Amino acid dipepetide frequency for Paracoccus jeotgali

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.861AlaAla: 18.861 ± 0.222	1.05AlaCys: 1.05 ± 0.034	7.583AlaAsp: 7.583 ± 0.1	8.711AlaGlu: 8.711 ± 0.129	3.948AlaPhe: 3.948 ± 0.069	11.335AlaGly: 11.335 ± 0.117	2.335AlaHis: 2.335 ± 0.052	5.919AlaIle: 5.919 ± 0.086	2.914AlaLys: 2.914 ± 0.068	14.279AlaLeu: 14.279 ± 0.148	4.024AlaMet: 4.024 ± 0.073	2.43AlaAsn: 2.43 ± 0.049	6.711AlaPro: 6.711 ± 0.107	5.086AlaGln: 5.086 ± 0.084	10.144AlaArg: 10.144 ± 0.133	5.833AlaSer: 5.833 ± 0.083	6.233AlaThr: 6.233 ± 0.093	8.67AlaVal: 8.67 ± 0.097	1.505AlaTrp: 1.505 ± 0.039	2.245AlaTyr: 2.245 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	1.028CysAla: 1.028 ± 0.034	0.098CysCys: 0.098 ± 0.009	0.575CysAsp: 0.575 ± 0.025	0.409CysGlu: 0.409 ± 0.02	0.287CysPhe: 0.287 ± 0.019	0.878CysGly: 0.878 ± 0.037	0.263CysHis: 0.263 ± 0.021	0.373CysIle: 0.373 ± 0.022	0.159CysLys: 0.159 ± 0.012	0.769CysLeu: 0.769 ± 0.027	0.137CysMet: 0.137 ± 0.012	0.181CysAsn: 0.181 ± 0.013	0.505CysPro: 0.505 ± 0.024	0.242CysGln: 0.242 ± 0.017	0.586CysArg: 0.586 ± 0.028	0.403CysSer: 0.403 ± 0.023	0.35CysThr: 0.35 ± 0.019	0.559CysVal: 0.559 ± 0.026	0.111CysTrp: 0.111 ± 0.011	0.177CysTyr: 0.177 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.92AspAla: 7.92 ± 0.113	0.526AspCys: 0.526 ± 0.027	3.677AspAsp: 3.677 ± 0.079	3.683AspGlu: 3.683 ± 0.067	2.157AspPhe: 2.157 ± 0.049	5.611AspGly: 5.611 ± 0.109	1.468AspHis: 1.468 ± 0.048	2.766AspIle: 2.766 ± 0.051	1.478AspLys: 1.478 ± 0.039	6.894AspLeu: 6.894 ± 0.086	1.588AspMet: 1.588 ± 0.044	1.217AspAsn: 1.217 ± 0.036	4.109AspPro: 4.109 ± 0.065	2.118AspGln: 2.118 ± 0.044	5.236AspArg: 5.236 ± 0.079	2.647AspSer: 2.647 ± 0.058	2.655AspThr: 2.655 ± 0.065	3.727AspVal: 3.727 ± 0.067	1.264AspTrp: 1.264 ± 0.04	1.527AspTyr: 1.527 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	7.905GluAla: 7.905 ± 0.111	0.336GluCys: 0.336 ± 0.022	3.027GluAsp: 3.027 ± 0.054	2.559GluGlu: 2.559 ± 0.065	1.699GluPhe: 1.699 ± 0.044	4.528GluGly: 4.528 ± 0.089	0.965GluHis: 0.965 ± 0.035	3.475GluIle: 3.475 ± 0.068	1.556GluLys: 1.556 ± 0.043	5.077GluLeu: 5.077 ± 0.069	1.731GluMet: 1.731 ± 0.043	1.473GluAsn: 1.473 ± 0.039	2.512GluPro: 2.512 ± 0.054	1.913GluGln: 1.913 ± 0.04	4.282GluArg: 4.282 ± 0.068	2.259GluSer: 2.259 ± 0.049	3.364GluThr: 3.364 ± 0.056	3.97GluVal: 3.97 ± 0.069	0.784GluTrp: 0.784 ± 0.027	1.003GluTyr: 1.003 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	4.34PheAla: 4.34 ± 0.081	0.369PheCys: 0.369 ± 0.019	2.766PheAsp: 2.766 ± 0.051	1.705PheGlu: 1.705 ± 0.046	1.237PhePhe: 1.237 ± 0.045	3.496PheGly: 3.496 ± 0.063	0.731PheHis: 0.731 ± 0.031	1.6PheIle: 1.6 ± 0.04	0.718PheLys: 0.718 ± 0.026	3.302PheLeu: 3.302 ± 0.073	0.827PheMet: 0.827 ± 0.03	0.91PheAsn: 0.91 ± 0.039	1.55PhePro: 1.55 ± 0.04	0.987PheGln: 0.987 ± 0.032	2.278PheArg: 2.278 ± 0.053	1.984PheSer: 1.984 ± 0.056	1.866PheThr: 1.866 ± 0.049	2.44PheVal: 2.44 ± 0.059	0.566PheTrp: 0.566 ± 0.028	0.809PheTyr: 0.809 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	10.452GlyAla: 10.452 ± 0.13	0.842GlyCys: 0.842 ± 0.03	4.882GlyAsp: 4.882 ± 0.081	4.556GlyGlu: 4.556 ± 0.074	3.636GlyPhe: 3.636 ± 0.067	7.524GlyGly: 7.524 ± 0.127	1.93GlyHis: 1.93 ± 0.047	4.637GlyIle: 4.637 ± 0.078	2.841GlyLys: 2.841 ± 0.054	9.616GlyLeu: 9.616 ± 0.116	2.621GlyMet: 2.621 ± 0.054	2.001GlyAsn: 2.001 ± 0.058	3.971GlyPro: 3.971 ± 0.073	3.576GlyGln: 3.576 ± 0.072	6.679GlyArg: 6.679 ± 0.104	4.304GlySer: 4.304 ± 0.082	4.369GlyThr: 4.369 ± 0.08	6.393GlyVal: 6.393 ± 0.091	1.589GlyTrp: 1.589 ± 0.045	2.093GlyTyr: 2.093 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.397HisAla: 2.397 ± 0.05	0.194HisCys: 0.194 ± 0.014	1.484HisAsp: 1.484 ± 0.037	1.059HisGlu: 1.059 ± 0.033	0.725HisPhe: 0.725 ± 0.031	2.051HisGly: 2.051 ± 0.047	0.588HisHis: 0.588 ± 0.027	0.898HisIle: 0.898 ± 0.034	0.433HisLys: 0.433 ± 0.02	2.163HisLeu: 2.163 ± 0.055	0.502HisMet: 0.502 ± 0.023	0.421HisAsn: 0.421 ± 0.022	1.39HisPro: 1.39 ± 0.038	0.633HisGln: 0.633 ± 0.026	1.545HisArg: 1.545 ± 0.039	0.917HisSer: 0.917 ± 0.032	0.692HisThr: 0.692 ± 0.028	1.515HisVal: 1.515 ± 0.043	0.336HisTrp: 0.336 ± 0.02	0.557HisTyr: 0.557 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	7.319IleAla: 7.319 ± 0.1	0.561IleCys: 0.561 ± 0.023	3.588IleAsp: 3.588 ± 0.061	3.48IleGlu: 3.48 ± 0.061	1.675IlePhe: 1.675 ± 0.048	5.082IleGly: 5.082 ± 0.077	0.98IleHis: 0.98 ± 0.032	2.262IleIle: 2.262 ± 0.053	1.099IleLys: 1.099 ± 0.036	4.79IleLeu: 4.79 ± 0.089	1.109IleMet: 1.109 ± 0.036	1.182IleAsn: 1.182 ± 0.038	2.311IlePro: 2.311 ± 0.051	1.14IleGln: 1.14 ± 0.031	3.708IleArg: 3.708 ± 0.067	2.729IleSer: 2.729 ± 0.06	2.663IleThr: 2.663 ± 0.064	3.622IleVal: 3.622 ± 0.072	0.749IleTrp: 0.749 ± 0.028	1.051IleTyr: 1.051 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	3.105LysAla: 3.105 ± 0.068	0.128LysCys: 0.128 ± 0.012	1.333LysAsp: 1.333 ± 0.042	1.094LysGlu: 1.094 ± 0.035	0.719LysPhe: 0.719 ± 0.03	2.314LysGly: 2.314 ± 0.05	0.489LysHis: 0.489 ± 0.022	1.281LysIle: 1.281 ± 0.04	0.799LysLys: 0.799 ± 0.033	2.57LysLeu: 2.57 ± 0.063	0.652LysMet: 0.652 ± 0.024	0.574LysAsn: 0.574 ± 0.025	1.618LysPro: 1.618 ± 0.045	0.806LysGln: 0.806 ± 0.03	1.854LysArg: 1.854 ± 0.049	1.449LysSer: 1.449 ± 0.041	1.538LysThr: 1.538 ± 0.035	1.81LysVal: 1.81 ± 0.043	0.311LysTrp: 0.311 ± 0.021	0.509LysTyr: 0.509 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	14.154LeuAla: 14.154 ± 0.157	0.87LeuCys: 0.87 ± 0.03	6.564LeuAsp: 6.564 ± 0.102	4.229LeuGlu: 4.229 ± 0.081	3.4LeuPhe: 3.4 ± 0.079	8.664LeuGly: 8.664 ± 0.101	2.052LeuHis: 2.052 ± 0.046	5.64LeuIle: 5.64 ± 0.079	2.512LeuLys: 2.512 ± 0.057	9.751LeuLeu: 9.751 ± 0.148	2.588LeuMet: 2.588 ± 0.055	2.657LeuAsn: 2.657 ± 0.048	6.364LeuPro: 6.364 ± 0.101	3.074LeuGln: 3.074 ± 0.058	8.212LeuArg: 8.212 ± 0.119	6.619LeuSer: 6.619 ± 0.085	6.504LeuThr: 6.504 ± 0.091	6.741LeuVal: 6.741 ± 0.105	1.257LeuTrp: 1.257 ± 0.043	1.836LeuTyr: 1.836 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	3.468MetAla: 3.468 ± 0.063	0.133MetCys: 0.133 ± 0.013	1.354MetAsp: 1.354 ± 0.035	1.053MetGlu: 1.053 ± 0.034	0.786MetPhe: 0.786 ± 0.03	2.293MetGly: 2.293 ± 0.053	0.381MetHis: 0.381 ± 0.021	1.533MetIle: 1.533 ± 0.04	0.885MetLys: 0.885 ± 0.032	2.845MetLeu: 2.845 ± 0.062	0.753MetMet: 0.753 ± 0.033	0.831MetAsn: 0.831 ± 0.031	1.661MetPro: 1.661 ± 0.042	1.116MetGln: 1.116 ± 0.038	2.081MetArg: 2.081 ± 0.048	1.641MetSer: 1.641 ± 0.045	2.15MetThr: 2.15 ± 0.048	1.797MetVal: 1.797 ± 0.041	0.257MetTrp: 0.257 ± 0.015	0.309MetTyr: 0.309 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.936AsnAla: 2.936 ± 0.058	0.214AsnCys: 0.214 ± 0.015	1.301AsnAsp: 1.301 ± 0.045	1.02AsnGlu: 1.02 ± 0.036	0.828AsnPhe: 0.828 ± 0.028	2.029AsnGly: 2.029 ± 0.049	0.472AsnHis: 0.472 ± 0.024	1.255AsnIle: 1.255 ± 0.037	0.524AsnLys: 0.524 ± 0.023	2.39AsnLeu: 2.39 ± 0.054	0.602AsnMet: 0.602 ± 0.024	0.554AsnAsn: 0.554 ± 0.03	1.695AsnPro: 1.695 ± 0.045	0.654AsnGln: 0.654 ± 0.028	1.805AsnArg: 1.805 ± 0.044	1.107AsnSer: 1.107 ± 0.033	1.064AsnThr: 1.064 ± 0.036	1.584AsnVal: 1.584 ± 0.044	0.431AsnTrp: 0.431 ± 0.022	0.6AsnTyr: 0.6 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	7.098ProAla: 7.098 ± 0.112	0.36ProCys: 0.36 ± 0.02	4.704ProAsp: 4.704 ± 0.081	4.129ProGlu: 4.129 ± 0.074	1.81ProPhe: 1.81 ± 0.046	5.135ProGly: 5.135 ± 0.072	1.101ProHis: 1.101 ± 0.036	2.268ProIle: 2.268 ± 0.043	1.304ProLys: 1.304 ± 0.041	5.064ProLeu: 5.064 ± 0.086	1.385ProMet: 1.385 ± 0.041	1.113ProAsn: 1.113 ± 0.038	3.11ProPro: 3.11 ± 0.068	2.17ProGln: 2.17 ± 0.048	3.497ProArg: 3.497 ± 0.062	2.426ProSer: 2.426 ± 0.044	2.425ProThr: 2.425 ± 0.047	4.501ProVal: 4.501 ± 0.077	0.706ProTrp: 0.706 ± 0.028	1.06ProTyr: 1.06 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.824GlnAla: 4.824 ± 0.078	0.178GlnCys: 0.178 ± 0.014	2.003GlnAsp: 2.003 ± 0.048	1.392GlnGlu: 1.392 ± 0.037	1.048GlnPhe: 1.048 ± 0.035	3.19GlnGly: 3.19 ± 0.064	0.656GlnHis: 0.656 ± 0.03	2.263GlnIle: 2.263 ± 0.047	0.945GlnLys: 0.945 ± 0.033	2.912GlnLeu: 2.912 ± 0.058	1.176GlnMet: 1.176 ± 0.034	0.836GlnAsn: 0.836 ± 0.03	2.134GlnPro: 2.134 ± 0.055	1.411GlnGln: 1.411 ± 0.048	2.605GlnArg: 2.605 ± 0.055	1.689GlnSer: 1.689 ± 0.04	1.943GlnThr: 1.943 ± 0.041	2.572GlnVal: 2.572 ± 0.052	0.376GlnTrp: 0.376 ± 0.018	0.518GlnTyr: 0.518 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	9.142ArgAla: 9.142 ± 0.129	0.504ArgCys: 0.504 ± 0.024	5.037ArgAsp: 5.037 ± 0.074	4.105ArgGlu: 4.105 ± 0.068	2.867ArgPhe: 2.867 ± 0.058	5.279ArgGly: 5.279 ± 0.086	1.889ArgHis: 1.889 ± 0.053	4.482ArgIle: 4.482 ± 0.078	2.098ArgLys: 2.098 ± 0.055	8.658ArgLeu: 8.658 ± 0.112	2.3ArgMet: 2.3 ± 0.044	1.778ArgAsn: 1.778 ± 0.045	4.049ArgPro: 4.049 ± 0.071	2.843ArgGln: 2.843 ± 0.055	6.123ArgArg: 6.123 ± 0.102	3.499ArgSer: 3.499 ± 0.067	2.983ArgThr: 2.983 ± 0.063	5.105ArgVal: 5.105 ± 0.076	1.018ArgTrp: 1.018 ± 0.033	1.481ArgTyr: 1.481 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	5.863SerAla: 5.863 ± 0.072	0.418SerCys: 0.418 ± 0.023	3.263SerAsp: 3.263 ± 0.064	2.453SerGlu: 2.453 ± 0.049	2.134SerPhe: 2.134 ± 0.05	5.451SerGly: 5.451 ± 0.087	1.02SerHis: 1.02 ± 0.036	2.348SerIle: 2.348 ± 0.052	1.097SerLys: 1.097 ± 0.038	5.066SerLeu: 5.066 ± 0.084	1.266SerMet: 1.266 ± 0.039	1.145SerAsn: 1.145 ± 0.037	2.677SerPro: 2.677 ± 0.052	1.661SerGln: 1.661 ± 0.04	3.676SerArg: 3.676 ± 0.063	2.341SerSer: 2.341 ± 0.056	2.338SerThr: 2.338 ± 0.049	3.632SerVal: 3.632 ± 0.064	0.757SerTrp: 0.757 ± 0.031	1.198SerTyr: 1.198 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	6.334ThrAla: 6.334 ± 0.1	0.432ThrCys: 0.432 ± 0.024	3.123ThrAsp: 3.123 ± 0.06	3.025ThrGlu: 3.025 ± 0.061	1.594ThrPhe: 1.594 ± 0.045	5.47ThrGly: 5.47 ± 0.08	1.086ThrHis: 1.086 ± 0.036	2.551ThrIle: 2.551 ± 0.055	1.067ThrLys: 1.067 ± 0.036	5.94ThrLeu: 5.94 ± 0.078	1.145ThrMet: 1.145 ± 0.037	1.135ThrAsn: 1.135 ± 0.034	3.627ThrPro: 3.627 ± 0.068	1.643ThrGln: 1.643 ± 0.042	3.819ThrArg: 3.819 ± 0.068	2.331ThrSer: 2.331 ± 0.052	2.671ThrThr: 2.671 ± 0.062	3.783ThrVal: 3.783 ± 0.063	0.556ThrTrp: 0.556 ± 0.027	0.948ThrTyr: 0.948 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	8.958ValAla: 8.958 ± 0.098	0.512ValCys: 0.512 ± 0.024	3.755ValAsp: 3.755 ± 0.066	4.18ValGlu: 4.18 ± 0.072	2.596ValPhe: 2.596 ± 0.059	5.209ValGly: 5.209 ± 0.077	1.261ValHis: 1.261 ± 0.038	4.152ValIle: 4.152 ± 0.069	1.699ValLys: 1.699 ± 0.048	7.601ValLeu: 7.601 ± 0.118	2.15ValMet: 2.15 ± 0.047	1.762ValAsn: 1.762 ± 0.044	3.534ValPro: 3.534 ± 0.061	2.127ValGln: 2.127 ± 0.048	4.252ValArg: 4.252 ± 0.072	3.869ValSer: 3.869 ± 0.064	4.766ValThr: 4.766 ± 0.081	5.469ValVal: 5.469 ± 0.081	1.027ValTrp: 1.027 ± 0.033	1.33ValTyr: 1.33 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.372TrpAla: 1.372 ± 0.039	0.139TrpCys: 0.139 ± 0.012	0.726TrpAsp: 0.726 ± 0.028	0.513TrpGlu: 0.513 ± 0.024	0.565TrpPhe: 0.565 ± 0.028	1.006TrpGly: 1.006 ± 0.036	0.304TrpHis: 0.304 ± 0.016	0.633TrpIle: 0.633 ± 0.031	0.367TrpLys: 0.367 ± 0.02	1.869TrpLeu: 1.869 ± 0.054	0.379TrpMet: 0.379 ± 0.019	0.372TrpAsn: 0.372 ± 0.022	0.782TrpPro: 0.782 ± 0.029	0.826TrpGln: 0.826 ± 0.029	1.276TrpArg: 1.276 ± 0.038	0.77TrpSer: 0.77 ± 0.028	0.786TrpThr: 0.786 ± 0.03	0.939TrpVal: 0.939 ± 0.035	0.261TrpTrp: 0.261 ± 0.019	0.288TrpTyr: 0.288 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.339TyrAla: 2.339 ± 0.054	0.229TyrCys: 0.229 ± 0.014	1.523TyrAsp: 1.523 ± 0.043	1.064TyrGlu: 1.064 ± 0.038	0.772TyrPhe: 0.772 ± 0.028	1.968TyrGly: 1.968 ± 0.046	0.527TyrHis: 0.527 ± 0.024	0.763TyrIle: 0.763 ± 0.032	0.461TyrLys: 0.461 ± 0.023	2.131TyrLeu: 2.131 ± 0.059	0.387TyrMet: 0.387 ± 0.02	0.492TyrAsn: 0.492 ± 0.025	1.059TyrPro: 1.059 ± 0.034	0.643TyrGln: 0.643 ± 0.027	1.581TyrArg: 1.581 ± 0.044	0.99TyrSer: 0.99 ± 0.032	0.918TyrThr: 0.918 ± 0.036	1.38TyrVal: 1.38 ± 0.039	0.31TyrTrp: 0.31 ± 0.02	0.501TyrTyr: 0.501 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2977 proteins (950684 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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