Amino acid dipepetide frequency for Mycobacterium lepraemurium

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.804AlaAla: 20.804 ± 0.269	1.039AlaCys: 1.039 ± 0.036	8.091AlaAsp: 8.091 ± 0.106	7.853AlaGlu: 7.853 ± 0.103	3.249AlaPhe: 3.249 ± 0.063	12.52AlaGly: 12.52 ± 0.145	2.642AlaHis: 2.642 ± 0.057	5.045AlaIle: 5.045 ± 0.089	3.24AlaLys: 3.24 ± 0.071	12.949AlaLeu: 12.949 ± 0.152	2.82AlaMet: 2.82 ± 0.06	2.646AlaAsn: 2.646 ± 0.064	6.649AlaPro: 6.649 ± 0.117	4.285AlaGln: 4.285 ± 0.077	9.189AlaArg: 9.189 ± 0.115	5.768AlaSer: 5.768 ± 0.094	6.894AlaThr: 6.894 ± 0.089	11.779AlaVal: 11.779 ± 0.139	1.568AlaTrp: 1.568 ± 0.049	2.225AlaTyr: 2.225 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	1.164CysAla: 1.164 ± 0.039	0.117CysCys: 0.117 ± 0.013	0.565CysAsp: 0.565 ± 0.027	0.425CysGlu: 0.425 ± 0.022	0.224CysPhe: 0.224 ± 0.016	1.001CysGly: 1.001 ± 0.035	0.192CysHis: 0.192 ± 0.014	0.277CysIle: 0.277 ± 0.017	0.151CysLys: 0.151 ± 0.014	0.644CysLeu: 0.644 ± 0.027	0.133CysMet: 0.133 ± 0.011	0.199CysAsn: 0.199 ± 0.017	0.548CysPro: 0.548 ± 0.029	0.205CysGln: 0.205 ± 0.015	0.688CysArg: 0.688 ± 0.036	0.508CysSer: 0.508 ± 0.025	0.526CysThr: 0.526 ± 0.026	0.678CysVal: 0.678 ± 0.032	0.151CysTrp: 0.151 ± 0.015	0.201CysTyr: 0.201 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	7.721AspAla: 7.721 ± 0.092	0.463AspCys: 0.463 ± 0.028	4.144AspAsp: 4.144 ± 0.076	4.043AspGlu: 4.043 ± 0.071	1.791AspPhe: 1.791 ± 0.041	5.677AspGly: 5.677 ± 0.095	1.351AspHis: 1.351 ± 0.039	2.627AspIle: 2.627 ± 0.058	1.4AspLys: 1.4 ± 0.044	5.652AspLeu: 5.652 ± 0.08	0.97AspMet: 0.97 ± 0.035	1.241AspAsn: 1.241 ± 0.037	4.381AspPro: 4.381 ± 0.078	1.733AspGln: 1.733 ± 0.049	4.506AspArg: 4.506 ± 0.081	2.79AspSer: 2.79 ± 0.054	3.117AspThr: 3.117 ± 0.065	5.276AspVal: 5.276 ± 0.082	0.952AspTrp: 0.952 ± 0.034	1.464AspTyr: 1.464 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	5.996GluAla: 5.996 ± 0.096	0.386GluCys: 0.386 ± 0.022	2.286GluAsp: 2.286 ± 0.054	2.446GluGlu: 2.446 ± 0.064	1.835GluPhe: 1.835 ± 0.048	3.202GluGly: 3.202 ± 0.067	1.603GluHis: 1.603 ± 0.042	2.541GluIle: 2.541 ± 0.053	1.345GluLys: 1.345 ± 0.039	6.649GluLeu: 6.649 ± 0.087	1.02GluMet: 1.02 ± 0.034	1.038GluAsn: 1.038 ± 0.038	2.937GluPro: 2.937 ± 0.056	2.255GluGln: 2.255 ± 0.055	4.293GluArg: 4.293 ± 0.07	2.615GluSer: 2.615 ± 0.062	2.551GluThr: 2.551 ± 0.062	4.49GluVal: 4.49 ± 0.081	0.687GluTrp: 0.687 ± 0.028	1.112GluTyr: 1.112 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.973PheAla: 3.973 ± 0.076	0.313PheCys: 0.313 ± 0.02	2.34PheAsp: 2.34 ± 0.054	1.51PheGlu: 1.51 ± 0.038	1.0PhePhe: 1.0 ± 0.042	3.316PheGly: 3.316 ± 0.07	0.622PheHis: 0.622 ± 0.029	1.016PheIle: 1.016 ± 0.042	0.578PheLys: 0.578 ± 0.027	2.369PheLeu: 2.369 ± 0.059	0.468PheMet: 0.468 ± 0.026	0.725PheAsn: 0.725 ± 0.028	1.374PhePro: 1.374 ± 0.043	0.652PheGln: 0.652 ± 0.031	1.608PheArg: 1.608 ± 0.049	1.691PheSer: 1.691 ± 0.049	1.99PheThr: 1.99 ± 0.054	2.521PheVal: 2.521 ± 0.061	0.405PheTrp: 0.405 ± 0.022	0.715PheTyr: 0.715 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	10.299GlyAla: 10.299 ± 0.122	0.92GlyCys: 0.92 ± 0.034	5.014GlyAsp: 5.014 ± 0.084	4.353GlyGlu: 4.353 ± 0.081	2.891GlyPhe: 2.891 ± 0.063	7.844GlyGly: 7.844 ± 0.122	2.144GlyHis: 2.144 ± 0.059	4.005GlyIle: 4.005 ± 0.069	2.571GlyLys: 2.571 ± 0.069	8.624GlyLeu: 8.624 ± 0.101	2.175GlyMet: 2.175 ± 0.053	1.916GlyAsn: 1.916 ± 0.044	4.934GlyPro: 4.934 ± 0.093	2.914GlyGln: 2.914 ± 0.06	6.689GlyArg: 6.689 ± 0.102	5.194GlySer: 5.194 ± 0.084	5.073GlyThr: 5.073 ± 0.078	7.788GlyVal: 7.788 ± 0.1	1.668GlyTrp: 1.668 ± 0.047	2.361GlyTyr: 2.361 ± 0.065	0.0GlyXaa: 0.0 ± 0.0
His	2.547HisAla: 2.547 ± 0.06	0.231HisCys: 0.231 ± 0.017	1.453HisAsp: 1.453 ± 0.045	1.057HisGlu: 1.057 ± 0.037	0.639HisPhe: 0.639 ± 0.026	2.191HisGly: 2.191 ± 0.063	0.715HisHis: 0.715 ± 0.036	0.826HisIle: 0.826 ± 0.034	0.406HisLys: 0.406 ± 0.021	2.013HisLeu: 2.013 ± 0.051	0.338HisMet: 0.338 ± 0.019	0.55HisAsn: 0.55 ± 0.023	1.823HisPro: 1.823 ± 0.051	0.707HisGln: 0.707 ± 0.027	2.107HisArg: 2.107 ± 0.054	1.085HisSer: 1.085 ± 0.038	1.275HisThr: 1.275 ± 0.041	1.779HisVal: 1.779 ± 0.047	0.387HisTrp: 0.387 ± 0.021	0.54HisTyr: 0.54 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.993IleAla: 5.993 ± 0.101	0.409IleCys: 0.409 ± 0.025	3.346IleAsp: 3.346 ± 0.063	2.571IleGlu: 2.571 ± 0.056	1.037IlePhe: 1.037 ± 0.038	4.387IleGly: 4.387 ± 0.069	0.784IleHis: 0.784 ± 0.036	1.441IleIle: 1.441 ± 0.047	0.965IleLys: 0.965 ± 0.036	2.901IleLeu: 2.901 ± 0.061	0.617IleMet: 0.617 ± 0.027	1.132IleAsn: 1.132 ± 0.037	2.441IlePro: 2.441 ± 0.053	0.937IleGln: 0.937 ± 0.033	2.647IleArg: 2.647 ± 0.055	2.245IleSer: 2.245 ± 0.052	2.83IleThr: 2.83 ± 0.061	3.617IleVal: 3.617 ± 0.072	0.467IleTrp: 0.467 ± 0.027	0.826IleTyr: 0.826 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	2.867LysAla: 2.867 ± 0.066	0.14LysCys: 0.14 ± 0.013	1.174LysAsp: 1.174 ± 0.039	1.028LysGlu: 1.028 ± 0.037	0.625LysPhe: 0.625 ± 0.03	1.604LysGly: 1.604 ± 0.053	0.573LysHis: 0.573 ± 0.028	1.126LysIle: 1.126 ± 0.036	0.746LysLys: 0.746 ± 0.044	2.377LysLeu: 2.377 ± 0.066	0.503LysMet: 0.503 ± 0.029	0.545LysAsn: 0.545 ± 0.024	1.607LysPro: 1.607 ± 0.042	0.827LysGln: 0.827 ± 0.035	1.657LysArg: 1.657 ± 0.048	1.338LysSer: 1.338 ± 0.046	1.465LysThr: 1.465 ± 0.041	2.116LysVal: 2.116 ± 0.059	0.329LysTrp: 0.329 ± 0.019	0.473LysTyr: 0.473 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	14.127LeuAla: 14.127 ± 0.151	0.846LeuCys: 0.846 ± 0.035	6.445LeuAsp: 6.445 ± 0.105	4.246LeuGlu: 4.246 ± 0.071	2.638LeuPhe: 2.638 ± 0.07	8.873LeuGly: 8.873 ± 0.092	2.134LeuHis: 2.134 ± 0.056	4.112LeuIle: 4.112 ± 0.081	1.876LeuLys: 1.876 ± 0.053	9.899LeuLeu: 9.899 ± 0.153	1.741LeuMet: 1.741 ± 0.05	2.075LeuAsn: 2.075 ± 0.055	5.914LeuPro: 5.914 ± 0.098	2.747LeuGln: 2.747 ± 0.061	8.019LeuArg: 8.019 ± 0.121	5.601LeuSer: 5.601 ± 0.074	6.096LeuThr: 6.096 ± 0.094	8.374LeuVal: 8.374 ± 0.117	1.21LeuTrp: 1.21 ± 0.041	1.69LeuTyr: 1.69 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	2.597MetAla: 2.597 ± 0.06	0.168MetCys: 0.168 ± 0.014	0.936MetAsp: 0.936 ± 0.033	0.701MetGlu: 0.701 ± 0.028	0.614MetPhe: 0.614 ± 0.025	1.428MetGly: 1.428 ± 0.048	0.448MetHis: 0.448 ± 0.022	0.858MetIle: 0.858 ± 0.036	0.431MetLys: 0.431 ± 0.024	2.179MetLeu: 2.179 ± 0.053	0.408MetMet: 0.408 ± 0.025	0.473MetAsn: 0.473 ± 0.024	1.251MetPro: 1.251 ± 0.042	0.54MetGln: 0.54 ± 0.025	1.519MetArg: 1.519 ± 0.046	1.444MetSer: 1.444 ± 0.039	1.729MetThr: 1.729 ± 0.042	1.716MetVal: 1.716 ± 0.045	0.258MetTrp: 0.258 ± 0.019	0.334MetTyr: 0.334 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.676AsnAla: 2.676 ± 0.065	0.207AsnCys: 0.207 ± 0.015	1.237AsnAsp: 1.237 ± 0.048	0.943AsnGlu: 0.943 ± 0.036	0.688AsnPhe: 0.688 ± 0.03	2.078AsnGly: 2.078 ± 0.05	0.473AsnHis: 0.473 ± 0.023	0.966AsnIle: 0.966 ± 0.037	0.542AsnLys: 0.542 ± 0.028	2.117AsnLeu: 2.117 ± 0.043	0.417AsnMet: 0.417 ± 0.025	0.565AsnAsn: 0.565 ± 0.026	1.806AsnPro: 1.806 ± 0.054	0.709AsnGln: 0.709 ± 0.027	1.608AsnArg: 1.608 ± 0.049	1.14AsnSer: 1.14 ± 0.041	1.291AsnThr: 1.291 ± 0.039	1.771AsnVal: 1.771 ± 0.041	0.407AsnTrp: 0.407 ± 0.022	0.582AsnTyr: 0.582 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	7.87ProAla: 7.87 ± 0.139	0.364ProCys: 0.364 ± 0.024	4.456ProAsp: 4.456 ± 0.071	3.566ProGlu: 3.566 ± 0.067	1.587ProPhe: 1.587 ± 0.045	6.264ProGly: 6.264 ± 0.104	1.282ProHis: 1.282 ± 0.037	2.242ProIle: 2.242 ± 0.056	1.319ProLys: 1.319 ± 0.048	4.979ProLeu: 4.979 ± 0.072	1.184ProMet: 1.184 ± 0.036	1.339ProAsn: 1.339 ± 0.034	4.152ProPro: 4.152 ± 0.119	1.994ProGln: 1.994 ± 0.064	3.817ProArg: 3.817 ± 0.075	3.196ProSer: 3.196 ± 0.07	3.29ProThr: 3.29 ± 0.068	5.248ProVal: 5.248 ± 0.094	0.841ProTrp: 0.841 ± 0.033	1.216ProTyr: 1.216 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	3.783GlnAla: 3.783 ± 0.07	0.236GlnCys: 0.236 ± 0.017	1.252GlnAsp: 1.252 ± 0.035	1.094GlnGlu: 1.094 ± 0.034	0.933GlnPhe: 0.933 ± 0.037	2.095GlnGly: 2.095 ± 0.044	0.844GlnHis: 0.844 ± 0.035	1.46GlnIle: 1.46 ± 0.045	0.664GlnLys: 0.664 ± 0.03	3.792GlnLeu: 3.792 ± 0.066	0.681GlnMet: 0.681 ± 0.027	0.624GlnAsn: 0.624 ± 0.027	2.078GlnPro: 2.078 ± 0.063	1.377GlnGln: 1.377 ± 0.051	3.034GlnArg: 3.034 ± 0.068	1.531GlnSer: 1.531 ± 0.04	1.587GlnThr: 1.587 ± 0.036	2.697GlnVal: 2.697 ± 0.057	0.5GlnTrp: 0.5 ± 0.023	0.664GlnTyr: 0.664 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	8.851ArgAla: 8.851 ± 0.11	0.696ArgCys: 0.696 ± 0.036	4.303ArgAsp: 4.303 ± 0.085	3.809ArgGlu: 3.809 ± 0.066	2.391ArgPhe: 2.391 ± 0.06	5.587ArgGly: 5.587 ± 0.082	1.922ArgHis: 1.922 ± 0.05	3.447ArgIle: 3.447 ± 0.07	1.715ArgLys: 1.715 ± 0.048	7.972ArgLeu: 7.972 ± 0.104	1.841ArgMet: 1.841 ± 0.045	1.727ArgAsn: 1.727 ± 0.045	4.488ArgPro: 4.488 ± 0.086	2.428ArgGln: 2.428 ± 0.059	7.47ArgArg: 7.47 ± 0.14	4.029ArgSer: 4.029 ± 0.069	3.916ArgThr: 3.916 ± 0.075	5.837ArgVal: 5.837 ± 0.083	1.451ArgTrp: 1.451 ± 0.052	1.965ArgTyr: 1.965 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	7.019SerAla: 7.019 ± 0.098	0.436SerCys: 0.436 ± 0.023	3.039SerAsp: 3.039 ± 0.052	2.454SerGlu: 2.454 ± 0.053	1.602SerPhe: 1.602 ± 0.044	5.545SerGly: 5.545 ± 0.086	1.018SerHis: 1.018 ± 0.031	2.063SerIle: 2.063 ± 0.043	1.251SerLys: 1.251 ± 0.039	4.718SerLeu: 4.718 ± 0.071	1.294SerMet: 1.294 ± 0.04	1.17SerAsn: 1.17 ± 0.039	3.111SerPro: 3.111 ± 0.063	1.5SerGln: 1.5 ± 0.051	3.824SerArg: 3.824 ± 0.068	3.13SerSer: 3.13 ± 0.07	3.268SerThr: 3.268 ± 0.074	4.4SerVal: 4.4 ± 0.079	0.956SerTrp: 0.956 ± 0.038	1.249SerTyr: 1.249 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	7.676ThrAla: 7.676 ± 0.11	0.415ThrCys: 0.415 ± 0.023	3.456ThrAsp: 3.456 ± 0.069	3.02ThrGlu: 3.02 ± 0.059	1.637ThrPhe: 1.637 ± 0.045	5.712ThrGly: 5.712 ± 0.078	1.168ThrHis: 1.168 ± 0.038	2.241ThrIle: 2.241 ± 0.051	1.353ThrLys: 1.353 ± 0.045	5.476ThrLeu: 5.476 ± 0.091	1.163ThrMet: 1.163 ± 0.044	1.259ThrAsn: 1.259 ± 0.043	3.772ThrPro: 3.772 ± 0.065	1.503ThrGln: 1.503 ± 0.042	3.787ThrArg: 3.787 ± 0.066	2.995ThrSer: 2.995 ± 0.068	3.593ThrThr: 3.593 ± 0.086	5.612ThrVal: 5.612 ± 0.084	0.765ThrTrp: 0.765 ± 0.03	1.197ThrTyr: 1.197 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	11.333ValAla: 11.333 ± 0.138	0.816ValCys: 0.816 ± 0.029	5.66ValAsp: 5.66 ± 0.08	4.46ValGlu: 4.46 ± 0.08	2.573ValPhe: 2.573 ± 0.059	7.01ValGly: 7.01 ± 0.094	1.929ValHis: 1.929 ± 0.049	4.008ValIle: 4.008 ± 0.063	1.871ValLys: 1.871 ± 0.048	9.22ValLeu: 9.22 ± 0.132	1.638ValMet: 1.638 ± 0.045	2.157ValAsn: 2.157 ± 0.053	4.755ValPro: 4.755 ± 0.083	2.251ValGln: 2.251 ± 0.049	6.164ValArg: 6.164 ± 0.086	4.754ValSer: 4.754 ± 0.079	5.311ValThr: 5.311 ± 0.087	8.553ValVal: 8.553 ± 0.113	0.97ValTrp: 0.97 ± 0.033	1.572ValTyr: 1.572 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	1.514TrpAla: 1.514 ± 0.037	0.171TrpCys: 0.171 ± 0.013	0.743TrpAsp: 0.743 ± 0.031	0.643TrpGlu: 0.643 ± 0.03	0.483TrpPhe: 0.483 ± 0.026	0.989TrpGly: 0.989 ± 0.035	0.351TrpHis: 0.351 ± 0.017	0.587TrpIle: 0.587 ± 0.03	0.326TrpLys: 0.326 ± 0.019	1.77TrpLeu: 1.77 ± 0.053	0.338TrpMet: 0.338 ± 0.021	0.389TrpAsn: 0.389 ± 0.023	0.889TrpPro: 0.889 ± 0.035	0.612TrpGln: 0.612 ± 0.024	1.334TrpArg: 1.334 ± 0.041	0.914TrpSer: 0.914 ± 0.037	0.845TrpThr: 0.845 ± 0.032	1.109TrpVal: 1.109 ± 0.043	0.344TrpTrp: 0.344 ± 0.023	0.329TrpTyr: 0.329 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.444TyrAla: 2.444 ± 0.054	0.223TyrCys: 0.223 ± 0.015	1.362TyrAsp: 1.362 ± 0.042	1.066TyrGlu: 1.066 ± 0.037	0.75TyrPhe: 0.75 ± 0.034	2.051TyrGly: 2.051 ± 0.06	0.476TyrHis: 0.476 ± 0.025	0.702TyrIle: 0.702 ± 0.029	0.371TyrLys: 0.371 ± 0.024	2.365TyrLeu: 2.365 ± 0.055	0.283TyrMet: 0.283 ± 0.018	0.453TyrAsn: 0.453 ± 0.025	1.296TyrPro: 1.296 ± 0.056	0.749TyrGln: 0.749 ± 0.032	1.885TyrArg: 1.885 ± 0.052	1.078TyrSer: 1.078 ± 0.036	1.153TyrThr: 1.153 ± 0.034	1.643TyrVal: 1.643 ± 0.044	0.365TyrTrp: 0.365 ± 0.02	0.474TyrTyr: 0.474 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2680 proteins (840175 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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