Amino acid dipepetide frequency for Aerococcus suis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.273AlaAla: 5.273 ± 0.151
0.347AlaCys: 0.347 ± 0.034
4.599AlaAsp: 4.599 ± 0.113
4.943AlaGlu: 4.943 ± 0.134
3.107AlaPhe: 3.107 ± 0.085
4.76AlaGly: 4.76 ± 0.131
1.429AlaHis: 1.429 ± 0.055
6.742AlaIle: 6.742 ± 0.146
5.298AlaLys: 5.298 ± 0.116
7.254AlaLeu: 7.254 ± 0.142
2.118AlaMet: 2.118 ± 0.077
3.788AlaAsn: 3.788 ± 0.107
2.002AlaPro: 2.002 ± 0.078
3.082AlaGln: 3.082 ± 0.101
2.597AlaArg: 2.597 ± 0.091
4.002AlaSer: 4.002 ± 0.115
4.147AlaThr: 4.147 ± 0.116
4.959AlaVal: 4.959 ± 0.153
0.593AlaTrp: 0.593 ± 0.044
2.693AlaTyr: 2.693 ± 0.082
0.0AlaXaa: 0.0 ± 0.0
Cys
0.304CysAla: 0.304 ± 0.029
0.065CysCys: 0.065 ± 0.014
0.301CysAsp: 0.301 ± 0.027
0.281CysGlu: 0.281 ± 0.028
0.219CysPhe: 0.219 ± 0.024
0.472CysGly: 0.472 ± 0.037
0.198CysHis: 0.198 ± 0.022
0.226CysIle: 0.226 ± 0.025
0.178CysLys: 0.178 ± 0.024
0.46CysLeu: 0.46 ± 0.034
0.113CysMet: 0.113 ± 0.019
0.186CysAsn: 0.186 ± 0.023
0.236CysPro: 0.236 ± 0.027
0.251CysGln: 0.251 ± 0.025
0.229CysArg: 0.229 ± 0.023
0.259CysSer: 0.259 ± 0.025
0.181CysThr: 0.181 ± 0.02
0.314CysVal: 0.314 ± 0.028
0.015CysTrp: 0.015 ± 0.007
0.181CysTyr: 0.181 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
4.318AspAla: 4.318 ± 0.116
0.259AspCys: 0.259 ± 0.023
4.574AspAsp: 4.574 ± 0.154
5.365AspGlu: 5.365 ± 0.123
2.884AspPhe: 2.884 ± 0.084
4.042AspGly: 4.042 ± 0.157
1.495AspHis: 1.495 ± 0.056
4.923AspIle: 4.923 ± 0.101
4.117AspLys: 4.117 ± 0.099
5.858AspLeu: 5.858 ± 0.112
1.821AspMet: 1.821 ± 0.07
3.12AspAsn: 3.12 ± 0.098
1.902AspPro: 1.902 ± 0.065
2.63AspGln: 2.63 ± 0.09
2.15AspArg: 2.15 ± 0.081
3.203AspSer: 3.203 ± 0.115
3.245AspThr: 3.245 ± 0.094
4.509AspVal: 4.509 ± 0.124
0.744AspTrp: 0.744 ± 0.046
3.178AspTyr: 3.178 ± 0.089
0.0AspXaa: 0.0 ± 0.0
Glu
6.323GluAla: 6.323 ± 0.145
0.266GluCys: 0.266 ± 0.029
4.81GluAsp: 4.81 ± 0.103
6.579GluGlu: 6.579 ± 0.159
2.303GluPhe: 2.303 ± 0.078
3.821GluGly: 3.821 ± 0.113
1.434GluHis: 1.434 ± 0.066
5.278GluIle: 5.278 ± 0.139
4.989GluLys: 4.989 ± 0.118
6.687GluLeu: 6.687 ± 0.138
2.396GluMet: 2.396 ± 0.079
3.748GluAsn: 3.748 ± 0.115
2.022GluPro: 2.022 ± 0.079
3.343GluGln: 3.343 ± 0.097
3.358GluArg: 3.358 ± 0.098
3.59GluSer: 3.59 ± 0.107
4.738GluThr: 4.738 ± 0.127
5.009GluVal: 5.009 ± 0.135
0.779GluTrp: 0.779 ± 0.044
2.248GluTyr: 2.248 ± 0.081
0.0GluXaa: 0.0 ± 0.0
Phe
2.911PheAla: 2.911 ± 0.093
0.214PheCys: 0.214 ± 0.021
2.798PheAsp: 2.798 ± 0.085
2.542PheGlu: 2.542 ± 0.084
1.809PhePhe: 1.809 ± 0.068
3.102PheGly: 3.102 ± 0.109
0.859PheHis: 0.859 ± 0.043
3.391PheIle: 3.391 ± 0.118
2.386PheLys: 2.386 ± 0.078
3.645PheLeu: 3.645 ± 0.105
1.053PheMet: 1.053 ± 0.051
2.228PheAsn: 2.228 ± 0.066
1.482PhePro: 1.482 ± 0.055
1.577PheGln: 1.577 ± 0.059
1.294PheArg: 1.294 ± 0.056
2.7PheSer: 2.7 ± 0.091
2.427PheThr: 2.427 ± 0.088
2.723PheVal: 2.723 ± 0.086
0.349PheTrp: 0.349 ± 0.029
1.54PheTyr: 1.54 ± 0.069
0.0PheXaa: 0.0 ± 0.0
Gly
4.388GlyAla: 4.388 ± 0.126
0.317GlyCys: 0.317 ± 0.031
3.748GlyAsp: 3.748 ± 0.093
4.715GlyGlu: 4.715 ± 0.142
2.929GlyPhe: 2.929 ± 0.094
4.346GlyGly: 4.346 ± 0.119
1.522GlyHis: 1.522 ± 0.07
5.23GlyIle: 5.23 ± 0.116
4.27GlyLys: 4.27 ± 0.105
6.174GlyLeu: 6.174 ± 0.142
1.934GlyMet: 1.934 ± 0.087
2.741GlyAsn: 2.741 ± 0.083
1.575GlyPro: 1.575 ± 0.069
2.68GlyGln: 2.68 ± 0.087
2.761GlyArg: 2.761 ± 0.1
3.552GlySer: 3.552 ± 0.099
3.62GlyThr: 3.62 ± 0.115
4.785GlyVal: 4.785 ± 0.127
0.54GlyTrp: 0.54 ± 0.041
2.713GlyTyr: 2.713 ± 0.077
0.0GlyXaa: 0.0 ± 0.0
His
1.409HisAla: 1.409 ± 0.062
0.131HisCys: 0.131 ± 0.021
1.309HisAsp: 1.309 ± 0.061
1.477HisGlu: 1.477 ± 0.065
1.211HisPhe: 1.211 ± 0.06
1.344HisGly: 1.344 ± 0.05
0.914HisHis: 0.914 ± 0.058
1.572HisIle: 1.572 ± 0.074
1.05HisLys: 1.05 ± 0.055
2.429HisLeu: 2.429 ± 0.077
0.578HisMet: 0.578 ± 0.043
0.852HisAsn: 0.852 ± 0.053
1.354HisPro: 1.354 ± 0.067
1.281HisGln: 1.281 ± 0.06
0.965HisArg: 0.965 ± 0.049
1.236HisSer: 1.236 ± 0.053
1.07HisThr: 1.07 ± 0.051
1.382HisVal: 1.382 ± 0.053
0.191HisTrp: 0.191 ± 0.022
1.11HisTyr: 1.11 ± 0.054
0.0HisXaa: 0.0 ± 0.0
Ile
6.187IleAla: 6.187 ± 0.147
0.465IleCys: 0.465 ± 0.032
5.23IleAsp: 5.23 ± 0.119
5.21IleGlu: 5.21 ± 0.108
3.105IlePhe: 3.105 ± 0.113
5.551IleGly: 5.551 ± 0.117
1.653IleHis: 1.653 ± 0.066
5.921IleIle: 5.921 ± 0.161
4.243IleLys: 4.243 ± 0.112
6.865IleLeu: 6.865 ± 0.166
1.678IleMet: 1.678 ± 0.061
3.411IleAsn: 3.411 ± 0.074
3.077IlePro: 3.077 ± 0.094
3.075IleGln: 3.075 ± 0.095
2.788IleArg: 2.788 ± 0.09
4.547IleSer: 4.547 ± 0.116
4.228IleThr: 4.228 ± 0.106
5.323IleVal: 5.323 ± 0.117
0.59IleTrp: 0.59 ± 0.042
2.605IleTyr: 2.605 ± 0.095
0.0IleXaa: 0.0 ± 0.0
Lys
4.738LysAla: 4.738 ± 0.12
0.188LysCys: 0.188 ± 0.022
4.022LysAsp: 4.022 ± 0.115
5.137LysGlu: 5.137 ± 0.12
1.68LysPhe: 1.68 ± 0.072
3.507LysGly: 3.507 ± 0.108
1.299LysHis: 1.299 ± 0.054
3.848LysIle: 3.848 ± 0.116
4.192LysLys: 4.192 ± 0.126
4.607LysLeu: 4.607 ± 0.111
1.864LysMet: 1.864 ± 0.079
3.102LysAsn: 3.102 ± 0.092
2.057LysPro: 2.057 ± 0.082
3.552LysGln: 3.552 ± 0.114
3.245LysArg: 3.245 ± 0.088
3.022LysSer: 3.022 ± 0.091
3.286LysThr: 3.286 ± 0.079
3.888LysVal: 3.888 ± 0.111
0.618LysTrp: 0.618 ± 0.038
2.052LysTyr: 2.052 ± 0.07
0.0LysXaa: 0.0 ± 0.0
Leu
7.827LeuAla: 7.827 ± 0.16
0.414LeuCys: 0.414 ± 0.037
5.672LeuAsp: 5.672 ± 0.131
6.174LeuGlu: 6.174 ± 0.124
3.856LeuPhe: 3.856 ± 0.128
5.943LeuGly: 5.943 ± 0.13
1.691LeuHis: 1.691 ± 0.062
6.724LeuIle: 6.724 ± 0.147
5.325LeuLys: 5.325 ± 0.119
8.757LeuLeu: 8.757 ± 0.193
2.643LeuMet: 2.643 ± 0.078
4.951LeuAsn: 4.951 ± 0.115
4.014LeuPro: 4.014 ± 0.093
3.537LeuGln: 3.537 ± 0.118
3.477LeuArg: 3.477 ± 0.094
6.689LeuSer: 6.689 ± 0.165
6.089LeuThr: 6.089 ± 0.138
6.076LeuVal: 6.076 ± 0.115
0.701LeuTrp: 0.701 ± 0.049
2.947LeuTyr: 2.947 ± 0.096
0.0LeuXaa: 0.0 ± 0.0
Met
2.334MetAla: 2.334 ± 0.087
0.103MetCys: 0.103 ± 0.016
1.593MetAsp: 1.593 ± 0.072
1.552MetGlu: 1.552 ± 0.072
0.902MetPhe: 0.902 ± 0.052
1.731MetGly: 1.731 ± 0.072
0.467MetHis: 0.467 ± 0.036
2.057MetIle: 2.057 ± 0.08
1.829MetLys: 1.829 ± 0.073
2.248MetLeu: 2.248 ± 0.088
0.786MetMet: 0.786 ± 0.046
1.417MetAsn: 1.417 ± 0.054
1.04MetPro: 1.04 ± 0.051
1.299MetGln: 1.299 ± 0.058
1.208MetArg: 1.208 ± 0.052
1.927MetSer: 1.927 ± 0.075
2.158MetThr: 2.158 ± 0.07
1.781MetVal: 1.781 ± 0.072
0.186MetTrp: 0.186 ± 0.02
0.673MetTyr: 0.673 ± 0.045
0.0MetXaa: 0.0 ± 0.0
Asn
2.964AsnAla: 2.964 ± 0.085
0.239AsnCys: 0.239 ± 0.022
3.409AsnAsp: 3.409 ± 0.116
3.605AsnGlu: 3.605 ± 0.086
1.65AsnPhe: 1.65 ± 0.068
3.288AsnGly: 3.288 ± 0.102
1.645AsnHis: 1.645 ± 0.073
3.474AsnIle: 3.474 ± 0.087
2.821AsnLys: 2.821 ± 0.093
3.783AsnLeu: 3.783 ± 0.094
1.269AsnMet: 1.269 ± 0.057
2.447AsnAsn: 2.447 ± 0.088
2.246AsnPro: 2.246 ± 0.078
3.107AsnGln: 3.107 ± 0.098
2.16AsnArg: 2.16 ± 0.08
2.14AsnSer: 2.14 ± 0.082
2.097AsnThr: 2.097 ± 0.067
2.979AsnVal: 2.979 ± 0.095
0.573AsnTrp: 0.573 ± 0.041
1.846AsnTyr: 1.846 ± 0.071
0.0AsnXaa: 0.0 ± 0.0
Pro
2.15ProAla: 2.15 ± 0.082
0.153ProCys: 0.153 ± 0.021
2.271ProAsp: 2.271 ± 0.094
3.461ProGlu: 3.461 ± 0.1
1.731ProPhe: 1.731 ± 0.072
2.409ProGly: 2.409 ± 0.111
0.869ProHis: 0.869 ± 0.047
2.911ProIle: 2.911 ± 0.097
2.248ProLys: 2.248 ± 0.074
3.052ProLeu: 3.052 ± 0.091
0.831ProMet: 0.831 ± 0.043
1.959ProAsn: 1.959 ± 0.069
0.628ProPro: 0.628 ± 0.041
1.422ProGln: 1.422 ± 0.056
1.078ProArg: 1.078 ± 0.056
2.118ProSer: 2.118 ± 0.077
2.173ProThr: 2.173 ± 0.08
2.633ProVal: 2.633 ± 0.089
0.301ProTrp: 0.301 ± 0.026
1.439ProTyr: 1.439 ± 0.063
0.0ProXaa: 0.0 ± 0.0
Gln
3.811GlnAla: 3.811 ± 0.091
0.151GlnCys: 0.151 ± 0.021
2.228GlnAsp: 2.228 ± 0.083
3.328GlnGlu: 3.328 ± 0.091
1.939GlnPhe: 1.939 ± 0.061
2.163GlnGly: 2.163 ± 0.077
0.942GlnHis: 0.942 ± 0.05
3.097GlnIle: 3.097 ± 0.087
2.723GlnLys: 2.723 ± 0.089
5.451GlnLeu: 5.451 ± 0.145
1.404GlnMet: 1.404 ± 0.056
1.949GlnAsn: 1.949 ± 0.063
1.683GlnPro: 1.683 ± 0.065
2.552GlnGln: 2.552 ± 0.112
2.057GlnArg: 2.057 ± 0.087
2.929GlnSer: 2.929 ± 0.089
2.879GlnThr: 2.879 ± 0.089
2.969GlnVal: 2.969 ± 0.094
0.502GlnTrp: 0.502 ± 0.035
1.547GlnTyr: 1.547 ± 0.069
0.0GlnXaa: 0.0 ± 0.0
Arg
2.366ArgAla: 2.366 ± 0.076
0.196ArgCys: 0.196 ± 0.026
2.462ArgAsp: 2.462 ± 0.102
3.245ArgGlu: 3.245 ± 0.094
1.788ArgPhe: 1.788 ± 0.061
2.243ArgGly: 2.243 ± 0.079
1.015ArgHis: 1.015 ± 0.053
3.044ArgIle: 3.044 ± 0.096
2.432ArgLys: 2.432 ± 0.082
4.225ArgLeu: 4.225 ± 0.113
1.196ArgMet: 1.196 ± 0.053
1.63ArgAsn: 1.63 ± 0.067
1.452ArgPro: 1.452 ± 0.059
2.477ArgGln: 2.477 ± 0.084
1.992ArgArg: 1.992 ± 0.085
1.929ArgSer: 1.929 ± 0.059
1.959ArgThr: 1.959 ± 0.073
2.653ArgVal: 2.653 ± 0.087
0.337ArgTrp: 0.337 ± 0.029
1.686ArgTyr: 1.686 ± 0.076
0.0ArgXaa: 0.0 ± 0.0
Ser
3.896SerAla: 3.896 ± 0.101
0.236SerCys: 0.236 ± 0.025
3.791SerAsp: 3.791 ± 0.098
4.71SerGlu: 4.71 ± 0.111
2.615SerPhe: 2.615 ± 0.099
4.491SerGly: 4.491 ± 0.098
1.457SerHis: 1.457 ± 0.057
3.841SerIle: 3.841 ± 0.119
3.203SerLys: 3.203 ± 0.084
5.597SerLeu: 5.597 ± 0.148
1.309SerMet: 1.309 ± 0.056
2.399SerAsn: 2.399 ± 0.077
1.932SerPro: 1.932 ± 0.075
2.859SerGln: 2.859 ± 0.097
2.261SerArg: 2.261 ± 0.073
3.323SerSer: 3.323 ± 0.117
3.08SerThr: 3.08 ± 0.091
3.74SerVal: 3.74 ± 0.092
0.51SerTrp: 0.51 ± 0.044
2.077SerTyr: 2.077 ± 0.075
0.0SerXaa: 0.0 ± 0.0
Thr
4.172ThrAla: 4.172 ± 0.098
0.234ThrCys: 0.234 ± 0.027
3.803ThrAsp: 3.803 ± 0.106
3.828ThrGlu: 3.828 ± 0.11
2.447ThrPhe: 2.447 ± 0.077
4.094ThrGly: 4.094 ± 0.102
1.276ThrHis: 1.276 ± 0.054
4.923ThrIle: 4.923 ± 0.105
2.906ThrLys: 2.906 ± 0.083
5.29ThrLeu: 5.29 ± 0.114
1.387ThrMet: 1.387 ± 0.058
2.62ThrAsn: 2.62 ± 0.09
2.715ThrPro: 2.715 ± 0.093
2.19ThrGln: 2.19 ± 0.073
1.967ThrArg: 1.967 ± 0.083
3.245ThrSer: 3.245 ± 0.089
3.414ThrThr: 3.414 ± 0.09
4.205ThrVal: 4.205 ± 0.11
0.507ThrTrp: 0.507 ± 0.039
2.261ThrTyr: 2.261 ± 0.076
0.0ThrXaa: 0.0 ± 0.0
Val
5.396ValAla: 5.396 ± 0.128
0.399ValCys: 0.399 ± 0.034
4.652ValAsp: 4.652 ± 0.121
4.647ValGlu: 4.647 ± 0.12
2.615ValPhe: 2.615 ± 0.085
4.401ValGly: 4.401 ± 0.115
1.314ValHis: 1.314 ± 0.057
5.358ValIle: 5.358 ± 0.132
3.71ValLys: 3.71 ± 0.098
6.051ValLeu: 6.051 ± 0.123
1.844ValMet: 1.844 ± 0.073
3.288ValAsn: 3.288 ± 0.094
2.555ValPro: 2.555 ± 0.09
2.366ValGln: 2.366 ± 0.082
2.507ValArg: 2.507 ± 0.094
4.542ValSer: 4.542 ± 0.098
4.313ValThr: 4.313 ± 0.122
4.868ValVal: 4.868 ± 0.128
0.512ValTrp: 0.512 ± 0.032
2.263ValTyr: 2.263 ± 0.072
0.0ValXaa: 0.0 ± 0.0
Trp
0.535TrpAla: 0.535 ± 0.035
0.028TrpCys: 0.028 ± 0.008
0.502TrpAsp: 0.502 ± 0.037
0.595TrpGlu: 0.595 ± 0.037
0.389TrpPhe: 0.389 ± 0.033
0.45TrpGly: 0.45 ± 0.036
0.224TrpHis: 0.224 ± 0.023
0.731TrpIle: 0.731 ± 0.039
0.502TrpLys: 0.502 ± 0.036
1.113TrpLeu: 1.113 ± 0.051
0.219TrpMet: 0.219 ± 0.026
0.399TrpAsn: 0.399 ± 0.038
0.286TrpPro: 0.286 ± 0.027
0.668TrpGln: 0.668 ± 0.041
0.404TrpArg: 0.404 ± 0.028
0.422TrpSer: 0.422 ± 0.034
0.48TrpThr: 0.48 ± 0.034
0.653TrpVal: 0.653 ± 0.043
0.118TrpTrp: 0.118 ± 0.017
0.274TrpTyr: 0.274 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.432TyrAla: 2.432 ± 0.074
0.266TyrCys: 0.266 ± 0.024
2.562TyrAsp: 2.562 ± 0.081
2.324TyrGlu: 2.324 ± 0.073
1.851TyrPhe: 1.851 ± 0.081
2.381TyrGly: 2.381 ± 0.072
1.161TyrHis: 1.161 ± 0.059
2.457TyrIle: 2.457 ± 0.071
1.482TyrLys: 1.482 ± 0.058
3.961TyrLeu: 3.961 ± 0.103
0.847TyrMet: 0.847 ± 0.046
1.507TyrAsn: 1.507 ± 0.057
1.58TyrPro: 1.58 ± 0.062
2.356TyrGln: 2.356 ± 0.082
1.829TyrArg: 1.829 ± 0.081
1.952TyrSer: 1.952 ± 0.07
1.904TyrThr: 1.904 ± 0.073
2.153TyrVal: 2.153 ± 0.07
0.329TyrTrp: 0.329 ± 0.032
1.708TyrTyr: 1.708 ± 0.069
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1259 proteins (398100 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski