Amino acid dipepetide frequency for Dishui lake virophage 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.115AlaCys: 0.115 ± 0.101
5.631AlaAsp: 5.631 ± 0.79
5.746AlaGlu: 5.746 ± 0.772
3.562AlaPhe: 3.562 ± 0.537
7.355AlaGly: 7.355 ± 1.736
0.804AlaHis: 0.804 ± 0.366
4.367AlaIle: 4.367 ± 0.573
4.597AlaLys: 4.597 ± 0.933
5.401AlaLeu: 5.401 ± 0.553
0.345AlaMet: 0.345 ± 0.183
5.286AlaAsn: 5.286 ± 0.793
4.367AlaPro: 4.367 ± 0.811
4.367AlaGln: 4.367 ± 0.913
2.758AlaArg: 2.758 ± 0.636
5.746AlaSer: 5.746 ± 0.938
8.504AlaThr: 8.504 ± 1.283
5.861AlaVal: 5.861 ± 0.927
0.919AlaTrp: 0.919 ± 0.242
2.643AlaTyr: 2.643 ± 0.424
0.0AlaXaa: 0.0 ± 0.0
Cys
0.46CysAla: 0.46 ± 0.289
0.689CysCys: 0.689 ± 0.298
0.46CysAsp: 0.46 ± 0.225
0.804CysGlu: 0.804 ± 0.327
0.575CysPhe: 0.575 ± 0.283
1.264CysGly: 1.264 ± 0.389
0.23CysHis: 0.23 ± 0.145
0.345CysIle: 0.345 ± 0.252
0.115CysLys: 0.115 ± 0.113
0.575CysLeu: 0.575 ± 0.204
0.46CysMet: 0.46 ± 0.189
0.689CysAsn: 0.689 ± 0.241
1.034CysPro: 1.034 ± 0.352
0.345CysGln: 0.345 ± 0.183
0.46CysArg: 0.46 ± 0.212
1.264CysSer: 1.264 ± 0.396
0.0CysThr: 0.0 ± 0.0
1.264CysVal: 1.264 ± 0.387
0.0CysTrp: 0.0 ± 0.0
0.23CysTyr: 0.23 ± 0.126
0.0CysXaa: 0.0 ± 0.0
Asp
4.597AspAla: 4.597 ± 0.654
0.575AspCys: 0.575 ± 0.223
3.907AspAsp: 3.907 ± 0.765
3.447AspGlu: 3.447 ± 0.68
3.333AspPhe: 3.333 ± 0.86
3.447AspGly: 3.447 ± 0.586
0.115AspHis: 0.115 ± 0.102
3.333AspIle: 3.333 ± 0.734
4.252AspLys: 4.252 ± 0.75
5.401AspLeu: 5.401 ± 0.655
1.839AspMet: 1.839 ± 0.483
2.068AspAsn: 2.068 ± 0.5
2.873AspPro: 2.873 ± 0.696
1.264AspGln: 1.264 ± 0.356
1.839AspArg: 1.839 ± 0.575
1.609AspSer: 1.609 ± 0.38
4.022AspThr: 4.022 ± 0.816
3.333AspVal: 3.333 ± 0.517
0.689AspTrp: 0.689 ± 0.369
3.447AspTyr: 3.447 ± 0.632
0.0AspXaa: 0.0 ± 0.0
Glu
5.171GluAla: 5.171 ± 0.847
0.46GluCys: 0.46 ± 0.3
4.022GluAsp: 4.022 ± 0.76
5.401GluGlu: 5.401 ± 1.616
1.839GluPhe: 1.839 ± 0.424
2.758GluGly: 2.758 ± 0.521
1.149GluHis: 1.149 ± 0.333
3.677GluIle: 3.677 ± 0.843
4.826GluLys: 4.826 ± 1.136
4.941GluLeu: 4.941 ± 0.749
1.264GluMet: 1.264 ± 0.483
3.447GluAsn: 3.447 ± 0.731
2.298GluPro: 2.298 ± 0.516
3.447GluGln: 3.447 ± 0.675
3.562GluArg: 3.562 ± 1.23
1.379GluSer: 1.379 ± 0.44
2.988GluThr: 2.988 ± 0.566
2.298GluVal: 2.298 ± 0.356
0.689GluTrp: 0.689 ± 0.273
3.103GluTyr: 3.103 ± 0.631
0.0GluXaa: 0.0 ± 0.0
Phe
2.988PheAla: 2.988 ± 0.592
0.46PheCys: 0.46 ± 0.18
2.298PheAsp: 2.298 ± 0.511
1.379PheGlu: 1.379 ± 0.507
2.643PhePhe: 2.643 ± 0.592
2.528PheGly: 2.528 ± 0.643
0.804PheHis: 0.804 ± 0.236
1.609PheIle: 1.609 ± 0.314
2.988PheLys: 2.988 ± 0.563
2.183PheLeu: 2.183 ± 0.492
0.804PheMet: 0.804 ± 0.262
2.528PheAsn: 2.528 ± 0.536
1.839PhePro: 1.839 ± 0.347
2.413PheGln: 2.413 ± 0.58
1.264PheArg: 1.264 ± 0.401
3.447PheSer: 3.447 ± 0.757
3.103PheThr: 3.103 ± 0.62
2.643PheVal: 2.643 ± 0.407
0.575PheTrp: 0.575 ± 0.318
1.264PheTyr: 1.264 ± 0.386
0.0PheXaa: 0.0 ± 0.0
Gly
5.861GlyAla: 5.861 ± 1.68
1.034GlyCys: 1.034 ± 0.307
5.401GlyAsp: 5.401 ± 1.412
3.677GlyGlu: 3.677 ± 0.771
1.954GlyPhe: 1.954 ± 0.556
15.399GlyGly: 15.399 ± 5.522
1.034GlyHis: 1.034 ± 0.284
3.677GlyIle: 3.677 ± 0.712
4.482GlyLys: 4.482 ± 1.192
4.941GlyLeu: 4.941 ± 0.737
2.528GlyMet: 2.528 ± 1.121
4.941GlyAsn: 4.941 ± 0.994
2.873GlyPro: 2.873 ± 1.664
2.988GlyGln: 2.988 ± 0.644
3.792GlyArg: 3.792 ± 0.718
5.631GlySer: 5.631 ± 1.196
4.826GlyThr: 4.826 ± 1.109
4.712GlyVal: 4.712 ± 0.584
0.575GlyTrp: 0.575 ± 0.259
2.758GlyTyr: 2.758 ± 0.739
0.0GlyXaa: 0.0 ± 0.0
His
1.379HisAla: 1.379 ± 0.362
0.0HisCys: 0.0 ± 0.0
0.804HisAsp: 0.804 ± 0.291
0.23HisGlu: 0.23 ± 0.228
0.689HisPhe: 0.689 ± 0.331
0.46HisGly: 0.46 ± 0.331
0.345HisHis: 0.345 ± 0.256
1.379HisIle: 1.379 ± 0.386
1.149HisLys: 1.149 ± 0.338
0.804HisLeu: 0.804 ± 0.31
0.115HisMet: 0.115 ± 0.102
1.149HisAsn: 1.149 ± 0.491
0.804HisPro: 0.804 ± 0.238
0.23HisGln: 0.23 ± 0.154
0.575HisArg: 0.575 ± 0.325
1.264HisSer: 1.264 ± 0.323
0.46HisThr: 0.46 ± 0.235
0.0HisVal: 0.0 ± 0.0
0.115HisTrp: 0.115 ± 0.1
0.46HisTyr: 0.46 ± 0.224
0.0HisXaa: 0.0 ± 0.0
Ile
4.482IleAla: 4.482 ± 0.611
0.919IleCys: 0.919 ± 0.31
2.528IleAsp: 2.528 ± 0.776
3.447IleGlu: 3.447 ± 0.702
2.183IlePhe: 2.183 ± 0.515
2.528IleGly: 2.528 ± 0.462
0.575IleHis: 0.575 ± 0.234
3.218IleIle: 3.218 ± 0.5
3.792IleLys: 3.792 ± 0.892
5.056IleLeu: 5.056 ± 0.726
1.609IleMet: 1.609 ± 0.421
2.413IleAsn: 2.413 ± 0.544
1.954IlePro: 1.954 ± 0.465
4.022IleGln: 4.022 ± 0.826
2.413IleArg: 2.413 ± 0.632
4.022IleSer: 4.022 ± 0.885
5.056IleThr: 5.056 ± 1.196
3.103IleVal: 3.103 ± 0.663
0.345IleTrp: 0.345 ± 0.171
2.413IleTyr: 2.413 ± 0.586
0.0IleXaa: 0.0 ± 0.0
Lys
5.631LysAla: 5.631 ± 1.265
0.575LysCys: 0.575 ± 0.212
3.447LysAsp: 3.447 ± 0.622
5.631LysGlu: 5.631 ± 1.344
2.183LysPhe: 2.183 ± 0.489
3.447LysGly: 3.447 ± 0.632
1.379LysHis: 1.379 ± 0.501
4.367LysIle: 4.367 ± 0.784
5.286LysLys: 5.286 ± 0.919
4.482LysLeu: 4.482 ± 0.765
1.954LysMet: 1.954 ± 0.486
3.218LysAsn: 3.218 ± 0.716
2.528LysPro: 2.528 ± 0.523
4.022LysGln: 4.022 ± 0.777
4.482LysArg: 4.482 ± 0.98
3.562LysSer: 3.562 ± 0.723
2.413LysThr: 2.413 ± 0.585
4.941LysVal: 4.941 ± 0.895
0.575LysTrp: 0.575 ± 0.254
2.988LysTyr: 2.988 ± 0.726
0.0LysXaa: 0.0 ± 0.0
Leu
4.712LeuAla: 4.712 ± 0.888
0.919LeuCys: 0.919 ± 0.323
4.826LeuAsp: 4.826 ± 0.731
4.482LeuGlu: 4.482 ± 0.751
2.758LeuPhe: 2.758 ± 0.513
6.091LeuGly: 6.091 ± 0.839
1.494LeuHis: 1.494 ± 0.567
3.792LeuIle: 3.792 ± 0.764
7.01LeuLys: 7.01 ± 1.32
6.665LeuLeu: 6.665 ± 1.0
1.149LeuMet: 1.149 ± 0.455
4.482LeuAsn: 4.482 ± 0.67
6.55LeuPro: 6.55 ± 0.77
3.218LeuGln: 3.218 ± 0.734
3.447LeuArg: 3.447 ± 0.637
5.516LeuSer: 5.516 ± 0.833
5.171LeuThr: 5.171 ± 0.825
3.103LeuVal: 3.103 ± 0.549
0.804LeuTrp: 0.804 ± 0.309
3.907LeuTyr: 3.907 ± 0.654
0.0LeuXaa: 0.0 ± 0.0
Met
1.149MetAla: 1.149 ± 0.397
0.689MetCys: 0.689 ± 0.311
1.034MetAsp: 1.034 ± 0.38
1.264MetGlu: 1.264 ± 0.49
0.804MetPhe: 0.804 ± 0.241
1.149MetGly: 1.149 ± 0.411
0.0MetHis: 0.0 ± 0.0
0.804MetIle: 0.804 ± 0.279
0.804MetLys: 0.804 ± 0.332
1.609MetLeu: 1.609 ± 0.482
0.345MetMet: 0.345 ± 0.168
1.379MetAsn: 1.379 ± 0.299
1.379MetPro: 1.379 ± 0.412
0.0MetGln: 0.0 ± 0.0
0.804MetArg: 0.804 ± 0.308
2.873MetSer: 2.873 ± 0.859
1.264MetThr: 1.264 ± 0.421
0.689MetVal: 0.689 ± 0.29
0.23MetTrp: 0.23 ± 0.166
0.46MetTyr: 0.46 ± 0.187
0.0MetXaa: 0.0 ± 0.0
Asn
5.401AsnAla: 5.401 ± 0.684
0.575AsnCys: 0.575 ± 0.286
2.873AsnAsp: 2.873 ± 0.671
2.643AsnGlu: 2.643 ± 0.761
1.379AsnPhe: 1.379 ± 0.428
3.447AsnGly: 3.447 ± 0.54
0.689AsnHis: 0.689 ± 0.283
3.562AsnIle: 3.562 ± 0.495
3.792AsnLys: 3.792 ± 0.801
5.056AsnLeu: 5.056 ± 0.622
1.494AsnMet: 1.494 ± 0.367
4.367AsnAsn: 4.367 ± 1.16
3.677AsnPro: 3.677 ± 0.485
2.298AsnGln: 2.298 ± 0.573
1.954AsnArg: 1.954 ± 0.393
4.712AsnSer: 4.712 ± 1.07
3.562AsnThr: 3.562 ± 0.8
2.413AsnVal: 2.413 ± 0.573
0.804AsnTrp: 0.804 ± 0.282
2.068AsnTyr: 2.068 ± 0.579
0.0AsnXaa: 0.0 ± 0.0
Pro
4.826ProAla: 4.826 ± 0.89
0.575ProCys: 0.575 ± 0.28
1.954ProAsp: 1.954 ± 0.495
3.103ProGlu: 3.103 ± 0.722
2.643ProPhe: 2.643 ± 0.596
0.0ProGly: 0.0 ± 0.0
0.46ProHis: 0.46 ± 0.202
1.839ProIle: 1.839 ± 0.536
2.643ProLys: 2.643 ± 0.494
5.171ProLeu: 5.171 ± 0.862
0.345ProMet: 0.345 ± 0.194
2.298ProAsn: 2.298 ± 0.536
3.103ProPro: 3.103 ± 1.296
4.137ProGln: 4.137 ± 1.039
1.954ProArg: 1.954 ± 0.353
3.333ProSer: 3.333 ± 0.565
4.367ProThr: 4.367 ± 0.804
4.022ProVal: 4.022 ± 0.457
0.575ProTrp: 0.575 ± 0.27
2.528ProTyr: 2.528 ± 0.604
0.0ProXaa: 0.0 ± 0.0
Gln
4.826GlnAla: 4.826 ± 1.019
0.0GlnCys: 0.0 ± 0.0
2.528GlnAsp: 2.528 ± 0.553
2.528GlnGlu: 2.528 ± 0.536
1.839GlnPhe: 1.839 ± 0.483
5.401GlnGly: 5.401 ± 1.673
0.575GlnHis: 0.575 ± 0.278
2.988GlnIle: 2.988 ± 0.45
2.183GlnLys: 2.183 ± 0.626
4.482GlnLeu: 4.482 ± 0.705
0.345GlnMet: 0.345 ± 0.167
2.068GlnAsn: 2.068 ± 0.54
2.298GlnPro: 2.298 ± 0.624
3.907GlnGln: 3.907 ± 1.253
2.298GlnArg: 2.298 ± 0.392
3.562GlnSer: 3.562 ± 0.738
3.562GlnThr: 3.562 ± 0.566
2.183GlnVal: 2.183 ± 0.449
0.0GlnTrp: 0.0 ± 0.0
1.724GlnTyr: 1.724 ± 0.441
0.0GlnXaa: 0.0 ± 0.0
Arg
2.528ArgAla: 2.528 ± 0.565
0.23ArgCys: 0.23 ± 0.151
1.724ArgAsp: 1.724 ± 0.298
3.562ArgGlu: 3.562 ± 0.995
1.954ArgPhe: 1.954 ± 0.472
2.298ArgGly: 2.298 ± 0.586
0.345ArgHis: 0.345 ± 0.204
3.103ArgIle: 3.103 ± 0.576
4.137ArgLys: 4.137 ± 0.954
4.252ArgLeu: 4.252 ± 0.711
0.575ArgMet: 0.575 ± 0.214
2.068ArgAsn: 2.068 ± 0.511
2.298ArgPro: 2.298 ± 0.586
2.298ArgGln: 2.298 ± 0.711
3.792ArgArg: 3.792 ± 0.949
2.183ArgSer: 2.183 ± 0.514
1.724ArgThr: 1.724 ± 0.324
1.724ArgVal: 1.724 ± 0.265
0.345ArgTrp: 0.345 ± 0.169
1.954ArgTyr: 1.954 ± 0.504
0.0ArgXaa: 0.0 ± 0.0
Ser
6.32SerAla: 6.32 ± 1.158
0.919SerCys: 0.919 ± 0.388
2.183SerAsp: 2.183 ± 0.649
1.954SerGlu: 1.954 ± 0.378
2.643SerPhe: 2.643 ± 0.518
8.389SerGly: 8.389 ± 2.288
0.919SerHis: 0.919 ± 0.273
4.712SerIle: 4.712 ± 0.891
4.022SerLys: 4.022 ± 0.483
4.482SerLeu: 4.482 ± 0.858
0.46SerMet: 0.46 ± 0.227
4.941SerAsn: 4.941 ± 0.805
3.562SerPro: 3.562 ± 0.727
3.447SerGln: 3.447 ± 0.867
1.609SerArg: 1.609 ± 0.537
7.929SerSer: 7.929 ± 1.492
3.677SerThr: 3.677 ± 0.652
6.091SerVal: 6.091 ± 0.863
0.23SerTrp: 0.23 ± 0.137
2.068SerTyr: 2.068 ± 0.47
0.0SerXaa: 0.0 ± 0.0
Thr
7.01ThrAla: 7.01 ± 1.478
0.919ThrCys: 0.919 ± 0.307
3.447ThrAsp: 3.447 ± 0.555
2.758ThrGlu: 2.758 ± 0.606
2.528ThrPhe: 2.528 ± 0.502
7.584ThrGly: 7.584 ± 1.727
0.919ThrHis: 0.919 ± 0.353
3.218ThrIle: 3.218 ± 0.649
3.447ThrLys: 3.447 ± 0.735
5.516ThrLeu: 5.516 ± 0.99
0.804ThrMet: 0.804 ± 0.356
2.873ThrAsn: 2.873 ± 0.741
2.758ThrPro: 2.758 ± 0.581
3.792ThrGln: 3.792 ± 0.632
1.724ThrArg: 1.724 ± 0.421
3.677ThrSer: 3.677 ± 0.829
3.677ThrThr: 3.677 ± 1.022
1.954ThrVal: 1.954 ± 0.644
0.689ThrTrp: 0.689 ± 0.276
2.528ThrTyr: 2.528 ± 0.486
0.0ThrXaa: 0.0 ± 0.0
Val
6.665ValAla: 6.665 ± 1.336
0.689ValCys: 0.689 ± 0.296
2.183ValAsp: 2.183 ± 0.469
3.103ValGlu: 3.103 ± 0.682
2.298ValPhe: 2.298 ± 0.536
6.435ValGly: 6.435 ± 1.394
0.115ValHis: 0.115 ± 0.104
2.298ValIle: 2.298 ± 0.565
4.022ValLys: 4.022 ± 0.595
5.056ValLeu: 5.056 ± 0.753
1.149ValMet: 1.149 ± 0.458
3.562ValAsn: 3.562 ± 0.586
2.528ValPro: 2.528 ± 0.396
1.379ValGln: 1.379 ± 0.301
2.298ValArg: 2.298 ± 0.548
5.401ValSer: 5.401 ± 0.828
0.23ValThr: 0.23 ± 0.257
3.333ValVal: 3.333 ± 0.687
0.689ValTrp: 0.689 ± 0.252
2.643ValTyr: 2.643 ± 0.644
0.0ValXaa: 0.0 ± 0.0
Trp
0.575TrpAla: 0.575 ± 0.229
0.345TrpCys: 0.345 ± 0.183
0.804TrpAsp: 0.804 ± 0.331
0.46TrpGlu: 0.46 ± 0.221
0.575TrpPhe: 0.575 ± 0.207
0.345TrpGly: 0.345 ± 0.167
0.0TrpHis: 0.0 ± 0.0
1.034TrpIle: 1.034 ± 0.322
0.804TrpLys: 0.804 ± 0.274
0.919TrpLeu: 0.919 ± 0.413
0.0TrpMet: 0.0 ± 0.0
1.034TrpAsn: 1.034 ± 0.347
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.46TrpArg: 0.46 ± 0.199
0.689TrpSer: 0.689 ± 0.336
0.689TrpThr: 0.689 ± 0.256
0.46TrpVal: 0.46 ± 0.183
0.115TrpTrp: 0.115 ± 0.102
0.23TrpTyr: 0.23 ± 0.146
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.792TyrAla: 3.792 ± 0.508
0.575TyrCys: 0.575 ± 0.263
3.333TyrAsp: 3.333 ± 0.517
3.103TyrGlu: 3.103 ± 0.554
1.379TyrPhe: 1.379 ± 0.409
2.758TyrGly: 2.758 ± 0.56
0.46TyrHis: 0.46 ± 0.216
2.758TyrIle: 2.758 ± 0.587
2.758TyrLys: 2.758 ± 0.475
3.103TyrLeu: 3.103 ± 0.628
1.034TyrMet: 1.034 ± 0.358
1.954TyrAsn: 1.954 ± 0.317
1.264TyrPro: 1.264 ± 0.385
1.724TyrGln: 1.724 ± 0.575
1.609TyrArg: 1.609 ± 0.447
2.758TyrSer: 2.758 ± 0.363
2.528TyrThr: 2.528 ± 0.561
1.954TyrVal: 1.954 ± 0.381
0.575TyrTrp: 0.575 ± 0.205
2.528TyrTyr: 2.528 ± 0.785
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 28 proteins (8703 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski