Amino acid dipepetide frequency for Mycobacterium phage Abrogate

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.386AlaAla: 11.386 ± 1.107
0.843AlaCys: 0.843 ± 0.223
6.627AlaAsp: 6.627 ± 0.574
5.663AlaGlu: 5.663 ± 0.654
2.651AlaPhe: 2.651 ± 0.39
8.073AlaGly: 8.073 ± 0.745
1.506AlaHis: 1.506 ± 0.337
4.157AlaIle: 4.157 ± 0.617
4.338AlaLys: 4.338 ± 0.553
8.434AlaLeu: 8.434 ± 0.967
2.53AlaMet: 2.53 ± 0.435
2.35AlaAsn: 2.35 ± 0.343
4.94AlaPro: 4.94 ± 0.582
3.313AlaGln: 3.313 ± 0.529
6.506AlaArg: 6.506 ± 0.546
4.639AlaSer: 4.639 ± 0.481
5.181AlaThr: 5.181 ± 0.594
8.615AlaVal: 8.615 ± 0.7
1.687AlaTrp: 1.687 ± 0.313
2.831AlaTyr: 2.831 ± 0.347
0.0AlaXaa: 0.0 ± 0.0
Cys
1.084CysAla: 1.084 ± 0.343
0.06CysCys: 0.06 ± 0.068
0.723CysAsp: 0.723 ± 0.255
0.723CysGlu: 0.723 ± 0.198
0.06CysPhe: 0.06 ± 0.053
0.783CysGly: 0.783 ± 0.269
0.241CysHis: 0.241 ± 0.108
0.301CysIle: 0.301 ± 0.127
0.301CysLys: 0.301 ± 0.12
0.602CysLeu: 0.602 ± 0.261
0.12CysMet: 0.12 ± 0.088
0.241CysAsn: 0.241 ± 0.113
0.361CysPro: 0.361 ± 0.166
0.12CysGln: 0.12 ± 0.083
0.482CysArg: 0.482 ± 0.148
0.542CysSer: 0.542 ± 0.169
0.482CysThr: 0.482 ± 0.254
0.301CysVal: 0.301 ± 0.118
0.241CysTrp: 0.241 ± 0.107
0.301CysTyr: 0.301 ± 0.126
0.0CysXaa: 0.0 ± 0.0
Asp
6.446AspAla: 6.446 ± 0.7
0.602AspCys: 0.602 ± 0.223
4.518AspAsp: 4.518 ± 0.55
3.554AspGlu: 3.554 ± 0.481
2.169AspPhe: 2.169 ± 0.349
6.024AspGly: 6.024 ± 0.636
1.145AspHis: 1.145 ± 0.252
2.831AspIle: 2.831 ± 0.413
2.711AspLys: 2.711 ± 0.478
6.446AspLeu: 6.446 ± 0.645
1.205AspMet: 1.205 ± 0.254
2.048AspAsn: 2.048 ± 0.359
4.82AspPro: 4.82 ± 0.547
1.747AspGln: 1.747 ± 0.293
3.856AspArg: 3.856 ± 0.38
3.434AspSer: 3.434 ± 0.488
3.916AspThr: 3.916 ± 0.386
4.398AspVal: 4.398 ± 0.581
1.687AspTrp: 1.687 ± 0.359
2.169AspTyr: 2.169 ± 0.335
0.0AspXaa: 0.0 ± 0.0
Glu
5.362GluAla: 5.362 ± 0.606
0.301GluCys: 0.301 ± 0.144
5.061GluAsp: 5.061 ± 0.464
4.88GluGlu: 4.88 ± 0.594
2.048GluPhe: 2.048 ± 0.329
3.976GluGly: 3.976 ± 0.459
1.446GluHis: 1.446 ± 0.328
3.434GluIle: 3.434 ± 0.403
2.41GluLys: 2.41 ± 0.322
6.868GluLeu: 6.868 ± 0.645
1.687GluMet: 1.687 ± 0.313
1.566GluAsn: 1.566 ± 0.33
2.41GluPro: 2.41 ± 0.367
2.651GluGln: 2.651 ± 0.465
3.735GluArg: 3.735 ± 0.552
3.313GluSer: 3.313 ± 0.43
3.795GluThr: 3.795 ± 0.481
5.241GluVal: 5.241 ± 0.559
1.506GluTrp: 1.506 ± 0.284
2.47GluTyr: 2.47 ± 0.46
0.0GluXaa: 0.0 ± 0.0
Phe
2.35PheAla: 2.35 ± 0.377
0.361PheCys: 0.361 ± 0.149
2.711PheAsp: 2.711 ± 0.342
2.35PheGlu: 2.35 ± 0.361
0.422PhePhe: 0.422 ± 0.157
3.735PheGly: 3.735 ± 0.48
0.602PheHis: 0.602 ± 0.241
1.325PheIle: 1.325 ± 0.243
1.084PheLys: 1.084 ± 0.242
2.591PheLeu: 2.591 ± 0.393
0.602PheMet: 0.602 ± 0.191
1.145PheAsn: 1.145 ± 0.265
1.747PhePro: 1.747 ± 0.264
0.843PheGln: 0.843 ± 0.217
1.566PheArg: 1.566 ± 0.335
1.868PheSer: 1.868 ± 0.409
2.048PheThr: 2.048 ± 0.312
1.928PheVal: 1.928 ± 0.361
0.482PheTrp: 0.482 ± 0.131
0.904PheTyr: 0.904 ± 0.223
0.0PheXaa: 0.0 ± 0.0
Gly
7.832GlyAla: 7.832 ± 1.338
0.723GlyCys: 0.723 ± 0.221
5.904GlyAsp: 5.904 ± 0.461
4.097GlyGlu: 4.097 ± 0.489
3.374GlyPhe: 3.374 ± 0.63
10.904GlyGly: 10.904 ± 2.964
2.109GlyHis: 2.109 ± 0.374
4.458GlyIle: 4.458 ± 0.75
4.036GlyLys: 4.036 ± 0.548
7.109GlyLeu: 7.109 ± 0.602
1.807GlyMet: 1.807 ± 0.351
3.615GlyAsn: 3.615 ± 0.458
3.795GlyPro: 3.795 ± 0.5
2.47GlyGln: 2.47 ± 0.289
5.422GlyArg: 5.422 ± 0.523
6.446GlySer: 6.446 ± 0.785
5.181GlyThr: 5.181 ± 0.618
5.241GlyVal: 5.241 ± 0.504
2.831GlyTrp: 2.831 ± 0.352
2.35GlyTyr: 2.35 ± 0.353
0.0GlyXaa: 0.0 ± 0.0
His
1.566HisAla: 1.566 ± 0.386
0.12HisCys: 0.12 ± 0.121
1.265HisAsp: 1.265 ± 0.215
1.386HisGlu: 1.386 ± 0.284
0.723HisPhe: 0.723 ± 0.185
1.627HisGly: 1.627 ± 0.339
0.723HisHis: 0.723 ± 0.214
0.843HisIle: 0.843 ± 0.193
1.084HisLys: 1.084 ± 0.291
1.506HisLeu: 1.506 ± 0.347
0.181HisMet: 0.181 ± 0.106
0.181HisAsn: 0.181 ± 0.085
1.386HisPro: 1.386 ± 0.281
1.084HisGln: 1.084 ± 0.229
1.566HisArg: 1.566 ± 0.304
0.723HisSer: 0.723 ± 0.196
1.024HisThr: 1.024 ± 0.243
1.747HisVal: 1.747 ± 0.286
0.602HisTrp: 0.602 ± 0.155
0.723HisTyr: 0.723 ± 0.264
0.0HisXaa: 0.0 ± 0.0
Ile
6.265IleAla: 6.265 ± 0.74
0.241IleCys: 0.241 ± 0.114
3.434IleAsp: 3.434 ± 0.354
3.976IleGlu: 3.976 ± 0.506
0.783IlePhe: 0.783 ± 0.207
4.097IleGly: 4.097 ± 0.595
0.843IleHis: 0.843 ± 0.231
1.868IleIle: 1.868 ± 0.362
1.747IleLys: 1.747 ± 0.324
3.253IleLeu: 3.253 ± 0.443
0.843IleMet: 0.843 ± 0.18
1.506IleAsn: 1.506 ± 0.289
2.831IlePro: 2.831 ± 0.342
1.325IleGln: 1.325 ± 0.292
3.072IleArg: 3.072 ± 0.437
3.434IleSer: 3.434 ± 0.469
3.554IleThr: 3.554 ± 0.441
2.892IleVal: 2.892 ± 0.474
0.663IleTrp: 0.663 ± 0.184
1.627IleTyr: 1.627 ± 0.248
0.0IleXaa: 0.0 ± 0.0
Lys
3.434LysAla: 3.434 ± 0.476
0.241LysCys: 0.241 ± 0.118
2.591LysAsp: 2.591 ± 0.425
2.109LysGlu: 2.109 ± 0.435
1.325LysPhe: 1.325 ± 0.243
2.41LysGly: 2.41 ± 0.359
1.205LysHis: 1.205 ± 0.33
2.41LysIle: 2.41 ± 0.373
1.747LysLys: 1.747 ± 0.34
3.193LysLeu: 3.193 ± 0.407
0.904LysMet: 0.904 ± 0.179
1.506LysAsn: 1.506 ± 0.301
3.253LysPro: 3.253 ± 0.431
1.868LysGln: 1.868 ± 0.563
2.711LysArg: 2.711 ± 0.456
2.591LysSer: 2.591 ± 0.366
2.47LysThr: 2.47 ± 0.323
3.072LysVal: 3.072 ± 0.399
0.783LysTrp: 0.783 ± 0.218
0.904LysTyr: 0.904 ± 0.218
0.0LysXaa: 0.0 ± 0.0
Leu
9.338LeuAla: 9.338 ± 0.903
0.542LeuCys: 0.542 ± 0.249
6.567LeuAsp: 6.567 ± 0.596
5.543LeuGlu: 5.543 ± 0.609
2.109LeuPhe: 2.109 ± 0.389
7.35LeuGly: 7.35 ± 0.861
1.446LeuHis: 1.446 ± 0.282
4.036LeuIle: 4.036 ± 0.528
3.976LeuLys: 3.976 ± 0.512
5.783LeuLeu: 5.783 ± 0.515
1.506LeuMet: 1.506 ± 0.273
3.133LeuAsn: 3.133 ± 0.449
5.362LeuPro: 5.362 ± 0.589
2.47LeuGln: 2.47 ± 0.434
6.567LeuArg: 6.567 ± 0.614
5.844LeuSer: 5.844 ± 0.573
5.964LeuThr: 5.964 ± 0.554
4.759LeuVal: 4.759 ± 0.565
1.024LeuTrp: 1.024 ± 0.309
2.169LeuTyr: 2.169 ± 0.375
0.0LeuXaa: 0.0 ± 0.0
Met
2.229MetAla: 2.229 ± 0.289
0.12MetCys: 0.12 ± 0.113
1.084MetAsp: 1.084 ± 0.235
1.265MetGlu: 1.265 ± 0.273
0.482MetPhe: 0.482 ± 0.153
1.265MetGly: 1.265 ± 0.267
0.241MetHis: 0.241 ± 0.11
0.422MetIle: 0.422 ± 0.149
1.145MetLys: 1.145 ± 0.203
1.325MetLeu: 1.325 ± 0.292
0.181MetMet: 0.181 ± 0.105
0.904MetAsn: 0.904 ± 0.183
1.265MetPro: 1.265 ± 0.273
0.602MetGln: 0.602 ± 0.168
1.747MetArg: 1.747 ± 0.333
2.35MetSer: 2.35 ± 0.431
2.048MetThr: 2.048 ± 0.332
1.024MetVal: 1.024 ± 0.253
0.361MetTrp: 0.361 ± 0.129
0.361MetTyr: 0.361 ± 0.123
0.0MetXaa: 0.0 ± 0.0
Asn
3.374AsnAla: 3.374 ± 0.506
0.12AsnCys: 0.12 ± 0.084
1.988AsnAsp: 1.988 ± 0.409
1.988AsnGlu: 1.988 ± 0.352
0.964AsnPhe: 0.964 ± 0.291
3.735AsnGly: 3.735 ± 0.502
0.663AsnHis: 0.663 ± 0.185
1.687AsnIle: 1.687 ± 0.316
0.602AsnLys: 0.602 ± 0.183
2.41AsnLeu: 2.41 ± 0.42
0.602AsnMet: 0.602 ± 0.177
0.843AsnAsn: 0.843 ± 0.224
2.771AsnPro: 2.771 ± 0.382
0.964AsnGln: 0.964 ± 0.216
1.386AsnArg: 1.386 ± 0.309
1.807AsnSer: 1.807 ± 0.397
1.988AsnThr: 1.988 ± 0.349
2.41AsnVal: 2.41 ± 0.442
0.843AsnTrp: 0.843 ± 0.191
1.325AsnTyr: 1.325 ± 0.27
0.0AsnXaa: 0.0 ± 0.0
Pro
5.0ProAla: 5.0 ± 0.633
0.542ProCys: 0.542 ± 0.192
4.217ProAsp: 4.217 ± 0.482
4.157ProGlu: 4.157 ± 0.468
1.988ProPhe: 1.988 ± 0.348
5.241ProGly: 5.241 ± 0.648
0.783ProHis: 0.783 ± 0.193
2.35ProIle: 2.35 ± 0.38
2.229ProLys: 2.229 ± 0.303
4.699ProLeu: 4.699 ± 0.595
1.205ProMet: 1.205 ± 0.312
1.566ProAsn: 1.566 ± 0.267
3.133ProPro: 3.133 ± 0.482
1.386ProGln: 1.386 ± 0.278
3.012ProArg: 3.012 ± 0.468
4.157ProSer: 4.157 ± 0.506
4.277ProThr: 4.277 ± 0.561
3.795ProVal: 3.795 ± 0.5
0.843ProTrp: 0.843 ± 0.294
1.687ProTyr: 1.687 ± 0.363
0.0ProXaa: 0.0 ± 0.0
Gln
3.072GlnAla: 3.072 ± 0.552
0.181GlnCys: 0.181 ± 0.099
1.145GlnAsp: 1.145 ± 0.296
1.627GlnGlu: 1.627 ± 0.291
1.024GlnPhe: 1.024 ± 0.221
2.651GlnGly: 2.651 ± 0.348
0.663GlnHis: 0.663 ± 0.194
2.771GlnIle: 2.771 ± 0.496
1.084GlnLys: 1.084 ± 0.295
4.036GlnLeu: 4.036 ± 0.537
0.843GlnMet: 0.843 ± 0.211
0.422GlnAsn: 0.422 ± 0.142
2.109GlnPro: 2.109 ± 0.328
1.807GlnGln: 1.807 ± 0.355
1.928GlnArg: 1.928 ± 0.388
1.747GlnSer: 1.747 ± 0.299
1.566GlnThr: 1.566 ± 0.271
2.35GlnVal: 2.35 ± 0.324
0.602GlnTrp: 0.602 ± 0.145
0.542GlnTyr: 0.542 ± 0.123
0.0GlnXaa: 0.0 ± 0.0
Arg
5.783ArgAla: 5.783 ± 0.682
0.964ArgCys: 0.964 ± 0.264
2.952ArgAsp: 2.952 ± 0.384
4.699ArgGlu: 4.699 ± 0.625
2.35ArgPhe: 2.35 ± 0.38
5.302ArgGly: 5.302 ± 0.668
1.145ArgHis: 1.145 ± 0.292
3.374ArgIle: 3.374 ± 0.501
3.313ArgLys: 3.313 ± 0.511
6.085ArgLeu: 6.085 ± 0.645
2.048ArgMet: 2.048 ± 0.378
2.47ArgAsn: 2.47 ± 0.466
2.711ArgPro: 2.711 ± 0.46
1.988ArgGln: 1.988 ± 0.363
5.422ArgArg: 5.422 ± 0.807
3.856ArgSer: 3.856 ± 0.547
2.831ArgThr: 2.831 ± 0.487
5.061ArgVal: 5.061 ± 0.512
1.205ArgTrp: 1.205 ± 0.29
1.506ArgTyr: 1.506 ± 0.224
0.0ArgXaa: 0.0 ± 0.0
Ser
5.964SerAla: 5.964 ± 0.633
0.422SerCys: 0.422 ± 0.172
3.133SerAsp: 3.133 ± 0.333
3.795SerGlu: 3.795 ± 0.471
2.109SerPhe: 2.109 ± 0.403
6.928SerGly: 6.928 ± 0.733
1.446SerHis: 1.446 ± 0.269
2.53SerIle: 2.53 ± 0.397
1.988SerLys: 1.988 ± 0.327
5.362SerLeu: 5.362 ± 0.57
1.506SerMet: 1.506 ± 0.346
2.35SerAsn: 2.35 ± 0.404
3.374SerPro: 3.374 ± 0.516
2.048SerGln: 2.048 ± 0.275
3.253SerArg: 3.253 ± 0.442
4.036SerSer: 4.036 ± 0.681
3.735SerThr: 3.735 ± 0.457
4.277SerVal: 4.277 ± 0.452
1.446SerTrp: 1.446 ± 0.279
1.506SerTyr: 1.506 ± 0.292
0.0SerXaa: 0.0 ± 0.0
Thr
5.302ThrAla: 5.302 ± 0.533
0.422ThrCys: 0.422 ± 0.198
4.036ThrAsp: 4.036 ± 0.513
3.976ThrGlu: 3.976 ± 0.45
2.41ThrPhe: 2.41 ± 0.412
6.506ThrGly: 6.506 ± 0.64
1.145ThrHis: 1.145 ± 0.256
3.072ThrIle: 3.072 ± 0.565
2.41ThrLys: 2.41 ± 0.382
5.844ThrLeu: 5.844 ± 0.602
0.723ThrMet: 0.723 ± 0.206
2.169ThrAsn: 2.169 ± 0.438
4.036ThrPro: 4.036 ± 0.454
1.566ThrGln: 1.566 ± 0.301
3.494ThrArg: 3.494 ± 0.554
3.434ThrSer: 3.434 ± 0.502
4.579ThrThr: 4.579 ± 0.492
5.0ThrVal: 5.0 ± 0.515
1.084ThrTrp: 1.084 ± 0.266
1.868ThrTyr: 1.868 ± 0.38
0.0ThrXaa: 0.0 ± 0.0
Val
6.868ValAla: 6.868 ± 0.693
0.723ValCys: 0.723 ± 0.256
5.181ValAsp: 5.181 ± 0.508
4.94ValGlu: 4.94 ± 0.493
2.35ValPhe: 2.35 ± 0.364
4.82ValGly: 4.82 ± 0.77
1.566ValHis: 1.566 ± 0.267
3.615ValIle: 3.615 ± 0.376
2.952ValLys: 2.952 ± 0.446
5.603ValLeu: 5.603 ± 0.501
1.024ValMet: 1.024 ± 0.272
2.53ValAsn: 2.53 ± 0.414
3.856ValPro: 3.856 ± 0.542
1.988ValGln: 1.988 ± 0.384
5.362ValArg: 5.362 ± 0.663
4.157ValSer: 4.157 ± 0.497
5.0ValThr: 5.0 ± 0.498
5.482ValVal: 5.482 ± 0.679
1.386ValTrp: 1.386 ± 0.27
2.169ValTyr: 2.169 ± 0.382
0.0ValXaa: 0.0 ± 0.0
Trp
1.386TrpAla: 1.386 ± 0.304
0.361TrpCys: 0.361 ± 0.134
1.446TrpAsp: 1.446 ± 0.279
1.024TrpGlu: 1.024 ± 0.224
0.783TrpPhe: 0.783 ± 0.235
1.747TrpGly: 1.747 ± 0.29
0.482TrpHis: 0.482 ± 0.191
1.205TrpIle: 1.205 ± 0.24
0.301TrpLys: 0.301 ± 0.197
2.048TrpLeu: 2.048 ± 0.309
0.422TrpMet: 0.422 ± 0.182
0.663TrpAsn: 0.663 ± 0.194
0.783TrpPro: 0.783 ± 0.249
0.783TrpGln: 0.783 ± 0.2
1.145TrpArg: 1.145 ± 0.296
1.084TrpSer: 1.084 ± 0.227
1.506TrpThr: 1.506 ± 0.357
2.169TrpVal: 2.169 ± 0.341
0.602TrpTrp: 0.602 ± 0.212
0.301TrpTyr: 0.301 ± 0.135
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.229TyrAla: 2.229 ± 0.395
0.181TyrCys: 0.181 ± 0.141
1.145TyrAsp: 1.145 ± 0.239
2.41TyrGlu: 2.41 ± 0.353
0.542TyrPhe: 0.542 ± 0.167
2.53TyrGly: 2.53 ± 0.368
0.663TyrHis: 0.663 ± 0.197
1.566TyrIle: 1.566 ± 0.291
1.265TyrLys: 1.265 ± 0.296
2.289TyrLeu: 2.289 ± 0.369
0.422TyrMet: 0.422 ± 0.147
1.265TyrAsn: 1.265 ± 0.264
1.325TyrPro: 1.325 ± 0.292
1.145TyrGln: 1.145 ± 0.266
2.892TyrArg: 2.892 ± 0.444
1.747TyrSer: 1.747 ± 0.312
1.928TyrThr: 1.928 ± 0.382
1.807TyrVal: 1.807 ± 0.31
0.361TyrTrp: 0.361 ± 0.129
0.663TyrTyr: 0.663 ± 0.207
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 91 proteins (16600 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski