Amino acid dipepetide frequency for Streptococcus satellite phage Javan19

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.509AlaAla: 0.509 ± 0.524
1.273AlaCys: 1.273 ± 0.612
4.329AlaAsp: 4.329 ± 1.022
5.857AlaGlu: 5.857 ± 1.42
2.801AlaPhe: 2.801 ± 0.867
1.019AlaGly: 1.019 ± 0.484
0.764AlaHis: 0.764 ± 0.37
5.857AlaIle: 5.857 ± 1.1
4.329AlaLys: 4.329 ± 0.959
5.348AlaLeu: 5.348 ± 1.17
2.546AlaMet: 2.546 ± 0.933
3.82AlaAsn: 3.82 ± 0.967
0.764AlaPro: 0.764 ± 0.353
2.801AlaGln: 2.801 ± 0.644
2.292AlaArg: 2.292 ± 0.548
3.056AlaSer: 3.056 ± 0.805
4.074AlaThr: 4.074 ± 0.945
2.801AlaVal: 2.801 ± 1.016
0.764AlaTrp: 0.764 ± 0.576
2.801AlaTyr: 2.801 ± 0.756
0.0AlaXaa: 0.0 ± 0.0
Cys
0.509CysAla: 0.509 ± 0.455
0.255CysCys: 0.255 ± 0.236
0.509CysAsp: 0.509 ± 0.363
0.509CysGlu: 0.509 ± 0.314
0.0CysPhe: 0.0 ± 0.0
0.764CysGly: 0.764 ± 0.47
0.255CysHis: 0.255 ± 0.243
0.255CysIle: 0.255 ± 0.239
0.0CysLys: 0.0 ± 0.0
0.764CysLeu: 0.764 ± 0.408
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.509CysPro: 0.509 ± 0.351
0.509CysGln: 0.509 ± 0.299
0.509CysArg: 0.509 ± 0.319
0.509CysSer: 0.509 ± 0.398
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.509CysTyr: 0.509 ± 0.314
0.0CysXaa: 0.0 ± 0.0
Asp
1.019AspAla: 1.019 ± 0.406
0.509AspCys: 0.509 ± 0.331
3.31AspAsp: 3.31 ± 1.081
6.621AspGlu: 6.621 ± 1.316
3.82AspPhe: 3.82 ± 1.245
1.273AspGly: 1.273 ± 0.568
0.509AspHis: 0.509 ± 0.295
5.857AspIle: 5.857 ± 0.892
6.366AspLys: 6.366 ± 1.221
5.348AspLeu: 5.348 ± 1.002
2.546AspMet: 2.546 ± 0.978
3.82AspAsn: 3.82 ± 0.955
0.764AspPro: 0.764 ± 0.422
1.273AspGln: 1.273 ± 0.854
4.074AspArg: 4.074 ± 0.807
2.292AspSer: 2.292 ± 0.749
2.292AspThr: 2.292 ± 0.861
0.509AspVal: 0.509 ± 0.301
0.255AspTrp: 0.255 ± 0.277
2.546AspTyr: 2.546 ± 1.045
0.0AspXaa: 0.0 ± 0.0
Glu
6.112GluAla: 6.112 ± 1.134
0.764GluCys: 0.764 ± 0.386
5.093GluAsp: 5.093 ± 1.231
6.112GluGlu: 6.112 ± 1.684
3.056GluPhe: 3.056 ± 0.644
2.037GluGly: 2.037 ± 0.624
2.292GluHis: 2.292 ± 0.778
7.385GluIle: 7.385 ± 1.107
5.602GluLys: 5.602 ± 0.868
11.459GluLeu: 11.459 ± 1.399
3.056GluMet: 3.056 ± 0.785
5.093GluAsn: 5.093 ± 1.225
1.273GluPro: 1.273 ± 0.497
4.074GluGln: 4.074 ± 1.521
3.565GluArg: 3.565 ± 0.89
2.292GluSer: 2.292 ± 0.704
4.584GluThr: 4.584 ± 0.975
6.112GluVal: 6.112 ± 1.141
0.255GluTrp: 0.255 ± 0.254
2.292GluTyr: 2.292 ± 0.815
0.0GluXaa: 0.0 ± 0.0
Phe
1.273PheAla: 1.273 ± 0.484
0.0PheCys: 0.0 ± 0.0
2.037PheAsp: 2.037 ± 0.716
4.074PheGlu: 4.074 ± 0.71
2.037PhePhe: 2.037 ± 0.58
2.801PheGly: 2.801 ± 0.748
0.764PheHis: 0.764 ± 0.362
2.546PheIle: 2.546 ± 0.734
4.584PheLys: 4.584 ± 1.01
3.565PheLeu: 3.565 ± 0.939
0.255PheMet: 0.255 ± 0.323
3.565PheAsn: 3.565 ± 0.851
1.019PhePro: 1.019 ± 0.44
1.528PheGln: 1.528 ± 0.512
3.82PheArg: 3.82 ± 0.69
2.801PheSer: 2.801 ± 0.752
2.292PheThr: 2.292 ± 0.614
1.783PheVal: 1.783 ± 0.609
0.509PheTrp: 0.509 ± 0.32
1.783PheTyr: 1.783 ± 0.555
0.0PheXaa: 0.0 ± 0.0
Gly
2.292GlyAla: 2.292 ± 0.891
0.509GlyCys: 0.509 ± 0.32
3.31GlyAsp: 3.31 ± 0.746
2.037GlyGlu: 2.037 ± 0.586
2.801GlyPhe: 2.801 ± 0.823
2.292GlyGly: 2.292 ± 0.668
0.764GlyHis: 0.764 ± 0.401
4.074GlyIle: 4.074 ± 1.423
3.565GlyLys: 3.565 ± 0.921
6.875GlyLeu: 6.875 ± 1.155
1.273GlyMet: 1.273 ± 0.543
1.528GlyAsn: 1.528 ± 0.604
0.255GlyPro: 0.255 ± 0.239
3.565GlyGln: 3.565 ± 1.031
1.783GlyArg: 1.783 ± 0.594
1.273GlySer: 1.273 ± 0.474
2.801GlyThr: 2.801 ± 0.686
2.801GlyVal: 2.801 ± 0.839
0.509GlyTrp: 0.509 ± 0.338
3.565GlyTyr: 3.565 ± 0.758
0.0GlyXaa: 0.0 ± 0.0
His
1.783HisAla: 1.783 ± 0.705
0.0HisCys: 0.0 ± 0.0
1.273HisAsp: 1.273 ± 0.609
0.255HisGlu: 0.255 ± 0.236
1.019HisPhe: 1.019 ± 0.474
1.273HisGly: 1.273 ± 0.512
1.019HisHis: 1.019 ± 0.427
0.764HisIle: 0.764 ± 0.37
2.546HisLys: 2.546 ± 1.017
1.528HisLeu: 1.528 ± 0.649
0.0HisMet: 0.0 ± 0.0
1.019HisAsn: 1.019 ± 0.627
0.0HisPro: 0.0 ± 0.0
1.273HisGln: 1.273 ± 0.71
0.509HisArg: 0.509 ± 0.401
0.509HisSer: 0.509 ± 0.314
1.273HisThr: 1.273 ± 0.569
1.273HisVal: 1.273 ± 0.584
0.764HisTrp: 0.764 ± 0.49
2.546HisTyr: 2.546 ± 0.855
0.0HisXaa: 0.0 ± 0.0
Ile
6.366IleAla: 6.366 ± 1.224
0.255IleCys: 0.255 ± 0.243
6.366IleAsp: 6.366 ± 1.285
5.093IleGlu: 5.093 ± 1.007
3.056IlePhe: 3.056 ± 0.92
3.056IleGly: 3.056 ± 0.927
1.783IleHis: 1.783 ± 0.65
4.584IleIle: 4.584 ± 0.945
9.167IleLys: 9.167 ± 2.021
5.093IleLeu: 5.093 ± 0.972
2.292IleMet: 2.292 ± 0.644
4.584IleAsn: 4.584 ± 1.088
2.292IlePro: 2.292 ± 0.81
2.546IleGln: 2.546 ± 0.656
2.801IleArg: 2.801 ± 0.679
3.565IleSer: 3.565 ± 1.28
5.093IleThr: 5.093 ± 1.112
2.037IleVal: 2.037 ± 0.704
0.255IleTrp: 0.255 ± 0.225
2.546IleTyr: 2.546 ± 0.898
0.0IleXaa: 0.0 ± 0.0
Lys
7.894LysAla: 7.894 ± 2.064
0.509LysCys: 0.509 ± 0.385
3.82LysAsp: 3.82 ± 1.055
11.968LysGlu: 11.968 ± 1.722
2.292LysPhe: 2.292 ± 0.69
4.584LysGly: 4.584 ± 1.207
2.801LysHis: 2.801 ± 0.75
4.838LysIle: 4.838 ± 1.292
6.621LysLys: 6.621 ± 1.538
9.167LysLeu: 9.167 ± 2.274
1.273LysMet: 1.273 ± 0.436
2.801LysAsn: 2.801 ± 0.7
5.093LysPro: 5.093 ± 1.253
4.329LysGln: 4.329 ± 1.216
5.857LysArg: 5.857 ± 0.974
4.329LysSer: 4.329 ± 1.226
4.074LysThr: 4.074 ± 0.913
4.074LysVal: 4.074 ± 0.966
1.019LysTrp: 1.019 ± 0.555
3.82LysTyr: 3.82 ± 1.216
0.0LysXaa: 0.0 ± 0.0
Leu
8.658LeuAla: 8.658 ± 1.462
0.764LeuCys: 0.764 ± 0.471
5.602LeuAsp: 5.602 ± 1.104
7.13LeuGlu: 7.13 ± 1.488
4.584LeuPhe: 4.584 ± 1.054
5.093LeuGly: 5.093 ± 1.086
2.037LeuHis: 2.037 ± 0.577
8.149LeuIle: 8.149 ± 1.246
6.621LeuLys: 6.621 ± 1.049
8.149LeuLeu: 8.149 ± 1.501
1.783LeuMet: 1.783 ± 0.81
7.13LeuAsn: 7.13 ± 1.555
4.584LeuPro: 4.584 ± 1.18
3.565LeuGln: 3.565 ± 0.79
3.056LeuArg: 3.056 ± 0.931
6.112LeuSer: 6.112 ± 1.373
5.348LeuThr: 5.348 ± 1.2
5.348LeuVal: 5.348 ± 1.411
0.509LeuTrp: 0.509 ± 0.361
4.584LeuTyr: 4.584 ± 0.989
0.0LeuXaa: 0.0 ± 0.0
Met
2.801MetAla: 2.801 ± 0.959
0.0MetCys: 0.0 ± 0.0
1.273MetAsp: 1.273 ± 0.595
1.273MetGlu: 1.273 ± 0.584
0.764MetPhe: 0.764 ± 0.4
0.764MetGly: 0.764 ± 0.393
0.0MetHis: 0.0 ± 0.0
1.273MetIle: 1.273 ± 0.482
2.801MetLys: 2.801 ± 0.746
2.292MetLeu: 2.292 ± 0.774
0.0MetMet: 0.0 ± 0.0
3.82MetAsn: 3.82 ± 0.766
0.255MetPro: 0.255 ± 0.262
1.019MetGln: 1.019 ± 0.541
1.528MetArg: 1.528 ± 0.599
1.528MetSer: 1.528 ± 0.72
3.565MetThr: 3.565 ± 0.867
0.764MetVal: 0.764 ± 0.401
0.0MetTrp: 0.0 ± 0.0
0.255MetTyr: 0.255 ± 0.277
0.0MetXaa: 0.0 ± 0.0
Asn
3.056AsnAla: 3.056 ± 0.845
0.0AsnCys: 0.0 ± 0.0
1.528AsnAsp: 1.528 ± 0.526
3.82AsnGlu: 3.82 ± 0.886
2.037AsnPhe: 2.037 ± 1.303
4.074AsnGly: 4.074 ± 0.825
1.528AsnHis: 1.528 ± 0.505
2.546AsnIle: 2.546 ± 0.832
5.348AsnLys: 5.348 ± 1.349
6.112AsnLeu: 6.112 ± 1.43
2.037AsnMet: 2.037 ± 0.684
2.292AsnAsn: 2.292 ± 0.644
3.82AsnPro: 3.82 ± 0.784
3.565AsnGln: 3.565 ± 1.139
2.801AsnArg: 2.801 ± 0.711
2.292AsnSer: 2.292 ± 1.12
4.329AsnThr: 4.329 ± 1.08
2.801AsnVal: 2.801 ± 0.838
1.273AsnTrp: 1.273 ± 0.488
2.546AsnTyr: 2.546 ± 0.616
0.0AsnXaa: 0.0 ± 0.0
Pro
0.509ProAla: 0.509 ± 0.329
0.255ProCys: 0.255 ± 0.262
1.528ProAsp: 1.528 ± 0.607
4.074ProGlu: 4.074 ± 1.108
2.037ProPhe: 2.037 ± 0.632
0.509ProGly: 0.509 ± 0.365
0.0ProHis: 0.0 ± 0.0
3.056ProIle: 3.056 ± 0.951
4.584ProLys: 4.584 ± 0.921
3.056ProLeu: 3.056 ± 0.769
0.255ProMet: 0.255 ± 0.236
2.546ProAsn: 2.546 ± 1.108
0.764ProPro: 0.764 ± 0.345
0.255ProGln: 0.255 ± 0.262
2.546ProArg: 2.546 ± 0.601
1.019ProSer: 1.019 ± 0.401
1.783ProThr: 1.783 ± 0.617
0.764ProVal: 0.764 ± 0.363
0.0ProTrp: 0.0 ± 0.0
1.528ProTyr: 1.528 ± 0.587
0.0ProXaa: 0.0 ± 0.0
Gln
3.056GlnAla: 3.056 ± 1.076
0.255GlnCys: 0.255 ± 0.228
2.292GlnAsp: 2.292 ± 0.792
4.838GlnGlu: 4.838 ± 0.907
1.528GlnPhe: 1.528 ± 0.662
2.801GlnGly: 2.801 ± 0.867
1.019GlnHis: 1.019 ± 0.403
1.273GlnIle: 1.273 ± 0.478
4.838GlnLys: 4.838 ± 1.011
5.602GlnLeu: 5.602 ± 1.167
0.764GlnMet: 0.764 ± 0.396
2.546GlnAsn: 2.546 ± 0.987
2.037GlnPro: 2.037 ± 0.831
3.056GlnGln: 3.056 ± 0.87
2.546GlnArg: 2.546 ± 0.675
3.31GlnSer: 3.31 ± 0.842
2.037GlnThr: 2.037 ± 0.657
2.546GlnVal: 2.546 ± 0.853
0.0GlnTrp: 0.0 ± 0.0
1.273GlnTyr: 1.273 ± 0.696
0.0GlnXaa: 0.0 ± 0.0
Arg
3.565ArgAla: 3.565 ± 1.015
0.255ArgCys: 0.255 ± 0.236
2.801ArgAsp: 2.801 ± 0.873
3.565ArgGlu: 3.565 ± 0.831
2.037ArgPhe: 2.037 ± 0.528
2.546ArgGly: 2.546 ± 0.784
1.273ArgHis: 1.273 ± 0.579
3.056ArgIle: 3.056 ± 0.683
5.602ArgLys: 5.602 ± 0.766
5.857ArgLeu: 5.857 ± 0.836
1.019ArgMet: 1.019 ± 0.5
2.801ArgAsn: 2.801 ± 1.113
0.764ArgPro: 0.764 ± 0.34
3.31ArgGln: 3.31 ± 0.798
2.292ArgArg: 2.292 ± 0.789
2.037ArgSer: 2.037 ± 0.562
4.074ArgThr: 4.074 ± 1.045
1.783ArgVal: 1.783 ± 0.644
0.255ArgTrp: 0.255 ± 0.298
3.31ArgTyr: 3.31 ± 0.88
0.0ArgXaa: 0.0 ± 0.0
Ser
1.273SerAla: 1.273 ± 0.629
0.509SerCys: 0.509 ± 0.331
3.31SerAsp: 3.31 ± 0.775
4.838SerGlu: 4.838 ± 1.584
1.783SerPhe: 1.783 ± 0.553
2.292SerGly: 2.292 ± 0.828
0.764SerHis: 0.764 ± 0.514
4.329SerIle: 4.329 ± 1.17
4.838SerLys: 4.838 ± 1.003
5.348SerLeu: 5.348 ± 1.2
1.273SerMet: 1.273 ± 0.459
2.292SerAsn: 2.292 ± 0.783
0.509SerPro: 0.509 ± 0.297
2.037SerGln: 2.037 ± 0.713
3.31SerArg: 3.31 ± 1.102
1.528SerSer: 1.528 ± 0.504
2.546SerThr: 2.546 ± 0.66
2.546SerVal: 2.546 ± 0.856
0.509SerTrp: 0.509 ± 0.383
3.056SerTyr: 3.056 ± 1.038
0.0SerXaa: 0.0 ± 0.0
Thr
2.546ThrAla: 2.546 ± 1.04
0.0ThrCys: 0.0 ± 0.0
2.801ThrAsp: 2.801 ± 0.609
3.056ThrGlu: 3.056 ± 0.824
3.056ThrPhe: 3.056 ± 1.042
5.348ThrGly: 5.348 ± 1.45
1.019ThrHis: 1.019 ± 0.518
4.329ThrIle: 4.329 ± 1.072
4.074ThrLys: 4.074 ± 1.143
5.602ThrLeu: 5.602 ± 1.548
2.801ThrMet: 2.801 ± 0.842
1.273ThrAsn: 1.273 ± 0.468
3.056ThrPro: 3.056 ± 0.84
2.801ThrGln: 2.801 ± 0.759
3.056ThrArg: 3.056 ± 0.651
4.074ThrSer: 4.074 ± 0.885
3.31ThrThr: 3.31 ± 0.794
3.565ThrVal: 3.565 ± 1.03
1.019ThrTrp: 1.019 ± 0.365
2.037ThrTyr: 2.037 ± 0.883
0.0ThrXaa: 0.0 ± 0.0
Val
2.801ValAla: 2.801 ± 0.811
0.0ValCys: 0.0 ± 0.0
1.273ValAsp: 1.273 ± 0.538
3.056ValGlu: 3.056 ± 0.942
2.292ValPhe: 2.292 ± 0.862
2.292ValGly: 2.292 ± 0.717
1.019ValHis: 1.019 ± 0.529
6.112ValIle: 6.112 ± 0.935
4.074ValLys: 4.074 ± 0.911
4.074ValLeu: 4.074 ± 0.974
1.019ValMet: 1.019 ± 0.44
1.783ValAsn: 1.783 ± 0.721
1.273ValPro: 1.273 ± 0.514
2.801ValGln: 2.801 ± 0.929
0.764ValArg: 0.764 ± 0.362
3.82ValSer: 3.82 ± 1.197
3.31ValThr: 3.31 ± 1.267
2.292ValVal: 2.292 ± 0.768
0.255ValTrp: 0.255 ± 0.225
1.528ValTyr: 1.528 ± 0.568
0.0ValXaa: 0.0 ± 0.0
Trp
0.255TrpAla: 0.255 ± 0.254
0.0TrpCys: 0.0 ± 0.0
0.764TrpAsp: 0.764 ± 0.34
1.019TrpGlu: 1.019 ± 0.44
0.255TrpPhe: 0.255 ± 0.277
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.255TrpIle: 0.255 ± 0.275
0.764TrpLys: 0.764 ± 0.475
1.019TrpLeu: 1.019 ± 0.678
0.0TrpMet: 0.0 ± 0.0
0.255TrpAsn: 0.255 ± 0.254
0.255TrpPro: 0.255 ± 0.225
0.255TrpGln: 0.255 ± 0.284
0.764TrpArg: 0.764 ± 0.544
0.764TrpSer: 0.764 ± 0.394
0.509TrpThr: 0.509 ± 0.394
1.019TrpVal: 1.019 ± 0.455
0.764TrpTrp: 0.764 ± 0.429
0.509TrpTyr: 0.509 ± 0.388
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.528TyrAla: 1.528 ± 0.859
0.255TyrCys: 0.255 ± 0.239
2.037TyrAsp: 2.037 ± 0.518
3.31TyrGlu: 3.31 ± 1.069
1.783TyrPhe: 1.783 ± 0.492
3.056TyrGly: 3.056 ± 0.733
1.019TyrHis: 1.019 ± 0.572
2.292TyrIle: 2.292 ± 0.687
4.838TyrLys: 4.838 ± 1.525
2.546TyrLeu: 2.546 ± 0.673
1.528TyrMet: 1.528 ± 0.64
4.838TyrAsn: 4.838 ± 1.192
1.783TyrPro: 1.783 ± 0.754
3.056TyrGln: 3.056 ± 0.862
4.329TyrArg: 4.329 ± 1.377
1.783TyrSer: 1.783 ± 0.448
1.528TyrThr: 1.528 ± 0.439
1.019TyrVal: 1.019 ± 0.569
0.509TyrTrp: 0.509 ± 0.325
3.31TyrTyr: 3.31 ± 1.014
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 25 proteins (3928 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski