Amino acid dipepetide frequency for Micrococcus terreus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.557AlaAla: 17.557 ± 0.161	0.746AlaCys: 0.746 ± 0.03	7.214AlaAsp: 7.214 ± 0.094	9.001AlaGlu: 9.001 ± 0.108	3.131AlaPhe: 3.131 ± 0.067	12.292AlaGly: 12.292 ± 0.141	2.512AlaHis: 2.512 ± 0.052	3.851AlaIle: 3.851 ± 0.071	2.242AlaLys: 2.242 ± 0.068	12.737AlaLeu: 12.737 ± 0.144	2.598AlaMet: 2.598 ± 0.05	1.93AlaAsn: 1.93 ± 0.047	6.653AlaPro: 6.653 ± 0.116	5.257AlaGln: 5.257 ± 0.089	8.282AlaArg: 8.282 ± 0.102	6.27AlaSer: 6.27 ± 0.08	6.609AlaThr: 6.609 ± 0.094	11.236AlaVal: 11.236 ± 0.122	1.884AlaTrp: 1.884 ± 0.046	2.027AlaTyr: 2.027 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.734CysAla: 0.734 ± 0.027	0.061CysCys: 0.061 ± 0.009	0.263CysAsp: 0.263 ± 0.017	0.27CysGlu: 0.27 ± 0.018	0.186CysPhe: 0.186 ± 0.014	0.635CysGly: 0.635 ± 0.027	0.135CysHis: 0.135 ± 0.012	0.222CysIle: 0.222 ± 0.015	0.074CysLys: 0.074 ± 0.008	0.571CysLeu: 0.571 ± 0.025	0.116CysMet: 0.116 ± 0.013	0.101CysAsn: 0.101 ± 0.012	0.349CysPro: 0.349 ± 0.018	0.179CysGln: 0.179 ± 0.014	0.405CysArg: 0.405 ± 0.02	0.336CysSer: 0.336 ± 0.02	0.384CysThr: 0.384 ± 0.022	0.45CysVal: 0.45 ± 0.022	0.097CysTrp: 0.097 ± 0.009	0.111CysTyr: 0.111 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	6.908AspAla: 6.908 ± 0.091	0.3AspCys: 0.3 ± 0.019	3.186AspAsp: 3.186 ± 0.073	3.947AspGlu: 3.947 ± 0.07	1.566AspPhe: 1.566 ± 0.041	5.853AspGly: 5.853 ± 0.084	1.635AspHis: 1.635 ± 0.044	1.888AspIle: 1.888 ± 0.049	0.864AspLys: 0.864 ± 0.035	6.522AspLeu: 6.522 ± 0.088	0.917AspMet: 0.917 ± 0.03	0.785AspAsn: 0.785 ± 0.029	4.638AspPro: 4.638 ± 0.074	2.566AspGln: 2.566 ± 0.058	4.808AspArg: 4.808 ± 0.081	2.955AspSer: 2.955 ± 0.064	3.092AspThr: 3.092 ± 0.056	4.588AspVal: 4.588 ± 0.09	1.016AspTrp: 1.016 ± 0.034	1.223AspTyr: 1.223 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	7.327GluAla: 7.327 ± 0.108	0.283GluCys: 0.283 ± 0.016	4.104GluAsp: 4.104 ± 0.075	3.718GluGlu: 3.718 ± 0.079	1.688GluPhe: 1.688 ± 0.048	4.77GluGly: 4.77 ± 0.076	1.877GluHis: 1.877 ± 0.044	2.533GluIle: 2.533 ± 0.064	1.625GluLys: 1.625 ± 0.053	6.733GluLeu: 6.733 ± 0.099	1.112GluMet: 1.112 ± 0.04	1.354GluAsn: 1.354 ± 0.043	3.207GluPro: 3.207 ± 0.071	3.446GluGln: 3.446 ± 0.068	5.043GluArg: 5.043 ± 0.083	3.377GluSer: 3.377 ± 0.058	3.209GluThr: 3.209 ± 0.06	4.926GluVal: 4.926 ± 0.075	0.75GluTrp: 0.75 ± 0.029	1.12GluTyr: 1.12 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.268PheAla: 3.268 ± 0.064	0.187PheCys: 0.187 ± 0.012	1.707PheAsp: 1.707 ± 0.047	1.621PheGlu: 1.621 ± 0.043	0.961PhePhe: 0.961 ± 0.042	3.019PheGly: 3.019 ± 0.062	0.664PheHis: 0.664 ± 0.029	1.148PheIle: 1.148 ± 0.037	0.48PheLys: 0.48 ± 0.024	2.664PheLeu: 2.664 ± 0.055	0.545PheMet: 0.545 ± 0.023	0.66PheAsn: 0.66 ± 0.031	1.317PhePro: 1.317 ± 0.035	0.834PheGln: 0.834 ± 0.03	1.677PheArg: 1.677 ± 0.048	1.773PheSer: 1.773 ± 0.043	2.142PheThr: 2.142 ± 0.054	2.167PheVal: 2.167 ± 0.057	0.477PheTrp: 0.477 ± 0.027	0.586PheTyr: 0.586 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	10.116GlyAla: 10.116 ± 0.144	0.561GlyCys: 0.561 ± 0.026	4.208GlyAsp: 4.208 ± 0.071	5.285GlyGlu: 5.285 ± 0.084	2.855GlyPhe: 2.855 ± 0.067	7.589GlyGly: 7.589 ± 0.119	2.203GlyHis: 2.203 ± 0.053	3.964GlyIle: 3.964 ± 0.074	2.119GlyLys: 2.119 ± 0.055	9.242GlyLeu: 9.242 ± 0.119	2.277GlyMet: 2.277 ± 0.062	1.712GlyAsn: 1.712 ± 0.044	4.666GlyPro: 4.666 ± 0.074	3.866GlyGln: 3.866 ± 0.079	6.679GlyArg: 6.679 ± 0.093	5.601GlySer: 5.601 ± 0.089	6.391GlyThr: 6.391 ± 0.097	7.413GlyVal: 7.413 ± 0.092	1.625GlyTrp: 1.625 ± 0.047	2.076GlyTyr: 2.076 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.516HisAla: 2.516 ± 0.055	0.161HisCys: 0.161 ± 0.013	1.233HisAsp: 1.233 ± 0.037	1.281HisGlu: 1.281 ± 0.041	0.577HisPhe: 0.577 ± 0.025	2.237HisGly: 2.237 ± 0.061	0.824HisHis: 0.824 ± 0.031	0.681HisIle: 0.681 ± 0.028	0.272HisLys: 0.272 ± 0.019	2.61HisLeu: 2.61 ± 0.061	0.376HisMet: 0.376 ± 0.019	0.332HisAsn: 0.332 ± 0.019	1.883HisPro: 1.883 ± 0.046	0.962HisGln: 0.962 ± 0.035	2.245HisArg: 2.245 ± 0.051	1.13HisSer: 1.13 ± 0.034	1.312HisThr: 1.312 ± 0.038	1.698HisVal: 1.698 ± 0.042	0.369HisTrp: 0.369 ± 0.019	0.475HisTyr: 0.475 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	4.842IleAla: 4.842 ± 0.067	0.289IleCys: 0.289 ± 0.019	2.325IleAsp: 2.325 ± 0.052	2.245IleGlu: 2.245 ± 0.049	1.008IlePhe: 1.008 ± 0.033	3.917IleGly: 3.917 ± 0.07	0.917IleHis: 0.917 ± 0.032	1.551IleIle: 1.551 ± 0.044	0.777IleLys: 0.777 ± 0.028	3.493IleLeu: 3.493 ± 0.072	0.692IleMet: 0.692 ± 0.028	0.846IleAsn: 0.846 ± 0.031	2.3IlePro: 2.3 ± 0.058	1.233IleGln: 1.233 ± 0.041	2.43IleArg: 2.43 ± 0.06	2.234IleSer: 2.234 ± 0.048	2.808IleThr: 2.808 ± 0.059	3.148IleVal: 3.148 ± 0.069	0.47IleTrp: 0.47 ± 0.021	0.682IleTyr: 0.682 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	2.353LysAla: 2.353 ± 0.068	0.07LysCys: 0.07 ± 0.009	1.467LysAsp: 1.467 ± 0.05	1.124LysGlu: 1.124 ± 0.032	0.469LysPhe: 0.469 ± 0.023	1.533LysGly: 1.533 ± 0.048	0.459LysHis: 0.459 ± 0.023	0.936LysIle: 0.936 ± 0.037	0.829LysLys: 0.829 ± 0.043	1.756LysLeu: 1.756 ± 0.049	0.451LysMet: 0.451 ± 0.025	0.544LysAsn: 0.544 ± 0.025	1.064LysPro: 1.064 ± 0.04	0.619LysGln: 0.619 ± 0.025	1.335LysArg: 1.335 ± 0.044	1.108LysSer: 1.108 ± 0.037	1.336LysThr: 1.336 ± 0.045	1.825LysVal: 1.825 ± 0.046	0.214LysTrp: 0.214 ± 0.015	0.448LysTyr: 0.448 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	13.495LeuAla: 13.495 ± 0.143	0.615LeuCys: 0.615 ± 0.025	6.658LeuAsp: 6.658 ± 0.095	6.077LeuGlu: 6.077 ± 0.097	2.66LeuPhe: 2.66 ± 0.066	8.855LeuGly: 8.855 ± 0.139	2.131LeuHis: 2.131 ± 0.051	4.069LeuIle: 4.069 ± 0.074	2.103LeuLys: 2.103 ± 0.056	9.981LeuLeu: 9.981 ± 0.139	2.181LeuMet: 2.181 ± 0.048	2.051LeuAsn: 2.051 ± 0.05	5.72LeuPro: 5.72 ± 0.084	3.211LeuGln: 3.211 ± 0.055	6.808LeuArg: 6.808 ± 0.09	5.715LeuSer: 5.715 ± 0.084	6.792LeuThr: 6.792 ± 0.092	8.897LeuVal: 8.897 ± 0.116	1.303LeuTrp: 1.303 ± 0.047	1.626LeuTyr: 1.626 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	2.568MetAla: 2.568 ± 0.054	0.103MetCys: 0.103 ± 0.011	1.23MetAsp: 1.23 ± 0.036	1.038MetGlu: 1.038 ± 0.033	0.595MetPhe: 0.595 ± 0.026	1.698MetGly: 1.698 ± 0.042	0.36MetHis: 0.36 ± 0.021	0.923MetIle: 0.923 ± 0.032	0.489MetLys: 0.489 ± 0.024	1.967MetLeu: 1.967 ± 0.047	0.429MetMet: 0.429 ± 0.023	0.531MetAsn: 0.531 ± 0.026	1.177MetPro: 1.177 ± 0.041	0.585MetGln: 0.585 ± 0.025	1.291MetArg: 1.291 ± 0.039	1.555MetSer: 1.555 ± 0.042	1.811MetThr: 1.811 ± 0.049	1.878MetVal: 1.878 ± 0.044	0.23MetTrp: 0.23 ± 0.016	0.294MetTyr: 0.294 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.24AsnAla: 2.24 ± 0.052	0.114AsnCys: 0.114 ± 0.011	1.005AsnAsp: 1.005 ± 0.036	1.007AsnGlu: 1.007 ± 0.033	0.523AsnPhe: 0.523 ± 0.024	1.824AsnGly: 1.824 ± 0.052	0.429AsnHis: 0.429 ± 0.023	0.847AsnIle: 0.847 ± 0.028	0.382AsnLys: 0.382 ± 0.022	1.934AsnLeu: 1.934 ± 0.044	0.367AsnMet: 0.367 ± 0.022	0.457AsnAsn: 0.457 ± 0.026	1.517AsnPro: 1.517 ± 0.038	0.704AsnGln: 0.704 ± 0.027	1.454AsnArg: 1.454 ± 0.043	0.934AsnSer: 0.934 ± 0.031	1.165AsnThr: 1.165 ± 0.04	1.448AsnVal: 1.448 ± 0.036	0.308AsnTrp: 0.308 ± 0.021	0.415AsnTyr: 0.415 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	7.644ProAla: 7.644 ± 0.125	0.222ProCys: 0.222 ± 0.015	4.309ProAsp: 4.309 ± 0.071	4.906ProGlu: 4.906 ± 0.073	1.499ProPhe: 1.499 ± 0.039	5.647ProGly: 5.647 ± 0.085	1.252ProHis: 1.252 ± 0.037	1.618ProIle: 1.618 ± 0.045	0.995ProLys: 0.995 ± 0.039	4.921ProLeu: 4.921 ± 0.069	0.991ProMet: 0.991 ± 0.029	0.961ProAsn: 0.961 ± 0.031	2.358ProPro: 2.358 ± 0.068	2.343ProGln: 2.343 ± 0.061	3.315ProArg: 3.315 ± 0.061	3.62ProSer: 3.62 ± 0.069	3.551ProThr: 3.551 ± 0.069	5.349ProVal: 5.349 ± 0.08	0.964ProTrp: 0.964 ± 0.033	0.973ProTyr: 0.973 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.982GlnAla: 4.982 ± 0.079	0.16GlnCys: 0.16 ± 0.012	2.753GlnAsp: 2.753 ± 0.062	2.346GlnGlu: 2.346 ± 0.056	0.915GlnPhe: 0.915 ± 0.034	2.984GlnGly: 2.984 ± 0.062	0.986GlnHis: 0.986 ± 0.034	1.723GlnIle: 1.723 ± 0.04	0.79GlnLys: 0.79 ± 0.032	3.723GlnLeu: 3.723 ± 0.065	0.895GlnMet: 0.895 ± 0.031	0.819GlnAsn: 0.819 ± 0.032	2.015GlnPro: 2.015 ± 0.05	1.848GlnGln: 1.848 ± 0.052	2.948GlnArg: 2.948 ± 0.06	1.874GlnSer: 1.874 ± 0.046	2.179GlnThr: 2.179 ± 0.051	3.487GlnVal: 3.487 ± 0.063	0.615GlnTrp: 0.615 ± 0.027	0.685GlnTyr: 0.685 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	7.917ArgAla: 7.917 ± 0.104	0.356ArgCys: 0.356 ± 0.021	3.782ArgAsp: 3.782 ± 0.065	4.362ArgGlu: 4.362 ± 0.084	2.195ArgPhe: 2.195 ± 0.055	5.237ArgGly: 5.237 ± 0.075	1.843ArgHis: 1.843 ± 0.053	3.156ArgIle: 3.156 ± 0.056	1.377ArgLys: 1.377 ± 0.042	7.417ArgLeu: 7.417 ± 0.109	1.825ArgMet: 1.825 ± 0.046	1.369ArgAsn: 1.369 ± 0.041	4.114ArgPro: 4.114 ± 0.08	3.017ArgGln: 3.017 ± 0.063	6.697ArgArg: 6.697 ± 0.114	4.315ArgSer: 4.315 ± 0.08	4.743ArgThr: 4.743 ± 0.075	5.069ArgVal: 5.069 ± 0.077	1.323ArgTrp: 1.323 ± 0.042	1.465ArgTyr: 1.465 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	7.501SerAla: 7.501 ± 0.112	0.312SerCys: 0.312 ± 0.021	2.778SerAsp: 2.778 ± 0.067	3.062SerGlu: 3.062 ± 0.061	1.667SerPhe: 1.667 ± 0.039	6.168SerGly: 6.168 ± 0.085	1.106SerHis: 1.106 ± 0.038	1.972SerIle: 1.972 ± 0.043	0.99SerLys: 0.99 ± 0.033	5.192SerLeu: 5.192 ± 0.077	1.312SerMet: 1.312 ± 0.039	1.063SerAsn: 1.063 ± 0.039	3.513SerPro: 3.513 ± 0.072	1.824SerGln: 1.824 ± 0.046	3.843SerArg: 3.843 ± 0.076	3.87SerSer: 3.87 ± 0.073	4.05SerThr: 4.05 ± 0.066	4.825SerVal: 4.825 ± 0.078	0.989SerTrp: 0.989 ± 0.034	1.152SerTyr: 1.152 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	8.485ThrAla: 8.485 ± 0.114	0.31ThrCys: 0.31 ± 0.016	3.678ThrAsp: 3.678 ± 0.069	3.798ThrGlu: 3.798 ± 0.061	1.683ThrPhe: 1.683 ± 0.052	6.572ThrGly: 6.572 ± 0.101	1.296ThrHis: 1.296 ± 0.035	2.06ThrIle: 2.06 ± 0.048	1.057ThrLys: 1.057 ± 0.037	5.993ThrLeu: 5.993 ± 0.091	1.072ThrMet: 1.072 ± 0.032	1.014ThrAsn: 1.014 ± 0.037	4.383ThrPro: 4.383 ± 0.075	1.928ThrGln: 1.928 ± 0.047	3.744ThrArg: 3.744 ± 0.063	3.682ThrSer: 3.682 ± 0.072	4.018ThrThr: 4.018 ± 0.082	6.544ThrVal: 6.544 ± 0.098	0.911ThrTrp: 0.911 ± 0.035	1.208ThrTyr: 1.208 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	9.755ValAla: 9.755 ± 0.109	0.562ValCys: 0.562 ± 0.025	5.371ValAsp: 5.371 ± 0.079	5.235ValGlu: 5.235 ± 0.073	2.556ValPhe: 2.556 ± 0.057	6.659ValGly: 6.659 ± 0.094	1.919ValHis: 1.919 ± 0.048	3.734ValIle: 3.734 ± 0.068	1.807ValLys: 1.807 ± 0.053	9.692ValLeu: 9.692 ± 0.132	1.905ValMet: 1.905 ± 0.047	1.763ValAsn: 1.763 ± 0.043	4.921ValPro: 4.921 ± 0.07	3.048ValGln: 3.048 ± 0.052	5.738ValArg: 5.738 ± 0.079	4.822ValSer: 4.822 ± 0.079	5.593ValThr: 5.593 ± 0.087	8.372ValVal: 8.372 ± 0.105	1.105ValTrp: 1.105 ± 0.039	1.435ValTyr: 1.435 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.641TrpAla: 1.641 ± 0.044	0.124TrpCys: 0.124 ± 0.011	0.888TrpAsp: 0.888 ± 0.035	0.772TrpGlu: 0.772 ± 0.03	0.53TrpPhe: 0.53 ± 0.027	1.09TrpGly: 1.09 ± 0.037	0.294TrpHis: 0.294 ± 0.018	0.739TrpIle: 0.739 ± 0.03	0.365TrpLys: 0.365 ± 0.02	1.781TrpLeu: 1.781 ± 0.051	0.4TrpMet: 0.4 ± 0.022	0.398TrpAsn: 0.398 ± 0.021	0.684TrpPro: 0.684 ± 0.028	0.573TrpGln: 0.573 ± 0.028	1.143TrpArg: 1.143 ± 0.037	0.926TrpSer: 0.926 ± 0.032	1.061TrpThr: 1.061 ± 0.038	1.25TrpVal: 1.25 ± 0.046	0.378TrpTrp: 0.378 ± 0.022	0.291TrpTyr: 0.291 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.182TyrAla: 2.182 ± 0.041	0.146TyrCys: 0.146 ± 0.012	1.097TyrAsp: 1.097 ± 0.036	1.106TyrGlu: 1.106 ± 0.037	0.634TyrPhe: 0.634 ± 0.027	1.868TyrGly: 1.868 ± 0.048	0.332TyrHis: 0.332 ± 0.019	0.591TyrIle: 0.591 ± 0.025	0.302TyrLys: 0.302 ± 0.019	2.018TyrLeu: 2.018 ± 0.053	0.29TyrMet: 0.29 ± 0.019	0.384TyrAsn: 0.384 ± 0.021	0.96TyrPro: 0.96 ± 0.034	0.682TyrGln: 0.682 ± 0.031	1.695TyrArg: 1.695 ± 0.044	1.092TyrSer: 1.092 ± 0.036	1.191TyrThr: 1.191 ± 0.04	1.422TyrVal: 1.422 ± 0.044	0.3TyrTrp: 0.3 ± 0.019	0.412TyrTyr: 0.412 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2759 proteins (930413 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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