Amino acid dipepetide frequency for Flavobacterium phage FCOV-F12

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.085AlaAla: 2.085 ± 0.58
0.605AlaCys: 0.605 ± 0.188
2.555AlaAsp: 2.555 ± 0.369
3.295AlaGlu: 3.295 ± 0.623
2.623AlaPhe: 2.623 ± 0.415
2.959AlaGly: 2.959 ± 0.568
0.403AlaHis: 0.403 ± 0.158
3.9AlaIle: 3.9 ± 0.494
5.043AlaLys: 5.043 ± 0.725
3.698AlaLeu: 3.698 ± 0.715
1.143AlaMet: 1.143 ± 0.297
4.102AlaAsn: 4.102 ± 0.652
1.479AlaPro: 1.479 ± 0.313
1.816AlaGln: 1.816 ± 0.359
2.085AlaArg: 2.085 ± 0.389
4.236AlaSer: 4.236 ± 0.561
3.564AlaThr: 3.564 ± 0.647
3.161AlaVal: 3.161 ± 0.494
0.672AlaTrp: 0.672 ± 0.181
2.421AlaTyr: 2.421 ± 0.377
0.0AlaXaa: 0.0 ± 0.0
Cys
0.403CysAla: 0.403 ± 0.233
0.134CysCys: 0.134 ± 0.099
0.74CysAsp: 0.74 ± 0.19
0.538CysGlu: 0.538 ± 0.181
0.672CysPhe: 0.672 ± 0.256
0.336CysGly: 0.336 ± 0.168
0.202CysHis: 0.202 ± 0.102
0.672CysIle: 0.672 ± 0.22
1.143CysLys: 1.143 ± 0.321
1.009CysLeu: 1.009 ± 0.323
0.134CysMet: 0.134 ± 0.087
0.538CysAsn: 0.538 ± 0.213
0.202CysPro: 0.202 ± 0.12
0.202CysGln: 0.202 ± 0.108
0.403CysArg: 0.403 ± 0.168
0.471CysSer: 0.471 ± 0.157
0.807CysThr: 0.807 ± 0.244
0.605CysVal: 0.605 ± 0.207
0.0CysTrp: 0.0 ± 0.0
0.336CysTyr: 0.336 ± 0.165
0.0CysXaa: 0.0 ± 0.0
Asp
4.169AspAla: 4.169 ± 0.525
0.672AspCys: 0.672 ± 0.222
2.892AspAsp: 2.892 ± 0.409
4.169AspGlu: 4.169 ± 0.486
3.698AspPhe: 3.698 ± 0.394
3.228AspGly: 3.228 ± 0.435
0.605AspHis: 0.605 ± 0.204
3.967AspIle: 3.967 ± 0.42
3.766AspLys: 3.766 ± 0.476
6.993AspLeu: 6.993 ± 0.566
0.807AspMet: 0.807 ± 0.227
4.505AspAsn: 4.505 ± 0.591
1.547AspPro: 1.547 ± 0.313
1.278AspGln: 1.278 ± 0.287
1.412AspArg: 1.412 ± 0.328
3.9AspSer: 3.9 ± 0.625
2.354AspThr: 2.354 ± 0.426
3.766AspVal: 3.766 ± 0.553
0.941AspTrp: 0.941 ± 0.295
3.026AspTyr: 3.026 ± 0.471
0.0AspXaa: 0.0 ± 0.0
Glu
3.429GluAla: 3.429 ± 0.56
0.403GluCys: 0.403 ± 0.146
2.757GluAsp: 2.757 ± 0.433
4.573GluGlu: 4.573 ± 0.801
3.631GluPhe: 3.631 ± 0.489
2.152GluGly: 2.152 ± 0.432
1.143GluHis: 1.143 ± 0.318
5.985GluIle: 5.985 ± 0.628
7.128GluLys: 7.128 ± 1.012
7.8GluLeu: 7.8 ± 0.804
2.555GluMet: 2.555 ± 0.383
5.447GluAsn: 5.447 ± 0.868
1.479GluPro: 1.479 ± 0.35
2.623GluGln: 2.623 ± 0.397
3.228GluArg: 3.228 ± 0.708
4.64GluSer: 4.64 ± 0.572
4.169GluThr: 4.169 ± 0.571
3.295GluVal: 3.295 ± 0.441
0.807GluTrp: 0.807 ± 0.254
2.69GluTyr: 2.69 ± 0.461
0.0GluXaa: 0.0 ± 0.0
Phe
1.748PheAla: 1.748 ± 0.321
0.538PheCys: 0.538 ± 0.173
3.9PheAsp: 3.9 ± 0.466
3.967PheGlu: 3.967 ± 0.501
1.95PhePhe: 1.95 ± 0.363
3.429PheGly: 3.429 ± 0.562
0.605PheHis: 0.605 ± 0.202
3.9PheIle: 3.9 ± 0.466
5.043PheLys: 5.043 ± 0.526
3.631PheLeu: 3.631 ± 0.508
1.009PheMet: 1.009 ± 0.233
3.429PheAsn: 3.429 ± 0.513
1.076PhePro: 1.076 ± 0.239
1.345PheGln: 1.345 ± 0.25
1.479PheArg: 1.479 ± 0.28
2.757PheSer: 2.757 ± 0.515
2.892PheThr: 2.892 ± 0.438
2.555PheVal: 2.555 ± 0.443
0.538PheTrp: 0.538 ± 0.165
2.152PheTyr: 2.152 ± 0.453
0.0PheXaa: 0.0 ± 0.0
Gly
2.824GlyAla: 2.824 ± 0.497
0.403GlyCys: 0.403 ± 0.149
3.9GlyAsp: 3.9 ± 0.562
3.362GlyGlu: 3.362 ± 0.467
3.295GlyPhe: 3.295 ± 0.442
4.236GlyGly: 4.236 ± 0.631
0.202GlyHis: 0.202 ± 0.098
4.304GlyIle: 4.304 ± 0.499
4.842GlyLys: 4.842 ± 0.63
4.707GlyLeu: 4.707 ± 0.504
0.672GlyMet: 0.672 ± 0.251
3.497GlyAsn: 3.497 ± 0.426
0.538GlyPro: 0.538 ± 0.165
1.748GlyGln: 1.748 ± 0.341
1.95GlyArg: 1.95 ± 0.435
4.236GlySer: 4.236 ± 0.499
2.959GlyThr: 2.959 ± 0.536
3.967GlyVal: 3.967 ± 0.594
0.74GlyTrp: 0.74 ± 0.206
2.69GlyTyr: 2.69 ± 0.426
0.0GlyXaa: 0.0 ± 0.0
His
0.269HisAla: 0.269 ± 0.166
0.269HisCys: 0.269 ± 0.159
0.74HisAsp: 0.74 ± 0.222
0.874HisGlu: 0.874 ± 0.255
0.672HisPhe: 0.672 ± 0.171
0.941HisGly: 0.941 ± 0.331
0.134HisHis: 0.134 ± 0.084
1.278HisIle: 1.278 ± 0.371
1.143HisLys: 1.143 ± 0.269
0.874HisLeu: 0.874 ± 0.249
0.134HisMet: 0.134 ± 0.088
1.21HisAsn: 1.21 ± 0.297
0.74HisPro: 0.74 ± 0.22
0.538HisGln: 0.538 ± 0.19
0.874HisArg: 0.874 ± 0.264
0.74HisSer: 0.74 ± 0.215
0.538HisThr: 0.538 ± 0.166
0.605HisVal: 0.605 ± 0.219
0.403HisTrp: 0.403 ± 0.189
0.538HisTyr: 0.538 ± 0.169
0.0HisXaa: 0.0 ± 0.0
Ile
4.909IleAla: 4.909 ± 0.623
0.403IleCys: 0.403 ± 0.158
5.312IleAsp: 5.312 ± 0.482
6.388IleGlu: 6.388 ± 0.738
2.555IlePhe: 2.555 ± 0.417
4.573IleGly: 4.573 ± 0.565
1.143IleHis: 1.143 ± 0.263
6.321IleIle: 6.321 ± 0.671
8.002IleLys: 8.002 ± 0.812
6.321IleLeu: 6.321 ± 0.679
1.547IleMet: 1.547 ± 0.298
5.514IleAsn: 5.514 ± 0.669
2.824IlePro: 2.824 ± 0.469
3.766IleGln: 3.766 ± 0.493
2.286IleArg: 2.286 ± 0.418
4.976IleSer: 4.976 ± 0.688
4.842IleThr: 4.842 ± 0.546
4.236IleVal: 4.236 ± 0.547
0.672IleTrp: 0.672 ± 0.237
2.959IleTyr: 2.959 ± 0.449
0.0IleXaa: 0.0 ± 0.0
Lys
5.245LysAla: 5.245 ± 0.663
0.807LysCys: 0.807 ± 0.251
4.774LysAsp: 4.774 ± 0.544
6.993LysGlu: 6.993 ± 0.979
3.295LysPhe: 3.295 ± 0.537
5.716LysGly: 5.716 ± 0.646
1.547LysHis: 1.547 ± 0.296
6.523LysIle: 6.523 ± 0.667
8.204LysLys: 8.204 ± 0.881
8.607LysLeu: 8.607 ± 0.762
2.623LysMet: 2.623 ± 0.354
6.59LysAsn: 6.59 ± 0.688
3.429LysPro: 3.429 ± 0.545
3.631LysGln: 3.631 ± 0.429
4.236LysArg: 4.236 ± 0.585
6.052LysSer: 6.052 ± 0.639
5.783LysThr: 5.783 ± 0.58
4.707LysVal: 4.707 ± 0.493
1.009LysTrp: 1.009 ± 0.21
4.438LysTyr: 4.438 ± 0.582
0.0LysXaa: 0.0 ± 0.0
Leu
4.774LeuAla: 4.774 ± 0.67
0.807LeuCys: 0.807 ± 0.209
5.312LeuAsp: 5.312 ± 0.707
8.069LeuGlu: 8.069 ± 1.001
4.035LeuPhe: 4.035 ± 0.576
4.573LeuGly: 4.573 ± 0.6
1.009LeuHis: 1.009 ± 0.272
7.599LeuIle: 7.599 ± 0.798
8.607LeuLys: 8.607 ± 0.687
6.321LeuLeu: 6.321 ± 0.545
2.152LeuMet: 2.152 ± 0.368
6.119LeuAsn: 6.119 ± 0.807
3.161LeuPro: 3.161 ± 0.486
2.892LeuGln: 2.892 ± 0.331
3.295LeuArg: 3.295 ± 0.407
5.783LeuSer: 5.783 ± 0.667
5.312LeuThr: 5.312 ± 0.715
5.245LeuVal: 5.245 ± 0.509
0.874LeuTrp: 0.874 ± 0.273
2.555LeuTyr: 2.555 ± 0.419
0.0LeuXaa: 0.0 ± 0.0
Met
1.816MetAla: 1.816 ± 0.338
0.269MetCys: 0.269 ± 0.139
1.009MetAsp: 1.009 ± 0.301
0.74MetGlu: 0.74 ± 0.214
0.74MetPhe: 0.74 ± 0.206
1.076MetGly: 1.076 ± 0.257
0.134MetHis: 0.134 ± 0.08
2.085MetIle: 2.085 ± 0.409
2.555MetLys: 2.555 ± 0.377
1.479MetLeu: 1.479 ± 0.284
0.067MetMet: 0.067 ± 0.059
1.547MetAsn: 1.547 ± 0.379
0.605MetPro: 0.605 ± 0.226
1.278MetGln: 1.278 ± 0.259
1.143MetArg: 1.143 ± 0.301
1.412MetSer: 1.412 ± 0.352
1.009MetThr: 1.009 ± 0.27
0.941MetVal: 0.941 ± 0.244
0.269MetTrp: 0.269 ± 0.157
1.076MetTyr: 1.076 ± 0.28
0.0MetXaa: 0.0 ± 0.0
Asn
3.429AsnAla: 3.429 ± 0.471
0.941AsnCys: 0.941 ± 0.223
3.9AsnAsp: 3.9 ± 0.474
5.918AsnGlu: 5.918 ± 0.666
3.295AsnPhe: 3.295 ± 0.531
4.842AsnGly: 4.842 ± 0.824
1.143AsnHis: 1.143 ± 0.294
5.85AsnIle: 5.85 ± 0.598
6.523AsnLys: 6.523 ± 0.843
6.657AsnLeu: 6.657 ± 0.676
0.941AsnMet: 0.941 ± 0.241
6.724AsnAsn: 6.724 ± 0.734
2.286AsnPro: 2.286 ± 0.355
2.488AsnGln: 2.488 ± 0.48
2.152AsnArg: 2.152 ± 0.314
5.38AsnSer: 5.38 ± 0.656
4.371AsnThr: 4.371 ± 0.561
3.564AsnVal: 3.564 ± 0.685
0.403AsnTrp: 0.403 ± 0.165
3.026AsnTyr: 3.026 ± 0.43
0.0AsnXaa: 0.0 ± 0.0
Pro
1.278ProAla: 1.278 ± 0.391
0.403ProCys: 0.403 ± 0.148
2.354ProAsp: 2.354 ± 0.475
1.816ProGlu: 1.816 ± 0.363
1.614ProPhe: 1.614 ± 0.332
0.605ProGly: 0.605 ± 0.214
0.605ProHis: 0.605 ± 0.185
2.152ProIle: 2.152 ± 0.325
2.959ProLys: 2.959 ± 0.551
2.085ProLeu: 2.085 ± 0.39
0.202ProMet: 0.202 ± 0.127
2.286ProAsn: 2.286 ± 0.353
0.403ProPro: 0.403 ± 0.151
1.076ProGln: 1.076 ± 0.361
0.672ProArg: 0.672 ± 0.243
1.883ProSer: 1.883 ± 0.41
2.354ProThr: 2.354 ± 0.429
2.219ProVal: 2.219 ± 0.444
0.202ProTrp: 0.202 ± 0.124
1.412ProTyr: 1.412 ± 0.264
0.0ProXaa: 0.0 ± 0.0
Gln
1.95GlnAla: 1.95 ± 0.364
0.202GlnCys: 0.202 ± 0.091
1.614GlnAsp: 1.614 ± 0.264
2.623GlnGlu: 2.623 ± 0.499
1.547GlnPhe: 1.547 ± 0.267
2.085GlnGly: 2.085 ± 0.322
0.672GlnHis: 0.672 ± 0.275
2.757GlnIle: 2.757 ± 0.388
3.026GlnLys: 3.026 ± 0.49
3.833GlnLeu: 3.833 ± 0.491
1.278GlnMet: 1.278 ± 0.358
2.354GlnAsn: 2.354 ± 0.411
1.009GlnPro: 1.009 ± 0.338
1.95GlnGln: 1.95 ± 0.502
1.143GlnArg: 1.143 ± 0.26
2.757GlnSer: 2.757 ± 0.454
1.748GlnThr: 1.748 ± 0.275
1.479GlnVal: 1.479 ± 0.303
0.403GlnTrp: 0.403 ± 0.191
1.748GlnTyr: 1.748 ± 0.304
0.0GlnXaa: 0.0 ± 0.0
Arg
1.614ArgAla: 1.614 ± 0.316
0.403ArgCys: 0.403 ± 0.157
2.152ArgAsp: 2.152 ± 0.413
2.219ArgGlu: 2.219 ± 0.536
2.421ArgPhe: 2.421 ± 0.443
1.21ArgGly: 1.21 ± 0.231
0.74ArgHis: 0.74 ± 0.215
3.161ArgIle: 3.161 ± 0.404
3.766ArgLys: 3.766 ± 0.591
3.429ArgLeu: 3.429 ± 0.617
0.672ArgMet: 0.672 ± 0.211
2.286ArgAsn: 2.286 ± 0.381
0.471ArgPro: 0.471 ± 0.174
1.143ArgGln: 1.143 ± 0.293
0.941ArgArg: 0.941 ± 0.279
1.681ArgSer: 1.681 ± 0.282
2.152ArgThr: 2.152 ± 0.348
2.824ArgVal: 2.824 ± 0.439
0.134ArgTrp: 0.134 ± 0.093
1.681ArgTyr: 1.681 ± 0.37
0.0ArgXaa: 0.0 ± 0.0
Ser
3.228SerAla: 3.228 ± 0.651
0.269SerCys: 0.269 ± 0.13
3.429SerAsp: 3.429 ± 0.371
4.102SerGlu: 4.102 ± 0.532
3.161SerPhe: 3.161 ± 0.499
4.371SerGly: 4.371 ± 0.56
0.874SerHis: 0.874 ± 0.244
5.716SerIle: 5.716 ± 0.74
7.8SerLys: 7.8 ± 0.681
6.119SerLeu: 6.119 ± 0.513
1.681SerMet: 1.681 ± 0.29
4.371SerAsn: 4.371 ± 0.722
1.345SerPro: 1.345 ± 0.335
2.555SerGln: 2.555 ± 0.38
1.95SerArg: 1.95 ± 0.367
2.892SerSer: 2.892 ± 0.496
3.698SerThr: 3.698 ± 0.436
4.573SerVal: 4.573 ± 0.543
0.807SerTrp: 0.807 ± 0.182
3.161SerTyr: 3.161 ± 0.454
0.0SerXaa: 0.0 ± 0.0
Thr
3.833ThrAla: 3.833 ± 0.676
0.471ThrCys: 0.471 ± 0.251
3.497ThrAsp: 3.497 ± 0.432
3.497ThrGlu: 3.497 ± 0.596
3.093ThrPhe: 3.093 ± 0.371
3.833ThrGly: 3.833 ± 0.579
0.807ThrHis: 0.807 ± 0.261
5.245ThrIle: 5.245 ± 0.483
3.967ThrLys: 3.967 ± 0.548
5.043ThrLeu: 5.043 ± 0.676
1.21ThrMet: 1.21 ± 0.324
4.304ThrAsn: 4.304 ± 0.609
2.488ThrPro: 2.488 ± 0.418
1.816ThrGln: 1.816 ± 0.352
1.883ThrArg: 1.883 ± 0.45
3.093ThrSer: 3.093 ± 0.424
3.093ThrThr: 3.093 ± 0.578
4.169ThrVal: 4.169 ± 0.703
0.807ThrTrp: 0.807 ± 0.198
2.286ThrTyr: 2.286 ± 0.42
0.0ThrXaa: 0.0 ± 0.0
Val
2.824ValAla: 2.824 ± 0.516
0.807ValCys: 0.807 ± 0.241
3.564ValAsp: 3.564 ± 0.409
3.967ValGlu: 3.967 ± 0.545
2.623ValPhe: 2.623 ± 0.317
2.286ValGly: 2.286 ± 0.346
0.807ValHis: 0.807 ± 0.267
4.976ValIle: 4.976 ± 0.688
5.111ValLys: 5.111 ± 0.67
4.909ValLeu: 4.909 ± 0.595
1.009ValMet: 1.009 ± 0.217
5.245ValAsn: 5.245 ± 0.535
1.345ValPro: 1.345 ± 0.302
1.547ValGln: 1.547 ± 0.28
2.421ValArg: 2.421 ± 0.368
4.573ValSer: 4.573 ± 0.527
3.564ValThr: 3.564 ± 0.553
3.295ValVal: 3.295 ± 0.382
0.471ValTrp: 0.471 ± 0.186
3.026ValTyr: 3.026 ± 0.471
0.0ValXaa: 0.0 ± 0.0
Trp
0.807TrpAla: 0.807 ± 0.222
0.134TrpCys: 0.134 ± 0.095
0.471TrpAsp: 0.471 ± 0.194
0.538TrpGlu: 0.538 ± 0.201
0.471TrpPhe: 0.471 ± 0.169
0.807TrpGly: 0.807 ± 0.201
0.134TrpHis: 0.134 ± 0.103
0.874TrpIle: 0.874 ± 0.294
1.076TrpLys: 1.076 ± 0.242
0.74TrpLeu: 0.74 ± 0.228
0.538TrpMet: 0.538 ± 0.177
0.672TrpAsn: 0.672 ± 0.186
0.134TrpPro: 0.134 ± 0.102
0.403TrpGln: 0.403 ± 0.181
0.269TrpArg: 0.269 ± 0.145
0.74TrpSer: 0.74 ± 0.282
0.672TrpThr: 0.672 ± 0.201
0.538TrpVal: 0.538 ± 0.214
0.134TrpTrp: 0.134 ± 0.084
0.538TrpTyr: 0.538 ± 0.175
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.21TyrAla: 1.21 ± 0.269
0.605TyrCys: 0.605 ± 0.205
2.824TyrAsp: 2.824 ± 0.446
2.354TyrGlu: 2.354 ± 0.362
2.555TyrPhe: 2.555 ± 0.376
1.816TyrGly: 1.816 ± 0.416
0.605TyrHis: 0.605 ± 0.192
2.286TyrIle: 2.286 ± 0.438
4.505TyrLys: 4.505 ± 0.496
4.236TyrLeu: 4.236 ± 0.456
0.807TyrMet: 0.807 ± 0.232
3.093TyrAsn: 3.093 ± 0.528
2.017TyrPro: 2.017 ± 0.358
2.085TyrGln: 2.085 ± 0.415
1.278TyrArg: 1.278 ± 0.342
3.9TyrSer: 3.9 ± 0.548
2.555TyrThr: 2.555 ± 0.402
2.623TyrVal: 2.623 ± 0.471
0.403TyrTrp: 0.403 ± 0.158
1.883TyrTyr: 1.883 ± 0.453
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 76 proteins (14872 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski