Amino acid dipepetide frequency for Streptococcus phage SW15

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.407AlaAla: 6.407 ± 2.814
0.383AlaCys: 0.383 ± 0.234
5.26AlaAsp: 5.26 ± 1.095
3.443AlaGlu: 3.443 ± 0.586
2.869AlaPhe: 2.869 ± 1.346
5.642AlaGly: 5.642 ± 1.536
1.148AlaHis: 1.148 ± 0.32
6.694AlaIle: 6.694 ± 2.094
5.164AlaLys: 5.164 ± 0.905
7.363AlaLeu: 7.363 ± 1.71
2.582AlaMet: 2.582 ± 1.265
3.921AlaAsn: 3.921 ± 0.721
2.391AlaPro: 2.391 ± 0.447
3.347AlaGln: 3.347 ± 1.193
3.156AlaArg: 3.156 ± 0.665
6.694AlaSer: 6.694 ± 1.874
5.164AlaThr: 5.164 ± 1.355
4.016AlaVal: 4.016 ± 1.248
0.383AlaTrp: 0.383 ± 0.148
2.391AlaTyr: 2.391 ± 0.537
0.0AlaXaa: 0.0 ± 0.0
Cys
0.096CysAla: 0.096 ± 0.103
0.0CysCys: 0.0 ± 0.0
0.478CysAsp: 0.478 ± 0.238
0.478CysGlu: 0.478 ± 0.256
0.0CysPhe: 0.0 ± 0.0
0.383CysGly: 0.383 ± 0.225
0.096CysHis: 0.096 ± 0.092
0.191CysIle: 0.191 ± 0.123
0.478CysLys: 0.478 ± 0.242
0.383CysLeu: 0.383 ± 0.171
0.096CysMet: 0.096 ± 0.105
0.287CysAsn: 0.287 ± 0.183
0.191CysPro: 0.191 ± 0.116
0.191CysGln: 0.191 ± 0.141
0.287CysArg: 0.287 ± 0.163
0.383CysSer: 0.383 ± 0.177
0.0CysThr: 0.0 ± 0.0
0.191CysVal: 0.191 ± 0.14
0.096CysTrp: 0.096 ± 0.091
0.478CysTyr: 0.478 ± 0.184
0.0CysXaa: 0.0 ± 0.0
Asp
3.156AspAla: 3.156 ± 0.459
0.383AspCys: 0.383 ± 0.199
4.781AspAsp: 4.781 ± 0.525
4.399AspGlu: 4.399 ± 0.862
3.347AspPhe: 3.347 ± 0.615
5.929AspGly: 5.929 ± 1.095
0.478AspHis: 0.478 ± 0.159
3.634AspIle: 3.634 ± 0.804
4.877AspLys: 4.877 ± 0.799
4.59AspLeu: 4.59 ± 0.741
1.243AspMet: 1.243 ± 0.297
4.59AspAsn: 4.59 ± 0.884
0.861AspPro: 0.861 ± 0.319
1.339AspGln: 1.339 ± 0.346
2.582AspArg: 2.582 ± 0.432
4.208AspSer: 4.208 ± 0.73
4.016AspThr: 4.016 ± 0.741
3.825AspVal: 3.825 ± 0.728
0.956AspTrp: 0.956 ± 0.31
3.443AspTyr: 3.443 ± 0.803
0.0AspXaa: 0.0 ± 0.0
Glu
5.068GluAla: 5.068 ± 0.618
0.191GluCys: 0.191 ± 0.126
2.199GluAsp: 2.199 ± 0.506
2.773GluGlu: 2.773 ± 0.718
2.773GluPhe: 2.773 ± 0.545
3.443GluGly: 3.443 ± 0.572
1.052GluHis: 1.052 ± 0.363
4.59GluIle: 4.59 ± 0.763
4.303GluLys: 4.303 ± 0.972
7.172GluLeu: 7.172 ± 1.429
1.913GluMet: 1.913 ± 0.596
4.59GluAsn: 4.59 ± 0.701
1.817GluPro: 1.817 ± 0.632
2.582GluGln: 2.582 ± 0.532
3.921GluArg: 3.921 ± 0.866
2.582GluSer: 2.582 ± 0.639
3.634GluThr: 3.634 ± 0.844
5.547GluVal: 5.547 ± 0.9
1.243GluTrp: 1.243 ± 0.336
2.965GluTyr: 2.965 ± 1.042
0.0GluXaa: 0.0 ± 0.0
Phe
2.678PheAla: 2.678 ± 0.555
0.191PheCys: 0.191 ± 0.157
2.773PheAsp: 2.773 ± 0.579
3.825PheGlu: 3.825 ± 0.619
1.53PhePhe: 1.53 ± 0.394
3.921PheGly: 3.921 ± 0.662
0.383PheHis: 0.383 ± 0.169
2.869PheIle: 2.869 ± 0.448
4.112PheLys: 4.112 ± 0.625
2.295PheLeu: 2.295 ± 0.709
0.574PheMet: 0.574 ± 0.251
3.156PheAsn: 3.156 ± 0.551
0.478PhePro: 0.478 ± 0.257
1.339PheGln: 1.339 ± 0.335
1.243PheArg: 1.243 ± 0.304
2.869PheSer: 2.869 ± 0.841
3.06PheThr: 3.06 ± 0.62
2.391PheVal: 2.391 ± 0.59
0.574PheTrp: 0.574 ± 0.224
1.243PheTyr: 1.243 ± 0.378
0.0PheXaa: 0.0 ± 0.0
Gly
5.929GlyAla: 5.929 ± 1.37
0.383GlyCys: 0.383 ± 0.274
3.347GlyAsp: 3.347 ± 0.368
2.965GlyGlu: 2.965 ± 0.377
3.156GlyPhe: 3.156 ± 0.587
3.73GlyGly: 3.73 ± 0.583
0.574GlyHis: 0.574 ± 0.228
6.694GlyIle: 6.694 ± 2.355
6.598GlyLys: 6.598 ± 0.851
6.025GlyLeu: 6.025 ± 0.821
1.626GlyMet: 1.626 ± 1.019
3.347GlyAsn: 3.347 ± 0.459
0.669GlyPro: 0.669 ± 0.215
2.869GlyGln: 2.869 ± 0.629
2.869GlyArg: 2.869 ± 0.522
4.781GlySer: 4.781 ± 0.913
5.26GlyThr: 5.26 ± 0.813
4.781GlyVal: 4.781 ± 0.706
0.956GlyTrp: 0.956 ± 0.323
2.965GlyTyr: 2.965 ± 0.681
0.0GlyXaa: 0.0 ± 0.0
His
0.861HisAla: 0.861 ± 0.261
0.0HisCys: 0.0 ± 0.0
0.861HisAsp: 0.861 ± 0.281
0.478HisGlu: 0.478 ± 0.179
0.669HisPhe: 0.669 ± 0.225
0.956HisGly: 0.956 ± 0.301
0.478HisHis: 0.478 ± 0.231
1.052HisIle: 1.052 ± 0.334
0.861HisLys: 0.861 ± 0.288
0.765HisLeu: 0.765 ± 0.283
0.574HisMet: 0.574 ± 0.24
0.574HisAsn: 0.574 ± 0.26
0.478HisPro: 0.478 ± 0.196
0.287HisGln: 0.287 ± 0.18
0.669HisArg: 0.669 ± 0.311
0.765HisSer: 0.765 ± 0.31
0.383HisThr: 0.383 ± 0.151
1.052HisVal: 1.052 ± 0.324
0.096HisTrp: 0.096 ± 0.107
0.383HisTyr: 0.383 ± 0.16
0.0HisXaa: 0.0 ± 0.0
Ile
5.547IleAla: 5.547 ± 1.434
0.478IleCys: 0.478 ± 0.212
5.929IleAsp: 5.929 ± 0.724
3.634IleGlu: 3.634 ± 0.628
1.626IlePhe: 1.626 ± 0.426
6.025IleGly: 6.025 ± 1.3
0.956IleHis: 0.956 ± 0.281
3.251IleIle: 3.251 ± 1.004
5.833IleLys: 5.833 ± 0.607
3.538IleLeu: 3.538 ± 0.498
2.295IleMet: 2.295 ± 0.386
4.303IleAsn: 4.303 ± 0.508
2.869IlePro: 2.869 ± 0.719
2.678IleGln: 2.678 ± 0.471
2.965IleArg: 2.965 ± 0.723
6.216IleSer: 6.216 ± 1.923
4.208IleThr: 4.208 ± 0.487
4.495IleVal: 4.495 ± 0.946
0.669IleTrp: 0.669 ± 0.219
3.251IleTyr: 3.251 ± 0.677
0.0IleXaa: 0.0 ± 0.0
Lys
6.598LysAla: 6.598 ± 1.026
0.287LysCys: 0.287 ± 0.172
3.634LysAsp: 3.634 ± 0.616
7.268LysGlu: 7.268 ± 1.185
2.678LysPhe: 2.678 ± 0.482
4.877LysGly: 4.877 ± 0.415
1.052LysHis: 1.052 ± 0.42
4.399LysIle: 4.399 ± 0.659
6.12LysLys: 6.12 ± 1.268
6.694LysLeu: 6.694 ± 0.861
1.721LysMet: 1.721 ± 0.512
4.303LysAsn: 4.303 ± 0.778
2.869LysPro: 2.869 ± 0.587
2.486LysGln: 2.486 ± 0.507
4.59LysArg: 4.59 ± 0.786
4.495LysSer: 4.495 ± 0.591
5.738LysThr: 5.738 ± 0.854
3.825LysVal: 3.825 ± 0.638
0.765LysTrp: 0.765 ± 0.228
3.443LysTyr: 3.443 ± 0.85
0.0LysXaa: 0.0 ± 0.0
Leu
6.216LeuAla: 6.216 ± 0.906
0.287LeuCys: 0.287 ± 0.154
4.877LeuAsp: 4.877 ± 0.701
6.12LeuGlu: 6.12 ± 1.294
2.869LeuPhe: 2.869 ± 0.476
5.833LeuGly: 5.833 ± 1.299
0.669LeuHis: 0.669 ± 0.311
4.781LeuIle: 4.781 ± 0.687
6.12LeuLys: 6.12 ± 0.939
5.26LeuLeu: 5.26 ± 0.814
1.434LeuMet: 1.434 ± 0.311
5.738LeuAsn: 5.738 ± 0.673
2.965LeuPro: 2.965 ± 0.559
2.965LeuGln: 2.965 ± 0.532
3.251LeuArg: 3.251 ± 0.578
5.068LeuSer: 5.068 ± 0.749
5.738LeuThr: 5.738 ± 0.981
4.877LeuVal: 4.877 ± 0.505
0.669LeuTrp: 0.669 ± 0.314
2.773LeuTyr: 2.773 ± 0.643
0.0LeuXaa: 0.0 ± 0.0
Met
2.965MetAla: 2.965 ± 0.922
0.0MetCys: 0.0 ± 0.0
0.669MetAsp: 0.669 ± 0.249
1.052MetGlu: 1.052 ± 0.423
1.243MetPhe: 1.243 ± 0.257
1.148MetGly: 1.148 ± 0.486
0.096MetHis: 0.096 ± 0.098
1.817MetIle: 1.817 ± 0.448
2.678MetLys: 2.678 ± 0.562
1.53MetLeu: 1.53 ± 0.349
0.956MetMet: 0.956 ± 0.645
0.669MetAsn: 0.669 ± 0.263
0.765MetPro: 0.765 ± 0.263
1.53MetGln: 1.53 ± 0.567
1.052MetArg: 1.052 ± 0.391
2.008MetSer: 2.008 ± 0.509
1.434MetThr: 1.434 ± 0.357
2.295MetVal: 2.295 ± 0.577
0.096MetTrp: 0.096 ± 0.098
0.574MetTyr: 0.574 ± 0.212
0.0MetXaa: 0.0 ± 0.0
Asn
4.112AsnAla: 4.112 ± 0.472
0.383AsnCys: 0.383 ± 0.158
3.825AsnAsp: 3.825 ± 0.803
4.686AsnGlu: 4.686 ± 1.037
2.104AsnPhe: 2.104 ± 0.468
5.547AsnGly: 5.547 ± 0.986
1.148AsnHis: 1.148 ± 0.426
2.965AsnIle: 2.965 ± 0.463
3.634AsnLys: 3.634 ± 0.681
3.825AsnLeu: 3.825 ± 0.554
1.148AsnMet: 1.148 ± 0.289
4.208AsnAsn: 4.208 ± 0.997
2.486AsnPro: 2.486 ± 0.544
1.817AsnGln: 1.817 ± 0.431
2.391AsnArg: 2.391 ± 0.685
3.06AsnSer: 3.06 ± 0.518
3.443AsnThr: 3.443 ± 0.561
3.251AsnVal: 3.251 ± 0.475
1.243AsnTrp: 1.243 ± 0.388
2.582AsnTyr: 2.582 ± 0.671
0.0AsnXaa: 0.0 ± 0.0
Pro
1.243ProAla: 1.243 ± 0.277
0.0ProCys: 0.0 ± 0.0
2.486ProAsp: 2.486 ± 0.619
2.008ProGlu: 2.008 ± 0.564
1.148ProPhe: 1.148 ± 0.223
1.148ProGly: 1.148 ± 0.366
0.191ProHis: 0.191 ± 0.124
1.817ProIle: 1.817 ± 0.5
2.773ProLys: 2.773 ± 0.507
1.913ProLeu: 1.913 ± 0.416
0.096ProMet: 0.096 ± 0.098
1.913ProAsn: 1.913 ± 0.588
1.052ProPro: 1.052 ± 0.365
1.243ProGln: 1.243 ± 0.335
1.339ProArg: 1.339 ± 0.469
2.199ProSer: 2.199 ± 0.485
1.913ProThr: 1.913 ± 0.455
2.104ProVal: 2.104 ± 0.463
0.383ProTrp: 0.383 ± 0.193
1.148ProTyr: 1.148 ± 0.417
0.0ProXaa: 0.0 ± 0.0
Gln
4.495GlnAla: 4.495 ± 1.212
0.287GlnCys: 0.287 ± 0.133
1.721GlnAsp: 1.721 ± 0.357
2.773GlnGlu: 2.773 ± 0.666
2.199GlnPhe: 2.199 ± 0.461
2.104GlnGly: 2.104 ± 0.726
0.478GlnHis: 0.478 ± 0.184
2.391GlnIle: 2.391 ± 0.584
2.869GlnLys: 2.869 ± 0.547
3.634GlnLeu: 3.634 ± 0.459
1.339GlnMet: 1.339 ± 0.4
2.008GlnAsn: 2.008 ± 0.33
0.861GlnPro: 0.861 ± 0.267
1.434GlnGln: 1.434 ± 0.337
1.148GlnArg: 1.148 ± 0.339
2.773GlnSer: 2.773 ± 0.528
2.678GlnThr: 2.678 ± 0.351
2.104GlnVal: 2.104 ± 0.406
0.478GlnTrp: 0.478 ± 0.192
0.956GlnTyr: 0.956 ± 0.272
0.0GlnXaa: 0.0 ± 0.0
Arg
3.251ArgAla: 3.251 ± 0.524
0.574ArgCys: 0.574 ± 0.261
2.295ArgAsp: 2.295 ± 0.469
2.869ArgGlu: 2.869 ± 0.738
1.817ArgPhe: 1.817 ± 0.462
2.678ArgGly: 2.678 ± 0.458
0.478ArgHis: 0.478 ± 0.233
3.06ArgIle: 3.06 ± 0.669
3.443ArgLys: 3.443 ± 0.682
3.921ArgLeu: 3.921 ± 0.564
1.721ArgMet: 1.721 ± 0.379
1.817ArgAsn: 1.817 ± 0.421
1.434ArgPro: 1.434 ± 0.421
1.434ArgGln: 1.434 ± 0.376
1.721ArgArg: 1.721 ± 0.578
2.008ArgSer: 2.008 ± 0.338
1.721ArgThr: 1.721 ± 0.502
3.251ArgVal: 3.251 ± 0.705
0.669ArgTrp: 0.669 ± 0.262
2.391ArgTyr: 2.391 ± 0.449
0.0ArgXaa: 0.0 ± 0.0
Ser
6.981SerAla: 6.981 ± 3.581
0.287SerCys: 0.287 ± 0.202
4.303SerAsp: 4.303 ± 0.805
3.634SerGlu: 3.634 ± 0.734
2.965SerPhe: 2.965 ± 0.52
4.59SerGly: 4.59 ± 0.591
0.574SerHis: 0.574 ± 0.228
5.738SerIle: 5.738 ± 1.04
4.399SerLys: 4.399 ± 0.624
5.26SerLeu: 5.26 ± 0.918
1.721SerMet: 1.721 ± 0.337
3.443SerAsn: 3.443 ± 0.52
1.53SerPro: 1.53 ± 0.345
3.156SerGln: 3.156 ± 1.129
1.817SerArg: 1.817 ± 0.396
4.781SerSer: 4.781 ± 1.445
4.495SerThr: 4.495 ± 0.698
4.973SerVal: 4.973 ± 0.727
0.669SerTrp: 0.669 ± 0.224
1.817SerTyr: 1.817 ± 0.394
0.0SerXaa: 0.0 ± 0.0
Thr
5.068ThrAla: 5.068 ± 2.299
0.096ThrCys: 0.096 ± 0.081
3.538ThrAsp: 3.538 ± 0.804
3.634ThrGlu: 3.634 ± 0.703
3.921ThrPhe: 3.921 ± 0.506
4.495ThrGly: 4.495 ± 0.719
1.243ThrHis: 1.243 ± 0.343
5.451ThrIle: 5.451 ± 0.747
5.355ThrLys: 5.355 ± 0.726
5.451ThrLeu: 5.451 ± 0.718
1.434ThrMet: 1.434 ± 0.802
2.104ThrAsn: 2.104 ± 0.279
1.53ThrPro: 1.53 ± 0.368
2.773ThrGln: 2.773 ± 0.415
1.913ThrArg: 1.913 ± 0.384
4.016ThrSer: 4.016 ± 1.15
3.538ThrThr: 3.538 ± 0.47
5.547ThrVal: 5.547 ± 0.654
0.287ThrTrp: 0.287 ± 0.163
2.391ThrTyr: 2.391 ± 0.712
0.0ThrXaa: 0.0 ± 0.0
Val
4.399ValAla: 4.399 ± 1.259
0.096ValCys: 0.096 ± 0.081
5.642ValAsp: 5.642 ± 0.975
5.26ValGlu: 5.26 ± 1.11
2.486ValPhe: 2.486 ± 0.455
4.208ValGly: 4.208 ± 0.689
0.478ValHis: 0.478 ± 0.201
5.547ValIle: 5.547 ± 0.597
5.26ValLys: 5.26 ± 0.55
4.208ValLeu: 4.208 ± 0.41
0.861ValMet: 0.861 ± 0.252
4.016ValAsn: 4.016 ± 0.807
1.913ValPro: 1.913 ± 0.321
2.869ValGln: 2.869 ± 0.754
2.199ValArg: 2.199 ± 0.424
5.068ValSer: 5.068 ± 0.766
4.303ValThr: 4.303 ± 0.669
4.59ValVal: 4.59 ± 0.665
0.956ValTrp: 0.956 ± 0.317
1.53ValTyr: 1.53 ± 0.411
0.0ValXaa: 0.0 ± 0.0
Trp
0.383TrpAla: 0.383 ± 0.147
0.096TrpCys: 0.096 ± 0.092
0.956TrpAsp: 0.956 ± 0.4
1.052TrpGlu: 1.052 ± 0.332
0.478TrpPhe: 0.478 ± 0.242
0.765TrpGly: 0.765 ± 0.227
0.096TrpHis: 0.096 ± 0.092
0.956TrpIle: 0.956 ± 0.279
0.669TrpLys: 0.669 ± 0.166
1.339TrpLeu: 1.339 ± 0.372
0.096TrpMet: 0.096 ± 0.093
0.669TrpAsn: 0.669 ± 0.293
0.096TrpPro: 0.096 ± 0.116
0.574TrpGln: 0.574 ± 0.225
0.574TrpArg: 0.574 ± 0.249
1.052TrpSer: 1.052 ± 0.41
0.956TrpThr: 0.956 ± 0.315
0.574TrpVal: 0.574 ± 0.175
0.383TrpTrp: 0.383 ± 0.197
0.191TrpTyr: 0.191 ± 0.114
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.965TyrAla: 2.965 ± 0.417
0.383TyrCys: 0.383 ± 0.194
3.06TyrAsp: 3.06 ± 0.813
2.008TyrGlu: 2.008 ± 0.52
1.626TyrPhe: 1.626 ± 0.416
2.104TyrGly: 2.104 ± 0.449
0.574TyrHis: 0.574 ± 0.346
2.869TyrIle: 2.869 ± 0.734
2.391TyrLys: 2.391 ± 0.496
3.347TyrLeu: 3.347 ± 0.768
1.052TyrMet: 1.052 ± 0.334
2.199TyrAsn: 2.199 ± 0.539
0.861TyrPro: 0.861 ± 0.267
1.817TyrGln: 1.817 ± 0.428
2.869TyrArg: 2.869 ± 0.954
2.104TyrSer: 2.104 ± 0.513
2.104TyrThr: 2.104 ± 0.522
2.199TyrVal: 2.199 ± 0.485
0.383TyrTrp: 0.383 ± 0.187
1.913TyrTyr: 1.913 ± 0.695
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 44 proteins (10458 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski