Amino acid dipepetide frequency for Streptococcus phage phiARI0468-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.128AlaAla: 2.128 ± 0.783
0.266AlaCys: 0.266 ± 0.171
5.587AlaAsp: 5.587 ± 0.709
6.74AlaGlu: 6.74 ± 0.864
2.749AlaPhe: 2.749 ± 0.725
5.232AlaGly: 5.232 ± 1.103
0.443AlaHis: 0.443 ± 0.176
4.878AlaIle: 4.878 ± 1.079
5.41AlaLys: 5.41 ± 0.754
6.031AlaLeu: 6.031 ± 1.119
2.306AlaMet: 2.306 ± 0.541
3.37AlaAsn: 3.37 ± 0.689
1.685AlaPro: 1.685 ± 0.428
2.838AlaGln: 2.838 ± 0.599
2.483AlaArg: 2.483 ± 0.572
2.306AlaSer: 2.306 ± 0.819
5.055AlaThr: 5.055 ± 0.729
5.498AlaVal: 5.498 ± 0.789
1.508AlaTrp: 1.508 ± 0.414
2.04AlaTyr: 2.04 ± 0.449
0.0AlaXaa: 0.0 ± 0.0
Cys
0.266CysAla: 0.266 ± 0.152
0.266CysCys: 0.266 ± 0.183
0.355CysAsp: 0.355 ± 0.208
0.532CysGlu: 0.532 ± 0.221
0.266CysPhe: 0.266 ± 0.146
0.443CysGly: 0.443 ± 0.293
0.089CysHis: 0.089 ± 0.087
0.355CysIle: 0.355 ± 0.247
0.798CysLys: 0.798 ± 0.226
0.266CysLeu: 0.266 ± 0.164
0.089CysMet: 0.089 ± 0.107
0.266CysAsn: 0.266 ± 0.242
0.355CysPro: 0.355 ± 0.212
0.443CysGln: 0.443 ± 0.196
0.355CysArg: 0.355 ± 0.15
0.266CysSer: 0.266 ± 0.164
0.355CysThr: 0.355 ± 0.178
0.177CysVal: 0.177 ± 0.121
0.089CysTrp: 0.089 ± 0.109
0.266CysTyr: 0.266 ± 0.129
0.0CysXaa: 0.0 ± 0.0
Asp
4.168AspAla: 4.168 ± 0.696
0.532AspCys: 0.532 ± 0.304
3.459AspAsp: 3.459 ± 0.653
5.055AspGlu: 5.055 ± 1.314
3.104AspPhe: 3.104 ± 0.499
4.878AspGly: 4.878 ± 0.803
0.266AspHis: 0.266 ± 0.169
5.055AspIle: 5.055 ± 0.511
4.966AspLys: 4.966 ± 0.894
5.498AspLeu: 5.498 ± 0.704
2.128AspMet: 2.128 ± 0.415
2.838AspAsn: 2.838 ± 0.42
2.572AspPro: 2.572 ± 0.658
1.862AspGln: 1.862 ± 0.388
2.927AspArg: 2.927 ± 0.55
3.281AspSer: 3.281 ± 0.508
3.37AspThr: 3.37 ± 0.454
3.725AspVal: 3.725 ± 0.555
1.508AspTrp: 1.508 ± 0.382
3.104AspTyr: 3.104 ± 0.565
0.0AspXaa: 0.0 ± 0.0
Glu
6.297GluAla: 6.297 ± 0.916
0.621GluCys: 0.621 ± 0.197
4.612GluAsp: 4.612 ± 0.796
6.119GluGlu: 6.119 ± 1.447
4.257GluPhe: 4.257 ± 0.762
3.813GluGly: 3.813 ± 0.683
0.976GluHis: 0.976 ± 0.329
6.917GluIle: 6.917 ± 1.033
5.232GluLys: 5.232 ± 1.121
9.4GluLeu: 9.4 ± 1.191
1.508GluMet: 1.508 ± 0.429
3.725GluAsn: 3.725 ± 0.551
1.685GluPro: 1.685 ± 0.434
4.523GluGln: 4.523 ± 1.022
4.168GluArg: 4.168 ± 0.647
4.7GluSer: 4.7 ± 0.593
3.725GluThr: 3.725 ± 0.673
5.676GluVal: 5.676 ± 0.829
