Amino acid dipepetide frequency for Streptococcus phage Javan496

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.066AlaAla: 5.066 ± 1.301
0.528AlaCys: 0.528 ± 0.265
3.905AlaAsp: 3.905 ± 0.511
5.91AlaGlu: 5.91 ± 0.779
1.794AlaPhe: 1.794 ± 0.319
5.172AlaGly: 5.172 ± 0.853
0.633AlaHis: 0.633 ± 0.323
4.538AlaIle: 4.538 ± 0.644
6.86AlaLys: 6.86 ± 0.827
7.282AlaLeu: 7.282 ± 1.02
1.689AlaMet: 1.689 ± 0.457
3.694AlaAsn: 3.694 ± 0.571
1.583AlaPro: 1.583 ± 0.365
3.483AlaGln: 3.483 ± 0.918
2.427AlaArg: 2.427 ± 0.528
5.699AlaSer: 5.699 ± 1.022
4.433AlaThr: 4.433 ± 0.909
5.066AlaVal: 5.066 ± 0.776
0.95AlaTrp: 0.95 ± 0.324
2.005AlaTyr: 2.005 ± 0.372
0.0AlaXaa: 0.0 ± 0.0
Cys
0.211CysAla: 0.211 ± 0.147
0.0CysCys: 0.0 ± 0.0
0.106CysAsp: 0.106 ± 0.112
0.422CysGlu: 0.422 ± 0.175
0.633CysPhe: 0.633 ± 0.241
0.528CysGly: 0.528 ± 0.249
0.106CysHis: 0.106 ± 0.1
0.106CysIle: 0.106 ± 0.115
0.633CysLys: 0.633 ± 0.245
0.95CysLeu: 0.95 ± 0.301
0.211CysMet: 0.211 ± 0.14
0.633CysAsn: 0.633 ± 0.249
0.106CysPro: 0.106 ± 0.094
0.211CysGln: 0.211 ± 0.14
0.317CysArg: 0.317 ± 0.168
0.106CysSer: 0.106 ± 0.094
0.317CysThr: 0.317 ± 0.168
0.317CysVal: 0.317 ± 0.226
0.211CysTrp: 0.211 ± 0.158
0.317CysTyr: 0.317 ± 0.186
0.0CysXaa: 0.0 ± 0.0
Asp
3.166AspAla: 3.166 ± 0.561
0.317AspCys: 0.317 ± 0.245
4.538AspAsp: 4.538 ± 0.73
4.96AspGlu: 4.96 ± 0.785
2.85AspPhe: 2.85 ± 0.521
4.96AspGly: 4.96 ± 0.886
0.739AspHis: 0.739 ± 0.24
4.116AspIle: 4.116 ± 0.799
6.966AspLys: 6.966 ± 0.665
7.071AspLeu: 7.071 ± 0.805
1.689AspMet: 1.689 ± 0.422
3.377AspAsn: 3.377 ± 0.465
1.478AspPro: 1.478 ± 0.356
1.689AspGln: 1.689 ± 0.444
1.689AspArg: 1.689 ± 0.353
3.799AspSer: 3.799 ± 0.597
4.116AspThr: 4.116 ± 0.64
3.905AspVal: 3.905 ± 0.681
0.528AspTrp: 0.528 ± 0.237
3.483AspTyr: 3.483 ± 0.753
0.0AspXaa: 0.0 ± 0.0
Glu
3.588GluAla: 3.588 ± 0.669
0.317GluCys: 0.317 ± 0.159
2.955GluAsp: 2.955 ± 0.815
6.544GluGlu: 6.544 ± 1.153
2.533GluPhe: 2.533 ± 0.447
2.955GluGly: 2.955 ± 0.543
0.739GluHis: 0.739 ± 0.356
8.338GluIle: 8.338 ± 0.951
6.438GluLys: 6.438 ± 1.023
7.282GluLeu: 7.282 ± 0.864
1.689GluMet: 1.689 ± 0.312
3.166GluAsn: 3.166 ± 0.567
1.478GluPro: 1.478 ± 0.492
2.427GluGln: 2.427 ± 0.445
2.639GluArg: 2.639 ± 0.661
4.749GluSer: 4.749 ± 0.687
5.594GluThr: 5.594 ± 0.803
4.855GluVal: 4.855 ± 0.886
0.95GluTrp: 0.95 ± 0.279
2.744GluTyr: 2.744 ± 0.708
0.0GluXaa: 0.0 ± 0.0
Phe
3.061PheAla: 3.061 ± 0.587
0.211PheCys: 0.211 ± 0.124
3.272PheAsp: 3.272 ± 0.618
2.427PheGlu: 2.427 ± 0.518
1.055PhePhe: 1.055 ± 0.468
3.377PheGly: 3.377 ± 0.564
0.317PheHis: 0.317 ± 0.168
2.533PheIle: 2.533 ± 0.622
3.166PheLys: 3.166 ± 0.533
2.533PheLeu: 2.533 ± 0.621
0.633PheMet: 0.633 ± 0.234
2.322PheAsn: 2.322 ± 0.545
0.844PhePro: 0.844 ± 0.248
0.844PheGln: 0.844 ± 0.294
1.689PheArg: 1.689 ± 0.495
2.427PheSer: 2.427 ± 0.517
2.85PheThr: 2.85 ± 0.611
2.322PheVal: 2.322 ± 0.597
0.633PheTrp: 0.633 ± 0.285
1.372PheTyr: 1.372 ± 0.397
0.0PheXaa: 0.0 ± 0.0
Gly
4.011GlyAla: 4.011 ± 0.74
0.739GlyCys: 0.739 ± 0.274
3.799GlyAsp: 3.799 ± 0.726
3.799GlyGlu: 3.799 ± 0.623
2.322GlyPhe: 2.322 ± 0.445
4.96GlyGly: 4.96 ± 0.761
1.266GlyHis: 1.266 ± 0.266
4.855GlyIle: 4.855 ± 0.738
6.86GlyLys: 6.86 ± 0.737
5.91GlyLeu: 5.91 ± 1.135
1.794GlyMet: 1.794 ± 0.47
4.116GlyAsn: 4.116 ± 0.679
1.266GlyPro: 1.266 ± 0.407
2.322GlyGln: 2.322 ± 0.344
2.744GlyArg: 2.744 ± 0.486
3.061GlySer: 3.061 ± 0.566
3.061GlyThr: 3.061 ± 0.646
5.172GlyVal: 5.172 ± 0.655
1.161GlyTrp: 1.161 ± 0.349
3.166GlyTyr: 3.166 ± 0.634
0.0GlyXaa: 0.0 ± 0.0
His
0.422HisAla: 0.422 ± 0.239
0.106HisCys: 0.106 ± 0.094
0.844HisAsp: 0.844 ± 0.403
0.633HisGlu: 0.633 ± 0.254
0.844HisPhe: 0.844 ± 0.274
0.95HisGly: 0.95 ± 0.284
0.0HisHis: 0.0 ± 0.0
1.055HisIle: 1.055 ± 0.338
0.422HisLys: 0.422 ± 0.237
0.844HisLeu: 0.844 ± 0.287
0.0HisMet: 0.0 ± 0.0
1.266HisAsn: 1.266 ± 0.404
0.422HisPro: 0.422 ± 0.191
0.633HisGln: 0.633 ± 0.221
0.739HisArg: 0.739 ± 0.275
0.528HisSer: 0.528 ± 0.263
1.161HisThr: 1.161 ± 0.392
1.055HisVal: 1.055 ± 0.367
0.106HisTrp: 0.106 ± 0.111
0.633HisTyr: 0.633 ± 0.201
0.0HisXaa: 0.0 ± 0.0
Ile
4.96IleAla: 4.96 ± 0.678
0.422IleCys: 0.422 ± 0.21
5.699IleAsp: 5.699 ± 0.76
5.488IleGlu: 5.488 ± 0.766
2.005IlePhe: 2.005 ± 0.552
3.483IleGly: 3.483 ± 0.505
1.372IleHis: 1.372 ± 0.366
4.327IleIle: 4.327 ± 1.018
8.021IleLys: 8.021 ± 0.897
6.016IleLeu: 6.016 ± 1.075
0.95IleMet: 0.95 ± 0.345
4.327IleAsn: 4.327 ± 0.755
1.689IlePro: 1.689 ± 0.505
1.689IleGln: 1.689 ± 0.341
2.85IleArg: 2.85 ± 0.518
4.327IleSer: 4.327 ± 0.661
4.749IleThr: 4.749 ± 0.684
4.116IleVal: 4.116 ± 0.653
0.739IleTrp: 0.739 ± 0.259
2.005IleTyr: 2.005 ± 0.48
0.0IleXaa: 0.0 ± 0.0
Lys
6.544LysAla: 6.544 ± 0.951
0.422LysCys: 0.422 ± 0.206
4.855LysAsp: 4.855 ± 0.924
6.544LysGlu: 6.544 ± 0.966
3.061LysPhe: 3.061 ± 0.471
5.172LysGly: 5.172 ± 0.724
1.478LysHis: 1.478 ± 0.352
7.177LysIle: 7.177 ± 1.282
7.599LysLys: 7.599 ± 1.113
7.177LysLeu: 7.177 ± 0.801
2.744LysMet: 2.744 ± 0.409
5.172LysAsn: 5.172 ± 0.718
2.639LysPro: 2.639 ± 0.556
5.172LysGln: 5.172 ± 0.84
3.588LysArg: 3.588 ± 0.758
4.749LysSer: 4.749 ± 0.666
6.332LysThr: 6.332 ± 0.85
6.649LysVal: 6.649 ± 0.839
0.739LysTrp: 0.739 ± 0.246
3.272LysTyr: 3.272 ± 0.571
0.0LysXaa: 0.0 ± 0.0
Leu
7.81LeuAla: 7.81 ± 1.128
0.422LeuCys: 0.422 ± 0.202
8.021LeuAsp: 8.021 ± 0.726
6.755LeuGlu: 6.755 ± 0.926
3.061LeuPhe: 3.061 ± 0.927
5.172LeuGly: 5.172 ± 0.985
0.633LeuHis: 0.633 ± 0.223
4.222LeuIle: 4.222 ± 0.636
8.021LeuLys: 8.021 ± 0.944
7.282LeuLeu: 7.282 ± 0.945
2.005LeuMet: 2.005 ± 0.463
5.172LeuAsn: 5.172 ± 0.629
3.799LeuPro: 3.799 ± 0.656
3.799LeuGln: 3.799 ± 0.583
4.116LeuArg: 4.116 ± 0.599
5.277LeuSer: 5.277 ± 0.74
5.699LeuThr: 5.699 ± 0.701
4.327LeuVal: 4.327 ± 0.688
0.211LeuTrp: 0.211 ± 0.137
2.533LeuTyr: 2.533 ± 0.566
0.0LeuXaa: 0.0 ± 0.0
Met
1.689MetAla: 1.689 ± 0.364
0.106MetCys: 0.106 ± 0.125
0.844MetAsp: 0.844 ± 0.351
1.478MetGlu: 1.478 ± 0.344
1.161MetPhe: 1.161 ± 0.365
1.161MetGly: 1.161 ± 0.344
0.106MetHis: 0.106 ± 0.091
1.9MetIle: 1.9 ± 0.386
2.005MetLys: 2.005 ± 0.441
2.216MetLeu: 2.216 ± 0.57
0.422MetMet: 0.422 ± 0.19
1.266MetAsn: 1.266 ± 0.357
0.633MetPro: 0.633 ± 0.239
0.739MetGln: 0.739 ± 0.285
2.005MetArg: 2.005 ± 0.4
2.639MetSer: 2.639 ± 0.586
1.689MetThr: 1.689 ± 0.517
1.266MetVal: 1.266 ± 0.336
0.211MetTrp: 0.211 ± 0.138
0.422MetTyr: 0.422 ± 0.191
0.0MetXaa: 0.0 ± 0.0
Asn
4.011AsnAla: 4.011 ± 0.911
0.317AsnCys: 0.317 ± 0.196
4.327AsnAsp: 4.327 ± 0.555
3.483AsnGlu: 3.483 ± 0.66
2.111AsnPhe: 2.111 ± 0.51
4.116AsnGly: 4.116 ± 0.66
0.528AsnHis: 0.528 ± 0.203
3.061AsnIle: 3.061 ± 0.586
4.222AsnLys: 4.222 ± 0.718
4.749AsnLeu: 4.749 ± 0.509
1.9AsnMet: 1.9 ± 0.472
4.011AsnAsn: 4.011 ± 0.586
2.533AsnPro: 2.533 ± 0.412
1.9AsnGln: 1.9 ± 0.547
2.427AsnArg: 2.427 ± 0.54
3.799AsnSer: 3.799 ± 0.823
2.322AsnThr: 2.322 ± 0.463
3.061AsnVal: 3.061 ± 0.566
0.95AsnTrp: 0.95 ± 0.316
2.111AsnTyr: 2.111 ± 0.474
0.0AsnXaa: 0.0 ± 0.0
Pro
1.583ProAla: 1.583 ± 0.428
0.106ProCys: 0.106 ± 0.077
1.794ProAsp: 1.794 ± 0.378
1.583ProGlu: 1.583 ± 0.434
1.478ProPhe: 1.478 ± 0.403
0.95ProGly: 0.95 ± 0.279
0.422ProHis: 0.422 ± 0.177
1.583ProIle: 1.583 ± 0.465
3.377ProLys: 3.377 ± 0.808
2.85ProLeu: 2.85 ± 0.696
0.211ProMet: 0.211 ± 0.148
1.478ProAsn: 1.478 ± 0.496
0.422ProPro: 0.422 ± 0.207
1.478ProGln: 1.478 ± 0.407
1.266ProArg: 1.266 ± 0.631
1.478ProSer: 1.478 ± 0.376
2.111ProThr: 2.111 ± 0.549
1.583ProVal: 1.583 ± 0.485
0.211ProTrp: 0.211 ± 0.151
1.055ProTyr: 1.055 ± 0.373
0.0ProXaa: 0.0 ± 0.0
Gln
2.85GlnAla: 2.85 ± 0.533
0.106GlnCys: 0.106 ± 0.077
1.9GlnAsp: 1.9 ± 0.295
3.166GlnGlu: 3.166 ± 0.458
2.427GlnPhe: 2.427 ± 0.473
2.322GlnGly: 2.322 ± 0.451
0.422GlnHis: 0.422 ± 0.202
2.533GlnIle: 2.533 ± 0.438
3.694GlnLys: 3.694 ± 0.614
3.272GlnLeu: 3.272 ± 0.47
1.266GlnMet: 1.266 ± 0.347
1.794GlnAsn: 1.794 ± 0.572
0.633GlnPro: 0.633 ± 0.324
1.055GlnGln: 1.055 ± 0.483
1.794GlnArg: 1.794 ± 0.49
2.955GlnSer: 2.955 ± 0.586
2.216GlnThr: 2.216 ± 0.572
1.478GlnVal: 1.478 ± 0.39
0.739GlnTrp: 0.739 ± 0.329
0.422GlnTyr: 0.422 ± 0.183
0.0GlnXaa: 0.0 ± 0.0
Arg
2.744ArgAla: 2.744 ± 0.452
0.317ArgCys: 0.317 ± 0.142
2.005ArgAsp: 2.005 ± 0.58
2.85ArgGlu: 2.85 ± 0.626
1.478ArgPhe: 1.478 ± 0.343
2.427ArgGly: 2.427 ± 0.518
0.95ArgHis: 0.95 ± 0.297
2.955ArgIle: 2.955 ± 0.507
3.799ArgLys: 3.799 ± 0.823
3.694ArgLeu: 3.694 ± 0.735
0.739ArgMet: 0.739 ± 0.317
2.427ArgAsn: 2.427 ± 0.543
0.633ArgPro: 0.633 ± 0.195
1.583ArgGln: 1.583 ± 0.434
2.216ArgArg: 2.216 ± 0.504
2.005ArgSer: 2.005 ± 0.444
2.955ArgThr: 2.955 ± 0.61
2.639ArgVal: 2.639 ± 0.632
0.633ArgTrp: 0.633 ± 0.251
1.9ArgTyr: 1.9 ± 0.461
0.0ArgXaa: 0.0 ± 0.0
Ser
6.332SerAla: 6.332 ± 1.179
0.422SerCys: 0.422 ± 0.22
4.116SerAsp: 4.116 ± 0.597
4.538SerGlu: 4.538 ± 0.693
3.061SerPhe: 3.061 ± 0.455
5.172SerGly: 5.172 ± 0.933
0.633SerHis: 0.633 ± 0.268
4.011SerIle: 4.011 ± 0.644
5.383SerLys: 5.383 ± 0.783
4.644SerLeu: 4.644 ± 0.792
1.583SerMet: 1.583 ± 0.39
2.639SerAsn: 2.639 ± 0.622
1.689SerPro: 1.689 ± 0.433
2.533SerGln: 2.533 ± 0.506
1.794SerArg: 1.794 ± 0.331
4.116SerSer: 4.116 ± 0.61
2.85SerThr: 2.85 ± 0.661
3.588SerVal: 3.588 ± 0.669
0.739SerTrp: 0.739 ± 0.346
2.322SerTyr: 2.322 ± 0.46
0.0SerXaa: 0.0 ± 0.0
Thr
6.544ThrAla: 6.544 ± 1.03
0.317ThrCys: 0.317 ± 0.188
3.483ThrAsp: 3.483 ± 0.515
3.694ThrGlu: 3.694 ± 0.667
2.322ThrPhe: 2.322 ± 0.377
5.594ThrGly: 5.594 ± 0.699
0.844ThrHis: 0.844 ± 0.326
5.066ThrIle: 5.066 ± 0.764
4.855ThrLys: 4.855 ± 0.593
4.96ThrLeu: 4.96 ± 0.68
2.005ThrMet: 2.005 ± 0.512
3.377ThrAsn: 3.377 ± 0.533
2.216ThrPro: 2.216 ± 0.449
1.9ThrGln: 1.9 ± 0.378
1.583ThrArg: 1.583 ± 0.512
4.011ThrSer: 4.011 ± 0.7
3.483ThrThr: 3.483 ± 0.605
4.116ThrVal: 4.116 ± 0.636
0.633ThrTrp: 0.633 ± 0.201
1.583ThrTyr: 1.583 ± 0.412
0.0ThrXaa: 0.0 ± 0.0
Val
4.855ValAla: 4.855 ± 0.886
0.422ValCys: 0.422 ± 0.212
5.066ValAsp: 5.066 ± 0.772
5.172ValGlu: 5.172 ± 0.713
2.216ValPhe: 2.216 ± 0.487
4.538ValGly: 4.538 ± 0.625
0.95ValHis: 0.95 ± 0.317
3.272ValIle: 3.272 ± 0.607
4.749ValLys: 4.749 ± 0.748
6.544ValLeu: 6.544 ± 0.964
1.583ValMet: 1.583 ± 0.459
4.116ValAsn: 4.116 ± 0.739
1.055ValPro: 1.055 ± 0.247
1.478ValGln: 1.478 ± 0.486
2.322ValArg: 2.322 ± 0.45
4.116ValSer: 4.116 ± 0.669
3.694ValThr: 3.694 ± 0.556
3.483ValVal: 3.483 ± 0.557
0.211ValTrp: 0.211 ± 0.135
2.216ValTyr: 2.216 ± 0.555
0.0ValXaa: 0.0 ± 0.0
Trp
0.317TrpAla: 0.317 ± 0.193
0.211TrpCys: 0.211 ± 0.149
1.372TrpAsp: 1.372 ± 0.349
0.422TrpGlu: 0.422 ± 0.224
0.317TrpPhe: 0.317 ± 0.159
1.266TrpGly: 1.266 ± 0.388
0.106TrpHis: 0.106 ± 0.105
1.055TrpIle: 1.055 ± 0.278
1.055TrpLys: 1.055 ± 0.359
0.528TrpLeu: 0.528 ± 0.233
0.211TrpMet: 0.211 ± 0.154
0.422TrpAsn: 0.422 ± 0.198
0.422TrpPro: 0.422 ± 0.18
0.422TrpGln: 0.422 ± 0.226
0.844TrpArg: 0.844 ± 0.379
0.422TrpSer: 0.422 ± 0.176
0.317TrpThr: 0.317 ± 0.175
0.739TrpVal: 0.739 ± 0.243
0.0TrpTrp: 0.0 ± 0.0
0.422TrpTyr: 0.422 ± 0.253
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.955TyrAla: 2.955 ± 0.462
0.633TyrCys: 0.633 ± 0.258
2.533TyrAsp: 2.533 ± 0.558
2.111TyrGlu: 2.111 ± 0.575
1.161TyrPhe: 1.161 ± 0.442
2.111TyrGly: 2.111 ± 0.489
0.422TyrHis: 0.422 ± 0.229
2.533TyrIle: 2.533 ± 0.568
2.955TyrLys: 2.955 ± 0.548
2.533TyrLeu: 2.533 ± 0.433
0.528TyrMet: 0.528 ± 0.259
1.266TyrAsn: 1.266 ± 0.396
1.478TyrPro: 1.478 ± 0.554
1.689TyrGln: 1.689 ± 0.4
1.9TyrArg: 1.9 ± 0.437
1.9TyrSer: 1.9 ± 0.431
2.639TyrThr: 2.639 ± 0.564
2.322TyrVal: 2.322 ± 0.535
0.317TyrTrp: 0.317 ± 0.141
1.266TyrTyr: 1.266 ± 0.319
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 49 proteins (9476 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski