Amino acid dipepetide frequency for Lederbergia galactosidilyticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.021AlaAla: 5.021 ± 0.098	0.556AlaCys: 0.556 ± 0.02	3.363AlaAsp: 3.363 ± 0.053	4.654AlaGlu: 4.654 ± 0.08	3.278AlaPhe: 3.278 ± 0.056	4.931AlaGly: 4.931 ± 0.072	1.251AlaHis: 1.251 ± 0.033	5.98AlaIle: 5.98 ± 0.095	4.804AlaLys: 4.804 ± 0.058	6.771AlaLeu: 6.771 ± 0.097	1.879AlaMet: 1.879 ± 0.038	2.973AlaAsn: 2.973 ± 0.047	1.979AlaPro: 1.979 ± 0.039	2.211AlaGln: 2.211 ± 0.047	2.428AlaArg: 2.428 ± 0.052	3.735AlaSer: 3.735 ± 0.066	3.553AlaThr: 3.553 ± 0.063	4.77AlaVal: 4.77 ± 0.08	0.622AlaTrp: 0.622 ± 0.023	2.266AlaTyr: 2.266 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.433CysAla: 0.433 ± 0.018	0.087CysCys: 0.087 ± 0.01	0.344CysAsp: 0.344 ± 0.018	0.45CysGlu: 0.45 ± 0.021	0.319CysPhe: 0.319 ± 0.015	0.607CysGly: 0.607 ± 0.023	0.209CysHis: 0.209 ± 0.012	0.463CysIle: 0.463 ± 0.021	0.331CysLys: 0.331 ± 0.016	0.73CysLeu: 0.73 ± 0.026	0.178CysMet: 0.178 ± 0.011	0.27CysAsn: 0.27 ± 0.015	0.322CysPro: 0.322 ± 0.019	0.259CysGln: 0.259 ± 0.013	0.259CysArg: 0.259 ± 0.015	0.5CysSer: 0.5 ± 0.018	0.361CysThr: 0.361 ± 0.019	0.407CysVal: 0.407 ± 0.019	0.074CysTrp: 0.074 ± 0.009	0.24CysTyr: 0.24 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	2.926AspAla: 2.926 ± 0.049	0.372AspCys: 0.372 ± 0.017	2.508AspAsp: 2.508 ± 0.054	4.431AspGlu: 4.431 ± 0.066	2.568AspPhe: 2.568 ± 0.04	3.544AspGly: 3.544 ± 0.057	1.28AspHis: 1.28 ± 0.039	4.172AspIle: 4.172 ± 0.064	3.059AspLys: 3.059 ± 0.058	5.171AspLeu: 5.171 ± 0.068	1.349AspMet: 1.349 ± 0.038	1.699AspAsn: 1.699 ± 0.041	2.291AspPro: 2.291 ± 0.049	2.527AspGln: 2.527 ± 0.051	2.248AspArg: 2.248 ± 0.039	2.564AspSer: 2.564 ± 0.051	2.338AspThr: 2.338 ± 0.044	3.444AspVal: 3.444 ± 0.059	0.781AspTrp: 0.781 ± 0.026	2.309AspTyr: 2.309 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	5.223GluAla: 5.223 ± 0.069	0.388GluCys: 0.388 ± 0.02	3.921GluAsp: 3.921 ± 0.068	7.301GluGlu: 7.301 ± 0.1	2.797GluPhe: 2.797 ± 0.049	4.212GluGly: 4.212 ± 0.069	1.44GluHis: 1.44 ± 0.034	5.959GluIle: 5.959 ± 0.078	7.1GluLys: 7.1 ± 0.088	7.126GluLeu: 7.126 ± 0.086	2.45GluMet: 2.45 ± 0.05	3.913GluAsn: 3.913 ± 0.059	1.969GluPro: 1.969 ± 0.042	3.651GluGln: 3.651 ± 0.069	3.396GluArg: 3.396 ± 0.057	3.429GluSer: 3.429 ± 0.056	3.888GluThr: 3.888 ± 0.055	4.745GluVal: 4.745 ± 0.065	1.0GluTrp: 1.0 ± 0.029	2.475GluTyr: 2.475 ± 0.052	0.0GluXaa: 0.0 ± 0.0
Phe	3.097PheAla: 3.097 ± 0.051	0.36PheCys: 0.36 ± 0.019	2.414PheAsp: 2.414 ± 0.041	2.77PheGlu: 2.77 ± 0.049	2.524PhePhe: 2.524 ± 0.051	3.262PheGly: 3.262 ± 0.05	1.088PheHis: 1.088 ± 0.034	4.336PheIle: 4.336 ± 0.071	2.55PheLys: 2.55 ± 0.046	4.839PheLeu: 4.839 ± 0.078	1.24PheMet: 1.24 ± 0.034	1.913PheAsn: 1.913 ± 0.04	1.759PhePro: 1.759 ± 0.038	1.917PheGln: 1.917 ± 0.041	1.669PheArg: 1.669 ± 0.041	3.387PheSer: 3.387 ± 0.054	2.669PheThr: 2.669 ± 0.049	3.024PheVal: 3.024 ± 0.051	0.562PheTrp: 0.562 ± 0.026	1.906PheTyr: 1.906 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	4.529GlyAla: 4.529 ± 0.079	0.61GlyCys: 0.61 ± 0.022	3.148GlyAsp: 3.148 ± 0.056	4.717GlyGlu: 4.717 ± 0.066	3.403GlyPhe: 3.403 ± 0.058	4.563GlyGly: 4.563 ± 0.07	1.379GlyHis: 1.379 ± 0.033	6.104GlyIle: 6.104 ± 0.083	5.174GlyLys: 5.174 ± 0.07	6.466GlyLeu: 6.466 ± 0.081	2.076GlyMet: 2.076 ± 0.038	2.832GlyAsn: 2.832 ± 0.054	1.809GlyPro: 1.809 ± 0.035	2.238GlyGln: 2.238 ± 0.043	2.461GlyArg: 2.461 ± 0.048	3.715GlySer: 3.715 ± 0.061	3.705GlyThr: 3.705 ± 0.059	4.615GlyVal: 4.615 ± 0.064	0.901GlyTrp: 0.901 ± 0.028	2.732GlyTyr: 2.732 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	1.209HisAla: 1.209 ± 0.029	0.202HisCys: 0.202 ± 0.013	1.029HisAsp: 1.029 ± 0.031	1.399HisGlu: 1.399 ± 0.036	1.225HisPhe: 1.225 ± 0.03	1.384HisGly: 1.384 ± 0.033	0.637HisHis: 0.637 ± 0.023	1.573HisIle: 1.573 ± 0.037	1.039HisLys: 1.039 ± 0.031	2.149HisLeu: 2.149 ± 0.046	0.499HisMet: 0.499 ± 0.021	0.83HisAsn: 0.83 ± 0.028	1.137HisPro: 1.137 ± 0.032	0.898HisGln: 0.898 ± 0.032	0.847HisArg: 0.847 ± 0.025	1.248HisSer: 1.248 ± 0.03	1.087HisThr: 1.087 ± 0.034	1.271HisVal: 1.271 ± 0.036	0.308HisTrp: 0.308 ± 0.018	1.03HisTyr: 1.03 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	5.99IleAla: 5.99 ± 0.094	0.664IleCys: 0.664 ± 0.025	4.464IleAsp: 4.464 ± 0.065	5.845IleGlu: 5.845 ± 0.065	3.799IlePhe: 3.799 ± 0.065	6.133IleGly: 6.133 ± 0.09	1.792IleHis: 1.792 ± 0.044	6.515IleIle: 6.515 ± 0.09	4.664IleLys: 4.664 ± 0.066	8.021IleLeu: 8.021 ± 0.095	2.004IleMet: 2.004 ± 0.04	3.187IleAsn: 3.187 ± 0.055	3.641IlePro: 3.641 ± 0.057	3.457IleGln: 3.457 ± 0.061	3.225IleArg: 3.225 ± 0.053	5.173IleSer: 5.173 ± 0.07	4.408IleThr: 4.408 ± 0.059	5.383IleVal: 5.383 ± 0.073	0.867IleTrp: 0.867 ± 0.035	2.716IleTyr: 2.716 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	4.523LysAla: 4.523 ± 0.068	0.262LysCys: 0.262 ± 0.019	3.782LysAsp: 3.782 ± 0.056	6.856LysGlu: 6.856 ± 0.098	2.066LysPhe: 2.066 ± 0.045	4.376LysGly: 4.376 ± 0.061	1.268LysHis: 1.268 ± 0.034	5.063LysIle: 5.063 ± 0.069	5.7LysLys: 5.7 ± 0.069	5.899LysLeu: 5.899 ± 0.067	2.274LysMet: 2.274 ± 0.041	3.309LysAsn: 3.309 ± 0.052	2.209LysPro: 2.209 ± 0.04	3.19LysGln: 3.19 ± 0.061	3.169LysArg: 3.169 ± 0.051	3.282LysSer: 3.282 ± 0.051	3.609LysThr: 3.609 ± 0.058	4.554LysVal: 4.554 ± 0.062	0.944LysTrp: 0.944 ± 0.028	2.336LysTyr: 2.336 ± 0.047	0.0LysXaa: 0.0 ± 0.0
Leu	7.313LeuAla: 7.313 ± 0.099	0.658LeuCys: 0.658 ± 0.024	5.067LeuAsp: 5.067 ± 0.062	6.942LeuGlu: 6.942 ± 0.093	5.044LeuPhe: 5.044 ± 0.081	6.331LeuGly: 6.331 ± 0.086	1.963LeuHis: 1.963 ± 0.046	7.777LeuIle: 7.777 ± 0.113	6.359LeuLys: 6.359 ± 0.065	10.561LeuLeu: 10.561 ± 0.118	2.506LeuMet: 2.506 ± 0.048	4.256LeuAsn: 4.256 ± 0.057	4.139LeuPro: 4.139 ± 0.068	3.991LeuGln: 3.991 ± 0.062	3.593LeuArg: 3.593 ± 0.061	6.536LeuSer: 6.536 ± 0.083	5.478LeuThr: 5.478 ± 0.069	6.061LeuVal: 6.061 ± 0.082	1.002LeuTrp: 1.002 ± 0.031	3.358LeuTyr: 3.358 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	1.998MetAla: 1.998 ± 0.045	0.14MetCys: 0.14 ± 0.01	1.585MetAsp: 1.585 ± 0.031	2.174MetGlu: 2.174 ± 0.045	1.075MetPhe: 1.075 ± 0.029	1.846MetGly: 1.846 ± 0.042	0.421MetHis: 0.421 ± 0.018	2.293MetIle: 2.293 ± 0.045	2.472MetLys: 2.472 ± 0.045	2.485MetLeu: 2.485 ± 0.052	0.825MetMet: 0.825 ± 0.027	1.627MetAsn: 1.627 ± 0.039	1.0MetPro: 1.0 ± 0.032	0.944MetGln: 0.944 ± 0.028	1.112MetArg: 1.112 ± 0.029	1.559MetSer: 1.559 ± 0.036	1.64MetThr: 1.64 ± 0.04	1.754MetVal: 1.754 ± 0.038	0.212MetTrp: 0.212 ± 0.014	0.74MetTyr: 0.74 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.589AsnAla: 2.589 ± 0.052	0.282AsnCys: 0.282 ± 0.016	2.216AsnAsp: 2.216 ± 0.049	3.538AsnGlu: 3.538 ± 0.053	1.783AsnPhe: 1.783 ± 0.04	3.339AsnGly: 3.339 ± 0.059	1.105AsnHis: 1.105 ± 0.033	3.602AsnIle: 3.602 ± 0.056	2.8AsnLys: 2.8 ± 0.055	3.908AsnLeu: 3.908 ± 0.062	1.221AsnMet: 1.221 ± 0.03	1.826AsnAsn: 1.826 ± 0.043	2.007AsnPro: 2.007 ± 0.043	2.231AsnGln: 2.231 ± 0.045	2.01AsnArg: 2.01 ± 0.045	2.344AsnSer: 2.344 ± 0.044	2.143AsnThr: 2.143 ± 0.036	2.744AsnVal: 2.744 ± 0.049	0.598AsnTrp: 0.598 ± 0.022	1.588AsnTyr: 1.588 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	2.319ProAla: 2.319 ± 0.048	0.208ProCys: 0.208 ± 0.014	2.166ProAsp: 2.166 ± 0.043	3.116ProGlu: 3.116 ± 0.054	2.092ProPhe: 2.092 ± 0.041	2.304ProGly: 2.304 ± 0.039	0.852ProHis: 0.852 ± 0.027	3.077ProIle: 3.077 ± 0.054	2.096ProLys: 2.096 ± 0.038	3.685ProLeu: 3.685 ± 0.06	0.855ProMet: 0.855 ± 0.026	1.863ProAsn: 1.863 ± 0.04	1.024ProPro: 1.024 ± 0.032	1.231ProGln: 1.231 ± 0.037	1.079ProArg: 1.079 ± 0.031	2.201ProSer: 2.201 ± 0.047	2.037ProThr: 2.037 ± 0.043	2.603ProVal: 2.603 ± 0.048	0.422ProTrp: 0.422 ± 0.019	1.508ProTyr: 1.508 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	3.041GlnAla: 3.041 ± 0.058	0.215GlnCys: 0.215 ± 0.014	1.863GlnAsp: 1.863 ± 0.041	3.24GlnGlu: 3.24 ± 0.059	1.844GlnPhe: 1.844 ± 0.043	2.259GlnGly: 2.259 ± 0.045	0.832GlnHis: 0.832 ± 0.029	2.974GlnIle: 2.974 ± 0.053	2.995GlnLys: 2.995 ± 0.054	4.42GlnLeu: 4.42 ± 0.065	1.182GlnMet: 1.182 ± 0.031	1.808GlnAsn: 1.808 ± 0.039	1.326GlnPro: 1.326 ± 0.034	1.941GlnGln: 1.941 ± 0.054	1.541GlnArg: 1.541 ± 0.037	2.365GlnSer: 2.365 ± 0.044	2.254GlnThr: 2.254 ± 0.044	2.474GlnVal: 2.474 ± 0.04	0.519GlnTrp: 0.519 ± 0.02	1.554GlnTyr: 1.554 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	2.294ArgAla: 2.294 ± 0.049	0.244ArgCys: 0.244 ± 0.014	2.002ArgAsp: 2.002 ± 0.039	3.155ArgGlu: 3.155 ± 0.058	1.887ArgPhe: 1.887 ± 0.036	2.209ArgGly: 2.209 ± 0.046	0.771ArgHis: 0.771 ± 0.024	3.075ArgIle: 3.075 ± 0.064	3.261ArgLys: 3.261 ± 0.05	3.874ArgLeu: 3.874 ± 0.055	1.196ArgMet: 1.196 ± 0.034	1.925ArgAsn: 1.925 ± 0.044	1.316ArgPro: 1.316 ± 0.038	1.564ArgGln: 1.564 ± 0.037	1.799ArgArg: 1.799 ± 0.046	2.16ArgSer: 2.16 ± 0.041	2.006ArgThr: 2.006 ± 0.041	2.436ArgVal: 2.436 ± 0.047	0.488ArgTrp: 0.488 ± 0.021	1.527ArgTyr: 1.527 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	3.598SerAla: 3.598 ± 0.052	0.37SerCys: 0.37 ± 0.02	2.671SerAsp: 2.671 ± 0.05	3.904SerGlu: 3.904 ± 0.055	3.243SerPhe: 3.243 ± 0.058	4.191SerGly: 4.191 ± 0.06	1.19SerHis: 1.19 ± 0.029	5.101SerIle: 5.101 ± 0.062	3.551SerLys: 3.551 ± 0.054	6.164SerLeu: 6.164 ± 0.08	1.691SerMet: 1.691 ± 0.039	2.286SerAsn: 2.286 ± 0.05	2.194SerPro: 2.194 ± 0.039	2.158SerGln: 2.158 ± 0.041	2.143SerArg: 2.143 ± 0.046	3.754SerSer: 3.754 ± 0.066	3.065SerThr: 3.065 ± 0.043	3.789SerVal: 3.789 ± 0.049	0.702SerTrp: 0.702 ± 0.03	2.203SerTyr: 2.203 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	3.755ThrAla: 3.755 ± 0.055	0.342ThrCys: 0.342 ± 0.016	2.806ThrAsp: 2.806 ± 0.052	3.591ThrGlu: 3.591 ± 0.057	2.688ThrPhe: 2.688 ± 0.042	3.991ThrGly: 3.991 ± 0.068	1.055ThrHis: 1.055 ± 0.03	4.811ThrIle: 4.811 ± 0.073	3.334ThrLys: 3.334 ± 0.054	5.213ThrLeu: 5.213 ± 0.06	1.351ThrMet: 1.351 ± 0.037	2.394ThrAsn: 2.394 ± 0.043	2.211ThrPro: 2.211 ± 0.043	1.489ThrGln: 1.489 ± 0.037	1.717ThrArg: 1.717 ± 0.042	3.185ThrSer: 3.185 ± 0.048	2.902ThrThr: 2.902 ± 0.056	3.865ThrVal: 3.865 ± 0.057	0.581ThrTrp: 0.581 ± 0.024	1.998ThrTyr: 1.998 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	4.41ValAla: 4.41 ± 0.069	0.5ValCys: 0.5 ± 0.02	3.641ValAsp: 3.641 ± 0.056	4.697ValGlu: 4.697 ± 0.058	3.048ValPhe: 3.048 ± 0.05	4.403ValGly: 4.403 ± 0.071	1.317ValHis: 1.317 ± 0.036	5.429ValIle: 5.429 ± 0.069	4.414ValLys: 4.414 ± 0.059	6.461ValLeu: 6.461 ± 0.074	1.812ValMet: 1.812 ± 0.039	2.826ValAsn: 2.826 ± 0.047	2.441ValPro: 2.441 ± 0.04	2.493ValGln: 2.493 ± 0.048	2.399ValArg: 2.399 ± 0.051	3.985ValSer: 3.985 ± 0.054	3.66ValThr: 3.66 ± 0.058	4.285ValVal: 4.285 ± 0.073	0.695ValTrp: 0.695 ± 0.026	2.178ValTyr: 2.178 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.639TrpAla: 0.639 ± 0.026	0.091TrpCys: 0.091 ± 0.01	0.661TrpAsp: 0.661 ± 0.025	0.887TrpGlu: 0.887 ± 0.03	0.563TrpPhe: 0.563 ± 0.026	0.8TrpGly: 0.8 ± 0.03	0.285TrpHis: 0.285 ± 0.014	0.98TrpIle: 0.98 ± 0.03	0.832TrpLys: 0.832 ± 0.028	1.26TrpLeu: 1.26 ± 0.036	0.397TrpMet: 0.397 ± 0.019	0.649TrpAsn: 0.649 ± 0.023	0.349TrpPro: 0.349 ± 0.02	0.502TrpGln: 0.502 ± 0.021	0.487TrpArg: 0.487 ± 0.02	0.654TrpSer: 0.654 ± 0.023	0.597TrpThr: 0.597 ± 0.023	0.708TrpVal: 0.708 ± 0.024	0.159TrpTrp: 0.159 ± 0.011	0.385TrpTyr: 0.385 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.116TyrAla: 2.116 ± 0.042	0.29TyrCys: 0.29 ± 0.018	1.931TyrAsp: 1.931 ± 0.048	2.72TyrGlu: 2.72 ± 0.051	2.039TyrPhe: 2.039 ± 0.039	2.49TyrGly: 2.49 ± 0.046	0.865TyrHis: 0.865 ± 0.029	2.664TyrIle: 2.664 ± 0.05	2.136TyrLys: 2.136 ± 0.045	3.733TyrLeu: 3.733 ± 0.063	0.916TyrMet: 0.916 ± 0.027	1.489TyrAsn: 1.489 ± 0.043	1.615TyrPro: 1.615 ± 0.04	1.754TyrGln: 1.754 ± 0.043	1.609TyrArg: 1.609 ± 0.042	2.193TyrSer: 2.193 ± 0.046	1.881TyrThr: 1.881 ± 0.04	2.163TyrVal: 2.163 ± 0.042	0.446TyrTrp: 0.446 ± 0.018	1.517TyrTyr: 1.517 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4048 proteins (1205544 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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