1.064GluTrp: 1.064 ± 0.316
2.572GluTyr: 2.572 ± 0.565
0.0GluXaa: 0.0 ± 0.0
Phe
2.394PheAla: 2.394 ± 0.604
0.177PheCys: 0.177 ± 0.159
4.346PheAsp: 4.346 ± 0.635
4.434PheGlu: 4.434 ± 0.884
1.153PhePhe: 1.153 ± 0.282
2.661PheGly: 2.661 ± 0.618
0.266PheHis: 0.266 ± 0.184
2.306PheIle: 2.306 ± 0.516
3.636PheLys: 3.636 ± 0.718
2.217PheLeu: 2.217 ± 0.393
1.596PheMet: 1.596 ± 0.444
2.661PheAsn: 2.661 ± 0.658
0.709PhePro: 0.709 ± 0.282
1.951PheGln: 1.951 ± 0.431
1.064PheArg: 1.064 ± 0.313
3.991PheSer: 3.991 ± 0.706
3.015PheThr: 3.015 ± 0.582
1.508PheVal: 1.508 ± 0.314
0.532PheTrp: 0.532 ± 0.24
1.596PheTyr: 1.596 ± 0.332
0.0PheXaa: 0.0 ± 0.0
Gly
3.547GlyAla: 3.547 ± 0.55
0.089GlyCys: 0.089 ± 0.107
3.725GlyAsp: 3.725 ± 0.625
4.789GlyGlu: 4.789 ± 0.891
2.661GlyPhe: 2.661 ± 0.662
5.321GlyGly: 5.321 ± 1.329
0.621GlyHis: 0.621 ± 0.202
3.636GlyIle: 3.636 ± 0.661
4.966GlyLys: 4.966 ± 0.589
5.764GlyLeu: 5.764 ± 1.16
1.951GlyMet: 1.951 ± 0.388
3.991GlyAsn: 3.991 ± 0.542
0.887GlyPro: 0.887 ± 0.327
4.257GlyGln: 4.257 ± 0.64
3.37GlyArg: 3.37 ± 0.683
4.434GlySer: 4.434 ± 0.802
3.459GlyThr: 3.459 ± 0.669
4.612GlyVal: 4.612 ± 0.662
1.153GlyTrp: 1.153 ± 0.572
3.281GlyTyr: 3.281 ± 0.698
0.0GlyXaa: 0.0 ± 0.0
His
0.887HisAla: 0.887 ± 0.357
0.089HisCys: 0.089 ± 0.093
0.621HisAsp: 0.621 ± 0.235
1.064HisGlu: 1.064 ± 0.289
0.887HisPhe: 0.887 ± 0.271
0.709HisGly: 0.709 ± 0.287
0.089HisHis: 0.089 ± 0.107
0.532HisIle: 0.532 ± 0.325
0.355HisLys: 0.355 ± 0.173
1.153HisLeu: 1.153 ± 0.386
0.266HisMet: 0.266 ± 0.168
0.798HisAsn: 0.798 ± 0.359
0.621HisPro: 0.621 ± 0.224
0.355HisGln: 0.355 ± 0.187
0.532HisArg: 0.532 ± 0.188
1.242HisSer: 1.242 ± 0.469
0.532HisThr: 0.532 ± 0.21
0.532HisVal: 0.532 ± 0.239
0.355HisTrp: 0.355 ± 0.192
0.532HisTyr: 0.532 ± 0.285
0.0HisXaa: 0.0 ± 0.0
Ile
4.789IleAla: 4.789 ± 0.876
0.266IleCys: 0.266 ± 0.127
3.459IleAsp: 3.459 ± 0.554
6.208IleGlu: 6.208 ± 0.928
3.015IlePhe: 3.015 ± 0.608
4.523IleGly: 4.523 ± 0.867
0.798IleHis: 0.798 ± 0.313
3.193IleIle: 3.193 ± 0.552
6.563IleLys: 6.563 ± 0.76
3.991IleLeu: 3.991 ± 0.62
1.242IleMet: 1.242 ± 0.314
3.813IleAsn: 3.813 ± 0.556
1.685IlePro: 1.685 ± 0.473
2.128IleGln: 2.128 ± 0.426
3.547IleArg: 3.547 ± 0.584
4.7IleSer: 4.7 ± 0.772
4.789IleThr: 4.789 ± 0.66
3.193IleVal: 3.193 ± 0.547
0.443IleTrp: 0.443 ± 0.192
1.774IleTyr: 1.774 ± 0.65
0.0IleXaa: 0.0 ± 0.0
Lys
4.878LysAla: 4.878 ± 0.838
0.798LysCys: 0.798 ± 0.308
5.942LysAsp: 5.942 ± 0.842
7.183LysGlu: 7.183 ± 0.886
2.927LysPhe: 2.927 ± 0.488
4.346LysGly: 4.346 ± 0.716
1.419LysHis: 1.419 ± 0.342
5.321LysIle: 5.321 ± 0.733
6.208LysLys: 6.208 ± 0.767
7.361LysLeu: 7.361 ± 0.802
2.217LysMet: 2.217 ± 0.433
5.321LysAsn: 5.321 ± 0.525
2.04LysPro: 2.04 ± 0.618
3.725LysGln: 3.725 ± 0.74
3.636LysArg: 3.636 ± 0.569
4.434LysSer: 4.434 ± 0.596
4.434LysThr: 4.434 ± 0.637
5.676LysVal: 5.676 ± 0.728
1.153LysTrp: 1.153 ± 0.447
3.015LysTyr: 3.015 ± 0.532
0.0LysXaa: 0.0 ± 0.0
Leu
6.651LeuAla: 6.651 ± 0.981
0.532LeuCys: 0.532 ± 0.364
6.208LeuAsp: 6.208 ± 0.842
7.095LeuGlu: 7.095 ± 1.144
2.483LeuPhe: 2.483 ± 0.522
6.031LeuGly: 6.031 ± 1.42
1.064LeuHis: 1.064 ± 0.295
4.434LeuIle: 4.434 ± 0.581
7.627LeuLys: 7.627 ± 0.893
6.651LeuLeu: 6.651 ± 0.968
1.596LeuMet: 1.596 ± 0.459
3.991LeuAsn: 3.991 ± 0.664
2.394LeuPro: 2.394 ± 0.659
2.749LeuGln: 2.749 ± 0.583
4.612LeuArg: 4.612 ± 0.777
4.966LeuSer: 4.966 ± 0.861
4.878LeuThr: 4.878 ± 0.703
3.725LeuVal: 3.725 ± 0.62
0.443LeuTrp: 0.443 ± 0.199
2.838LeuTyr: 2.838 ± 0.478
0.0LeuXaa: 0.0 ± 0.0
Met
1.951MetAla: 1.951 ± 0.43
0.089MetCys: 0.089 ± 0.097
1.419MetAsp: 1.419 ± 0.298
1.508MetGlu: 1.508 ± 0.423
1.064MetPhe: 1.064 ± 0.303
1.508MetGly: 1.508 ± 0.419
0.177MetHis: 0.177 ± 0.142
1.685MetIle: 1.685 ± 0.462
2.483MetLys: 2.483 ± 0.527
1.596MetLeu: 1.596 ± 0.331
0.355MetMet: 0.355 ± 0.198
1.153MetAsn: 1.153 ± 0.427
0.976MetPro: 0.976 ± 0.295
1.064MetGln: 1.064 ± 0.396
0.798MetArg: 0.798 ± 0.265
1.419MetSer: 1.419 ± 0.369
2.04MetThr: 2.04 ± 0.551
1.508MetVal: 1.508 ± 0.347
0.355MetTrp: 0.355 ± 0.19
0.621MetTyr: 0.621 ± 0.179
0.0MetXaa: 0.0 ± 0.0
Asn
4.346AsnAla: 4.346 ± 0.983
0.443AsnCys: 0.443 ± 0.191
2.749AsnAsp: 2.749 ± 0.416
3.902AsnGlu: 3.902 ± 0.656
2.128AsnPhe: 2.128 ± 0.492
3.991AsnGly: 3.991 ± 0.794
1.064AsnHis: 1.064 ± 0.297
2.838AsnIle: 2.838 ± 0.501
3.991AsnLys: 3.991 ± 0.592
3.991AsnLeu: 3.991 ± 0.677
1.064AsnMet: 1.064 ± 0.367
2.306AsnAsn: 2.306 ± 0.59
2.483AsnPro: 2.483 ± 0.449
3.193AsnGln: 3.193 ± 0.6
2.217AsnArg: 2.217 ± 0.57
3.104AsnSer: 3.104 ± 0.782
3.015AsnThr: 3.015 ± 0.566
3.459AsnVal: 3.459 ± 0.453
0.798AsnTrp: 0.798 ± 0.208
1.862AsnTyr: 1.862 ± 0.312
0.0AsnXaa: 0.0 ± 0.0
Pro
2.217ProAla: 2.217 ± 0.426
0.177ProCys: 0.177 ± 0.124
2.661ProAsp: 2.661 ± 0.644
3.015ProGlu: 3.015 ± 0.444
1.419ProPhe: 1.419 ± 0.5
1.064ProGly: 1.064 ± 0.259
0.266ProHis: 0.266 ± 0.142
1.508ProIle: 1.508 ± 0.452
3.015ProLys: 3.015 ± 0.442
1.33ProLeu: 1.33 ± 0.436
0.443ProMet: 0.443 ± 0.232
1.33ProAsn: 1.33 ± 0.553
0.976ProPro: 0.976 ± 0.398
0.887ProGln: 0.887 ± 0.301
1.596ProArg: 1.596 ± 0.399
1.064ProSer: 1.064 ± 0.348
0.887ProThr: 0.887 ± 0.351
1.685ProVal: 1.685 ± 0.406
0.532ProTrp: 0.532 ± 0.204
1.508ProTyr: 1.508 ± 0.516
0.0ProXaa: 0.0 ± 0.0
Gln
3.991GlnAla: 3.991 ± 0.589
0.355GlnCys: 0.355 ± 0.191
2.128GlnAsp: 2.128 ± 0.453
4.523GlnGlu: 4.523 ± 0.827
1.33GlnPhe: 1.33 ± 0.36
2.306GlnGly: 2.306 ± 0.442
0.355GlnHis: 0.355 ± 0.192
3.281GlnIle: 3.281 ± 0.524
3.813GlnLys: 3.813 ± 0.703
3.015GlnLeu: 3.015 ± 0.561
0.976GlnMet: 0.976 ± 0.256
2.128GlnAsn: 2.128 ± 0.487
1.242GlnPro: 1.242 ± 0.354
1.774GlnGln: 1.774 ± 0.533
2.128GlnArg: 2.128 ± 0.444
2.572GlnSer: 2.572 ± 0.37
3.104GlnThr: 3.104 ± 0.591
3.725GlnVal: 3.725 ± 0.659
0.443GlnTrp: 0.443 ± 0.191
1.419GlnTyr: 1.419 ± 0.351
0.0GlnXaa: 0.0 ± 0.0
Arg
3.37ArgAla: 3.37 ± 0.526
0.266ArgCys: 0.266 ± 0.146
2.661ArgAsp: 2.661 ± 0.506
2.749ArgGlu: 2.749 ± 0.634
1.951ArgPhe: 1.951 ± 0.503
2.217ArgGly: 2.217 ± 0.476
0.532ArgHis: 0.532 ± 0.281
3.37ArgIle: 3.37 ± 0.531
2.927ArgLys: 2.927 ± 0.653
4.878ArgLeu: 4.878 ± 0.662
1.33ArgMet: 1.33 ± 0.338
2.927ArgAsn: 2.927 ± 0.676
1.064ArgPro: 1.064 ± 0.313
3.104ArgGln: 3.104 ± 0.604
2.483ArgArg: 2.483 ± 0.718
2.483ArgSer: 2.483 ± 0.584
2.838ArgThr: 2.838 ± 0.708
2.572ArgVal: 2.572 ± 0.384
0.443ArgTrp: 0.443 ± 0.189
1.774ArgTyr: 1.774 ± 0.514
0.0ArgXaa: 0.0 ± 0.0
Ser
4.523SerAla: 4.523 ± 0.944
0.089SerCys: 0.089 ± 0.064
3.459SerAsp: 3.459 ± 0.671
4.079SerGlu: 4.079 ± 0.564
1.951SerPhe: 1.951 ± 0.396
4.966SerGly: 4.966 ± 0.723
1.153SerHis: 1.153 ± 0.418
3.725SerIle: 3.725 ± 0.716
4.878SerLys: 4.878 ± 0.603
5.055SerLeu: 5.055 ± 0.848
1.33SerMet: 1.33 ± 0.465
3.015SerAsn: 3.015 ± 0.654
1.33SerPro: 1.33 ± 0.304
2.04SerGln: 2.04 ± 0.403
3.459SerArg: 3.459 ± 0.655
3.547SerSer: 3.547 ± 0.827
3.991SerThr: 3.991 ± 0.512
3.813SerVal: 3.813 ± 0.857
0.976SerTrp: 0.976 ± 0.385
2.394SerTyr: 2.394 ± 0.638
0.0SerXaa: 0.0 ± 0.0
Thr
4.789ThrAla: 4.789 ± 0.714
0.177ThrCys: 0.177 ± 0.128
4.168ThrAsp: 4.168 ± 0.582
3.459ThrGlu: 3.459 ± 0.511
3.37ThrPhe: 3.37 ± 0.826
3.902ThrGly: 3.902 ± 0.785
0.443ThrHis: 0.443 ± 0.252
4.523ThrIle: 4.523 ± 0.638
4.168ThrLys: 4.168 ± 0.772
5.587ThrLeu: 5.587 ± 0.695
0.798ThrMet: 0.798 ± 0.319
3.636ThrAsn: 3.636 ± 0.656
1.33ThrPro: 1.33 ± 0.44
3.193ThrGln: 3.193 ± 0.55
1.596ThrArg: 1.596 ± 0.3
3.547ThrSer: 3.547 ± 0.595
4.612ThrThr: 4.612 ± 0.985
3.991ThrVal: 3.991 ± 0.766
0.887ThrTrp: 0.887 ± 0.346
2.572ThrTyr: 2.572 ± 0.57
0.0ThrXaa: 0.0 ± 0.0
Val
4.7ValAla: 4.7 ± 0.781
0.177ValCys: 0.177 ± 0.128
3.636ValAsp: 3.636 ± 0.648
5.41ValGlu: 5.41 ± 0.83
2.661ValPhe: 2.661 ± 0.494
5.498ValGly: 5.498 ± 0.881
1.153ValHis: 1.153 ± 0.402
2.927ValIle: 2.927 ± 0.484
5.853ValLys: 5.853 ± 0.771
3.37ValLeu: 3.37 ± 0.593
1.153ValMet: 1.153 ± 0.323
3.813ValAsn: 3.813 ± 0.789
2.04ValPro: 2.04 ± 0.36
1.774ValGln: 1.774 ± 0.46
2.306ValArg: 2.306 ± 0.302
4.7ValSer: 4.7 ± 0.702
4.434ValThr: 4.434 ± 0.715
4.966ValVal: 4.966 ± 0.813
0.709ValTrp: 0.709 ± 0.27
2.572ValTyr: 2.572 ± 0.508
0.0ValXaa: 0.0 ± 0.0
Trp
1.153TrpAla: 1.153 ± 0.426
0.177TrpCys: 0.177 ± 0.131
0.798TrpAsp: 0.798 ± 0.362
0.798TrpGlu: 0.798 ± 0.343
0.887TrpPhe: 0.887 ± 0.455
0.709TrpGly: 0.709 ± 0.298
0.177TrpHis: 0.177 ± 0.145
0.976TrpIle: 0.976 ± 0.366
1.33TrpLys: 1.33 ± 0.394
0.798TrpLeu: 0.798 ± 0.412
0.443TrpMet: 0.443 ± 0.179
0.976TrpAsn: 0.976 ± 0.324
0.0TrpPro: 0.0 ± 0.0
0.532TrpGln: 0.532 ± 0.306
0.621TrpArg: 0.621 ± 0.277
0.532TrpSer: 0.532 ± 0.264
0.976TrpThr: 0.976 ± 0.306
0.976TrpVal: 0.976 ± 0.233
0.266TrpTrp: 0.266 ± 0.153
0.798TrpTyr: 0.798 ± 0.649
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.508TyrAla: 1.508 ± 0.282
0.709TyrCys: 0.709 ± 0.3
2.306TyrAsp: 2.306 ± 0.447
2.927TyrGlu: 2.927 ± 0.647
1.951TyrPhe: 1.951 ± 0.59
2.394TyrGly: 2.394 ± 0.402
0.798TyrHis: 0.798 ± 0.276
2.749TyrIle: 2.749 ± 0.555
3.813TyrLys: 3.813 ± 0.778
3.015TyrLeu: 3.015 ± 0.61
0.887TyrMet: 0.887 ± 0.372
0.887TyrAsn: 0.887 ± 0.252
1.508TyrPro: 1.508 ± 0.437
2.217TyrGln: 2.217 ± 0.545
2.04TyrArg: 2.04 ± 0.478
2.483TyrSer: 2.483 ± 0.762
1.242TyrThr: 1.242 ± 0.258
2.838TyrVal: 2.838 ± 0.645
0.266TyrTrp: 0.266 ± 0.153
1.596TyrTyr: 1.596 ± 0.659
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 48 proteins (11277 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski