Amino acid dipepetide frequency for Enterococcus canis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.93AlaAla: 7.93 ± 0.142
0.524AlaCys: 0.524 ± 0.026
4.603AlaAsp: 4.603 ± 0.092
6.097AlaGlu: 6.097 ± 0.109
3.556AlaPhe: 3.556 ± 0.065
6.056AlaGly: 6.056 ± 0.107
1.448AlaHis: 1.448 ± 0.038
6.053AlaIle: 6.053 ± 0.1
4.909AlaLys: 4.909 ± 0.094
8.25AlaLeu: 8.25 ± 0.118
2.24AlaMet: 2.24 ± 0.058
3.054AlaAsn: 3.054 ± 0.062
2.663AlaPro: 2.663 ± 0.071
3.595AlaGln: 3.595 ± 0.07
3.041AlaArg: 3.041 ± 0.066
4.277AlaSer: 4.277 ± 0.071
4.818AlaThr: 4.818 ± 0.07
5.899AlaVal: 5.899 ± 0.091
0.757AlaTrp: 0.757 ± 0.032
2.743AlaTyr: 2.743 ± 0.067
0.0AlaXaa: 0.0 ± 0.0
Cys
0.36CysAla: 0.36 ± 0.018
0.068CysCys: 0.068 ± 0.01
0.318CysAsp: 0.318 ± 0.019
0.308CysGlu: 0.308 ± 0.02
0.286CysPhe: 0.286 ± 0.02
0.579CysGly: 0.579 ± 0.029
0.148CysHis: 0.148 ± 0.014
0.36CysIle: 0.36 ± 0.022
0.163CysLys: 0.163 ± 0.017
0.659CysLeu: 0.659 ± 0.032
0.14CysMet: 0.14 ± 0.012
0.176CysAsn: 0.176 ± 0.014
0.252CysPro: 0.252 ± 0.021
0.281CysGln: 0.281 ± 0.022
0.224CysArg: 0.224 ± 0.017
0.312CysSer: 0.312 ± 0.021
0.283CysThr: 0.283 ± 0.02
0.31CysVal: 0.31 ± 0.019
0.066CysTrp: 0.066 ± 0.009
0.237CysTyr: 0.237 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
3.82AspAla: 3.82 ± 0.073
0.257AspCys: 0.257 ± 0.017
2.482AspAsp: 2.482 ± 0.068
4.081AspGlu: 4.081 ± 0.091
2.859AspPhe: 2.859 ± 0.058
3.501AspGly: 3.501 ± 0.078
1.205AspHis: 1.205 ± 0.037
3.477AspIle: 3.477 ± 0.07
2.852AspLys: 2.852 ± 0.065
5.382AspLeu: 5.382 ± 0.08
1.365AspMet: 1.365 ± 0.043
1.819AspAsn: 1.819 ± 0.043
2.298AspPro: 2.298 ± 0.053
2.499AspGln: 2.499 ± 0.062
2.11AspArg: 2.11 ± 0.054
2.633AspSer: 2.633 ± 0.072
2.935AspThr: 2.935 ± 0.065
3.684AspVal: 3.684 ± 0.08
0.71AspTrp: 0.71 ± 0.03
2.529AspTyr: 2.529 ± 0.064
0.0AspXaa: 0.0 ± 0.0
Glu
6.211GluAla: 6.211 ± 0.107
0.251GluCys: 0.251 ± 0.02
3.489GluAsp: 3.489 ± 0.075
5.75GluGlu: 5.75 ± 0.11
2.389GluPhe: 2.389 ± 0.066
4.013GluGly: 4.013 ± 0.077
1.217GluHis: 1.217 ± 0.043
4.988GluIle: 4.988 ± 0.087
5.8GluLys: 5.8 ± 0.102
7.369GluLeu: 7.369 ± 0.118
2.161GluMet: 2.161 ± 0.057
3.271GluAsn: 3.271 ± 0.067
2.222GluPro: 2.222 ± 0.059
3.303GluGln: 3.303 ± 0.066
3.293GluArg: 3.293 ± 0.075
3.086GluSer: 3.086 ± 0.061
4.489GluThr: 4.489 ± 0.084
4.928GluVal: 4.928 ± 0.078
0.741GluTrp: 0.741 ± 0.035
2.007GluTyr: 2.007 ± 0.051
0.001GluXaa: 0.001 ± 0.001
Phe
3.493PheAla: 3.493 ± 0.067
0.308PheCys: 0.308 ± 0.02
2.654PheAsp: 2.654 ± 0.055
2.718PheGlu: 2.718 ± 0.063
2.46PhePhe: 2.46 ± 0.064
3.305PheGly: 3.305 ± 0.076
0.887PheHis: 0.887 ± 0.039
3.088PheIle: 3.088 ± 0.077
2.069PheLys: 2.069 ± 0.055
4.877PheLeu: 4.877 ± 0.1
1.187PheMet: 1.187 ± 0.039
1.786PheAsn: 1.786 ± 0.046
1.698PhePro: 1.698 ± 0.046
2.012PheGln: 2.012 ± 0.052
1.567PheArg: 1.567 ± 0.042
3.071PheSer: 3.071 ± 0.07
2.602PheThr: 2.602 ± 0.057
3.268PheVal: 3.268 ± 0.07
0.571PheTrp: 0.571 ± 0.027
1.868PheTyr: 1.868 ± 0.052
0.0PheXaa: 0.0 ± 0.0
Gly
5.241GlyAla: 5.241 ± 0.088
0.491GlyCys: 0.491 ± 0.025
3.301GlyAsp: 3.301 ± 0.072
4.3GlyGlu: 4.3 ± 0.082
3.234GlyPhe: 3.234 ± 0.069
4.818GlyGly: 4.818 ± 0.099
1.279GlyHis: 1.279 ± 0.043
5.578GlyIle: 5.578 ± 0.09
4.47GlyLys: 4.47 ± 0.072
7.057GlyLeu: 7.057 ± 0.12
1.934GlyMet: 1.934 ± 0.051
2.676GlyAsn: 2.676 ± 0.058
1.694GlyPro: 1.694 ± 0.05
2.764GlyGln: 2.764 ± 0.067
2.737GlyArg: 2.737 ± 0.069
3.746GlySer: 3.746 ± 0.077
4.336GlyThr: 4.336 ± 0.081
4.893GlyVal: 4.893 ± 0.093
0.796GlyTrp: 0.796 ± 0.031
2.837GlyTyr: 2.837 ± 0.053
0.0GlyXaa: 0.0 ± 0.0
His
1.186HisAla: 1.186 ± 0.038
0.124HisCys: 0.124 ± 0.012
1.046HisAsp: 1.046 ± 0.033
1.301HisGlu: 1.301 ± 0.039
1.151HisPhe: 1.151 ± 0.038
1.283HisGly: 1.283 ± 0.042
0.594HisHis: 0.594 ± 0.028
1.153HisIle: 1.153 ± 0.042
0.768HisLys: 0.768 ± 0.03
1.978HisLeu: 1.978 ± 0.051
0.485HisMet: 0.485 ± 0.026
0.647HisAsn: 0.647 ± 0.027
0.96HisPro: 0.96 ± 0.035
0.977HisGln: 0.977 ± 0.032
0.863HisArg: 0.863 ± 0.035
0.993HisSer: 0.993 ± 0.039
0.97HisThr: 0.97 ± 0.037
1.163HisVal: 1.163 ± 0.041
0.257HisTrp: 0.257 ± 0.019
1.038HisTyr: 1.038 ± 0.04
0.0HisXaa: 0.0 ± 0.0
Ile
6.021IleAla: 6.021 ± 0.106
0.487IleCys: 0.487 ± 0.027
3.938IleAsp: 3.938 ± 0.064
4.731IleGlu: 4.731 ± 0.082
3.201IlePhe: 3.201 ± 0.075
5.172IleGly: 5.172 ± 0.097
1.333IleHis: 1.333 ± 0.044
4.588IleIle: 4.588 ± 0.09
3.578IleLys: 3.578 ± 0.065
7.001IleLeu: 7.001 ± 0.127
1.624IleMet: 1.624 ± 0.043
2.748IleAsn: 2.748 ± 0.065
3.118IlePro: 3.118 ± 0.06
3.281IleGln: 3.281 ± 0.069
2.934IleArg: 2.934 ± 0.066
4.123IleSer: 4.123 ± 0.075
4.143IleThr: 4.143 ± 0.076
4.98IleVal: 4.98 ± 0.082
0.602IleTrp: 0.602 ± 0.029
2.31IleTyr: 2.31 ± 0.063
0.0IleXaa: 0.0 ± 0.0
Lys
4.834LysAla: 4.834 ± 0.091
0.169LysCys: 0.169 ± 0.016
3.374LysAsp: 3.374 ± 0.076
5.719LysGlu: 5.719 ± 0.095
1.656LysPhe: 1.656 ± 0.046
3.718LysGly: 3.718 ± 0.075
0.915LysHis: 0.915 ± 0.035
4.381LysIle: 4.381 ± 0.092
4.834LysLys: 4.834 ± 0.085
4.962LysLeu: 4.962 ± 0.086
2.11LysMet: 2.11 ± 0.05
2.875LysAsn: 2.875 ± 0.071
1.849LysPro: 1.849 ± 0.048
2.913LysGln: 2.913 ± 0.065
2.851LysArg: 2.851 ± 0.068
2.519LysSer: 2.519 ± 0.062
3.49LysThr: 3.49 ± 0.07
4.06LysVal: 4.06 ± 0.068
0.621LysTrp: 0.621 ± 0.031
1.839LysTyr: 1.839 ± 0.055
0.002LysXaa: 0.002 ± 0.002
Leu
10.161LeuAla: 10.161 ± 0.12
0.579LeuCys: 0.579 ± 0.029
5.159LeuAsp: 5.159 ± 0.088
6.123LeuGlu: 6.123 ± 0.096
4.956LeuPhe: 4.956 ± 0.108
6.852LeuGly: 6.852 ± 0.108
1.759LeuHis: 1.759 ± 0.052
6.675LeuIle: 6.675 ± 0.131
5.948LeuLys: 5.948 ± 0.086
11.481LeuLeu: 11.481 ± 0.2
2.546LeuMet: 2.546 ± 0.063
4.023LeuAsn: 4.023 ± 0.071
4.707LeuPro: 4.707 ± 0.079
4.258LeuGln: 4.258 ± 0.078
3.993LeuArg: 3.993 ± 0.077
6.497LeuSer: 6.497 ± 0.11
6.93LeuThr: 6.93 ± 0.095
7.166LeuVal: 7.166 ± 0.105
0.898LeuTrp: 0.898 ± 0.035
3.229LeuTyr: 3.229 ± 0.069
0.0LeuXaa: 0.0 ± 0.0
Met
2.256MetAla: 2.256 ± 0.053
0.129MetCys: 0.129 ± 0.012
1.475MetAsp: 1.475 ± 0.043
1.78MetGlu: 1.78 ± 0.047
0.888MetPhe: 0.888 ± 0.038
1.783MetGly: 1.783 ± 0.049
0.392MetHis: 0.392 ± 0.025
2.159MetIle: 2.159 ± 0.056
2.031MetLys: 2.031 ± 0.052
2.413MetLeu: 2.413 ± 0.055
0.902MetMet: 0.902 ± 0.036
1.301MetAsn: 1.301 ± 0.037
1.039MetPro: 1.039 ± 0.034
1.069MetGln: 1.069 ± 0.041
1.121MetArg: 1.121 ± 0.04
1.462MetSer: 1.462 ± 0.046
1.849MetThr: 1.849 ± 0.046
1.839MetVal: 1.839 ± 0.052
0.183MetTrp: 0.183 ± 0.014
0.726MetTyr: 0.726 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
2.715AsnAla: 2.715 ± 0.058
0.244AsnCys: 0.244 ± 0.016
2.101AsnAsp: 2.101 ± 0.056
2.869AsnGlu: 2.869 ± 0.065
1.812AsnPhe: 1.812 ± 0.045
3.109AsnGly: 3.109 ± 0.078
0.889AsnHis: 0.889 ± 0.037
2.702AsnIle: 2.702 ± 0.055
2.041AsnLys: 2.041 ± 0.058
3.752AsnLeu: 3.752 ± 0.076
1.045AsnMet: 1.045 ± 0.037
1.534AsnAsn: 1.534 ± 0.059
1.928AsnPro: 1.928 ± 0.054
2.231AsnGln: 2.231 ± 0.066
1.876AsnArg: 1.876 ± 0.06
2.058AsnSer: 2.058 ± 0.062
2.03AsnThr: 2.03 ± 0.053
2.543AsnVal: 2.543 ± 0.06
0.51AsnTrp: 0.51 ± 0.028
1.704AsnTyr: 1.704 ± 0.053
0.0AsnXaa: 0.0 ± 0.0
Pro
2.968ProAla: 2.968 ± 0.065
0.166ProCys: 0.166 ± 0.015
2.088ProAsp: 2.088 ± 0.052
3.52ProGlu: 3.52 ± 0.07
1.912ProPhe: 1.912 ± 0.044
2.174ProGly: 2.174 ± 0.055
0.761ProHis: 0.761 ± 0.031
2.626ProIle: 2.626 ± 0.059
2.119ProLys: 2.119 ± 0.048
3.971ProLeu: 3.971 ± 0.081
0.887ProMet: 0.887 ± 0.03
1.545ProAsn: 1.545 ± 0.043
0.909ProPro: 0.909 ± 0.033
1.682ProGln: 1.682 ± 0.049
1.213ProArg: 1.213 ± 0.044
1.816ProSer: 1.816 ± 0.052
2.382ProThr: 2.382 ± 0.06
3.028ProVal: 3.028 ± 0.069
0.37ProTrp: 0.37 ± 0.022
1.477ProTyr: 1.477 ± 0.042
0.0ProXaa: 0.0 ± 0.0
Gln
4.4GlnAla: 4.4 ± 0.082
0.146GlnCys: 0.146 ± 0.014
2.078GlnAsp: 2.078 ± 0.053
3.647GlnGlu: 3.647 ± 0.075
1.733GlnPhe: 1.733 ± 0.048
2.622GlnGly: 2.622 ± 0.055
0.929GlnHis: 0.929 ± 0.038
2.904GlnIle: 2.904 ± 0.072
3.042GlnLys: 3.042 ± 0.071
5.635GlnLeu: 5.635 ± 0.105
1.29GlnMet: 1.29 ± 0.039
1.834GlnAsn: 1.834 ± 0.064
1.673GlnPro: 1.673 ± 0.051
3.19GlnGln: 3.19 ± 0.088
2.017GlnArg: 2.017 ± 0.054
1.987GlnSer: 1.987 ± 0.048
2.802GlnThr: 2.802 ± 0.067
3.214GlnVal: 3.214 ± 0.064
0.395GlnTrp: 0.395 ± 0.023
1.449GlnTyr: 1.449 ± 0.046
0.0GlnXaa: 0.0 ± 0.0
Arg
2.441ArgAla: 2.441 ± 0.059
0.218ArgCys: 0.218 ± 0.018
1.976ArgAsp: 1.976 ± 0.058
2.986ArgGlu: 2.986 ± 0.077
2.193ArgPhe: 2.193 ± 0.051
2.357ArgGly: 2.357 ± 0.058
0.843ArgHis: 0.843 ± 0.031
3.01ArgIle: 3.01 ± 0.066
2.816ArgLys: 2.816 ± 0.064
4.582ArgLeu: 4.582 ± 0.085
1.112ArgMet: 1.112 ± 0.043
1.623ArgAsn: 1.623 ± 0.056
1.42ArgPro: 1.42 ± 0.043
2.211ArgGln: 2.211 ± 0.056
2.037ArgArg: 2.037 ± 0.057
2.065ArgSer: 2.065 ± 0.044
1.976ArgThr: 1.976 ± 0.048
2.571ArgVal: 2.571 ± 0.064
0.424ArgTrp: 0.424 ± 0.024
1.898ArgTyr: 1.898 ± 0.055
0.0ArgXaa: 0.0 ± 0.0
Ser
3.934SerAla: 3.934 ± 0.072
0.281SerCys: 0.281 ± 0.023
2.69SerAsp: 2.69 ± 0.061
3.766SerGlu: 3.766 ± 0.07
2.882SerPhe: 2.882 ± 0.066
4.322SerGly: 4.322 ± 0.083
1.02SerHis: 1.02 ± 0.042
3.709SerIle: 3.709 ± 0.077
2.976SerLys: 2.976 ± 0.07
5.959SerLeu: 5.959 ± 0.105
1.365SerMet: 1.365 ± 0.035
2.004SerAsn: 2.004 ± 0.057
1.715SerPro: 1.715 ± 0.05
2.586SerGln: 2.586 ± 0.068
2.083SerArg: 2.083 ± 0.054
3.23SerSer: 3.23 ± 0.077
2.91SerThr: 2.91 ± 0.06
3.614SerVal: 3.614 ± 0.08
0.662SerTrp: 0.662 ± 0.029
2.178SerTyr: 2.178 ± 0.053
0.0SerXaa: 0.0 ± 0.0
Thr
5.119ThrAla: 5.119 ± 0.086
0.302ThrCys: 0.302 ± 0.018
3.297ThrAsp: 3.297 ± 0.07
4.078ThrGlu: 4.078 ± 0.088
2.768ThrPhe: 2.768 ± 0.062
4.353ThrGly: 4.353 ± 0.086
1.09ThrHis: 1.09 ± 0.038
4.769ThrIle: 4.769 ± 0.078
3.312ThrLys: 3.312 ± 0.061
6.007ThrLeu: 6.007 ± 0.097
1.474ThrMet: 1.474 ± 0.044
2.372ThrAsn: 2.372 ± 0.062
2.773ThrPro: 2.773 ± 0.056
2.163ThrGln: 2.163 ± 0.054
1.933ThrArg: 1.933 ± 0.05
3.369ThrSer: 3.369 ± 0.068
3.965ThrThr: 3.965 ± 0.079
4.523ThrVal: 4.523 ± 0.078
0.558ThrTrp: 0.558 ± 0.029
1.984ThrTyr: 1.984 ± 0.047
0.0ThrXaa: 0.0 ± 0.0
Val
6.502ValAla: 6.502 ± 0.093
0.461ValCys: 0.461 ± 0.027
3.704ValAsp: 3.704 ± 0.071
4.248ValGlu: 4.248 ± 0.08
3.057ValPhe: 3.057 ± 0.063
4.964ValGly: 4.964 ± 0.083
1.135ValHis: 1.135 ± 0.042
5.141ValIle: 5.141 ± 0.098
4.064ValLys: 4.064 ± 0.08
7.031ValLeu: 7.031 ± 0.106
1.927ValMet: 1.927 ± 0.052
2.606ValAsn: 2.606 ± 0.059
2.842ValPro: 2.842 ± 0.065
2.459ValGln: 2.459 ± 0.055
2.501ValArg: 2.501 ± 0.063
4.17ValSer: 4.17 ± 0.079
4.857ValThr: 4.857 ± 0.1
5.342ValVal: 5.342 ± 0.1
0.601ValTrp: 0.601 ± 0.029
2.208ValTyr: 2.208 ± 0.051
0.0ValXaa: 0.0 ± 0.0
Trp
0.584TrpAla: 0.584 ± 0.03
0.068TrpCys: 0.068 ± 0.01
0.514TrpAsp: 0.514 ± 0.026
0.604TrpGlu: 0.604 ± 0.025
0.529TrpPhe: 0.529 ± 0.024
0.665TrpGly: 0.665 ± 0.032
0.237TrpHis: 0.237 ± 0.019
0.63TrpIle: 0.63 ± 0.026
0.413TrpLys: 0.413 ± 0.021
1.405TrpLeu: 1.405 ± 0.049
0.251TrpMet: 0.251 ± 0.019
0.472TrpAsn: 0.472 ± 0.024
0.267TrpPro: 0.267 ± 0.019
0.941TrpGln: 0.941 ± 0.037
0.566TrpArg: 0.566 ± 0.029
0.592TrpSer: 0.592 ± 0.03
0.497TrpThr: 0.497 ± 0.026
0.581TrpVal: 0.581 ± 0.027
0.169TrpTrp: 0.169 ± 0.014
0.372TrpTyr: 0.372 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.339TyrAla: 2.339 ± 0.052
0.255TyrCys: 0.255 ± 0.017
2.213TyrAsp: 2.213 ± 0.054
2.356TyrGlu: 2.356 ± 0.064
1.966TyrPhe: 1.966 ± 0.055
2.535TyrGly: 2.535 ± 0.06
0.853TyrHis: 0.853 ± 0.034
1.924TyrIle: 1.924 ± 0.052
1.488TyrLys: 1.488 ± 0.047
4.168TyrLeu: 4.168 ± 0.081
0.749TyrMet: 0.749 ± 0.028
1.327TyrAsn: 1.327 ± 0.047
1.583TyrPro: 1.583 ± 0.043
2.572TyrGln: 2.572 ± 0.067
1.801TyrArg: 1.801 ± 0.052
1.877TyrSer: 1.877 ± 0.048
1.943TyrThr: 1.943 ± 0.054
2.214TyrVal: 2.214 ± 0.05
0.47TyrTrp: 0.47 ± 0.023
1.532TyrTyr: 1.532 ± 0.047
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.002XaaCys: 0.002 ± 0.002
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.001XaaSer: 0.001 ± 0.001
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.031XaaXaa: 0.031 ± 0.027
Statistics based on 2671 proteins (808566 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski