0.42GluCys: 0.42 ± 0.24
5.292GluAsp: 5.292 ± 0.862
4.704GluGlu: 4.704 ± 0.857
2.856GluPhe: 2.856 ± 0.576
4.032GluGly: 4.032 ± 0.701
1.092GluHis: 1.092 ± 0.265
2.772GluIle: 2.772 ± 0.496
2.856GluLys: 2.856 ± 0.448
5.712GluLeu: 5.712 ± 0.676
2.268GluMet: 2.268 ± 0.45
2.1GluAsn: 2.1 ± 0.446
2.016GluPro: 2.016 ± 0.457
2.94GluGln: 2.94 ± 0.488
4.284GluArg: 4.284 ± 0.558
3.276GluSer: 3.276 ± 0.583
3.528GluThr: 3.528 ± 0.351
4.452GluVal: 4.452 ± 0.675
0.924GluTrp: 0.924 ± 0.214
2.94GluTyr: 2.94 ± 0.494
0.0GluXaa: 0.0 ± 0.0
Phe
2.604PheAla: 2.604 ± 0.395
0.504PheCys: 0.504 ± 0.259
3.276PheAsp: 3.276 ± 0.488
1.512PheGlu: 1.512 ± 0.312
1.092PhePhe: 1.092 ± 0.325
2.1PheGly: 2.1 ± 0.513
0.84PheHis: 0.84 ± 0.25
1.848PheIle: 1.848 ± 0.449
2.436PheLys: 2.436 ± 0.51
3.276PheLeu: 3.276 ± 0.381
1.008PheMet: 1.008 ± 0.346
2.352PheAsn: 2.352 ± 0.412
1.344PhePro: 1.344 ± 0.333
0.756PheGln: 0.756 ± 0.312
1.848PheArg: 1.848 ± 0.356
2.268PheSer: 2.268 ± 0.353
2.1PheThr: 2.1 ± 0.369
2.604PheVal: 2.604 ± 0.416
0.42PheTrp: 0.42 ± 0.184
0.924PheTyr: 0.924 ± 0.213
0.0PheXaa: 0.0 ± 0.0
Gly
5.376GlyAla: 5.376 ± 0.75
0.588GlyCys: 0.588 ± 0.253
4.956GlyAsp: 4.956 ± 0.844
5.124GlyGlu: 5.124 ± 0.635
2.268GlyPhe: 2.268 ± 0.442
5.544GlyGly: 5.544 ± 0.671
1.092GlyHis: 1.092 ± 0.318
3.444GlyIle: 3.444 ± 0.609
4.62GlyLys: 4.62 ± 0.748
6.384GlyLeu: 6.384 ± 0.825
2.856GlyMet: 2.856 ± 0.518
3.192GlyAsn: 3.192 ± 0.794
1.428GlyPro: 1.428 ± 0.54
2.604GlyGln: 2.604 ± 0.402
5.88GlyArg: 5.88 ± 0.631
6.048GlySer: 6.048 ± 0.716
4.704GlyThr: 4.704 ± 0.627
5.46GlyVal: 5.46 ± 0.712
1.344GlyTrp: 1.344 ± 0.339
3.36GlyTyr: 3.36 ± 0.496
0.0GlyXaa: 0.0 ± 0.0
His
0.756HisAla: 0.756 ± 0.264
0.336HisCys: 0.336 ± 0.179
1.512HisAsp: 1.512 ± 0.496
1.344HisGlu: 1.344 ± 0.429
0.336HisPhe: 0.336 ± 0.226
0.924HisGly: 0.924 ± 0.269
0.42HisHis: 0.42 ± 0.173
1.008HisIle: 1.008 ± 0.266
1.176HisLys: 1.176 ± 0.276
2.436HisLeu: 2.436 ± 0.435
0.588HisMet: 0.588 ± 0.197
0.588HisAsn: 0.588 ± 0.205
0.42HisPro: 0.42 ± 0.166
0.672HisGln: 0.672 ± 0.296
1.092HisArg: 1.092 ± 0.393
1.344HisSer: 1.344 ± 0.336
1.176HisThr: 1.176 ± 0.264
1.176HisVal: 1.176 ± 0.253
0.252HisTrp: 0.252 ± 0.124
0.672HisTyr: 0.672 ± 0.257
0.0HisXaa: 0.0 ± 0.0
Ile
4.284IleAla: 4.284 ± 0.841
0.588IleCys: 0.588 ± 0.246
2.856IleAsp: 2.856 ± 0.443
3.276IleGlu: 3.276 ± 0.41
1.092IlePhe: 1.092 ± 0.276
4.116IleGly: 4.116 ± 0.579
1.512IleHis: 1.512 ± 0.439
2.268IleIle: 2.268 ± 0.542
3.696IleLys: 3.696 ± 0.55
2.856IleLeu: 2.856 ± 0.423
0.756IleMet: 0.756 ± 0.206
2.772IleAsn: 2.772 ± 0.453
2.184IlePro: 2.184 ± 0.513
1.764IleGln: 1.764 ± 0.517
2.688IleArg: 2.688 ± 0.41
2.772IleSer: 2.772 ± 0.578
3.36IleThr: 3.36 ± 0.479
4.536IleVal: 4.536 ± 0.408
0.924IleTrp: 0.924 ± 0.293
1.092IleTyr: 1.092 ± 0.25
0.0IleXaa: 0.0 ± 0.0
Lys
7.392LysAla: 7.392 ± 0.895
0.504LysCys: 0.504 ± 0.236
3.78LysAsp: 3.78 ± 0.435
3.528LysGlu: 3.528 ± 0.436
2.184LysPhe: 2.184 ± 0.506
4.116LysGly: 4.116 ± 0.535
1.092LysHis: 1.092 ± 0.382
1.848LysIle: 1.848 ± 0.3
3.612LysLys: 3.612 ± 0.812
4.872LysLeu: 4.872 ± 0.627
1.596LysMet: 1.596 ± 0.343
1.68LysAsn: 1.68 ± 0.347
2.772LysPro: 2.772 ± 0.504
1.848LysGln: 1.848 ± 0.498
4.452LysArg: 4.452 ± 0.608
4.368LysSer: 4.368 ± 0.51
4.368LysThr: 4.368 ± 0.557
4.704LysVal: 4.704 ± 0.746
1.26LysTrp: 1.26 ± 0.339
2.184LysTyr: 2.184 ± 0.34
0.0LysXaa: 0.0 ± 0.0
Leu
6.384LeuAla: 6.384 ± 0.808
0.42LeuCys: 0.42 ± 0.212
4.032LeuAsp: 4.032 ± 0.479
6.3LeuGlu: 6.3 ± 0.761
1.932LeuPhe: 1.932 ± 0.349
5.46LeuGly: 5.46 ± 0.727
1.344LeuHis: 1.344 ± 0.318
3.36LeuIle: 3.36 ± 0.638
6.3LeuLys: 6.3 ± 0.715
5.292LeuLeu: 5.292 ± 0.582
2.94LeuMet: 2.94 ± 0.54
4.536LeuAsn: 4.536 ± 0.596
3.36LeuPro: 3.36 ± 0.348
4.032LeuGln: 4.032 ± 0.559
5.712LeuArg: 5.712 ± 0.527
5.796LeuSer: 5.796 ± 0.889
5.796LeuThr: 5.796 ± 0.729
6.3LeuVal: 6.3 ± 0.929
1.26LeuTrp: 1.26 ± 0.387
2.1LeuTyr: 2.1 ± 0.529
0.0LeuXaa: 0.0 ± 0.0
Met
3.192MetAla: 3.192 ± 0.474
0.504MetCys: 0.504 ± 0.184
1.428MetAsp: 1.428 ± 0.363
2.268MetGlu: 2.268 ± 0.498
1.428MetPhe: 1.428 ± 0.46
1.932MetGly: 1.932 ± 0.365
0.336MetHis: 0.336 ± 0.175
1.512MetIle: 1.512 ± 0.254
1.008MetLys: 1.008 ± 0.288
2.772MetLeu: 2.772 ± 0.446
0.588MetMet: 0.588 ± 0.208
1.092MetAsn: 1.092 ± 0.274
1.344MetPro: 1.344 ± 0.348
0.924MetGln: 0.924 ± 0.341
0.84MetArg: 0.84 ± 0.257
1.932MetSer: 1.932 ± 0.378
2.184MetThr: 2.184 ± 0.428
2.604MetVal: 2.604 ± 0.423
0.252MetTrp: 0.252 ± 0.18
0.84MetTyr: 0.84 ± 0.244
0.0MetXaa: 0.0 ± 0.0
Asn
4.536AsnAla: 4.536 ± 0.61
0.504AsnCys: 0.504 ± 0.206
2.1AsnAsp: 2.1 ± 0.511
2.268AsnGlu: 2.268 ± 0.391
1.344AsnPhe: 1.344 ± 0.225
4.368AsnGly: 4.368 ± 0.58
0.672AsnHis: 0.672 ± 0.206
2.688AsnIle: 2.688 ± 0.41
2.94AsnLys: 2.94 ± 0.46
3.612AsnLeu: 3.612 ± 0.688
0.924AsnMet: 0.924 ± 0.317
1.512AsnAsn: 1.512 ± 0.378
3.024AsnPro: 3.024 ± 0.479
1.176AsnGln: 1.176 ± 0.288
2.604AsnArg: 2.604 ± 0.512
2.352AsnSer: 2.352 ± 0.521
2.1AsnThr: 2.1 ± 0.443
2.94AsnVal: 2.94 ± 0.502
0.084AsnTrp: 0.084 ± 0.092
1.596AsnTyr: 1.596 ± 0.411
0.0AsnXaa: 0.0 ± 0.0
Pro
2.688ProAla: 2.688 ± 0.54
0.504ProCys: 0.504 ± 0.242
2.1ProAsp: 2.1 ± 0.409
3.192ProGlu: 3.192 ± 0.549
1.26ProPhe: 1.26 ± 0.271
1.176ProGly: 1.176 ± 0.299
0.504ProHis: 0.504 ± 0.154
2.016ProIle: 2.016 ± 0.343
3.696ProLys: 3.696 ± 0.537
2.52ProLeu: 2.52 ± 0.477
1.344ProMet: 1.344 ± 0.339
2.1ProAsn: 2.1 ± 0.367
0.588ProPro: 0.588 ± 0.197
1.596ProGln: 1.596 ± 0.358
1.512ProArg: 1.512 ± 0.358
2.772ProSer: 2.772 ± 0.435
3.024ProThr: 3.024 ± 0.558
3.696ProVal: 3.696 ± 0.499
0.588ProTrp: 0.588 ± 0.227
0.84ProTyr: 0.84 ± 0.245
0.0ProXaa: 0.0 ± 0.0
Gln
3.948GlnAla: 3.948 ± 0.485
0.252GlnCys: 0.252 ± 0.175
2.856GlnAsp: 2.856 ± 0.801
2.352GlnGlu: 2.352 ± 0.409
1.68GlnPhe: 1.68 ± 0.303
2.184GlnGly: 2.184 ± 0.518
0.504GlnHis: 0.504 ± 0.189
1.26GlnIle: 1.26 ± 0.357
2.016GlnLys: 2.016 ± 0.37
3.444GlnLeu: 3.444 ± 0.674
1.092GlnMet: 1.092 ± 0.365
1.512GlnAsn: 1.512 ± 0.439
1.428GlnPro: 1.428 ± 0.331
1.848GlnGln: 1.848 ± 0.464
2.352GlnArg: 2.352 ± 0.745
2.94GlnSer: 2.94 ± 0.36
2.352GlnThr: 2.352 ± 0.563
2.688GlnVal: 2.688 ± 0.417
0.588GlnTrp: 0.588 ± 0.224
1.092GlnTyr: 1.092 ± 0.348
0.0GlnXaa: 0.0 ± 0.0
Arg
4.032ArgAla: 4.032 ± 0.633
0.42ArgCys: 0.42 ± 0.17
4.452ArgAsp: 4.452 ± 0.53
3.444ArgGlu: 3.444 ± 0.521
2.772ArgPhe: 2.772 ± 0.396
3.864ArgGly: 3.864 ± 0.522
0.84ArgHis: 0.84 ± 0.274
4.032ArgIle: 4.032 ± 0.735
3.276ArgLys: 3.276 ± 0.581
5.712ArgLeu: 5.712 ± 0.801
1.26ArgMet: 1.26 ± 0.301
2.688ArgAsn: 2.688 ± 0.447
2.184ArgPro: 2.184 ± 0.365
2.688ArgGln: 2.688 ± 0.424
3.108ArgArg: 3.108 ± 0.485
3.612ArgSer: 3.612 ± 0.587
2.772ArgThr: 2.772 ± 0.344
2.688ArgVal: 2.688 ± 0.497
1.26ArgTrp: 1.26 ± 0.34
1.932ArgTyr: 1.932 ± 0.33
0.0ArgXaa: 0.0 ± 0.0
Ser
3.78SerAla: 3.78 ± 0.453
0.84SerCys: 0.84 ± 0.298
5.208SerAsp: 5.208 ± 0.475
3.696SerGlu: 3.696 ± 0.583
3.108SerPhe: 3.108 ± 0.378
6.3SerGly: 6.3 ± 0.87
2.184SerHis: 2.184 ± 0.36
3.024SerIle: 3.024 ± 0.638
2.856SerLys: 2.856 ± 0.404
4.452SerLeu: 4.452 ± 0.636
1.764SerMet: 1.764 ± 0.317
2.94SerAsn: 2.94 ± 0.41
2.94SerPro: 2.94 ± 0.385
2.436SerGln: 2.436 ± 0.565
3.444SerArg: 3.444 ± 0.595
3.78SerSer: 3.78 ± 0.592
3.612SerThr: 3.612 ± 0.462
4.2SerVal: 4.2 ± 0.498
0.756SerTrp: 0.756 ± 0.236
3.192SerTyr: 3.192 ± 0.668
0.0SerXaa: 0.0 ± 0.0
Thr
3.276ThrAla: 3.276 ± 0.622
0.336ThrCys: 0.336 ± 0.159
3.612ThrAsp: 3.612 ± 0.515
4.284ThrGlu: 4.284 ± 0.598
2.52ThrPhe: 2.52 ± 0.384
5.964ThrGly: 5.964 ± 0.763
0.672ThrHis: 0.672 ± 0.288
3.948ThrIle: 3.948 ± 0.677
3.192ThrLys: 3.192 ± 0.506
5.292ThrLeu: 5.292 ± 0.556
2.268ThrMet: 2.268 ± 0.43
2.352ThrAsn: 2.352 ± 0.474
2.688ThrPro: 2.688 ± 0.363
2.604ThrGln: 2.604 ± 0.503
2.772ThrArg: 2.772 ± 0.553
3.108ThrSer: 3.108 ± 0.557
3.696ThrThr: 3.696 ± 0.533
5.376ThrVal: 5.376 ± 0.672
0.504ThrTrp: 0.504 ± 0.172
1.512ThrTyr: 1.512 ± 0.302
0.0ThrXaa: 0.0 ± 0.0
Val
5.544ValAla: 5.544 ± 0.639
0.756ValCys: 0.756 ± 0.294
3.696ValAsp: 3.696 ± 0.586
4.872ValGlu: 4.872 ± 0.754
2.436ValPhe: 2.436 ± 0.485
6.132ValGly: 6.132 ± 0.855
1.26ValHis: 1.26 ± 0.54
3.108ValIle: 3.108 ± 0.566
5.208ValLys: 5.208 ± 0.682
5.46ValLeu: 5.46 ± 0.781
1.848ValMet: 1.848 ± 0.476
3.192ValAsn: 3.192 ± 0.475
3.192ValPro: 3.192 ± 0.405
3.192ValGln: 3.192 ± 0.564
4.284ValArg: 4.284 ± 0.62
5.628ValSer: 5.628 ± 0.723
4.284ValThr: 4.284 ± 0.685
6.3ValVal: 6.3 ± 0.95
0.84ValTrp: 0.84 ± 0.243
2.688ValTyr: 2.688 ± 0.447
0.0ValXaa: 0.0 ± 0.0
Trp
0.42TrpAla: 0.42 ± 0.143
0.0TrpCys: 0.0 ± 0.0
0.924TrpAsp: 0.924 ± 0.301
1.008TrpGlu: 1.008 ± 0.249
0.588TrpPhe: 0.588 ± 0.187
0.84TrpGly: 0.84 ± 0.302
0.336TrpHis: 0.336 ± 0.182
0.42TrpIle: 0.42 ± 0.17
1.26TrpLys: 1.26 ± 0.292
2.016TrpLeu: 2.016 ± 0.4
0.336TrpMet: 0.336 ± 0.173
1.092TrpAsn: 1.092 ± 0.309
0.168TrpPro: 0.168 ± 0.108
0.588TrpGln: 0.588 ± 0.268
0.756TrpArg: 0.756 ± 0.248
1.176TrpSer: 1.176 ± 0.522
0.756TrpThr: 0.756 ± 0.257
1.344TrpVal: 1.344 ± 0.349
0.252TrpTrp: 0.252 ± 0.157
0.42TrpTyr: 0.42 ± 0.187
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.696TyrAla: 3.696 ± 0.605
0.252TyrCys: 0.252 ± 0.132
1.932TyrAsp: 1.932 ± 0.344
1.848TyrGlu: 1.848 ± 0.494
1.008TyrPhe: 1.008 ± 0.312
2.688TyrGly: 2.688 ± 0.496
0.756TyrHis: 0.756 ± 0.323
1.68TyrIle: 1.68 ± 0.473
1.68TyrLys: 1.68 ± 0.407
2.604TyrLeu: 2.604 ± 0.417
0.924TyrMet: 0.924 ± 0.308
1.68TyrAsn: 1.68 ± 0.42
1.344TyrPro: 1.344 ± 0.428
1.596TyrGln: 1.596 ± 0.471
2.772TyrArg: 2.772 ± 0.586
1.932TyrSer: 1.932 ± 0.348
2.1TyrThr: 2.1 ± 0.422
2.016TyrVal: 2.016 ± 0.49
0.42TyrTrp: 0.42 ± 0.162
1.428TyrTyr: 1.428 ± 0.335
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 55 proteins (11906 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski