Amino acid dipepetide frequency for Wenzhouxiangella sp. XN24

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.238AlaAla: 18.238 ± 0.237
1.197AlaCys: 1.197 ± 0.039
6.947AlaAsp: 6.947 ± 0.093
8.352AlaGlu: 8.352 ± 0.114
4.044AlaPhe: 4.044 ± 0.065
12.079AlaGly: 12.079 ± 0.147
2.21AlaHis: 2.21 ± 0.049
5.21AlaIle: 5.21 ± 0.08
2.342AlaLys: 2.342 ± 0.055
14.214AlaLeu: 14.214 ± 0.141
3.011AlaMet: 3.011 ± 0.059
2.389AlaAsn: 2.389 ± 0.049
5.834AlaPro: 5.834 ± 0.089
3.703AlaGln: 3.703 ± 0.065
10.254AlaArg: 10.254 ± 0.151
5.802AlaSer: 5.802 ± 0.083
5.856AlaThr: 5.856 ± 0.074
9.336AlaVal: 9.336 ± 0.104
2.18AlaTrp: 2.18 ± 0.06
2.327AlaTyr: 2.327 ± 0.048
0.0AlaXaa: 0.0 ± 0.0
Cys
0.954CysAla: 0.954 ± 0.031
0.092CysCys: 0.092 ± 0.01
0.443CysAsp: 0.443 ± 0.021
0.482CysGlu: 0.482 ± 0.023
0.28CysPhe: 0.28 ± 0.018
0.903CysGly: 0.903 ± 0.032
0.347CysHis: 0.347 ± 0.034
0.367CysIle: 0.367 ± 0.019
0.142CysLys: 0.142 ± 0.013
0.839CysLeu: 0.839 ± 0.028
0.149CysMet: 0.149 ± 0.011
0.224CysAsn: 0.224 ± 0.014
0.478CysPro: 0.478 ± 0.026
0.195CysGln: 0.195 ± 0.014
0.736CysArg: 0.736 ± 0.029
0.435CysSer: 0.435 ± 0.023
0.4CysThr: 0.4 ± 0.019
0.556CysVal: 0.556 ± 0.025
0.124CysTrp: 0.124 ± 0.011
0.206CysTyr: 0.206 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
7.188AspAla: 7.188 ± 0.1
0.496AspCys: 0.496 ± 0.025
3.35AspAsp: 3.35 ± 0.073
4.196AspGlu: 4.196 ± 0.069
2.247AspPhe: 2.247 ± 0.057
5.695AspGly: 5.695 ± 0.117
1.159AspHis: 1.159 ± 0.038
2.664AspIle: 2.664 ± 0.052
1.166AspLys: 1.166 ± 0.043
5.747AspLeu: 5.747 ± 0.079
1.236AspMet: 1.236 ± 0.037
1.199AspAsn: 1.199 ± 0.033
3.926AspPro: 3.926 ± 0.065
1.578AspGln: 1.578 ± 0.038
4.415AspArg: 4.415 ± 0.072
2.571AspSer: 2.571 ± 0.058
2.834AspThr: 2.834 ± 0.059
4.002AspVal: 4.002 ± 0.07
1.149AspTrp: 1.149 ± 0.034
1.611AspTyr: 1.611 ± 0.042
0.0AspXaa: 0.0 ± 0.0
Glu
8.206GluAla: 8.206 ± 0.126
0.408GluCys: 0.408 ± 0.019
3.324GluAsp: 3.324 ± 0.063
3.694GluGlu: 3.694 ± 0.075
2.299GluPhe: 2.299 ± 0.056
4.654GluGly: 4.654 ± 0.074
1.438GluHis: 1.438 ± 0.045
3.568GluIle: 3.568 ± 0.059
1.694GluLys: 1.694 ± 0.046
7.384GluLeu: 7.384 ± 0.107
1.421GluMet: 1.421 ± 0.037
1.528GluAsn: 1.528 ± 0.037
3.171GluPro: 3.171 ± 0.06
2.652GluGln: 2.652 ± 0.049
6.046GluArg: 6.046 ± 0.097
3.169GluSer: 3.169 ± 0.051
3.474GluThr: 3.474 ± 0.064
4.578GluVal: 4.578 ± 0.076
0.832GluTrp: 0.832 ± 0.032
1.34GluTyr: 1.34 ± 0.037
0.0GluXaa: 0.0 ± 0.0
Phe
4.128PheAla: 4.128 ± 0.073
0.354PheCys: 0.354 ± 0.021
2.569PheAsp: 2.569 ± 0.054
2.445PheGlu: 2.445 ± 0.051
1.385PhePhe: 1.385 ± 0.042
3.501PheGly: 3.501 ± 0.067
0.731PheHis: 0.731 ± 0.028
1.578PheIle: 1.578 ± 0.045
0.668PheLys: 0.668 ± 0.028
3.437PheLeu: 3.437 ± 0.067
0.788PheMet: 0.788 ± 0.028
0.947PheAsn: 0.947 ± 0.036
1.666PhePro: 1.666 ± 0.042
0.901PheGln: 0.901 ± 0.036
2.698PheArg: 2.698 ± 0.05
2.175PheSer: 2.175 ± 0.054
1.861PheThr: 1.861 ± 0.043
2.855PheVal: 2.855 ± 0.063
0.499PheTrp: 0.499 ± 0.023
0.882PheTyr: 0.882 ± 0.034
0.0PheXaa: 0.0 ± 0.0
Gly
9.325GlyAla: 9.325 ± 0.111
0.89GlyCys: 0.89 ± 0.032
5.027GlyAsp: 5.027 ± 0.078
5.691GlyGlu: 5.691 ± 0.074
3.481GlyPhe: 3.481 ± 0.067
7.384GlyGly: 7.384 ± 0.125
1.937GlyHis: 1.937 ± 0.047
4.317GlyIle: 4.317 ± 0.081
2.281GlyLys: 2.281 ± 0.055
9.825GlyLeu: 9.825 ± 0.115
2.263GlyMet: 2.263 ± 0.055
2.066GlyAsn: 2.066 ± 0.061
3.759GlyPro: 3.759 ± 0.072
2.659GlyGln: 2.659 ± 0.056
7.455GlyArg: 7.455 ± 0.082
4.303GlySer: 4.303 ± 0.088
4.465GlyThr: 4.465 ± 0.077
6.408GlyVal: 6.408 ± 0.081
1.51GlyTrp: 1.51 ± 0.043
2.303GlyTyr: 2.303 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
2.518HisAla: 2.518 ± 0.05
0.248HisCys: 0.248 ± 0.017
1.256HisAsp: 1.256 ± 0.04
1.319HisGlu: 1.319 ± 0.035
0.76HisPhe: 0.76 ± 0.029
2.095HisGly: 2.095 ± 0.05
0.538HisHis: 0.538 ± 0.023
0.742HisIle: 0.742 ± 0.025
0.397HisLys: 0.397 ± 0.021
2.06HisLeu: 2.06 ± 0.052
0.409HisMet: 0.409 ± 0.019
0.446HisAsn: 0.446 ± 0.021
1.395HisPro: 1.395 ± 0.041
0.58HisGln: 0.58 ± 0.023
1.687HisArg: 1.687 ± 0.042
0.911HisSer: 0.911 ± 0.036
0.863HisThr: 0.863 ± 0.032
1.502HisVal: 1.502 ± 0.039
0.384HisTrp: 0.384 ± 0.021
0.599HisTyr: 0.599 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
5.839IleAla: 5.839 ± 0.082
0.394IleCys: 0.394 ± 0.025
3.174IleAsp: 3.174 ± 0.057
3.502IleGlu: 3.502 ± 0.054
1.325IlePhe: 1.325 ± 0.039
4.343IleGly: 4.343 ± 0.081
0.913IleHis: 0.913 ± 0.032
1.821IleIle: 1.821 ± 0.05
0.986IleLys: 0.986 ± 0.036
3.883IleLeu: 3.883 ± 0.078
0.797IleMet: 0.797 ± 0.028
1.17IleAsn: 1.17 ± 0.036
2.164IlePro: 2.164 ± 0.052
1.138IleGln: 1.138 ± 0.033
3.347IleArg: 3.347 ± 0.059
2.406IleSer: 2.406 ± 0.046
2.237IleThr: 2.237 ± 0.057
3.716IleVal: 3.716 ± 0.067
0.474IleTrp: 0.474 ± 0.023
1.051IleTyr: 1.051 ± 0.036
0.0IleXaa: 0.0 ± 0.0
Lys
2.626LysAla: 2.626 ± 0.058
0.134LysCys: 0.134 ± 0.012
1.138LysAsp: 1.138 ± 0.042
1.185LysGlu: 1.185 ± 0.046
0.657LysPhe: 0.657 ± 0.03
1.621LysGly: 1.621 ± 0.045
0.461LysHis: 0.461 ± 0.02
1.103LysIle: 1.103 ± 0.039
0.914LysLys: 0.914 ± 0.062
2.471LysLeu: 2.471 ± 0.052
0.493LysMet: 0.493 ± 0.024
0.609LysAsn: 0.609 ± 0.027
1.355LysPro: 1.355 ± 0.043
0.744LysGln: 0.744 ± 0.03
1.908LysArg: 1.908 ± 0.047
1.205LysSer: 1.205 ± 0.042
1.309LysThr: 1.309 ± 0.041
1.708LysVal: 1.708 ± 0.044
0.22LysTrp: 0.22 ± 0.013
0.481LysTyr: 0.481 ± 0.023
0.0LysXaa: 0.0 ± 0.0
Leu
15.591LeuAla: 15.591 ± 0.171
0.864LeuCys: 0.864 ± 0.034
6.917LeuAsp: 6.917 ± 0.093
7.697LeuGlu: 7.697 ± 0.112
3.689LeuPhe: 3.689 ± 0.069
9.437LeuGly: 9.437 ± 0.118
2.14LeuHis: 2.14 ± 0.052
3.784LeuIle: 3.784 ± 0.069
2.631LeuLys: 2.631 ± 0.053
12.129LeuLeu: 12.129 ± 0.163
2.142LeuMet: 2.142 ± 0.048
2.343LeuAsn: 2.343 ± 0.05
5.982LeuPro: 5.982 ± 0.077
3.362LeuGln: 3.362 ± 0.072
8.283LeuArg: 8.283 ± 0.1
5.723LeuSer: 5.723 ± 0.084
4.545LeuThr: 4.545 ± 0.075
8.836LeuVal: 8.836 ± 0.131
1.292LeuTrp: 1.292 ± 0.039
2.123LeuTyr: 2.123 ± 0.053
0.0LeuXaa: 0.0 ± 0.0
Met
2.817MetAla: 2.817 ± 0.062
0.136MetCys: 0.136 ± 0.011
1.142MetAsp: 1.142 ± 0.036
1.179MetGlu: 1.179 ± 0.032
0.703MetPhe: 0.703 ± 0.03
1.519MetGly: 1.519 ± 0.04
0.474MetHis: 0.474 ± 0.022
1.05MetIle: 1.05 ± 0.034
0.799MetLys: 0.799 ± 0.03
2.463MetLeu: 2.463 ± 0.049
0.539MetMet: 0.539 ± 0.027
0.763MetAsn: 0.763 ± 0.024
1.331MetPro: 1.331 ± 0.036
0.798MetGln: 0.798 ± 0.026
1.75MetArg: 1.75 ± 0.044
1.553MetSer: 1.553 ± 0.043
1.344MetThr: 1.344 ± 0.03
1.518MetVal: 1.518 ± 0.039
0.195MetTrp: 0.195 ± 0.013
0.356MetTyr: 0.356 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
2.547AsnAla: 2.547 ± 0.058
0.218AsnCys: 0.218 ± 0.017
1.252AsnAsp: 1.252 ± 0.037
1.243AsnGlu: 1.243 ± 0.037
0.873AsnPhe: 0.873 ± 0.028
1.803AsnGly: 1.803 ± 0.053
0.466AsnHis: 0.466 ± 0.023
1.218AsnIle: 1.218 ± 0.042
0.51AsnLys: 0.51 ± 0.023
2.466AsnLeu: 2.466 ± 0.055
0.523AsnMet: 0.523 ± 0.022
0.588AsnAsn: 0.588 ± 0.028
1.675AsnPro: 1.675 ± 0.043
0.671AsnGln: 0.671 ± 0.029
1.809AsnArg: 1.809 ± 0.043
1.096AsnSer: 1.096 ± 0.035
1.19AsnThr: 1.19 ± 0.04
1.7AsnVal: 1.7 ± 0.044
0.358AsnTrp: 0.358 ± 0.018
0.595AsnTyr: 0.595 ± 0.024
0.0AsnXaa: 0.0 ± 0.0
Pro
7.323ProAla: 7.323 ± 0.107
0.347ProCys: 0.347 ± 0.021
3.921ProAsp: 3.921 ± 0.069
4.451ProGlu: 4.451 ± 0.089
1.737ProPhe: 1.737 ± 0.039
5.767ProGly: 5.767 ± 0.1
0.89ProHis: 0.89 ± 0.029
1.872ProIle: 1.872 ± 0.044
0.937ProLys: 0.937 ± 0.033
5.043ProLeu: 5.043 ± 0.079
1.142ProMet: 1.142 ± 0.032
0.978ProAsn: 0.978 ± 0.033
3.153ProPro: 3.153 ± 0.075
1.466ProGln: 1.466 ± 0.043
3.399ProArg: 3.399 ± 0.059
2.289ProSer: 2.289 ± 0.05
2.181ProThr: 2.181 ± 0.049
4.525ProVal: 4.525 ± 0.071
0.859ProTrp: 0.859 ± 0.031
1.04ProTyr: 1.04 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
4.199GlnAla: 4.199 ± 0.075
0.205GlnCys: 0.205 ± 0.014
1.487GlnAsp: 1.487 ± 0.042
1.648GlnGlu: 1.648 ± 0.042
1.015GlnPhe: 1.015 ± 0.03
2.403GlnGly: 2.403 ± 0.055
0.669GlnHis: 0.669 ± 0.028
1.219GlnIle: 1.219 ± 0.037
0.649GlnLys: 0.649 ± 0.027
3.526GlnLeu: 3.526 ± 0.062
0.685GlnMet: 0.685 ± 0.023
0.603GlnAsn: 0.603 ± 0.023
1.725GlnPro: 1.725 ± 0.042
1.271GlnGln: 1.271 ± 0.042
2.839GlnArg: 2.839 ± 0.066
1.526GlnSer: 1.526 ± 0.045
1.226GlnThr: 1.226 ± 0.036
2.729GlnVal: 2.729 ± 0.05
0.438GlnTrp: 0.438 ± 0.018
0.6GlnTyr: 0.6 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
8.802ArgAla: 8.802 ± 0.13
0.608ArgCys: 0.608 ± 0.027
4.759ArgAsp: 4.759 ± 0.077
5.428ArgGlu: 5.428 ± 0.092
3.308ArgPhe: 3.308 ± 0.056
5.589ArgGly: 5.589 ± 0.075
2.037ArgHis: 2.037 ± 0.054
4.227ArgIle: 4.227 ± 0.072
2.028ArgLys: 2.028 ± 0.052
9.48ArgLeu: 9.48 ± 0.121
2.032ArgMet: 2.032 ± 0.047
1.895ArgAsn: 1.895 ± 0.044
3.98ArgPro: 3.98 ± 0.066
2.787ArgGln: 2.787 ± 0.06
7.351ArgArg: 7.351 ± 0.119
3.847ArgSer: 3.847 ± 0.066
3.259ArgThr: 3.259 ± 0.055
6.006ArgVal: 6.006 ± 0.066
1.285ArgTrp: 1.285 ± 0.038
2.259ArgTyr: 2.259 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
5.849SerAla: 5.849 ± 0.09
0.434SerCys: 0.434 ± 0.02
2.68SerAsp: 2.68 ± 0.062
2.69SerGlu: 2.69 ± 0.056
2.077SerPhe: 2.077 ± 0.048
5.242SerGly: 5.242 ± 0.085
1.05SerHis: 1.05 ± 0.032
2.395SerIle: 2.395 ± 0.044
1.014SerLys: 1.014 ± 0.033
5.465SerLeu: 5.465 ± 0.078
1.318SerMet: 1.318 ± 0.041
1.18SerAsn: 1.18 ± 0.036
2.775SerPro: 2.775 ± 0.057
1.381SerGln: 1.381 ± 0.042
4.084SerArg: 4.084 ± 0.061
2.636SerSer: 2.636 ± 0.053
2.358SerThr: 2.358 ± 0.055
3.691SerVal: 3.691 ± 0.068
0.785SerTrp: 0.785 ± 0.028
1.153SerTyr: 1.153 ± 0.039
0.0SerXaa: 0.0 ± 0.0
Thr
5.818ThrAla: 5.818 ± 0.08
0.377ThrCys: 0.377 ± 0.021
2.546ThrAsp: 2.546 ± 0.053
2.585ThrGlu: 2.585 ± 0.049
1.578ThrPhe: 1.578 ± 0.046
4.876ThrGly: 4.876 ± 0.073
0.892ThrHis: 0.892 ± 0.029
2.194ThrIle: 2.194 ± 0.052
0.793ThrLys: 0.793 ± 0.031
5.767ThrLeu: 5.767 ± 0.082
0.933ThrMet: 0.933 ± 0.03
1.008ThrAsn: 1.008 ± 0.032
3.09ThrPro: 3.09 ± 0.057
1.237ThrGln: 1.237 ± 0.038
3.745ThrArg: 3.745 ± 0.064
2.348ThrSer: 2.348 ± 0.055
2.361ThrThr: 2.361 ± 0.051
4.001ThrVal: 4.001 ± 0.068
0.722ThrTrp: 0.722 ± 0.029
0.989ThrTyr: 0.989 ± 0.033
0.0ThrXaa: 0.0 ± 0.0
Val
9.832ValAla: 9.832 ± 0.109
0.601ValCys: 0.601 ± 0.022
4.379ValAsp: 4.379 ± 0.071
5.008ValGlu: 5.008 ± 0.083
2.949ValPhe: 2.949 ± 0.064
5.545ValGly: 5.545 ± 0.087
1.518ValHis: 1.518 ± 0.038
3.848ValIle: 3.848 ± 0.075
1.653ValLys: 1.653 ± 0.055
8.682ValLeu: 8.682 ± 0.115
1.769ValMet: 1.769 ± 0.046
1.959ValAsn: 1.959 ± 0.049
3.983ValPro: 3.983 ± 0.078
2.117ValGln: 2.117 ± 0.054
5.523ValArg: 5.523 ± 0.08
4.234ValSer: 4.234 ± 0.081
4.252ValThr: 4.252 ± 0.068
6.468ValVal: 6.468 ± 0.105
0.791ValTrp: 0.791 ± 0.027
1.577ValTyr: 1.577 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
1.294TrpAla: 1.294 ± 0.04
0.125TrpCys: 0.125 ± 0.012
0.726TrpAsp: 0.726 ± 0.03
0.657TrpGlu: 0.657 ± 0.028
0.644TrpPhe: 0.644 ± 0.031
0.917TrpGly: 0.917 ± 0.032
0.373TrpHis: 0.373 ± 0.02
0.694TrpIle: 0.694 ± 0.027
0.312TrpLys: 0.312 ± 0.016
2.16TrpLeu: 2.16 ± 0.051
0.365TrpMet: 0.365 ± 0.02
0.403TrpAsn: 0.403 ± 0.02
0.748TrpPro: 0.748 ± 0.026
0.638TrpGln: 0.638 ± 0.024
1.44TrpArg: 1.44 ± 0.043
0.853TrpSer: 0.853 ± 0.036
0.76TrpThr: 0.76 ± 0.03
1.025TrpVal: 1.025 ± 0.03
0.259TrpTrp: 0.259 ± 0.017
0.335TrpTyr: 0.335 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.429TyrAla: 2.429 ± 0.05
0.223TyrCys: 0.223 ± 0.015
1.391TyrAsp: 1.391 ± 0.051
1.431TyrGlu: 1.431 ± 0.037
1.013TyrPhe: 1.013 ± 0.031
1.978TyrGly: 1.978 ± 0.049
0.466TyrHis: 0.466 ± 0.021
0.809TyrIle: 0.809 ± 0.027
0.425TyrLys: 0.425 ± 0.023
2.473TyrLeu: 2.473 ± 0.049
0.411TyrMet: 0.411 ± 0.021
0.506TyrAsn: 0.506 ± 0.022
1.128TyrPro: 1.128 ± 0.039
0.786TyrGln: 0.786 ± 0.031
2.196TyrArg: 2.196 ± 0.051
1.176TyrSer: 1.176 ± 0.043
1.086TyrThr: 1.086 ± 0.037
1.526TyrVal: 1.526 ± 0.04
0.376TyrTrp: 0.376 ± 0.016
0.617TyrTyr: 0.617 ± 0.027
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3004 proteins (1008693 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski