Amino acid dipepetide frequency for Hondaea fermentalgiana

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.336AlaAla: 13.336 ± 0.081	1.58AlaCys: 1.58 ± 0.02	5.813AlaAsp: 5.813 ± 0.032	6.964AlaGlu: 6.964 ± 0.047	3.388AlaPhe: 3.388 ± 0.028	6.72AlaGly: 6.72 ± 0.072	2.262AlaHis: 2.262 ± 0.021	3.904AlaIle: 3.904 ± 0.027	5.08AlaLys: 5.08 ± 0.039	10.442AlaLeu: 10.442 ± 0.057	2.349AlaMet: 2.349 ± 0.02	3.359AlaAsn: 3.359 ± 0.024	4.645AlaPro: 4.645 ± 0.035	4.597AlaGln: 4.597 ± 0.032	7.26AlaArg: 7.26 ± 0.046	9.438AlaSer: 9.438 ± 0.053	5.686AlaThr: 5.686 ± 0.038	6.41AlaVal: 6.41 ± 0.038	1.189AlaTrp: 1.189 ± 0.015	1.975AlaTyr: 1.975 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	1.536CysAla: 1.536 ± 0.02	0.32CysCys: 0.32 ± 0.008	0.855CysAsp: 0.855 ± 0.014	0.997CysGlu: 0.997 ± 0.016	0.624CysPhe: 0.624 ± 0.011	1.089CysGly: 1.089 ± 0.015	0.295CysHis: 0.295 ± 0.007	0.684CysIle: 0.684 ± 0.012	0.724CysLys: 0.724 ± 0.012	1.312CysLeu: 1.312 ± 0.017	0.35CysMet: 0.35 ± 0.007	0.488CysAsn: 0.488 ± 0.01	0.674CysPro: 0.674 ± 0.018	0.445CysGln: 0.445 ± 0.009	0.833CysArg: 0.833 ± 0.013	1.094CysSer: 1.094 ± 0.016	0.833CysThr: 0.833 ± 0.015	1.13CysVal: 1.13 ± 0.015	0.186CysTrp: 0.186 ± 0.006	0.337CysTyr: 0.337 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.531AspAla: 7.531 ± 0.038	0.79AspCys: 0.79 ± 0.017	6.4AspAsp: 6.4 ± 0.068	5.879AspGlu: 5.879 ± 0.047	2.36AspPhe: 2.36 ± 0.021	4.593AspGly: 4.593 ± 0.035	1.246AspHis: 1.246 ± 0.016	2.435AspIle: 2.435 ± 0.021	2.44AspLys: 2.44 ± 0.024	5.981AspLeu: 5.981 ± 0.038	1.322AspMet: 1.322 ± 0.014	1.896AspAsn: 1.896 ± 0.019	3.019AspPro: 3.019 ± 0.024	1.928AspGln: 1.928 ± 0.018	3.213AspArg: 3.213 ± 0.026	3.864AspSer: 3.864 ± 0.03	2.876AspThr: 2.876 ± 0.024	4.304AspVal: 4.304 ± 0.026	0.68AspTrp: 0.68 ± 0.01	1.199AspTyr: 1.199 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	7.922GluAla: 7.922 ± 0.055	0.82GluCys: 0.82 ± 0.014	5.681GluAsp: 5.681 ± 0.05	6.865GluGlu: 6.865 ± 0.066	1.997GluPhe: 1.997 ± 0.017	4.055GluGly: 4.055 ± 0.028	1.675GluHis: 1.675 ± 0.015	2.945GluIle: 2.945 ± 0.024	3.414GluLys: 3.414 ± 0.033	6.447GluLeu: 6.447 ± 0.04	1.605GluMet: 1.605 ± 0.015	2.638GluAsn: 2.638 ± 0.023	2.456GluPro: 2.456 ± 0.023	2.847GluGln: 2.847 ± 0.027	4.9GluArg: 4.9 ± 0.04	4.806GluSer: 4.806 ± 0.032	4.084GluThr: 4.084 ± 0.032	4.353GluVal: 4.353 ± 0.031	0.677GluTrp: 0.677 ± 0.01	1.409GluTyr: 1.409 ± 0.015	0.0GluXaa: 0.0 ± 0.0
Phe	3.757PheAla: 3.757 ± 0.024	0.658PheCys: 0.658 ± 0.011	2.468PheAsp: 2.468 ± 0.019	2.448PheGlu: 2.448 ± 0.022	1.513PhePhe: 1.513 ± 0.016	2.706PheGly: 2.706 ± 0.027	0.79PheHis: 0.79 ± 0.013	1.339PheIle: 1.339 ± 0.015	1.391PheLys: 1.391 ± 0.015	3.212PheLeu: 3.212 ± 0.027	0.818PheMet: 0.818 ± 0.012	1.067PheAsn: 1.067 ± 0.013	1.464PhePro: 1.464 ± 0.017	1.244PheGln: 1.244 ± 0.013	2.187PheArg: 2.187 ± 0.021	2.581PheSer: 2.581 ± 0.021	1.697PheThr: 1.697 ± 0.017	2.871PheVal: 2.871 ± 0.024	0.468PheTrp: 0.468 ± 0.008	0.937PheTyr: 0.937 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	7.2GlyAla: 7.2 ± 0.066	0.913GlyCys: 0.913 ± 0.015	4.431GlyAsp: 4.431 ± 0.051	4.127GlyGlu: 4.127 ± 0.028	2.494GlyPhe: 2.494 ± 0.022	5.961GlyGly: 5.961 ± 0.099	1.601GlyHis: 1.601 ± 0.02	2.752GlyIle: 2.752 ± 0.021	3.216GlyLys: 3.216 ± 0.032	5.777GlyLeu: 5.777 ± 0.032	1.416GlyMet: 1.416 ± 0.018	2.455GlyAsn: 2.455 ± 0.036	2.942GlyPro: 2.942 ± 0.023	2.25GlyGln: 2.25 ± 0.021	3.991GlyArg: 3.991 ± 0.029	5.879GlySer: 5.879 ± 0.071	3.75GlyThr: 3.75 ± 0.046	4.426GlyVal: 4.426 ± 0.035	0.744GlyTrp: 0.744 ± 0.011	1.435GlyTyr: 1.435 ± 0.018	0.0GlyXaa: 0.0 ± 0.0
His	2.439HisAla: 2.439 ± 0.021	0.353HisCys: 0.353 ± 0.007	1.379HisAsp: 1.379 ± 0.014	1.723HisGlu: 1.723 ± 0.017	0.946HisPhe: 0.946 ± 0.013	1.807HisGly: 1.807 ± 0.019	0.757HisHis: 0.757 ± 0.015	0.92HisIle: 0.92 ± 0.011	0.917HisLys: 0.917 ± 0.012	2.158HisLeu: 2.158 ± 0.023	0.513HisMet: 0.513 ± 0.009	0.686HisAsn: 0.686 ± 0.011	1.14HisPro: 1.14 ± 0.016	0.912HisGln: 0.912 ± 0.015	1.492HisArg: 1.492 ± 0.016	1.441HisSer: 1.441 ± 0.02	0.99HisThr: 0.99 ± 0.016	1.832HisVal: 1.832 ± 0.018	0.263HisTrp: 0.263 ± 0.006	0.509HisTyr: 0.509 ± 0.01	0.0HisXaa: 0.0 ± 0.0
Ile	3.851IleAla: 3.851 ± 0.026	0.708IleCys: 0.708 ± 0.01	2.561IleAsp: 2.561 ± 0.025	2.763IleGlu: 2.763 ± 0.021	1.698IlePhe: 1.698 ± 0.019	2.422IleGly: 2.422 ± 0.021	0.798IleHis: 0.798 ± 0.011	1.647IleIle: 1.647 ± 0.019	1.725IleLys: 1.725 ± 0.017	3.649IleLeu: 3.649 ± 0.029	0.892IleMet: 0.892 ± 0.011	1.231IleAsn: 1.231 ± 0.013	1.764IlePro: 1.764 ± 0.018	1.345IleGln: 1.345 ± 0.015	2.394IleArg: 2.394 ± 0.019	2.906IleSer: 2.906 ± 0.037	1.83IleThr: 1.83 ± 0.028	3.123IleVal: 3.123 ± 0.025	0.485IleTrp: 0.485 ± 0.01	0.86IleTyr: 0.86 ± 0.013	0.0IleXaa: 0.0 ± 0.0
Lys	4.473LysAla: 4.473 ± 0.037	0.546LysCys: 0.546 ± 0.01	2.677LysAsp: 2.677 ± 0.024	3.219LysGlu: 3.219 ± 0.034	1.34LysPhe: 1.34 ± 0.014	2.508LysGly: 2.508 ± 0.024	1.091LysHis: 1.091 ± 0.011	1.774LysIle: 1.774 ± 0.017	2.852LysLys: 2.852 ± 0.044	4.439LysLeu: 4.439 ± 0.031	1.07LysMet: 1.07 ± 0.013	1.491LysAsn: 1.491 ± 0.017	2.004LysPro: 2.004 ± 0.021	1.802LysGln: 1.802 ± 0.022	3.681LysArg: 3.681 ± 0.029	3.325LysSer: 3.325 ± 0.028	2.567LysThr: 2.567 ± 0.024	2.928LysVal: 2.928 ± 0.025	0.464LysTrp: 0.464 ± 0.009	1.025LysTyr: 1.025 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	10.009LeuAla: 10.009 ± 0.052	1.62LeuCys: 1.62 ± 0.018	5.877LeuAsp: 5.877 ± 0.034	7.202LeuGlu: 7.202 ± 0.049	3.22LeuPhe: 3.22 ± 0.025	6.148LeuGly: 6.148 ± 0.032	2.421LeuHis: 2.421 ± 0.022	3.041LeuIle: 3.041 ± 0.029	3.709LeuLys: 3.709 ± 0.033	8.809LeuLeu: 8.809 ± 0.051	1.945LeuMet: 1.945 ± 0.02	2.605LeuAsn: 2.605 ± 0.022	4.018LeuPro: 4.018 ± 0.029	4.429LeuGln: 4.429 ± 0.033	7.531LeuArg: 7.531 ± 0.049	6.826LeuSer: 6.826 ± 0.047	4.349LeuThr: 4.349 ± 0.04	6.694LeuVal: 6.694 ± 0.038	1.033LeuTrp: 1.033 ± 0.014	1.983LeuTyr: 1.983 ± 0.02	0.0LeuXaa: 0.0 ± 0.0
Met	2.277MetAla: 2.277 ± 0.02	0.331MetCys: 0.331 ± 0.007	1.318MetAsp: 1.318 ± 0.014	1.432MetGlu: 1.432 ± 0.018	0.669MetPhe: 0.669 ± 0.011	1.375MetGly: 1.375 ± 0.015	0.638MetHis: 0.638 ± 0.011	0.805MetIle: 0.805 ± 0.013	0.82MetLys: 0.82 ± 0.012	2.301MetLeu: 2.301 ± 0.02	0.583MetMet: 0.583 ± 0.011	0.728MetAsn: 0.728 ± 0.01	1.091MetPro: 1.091 ± 0.012	1.15MetGln: 1.15 ± 0.014	1.687MetArg: 1.687 ± 0.015	1.727MetSer: 1.727 ± 0.021	1.165MetThr: 1.165 ± 0.016	1.333MetVal: 1.333 ± 0.013	0.23MetTrp: 0.23 ± 0.006	0.569MetTyr: 0.569 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.596AsnAla: 3.596 ± 0.026	0.422AsnCys: 0.422 ± 0.009	2.095AsnAsp: 2.095 ± 0.019	2.431AsnGlu: 2.431 ± 0.018	1.231AsnPhe: 1.231 ± 0.014	2.55AsnGly: 2.55 ± 0.024	0.632AsnHis: 0.632 ± 0.011	1.32AsnIle: 1.32 ± 0.017	1.501AsnLys: 1.501 ± 0.017	2.995AsnLeu: 2.995 ± 0.024	0.797AsnMet: 0.797 ± 0.011	1.388AsnAsn: 1.388 ± 0.026	1.587AsnPro: 1.587 ± 0.015	1.069AsnGln: 1.069 ± 0.014	1.718AsnArg: 1.718 ± 0.017	2.198AsnSer: 2.198 ± 0.02	1.597AsnThr: 1.597 ± 0.016	2.365AsnVal: 2.365 ± 0.019	0.342AsnTrp: 0.342 ± 0.007	0.683AsnTyr: 0.683 ± 0.01	0.0AsnXaa: 0.0 ± 0.0
Pro	4.42ProAla: 4.42 ± 0.033	0.585ProCys: 0.585 ± 0.012	2.614ProAsp: 2.614 ± 0.025	3.337ProGlu: 3.337 ± 0.023	1.604ProPhe: 1.604 ± 0.015	3.217ProGly: 3.217 ± 0.023	0.995ProHis: 0.995 ± 0.013	1.511ProIle: 1.511 ± 0.014	1.878ProLys: 1.878 ± 0.02	3.847ProLeu: 3.847 ± 0.028	0.936ProMet: 0.936 ± 0.013	1.393ProAsn: 1.393 ± 0.015	2.852ProPro: 2.852 ± 0.037	1.716ProGln: 1.716 ± 0.021	3.024ProArg: 3.024 ± 0.024	4.175ProSer: 4.175 ± 0.033	2.64ProThr: 2.64 ± 0.038	2.889ProVal: 2.889 ± 0.024	0.537ProTrp: 0.537 ± 0.01	0.932ProTyr: 0.932 ± 0.012	0.0ProXaa: 0.0 ± 0.0
Gln	4.002GlnAla: 4.002 ± 0.031	0.464GlnCys: 0.464 ± 0.009	2.433GlnAsp: 2.433 ± 0.022	2.994GlnGlu: 2.994 ± 0.031	1.093GlnPhe: 1.093 ± 0.012	2.651GlnGly: 2.651 ± 0.024	1.193GlnHis: 1.193 ± 0.019	1.518GlnIle: 1.518 ± 0.018	1.606GlnLys: 1.606 ± 0.017	3.621GlnLeu: 3.621 ± 0.026	0.869GlnMet: 0.869 ± 0.012	1.285GlnAsn: 1.285 ± 0.014	1.591GlnPro: 1.591 ± 0.02	3.425GlnGln: 3.425 ± 0.069	3.213GlnArg: 3.213 ± 0.027	2.671GlnSer: 2.671 ± 0.025	2.108GlnThr: 2.108 ± 0.019	2.543GlnVal: 2.543 ± 0.02	0.404GlnTrp: 0.404 ± 0.008	0.811GlnTyr: 0.811 ± 0.012	0.0GlnXaa: 0.0 ± 0.0
Arg	7.142ArgAla: 7.142 ± 0.046	0.962ArgCys: 0.962 ± 0.014	3.828ArgAsp: 3.828 ± 0.032	4.927ArgGlu: 4.927 ± 0.034	2.455ArgPhe: 2.455 ± 0.019	4.206ArgGly: 4.206 ± 0.034	1.622ArgHis: 1.622 ± 0.019	2.933ArgIle: 2.933 ± 0.022	3.818ArgLys: 3.818 ± 0.032	6.188ArgLeu: 6.188 ± 0.041	1.479ArgMet: 1.479 ± 0.014	2.225ArgAsn: 2.225 ± 0.02	2.717ArgPro: 2.717 ± 0.022	2.663ArgGln: 2.663 ± 0.026	5.789ArgArg: 5.789 ± 0.041	4.839ArgSer: 4.839 ± 0.037	3.26ArgThr: 3.26 ± 0.021	4.558ArgVal: 4.558 ± 0.029	0.808ArgTrp: 0.808 ± 0.011	1.402ArgTyr: 1.402 ± 0.017	0.0ArgXaa: 0.0 ± 0.0
Ser	7.971SerAla: 7.971 ± 0.053	1.106SerCys: 1.106 ± 0.016	4.395SerAsp: 4.395 ± 0.032	4.624SerGlu: 4.624 ± 0.032	2.912SerPhe: 2.912 ± 0.027	6.077SerGly: 6.077 ± 0.109	1.598SerHis: 1.598 ± 0.017	3.005SerIle: 3.005 ± 0.032	3.66SerLys: 3.66 ± 0.029	7.113SerLeu: 7.113 ± 0.043	1.838SerMet: 1.838 ± 0.016	2.561SerAsn: 2.561 ± 0.023	3.781SerPro: 3.781 ± 0.033	2.818SerGln: 2.818 ± 0.022	4.92SerArg: 4.92 ± 0.036	9.092SerSer: 9.092 ± 0.08	4.507SerThr: 4.507 ± 0.039	4.866SerVal: 4.866 ± 0.035	0.897SerTrp: 0.897 ± 0.013	1.484SerTyr: 1.484 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	5.101ThrAla: 5.101 ± 0.035	0.924ThrCys: 0.924 ± 0.017	2.625ThrAsp: 2.625 ± 0.022	2.958ThrGlu: 2.958 ± 0.026	2.022ThrPhe: 2.022 ± 0.023	3.569ThrGly: 3.569 ± 0.061	1.072ThrHis: 1.072 ± 0.016	2.178ThrIle: 2.178 ± 0.029	2.299ThrLys: 2.299 ± 0.022	5.234ThrLeu: 5.234 ± 0.04	1.241ThrMet: 1.241 ± 0.015	1.648ThrAsn: 1.648 ± 0.016	2.881ThrPro: 2.881 ± 0.033	1.926ThrGln: 1.926 ± 0.018	3.249ThrArg: 3.249 ± 0.025	4.947ThrSer: 4.947 ± 0.05	3.078ThrThr: 3.078 ± 0.031	3.389ThrVal: 3.389 ± 0.035	0.68ThrTrp: 0.68 ± 0.011	1.145ThrTyr: 1.145 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	6.856ValAla: 6.856 ± 0.035	1.09ValCys: 1.09 ± 0.016	4.429ValAsp: 4.429 ± 0.029	4.523ValGlu: 4.523 ± 0.031	2.62ValPhe: 2.62 ± 0.022	3.983ValGly: 3.983 ± 0.032	1.707ValHis: 1.707 ± 0.016	2.538ValIle: 2.538 ± 0.023	2.746ValLys: 2.746 ± 0.022	6.845ValLeu: 6.845 ± 0.036	1.381ValMet: 1.381 ± 0.012	2.117ValAsn: 2.117 ± 0.019	3.204ValPro: 3.204 ± 0.023	2.814ValGln: 2.814 ± 0.023	4.612ValArg: 4.612 ± 0.031	5.176ValSer: 5.176 ± 0.043	3.287ValThr: 3.287 ± 0.04	4.956ValVal: 4.956 ± 0.033	0.784ValTrp: 0.784 ± 0.012	1.548ValTyr: 1.548 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	0.995TrpAla: 0.995 ± 0.012	0.198TrpCys: 0.198 ± 0.005	0.735TrpAsp: 0.735 ± 0.01	0.637TrpGlu: 0.637 ± 0.01	0.455TrpPhe: 0.455 ± 0.009	0.585TrpGly: 0.585 ± 0.01	0.289TrpHis: 0.289 ± 0.006	0.533TrpIle: 0.533 ± 0.009	0.55TrpLys: 0.55 ± 0.01	1.083TrpLeu: 1.083 ± 0.014	0.271TrpMet: 0.271 ± 0.007	0.485TrpAsn: 0.485 ± 0.011	0.43TrpPro: 0.43 ± 0.009	0.418TrpGln: 0.418 ± 0.007	0.858TrpArg: 0.858 ± 0.012	0.867TrpSer: 0.867 ± 0.013	0.766TrpThr: 0.766 ± 0.013	0.698TrpVal: 0.698 ± 0.01	0.174TrpTrp: 0.174 ± 0.005	0.3TrpTyr: 0.3 ± 0.007	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.984TyrAla: 1.984 ± 0.02	0.416TyrCys: 0.416 ± 0.01	1.344TyrAsp: 1.344 ± 0.018	1.547TyrGlu: 1.547 ± 0.019	0.978TyrPhe: 0.978 ± 0.015	1.542TyrGly: 1.542 ± 0.017	0.495TyrHis: 0.495 ± 0.009	0.869TyrIle: 0.869 ± 0.012	0.932TyrLys: 0.932 ± 0.015	2.016TyrLeu: 2.016 ± 0.019	0.551TyrMet: 0.551 ± 0.011	0.769TyrAsn: 0.769 ± 0.014	0.841TyrPro: 0.841 ± 0.012	0.697TyrGln: 0.697 ± 0.01	1.271TyrArg: 1.271 ± 0.014	1.373TyrSer: 1.373 ± 0.015	1.093TyrThr: 1.093 ± 0.015	1.545TyrVal: 1.545 ± 0.017	0.28TyrTrp: 0.28 ± 0.007	0.652TyrTyr: 0.652 ± 0.012	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 11849 proteins (7193445 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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