Amino acid dipepetide frequency for Ichthyenterobacterium magnum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.607AlaAla: 3.607 ± 0.082	0.553AlaCys: 0.553 ± 0.029	2.955AlaAsp: 2.955 ± 0.067	3.649AlaGlu: 3.649 ± 0.071	3.368AlaPhe: 3.368 ± 0.063	3.566AlaGly: 3.566 ± 0.09	1.094AlaHis: 1.094 ± 0.034	5.572AlaIle: 5.572 ± 0.083	4.687AlaLys: 4.687 ± 0.1	6.367AlaLeu: 6.367 ± 0.102	1.447AlaMet: 1.447 ± 0.048	3.741AlaAsn: 3.741 ± 0.08	1.628AlaPro: 1.628 ± 0.048	2.211AlaGln: 2.211 ± 0.055	1.767AlaArg: 1.767 ± 0.049	4.242AlaSer: 4.242 ± 0.074	3.746AlaThr: 3.746 ± 0.094	3.667AlaVal: 3.667 ± 0.078	0.522AlaTrp: 0.522 ± 0.026	2.561AlaTyr: 2.561 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	0.435CysAla: 0.435 ± 0.023	0.102CysCys: 0.102 ± 0.012	0.514CysAsp: 0.514 ± 0.035	0.5CysGlu: 0.5 ± 0.028	0.464CysPhe: 0.464 ± 0.022	0.635CysGly: 0.635 ± 0.038	0.193CysHis: 0.193 ± 0.016	0.645CysIle: 0.645 ± 0.029	0.491CysLys: 0.491 ± 0.022	0.653CysLeu: 0.653 ± 0.027	0.14CysMet: 0.14 ± 0.012	0.517CysAsn: 0.517 ± 0.028	0.38CysPro: 0.38 ± 0.028	0.212CysGln: 0.212 ± 0.017	0.178CysArg: 0.178 ± 0.014	0.555CysSer: 0.555 ± 0.026	0.428CysThr: 0.428 ± 0.03	0.455CysVal: 0.455 ± 0.022	0.068CysTrp: 0.068 ± 0.009	0.319CysTyr: 0.319 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.907AspAla: 3.907 ± 0.075	0.537AspCys: 0.537 ± 0.031	3.48AspAsp: 3.48 ± 0.076	3.769AspGlu: 3.769 ± 0.068	3.586AspPhe: 3.586 ± 0.067	3.606AspGly: 3.606 ± 0.094	0.749AspHis: 0.749 ± 0.031	4.878AspIle: 4.878 ± 0.075	4.304AspLys: 4.304 ± 0.086	5.231AspLeu: 5.231 ± 0.08	1.109AspMet: 1.109 ± 0.035	3.651AspAsn: 3.651 ± 0.064	1.393AspPro: 1.393 ± 0.047	1.248AspGln: 1.248 ± 0.04	1.632AspArg: 1.632 ± 0.04	3.314AspSer: 3.314 ± 0.061	3.052AspThr: 3.052 ± 0.064	3.901AspVal: 3.901 ± 0.071	0.695AspTrp: 0.695 ± 0.029	3.057AspTyr: 3.057 ± 0.057	0.0AspXaa: 0.0 ± 0.0
Glu	4.488GluAla: 4.488 ± 0.078	0.368GluCys: 0.368 ± 0.026	3.768GluAsp: 3.768 ± 0.067	4.094GluGlu: 4.094 ± 0.088	3.11GluPhe: 3.11 ± 0.059	3.326GluGly: 3.326 ± 0.076	1.258GluHis: 1.258 ± 0.039	5.137GluIle: 5.137 ± 0.088	5.028GluLys: 5.028 ± 0.105	6.111GluLeu: 6.111 ± 0.074	1.394GluMet: 1.394 ± 0.037	4.531GluAsn: 4.531 ± 0.087	1.49GluPro: 1.49 ± 0.042	2.278GluGln: 2.278 ± 0.059	2.318GluArg: 2.318 ± 0.057	3.356GluSer: 3.356 ± 0.062	3.945GluThr: 3.945 ± 0.077	3.99GluVal: 3.99 ± 0.07	0.529GluTrp: 0.529 ± 0.028	2.263GluTyr: 2.263 ± 0.055	0.0GluXaa: 0.0 ± 0.0
Phe	2.866PheAla: 2.866 ± 0.053	0.436PheCys: 0.436 ± 0.021	3.33PheAsp: 3.33 ± 0.055	3.392PheGlu: 3.392 ± 0.059	2.716PhePhe: 2.716 ± 0.068	3.678PheGly: 3.678 ± 0.077	0.827PheHis: 0.827 ± 0.03	4.263PheIle: 4.263 ± 0.082	4.328PheLys: 4.328 ± 0.083	4.577PheLeu: 4.577 ± 0.083	1.062PheMet: 1.062 ± 0.036	3.971PheAsn: 3.971 ± 0.079	1.616PhePro: 1.616 ± 0.04	1.452PheGln: 1.452 ± 0.037	1.489PheArg: 1.489 ± 0.044	4.203PheSer: 4.203 ± 0.079	3.153PheThr: 3.153 ± 0.066	3.113PheVal: 3.113 ± 0.054	0.541PheTrp: 0.541 ± 0.027	2.212PheTyr: 2.212 ± 0.051	0.0PheXaa: 0.0 ± 0.0
Gly	3.769GlyAla: 3.769 ± 0.08	0.599GlyCys: 0.599 ± 0.039	3.406GlyAsp: 3.406 ± 0.085	3.405GlyGlu: 3.405 ± 0.064	3.631GlyPhe: 3.631 ± 0.063	4.233GlyGly: 4.233 ± 0.109	1.082GlyHis: 1.082 ± 0.037	5.063GlyIle: 5.063 ± 0.075	4.669GlyLys: 4.669 ± 0.083	5.57GlyLeu: 5.57 ± 0.083	1.413GlyMet: 1.413 ± 0.045	3.787GlyAsn: 3.787 ± 0.081	1.214GlyPro: 1.214 ± 0.044	1.813GlyGln: 1.813 ± 0.053	1.906GlyArg: 1.906 ± 0.057	3.718GlySer: 3.718 ± 0.085	3.922GlyThr: 3.922 ± 0.107	4.046GlyVal: 4.046 ± 0.077	0.676GlyTrp: 0.676 ± 0.025	2.532GlyTyr: 2.532 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	0.909HisAla: 0.909 ± 0.033	0.174HisCys: 0.174 ± 0.014	0.859HisAsp: 0.859 ± 0.035	0.938HisGlu: 0.938 ± 0.032	1.175HisPhe: 1.175 ± 0.036	0.95HisGly: 0.95 ± 0.036	0.467HisHis: 0.467 ± 0.025	1.537HisIle: 1.537 ± 0.041	1.377HisLys: 1.377 ± 0.046	1.749HisLeu: 1.749 ± 0.049	0.331HisMet: 0.331 ± 0.018	1.122HisAsn: 1.122 ± 0.036	0.812HisPro: 0.812 ± 0.028	0.67HisGln: 0.67 ± 0.024	0.625HisArg: 0.625 ± 0.028	1.023HisSer: 1.023 ± 0.038	0.947HisThr: 0.947 ± 0.033	1.025HisVal: 1.025 ± 0.037	0.211HisTrp: 0.211 ± 0.015	0.909HisTyr: 0.909 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.603IleAla: 5.603 ± 0.087	0.644IleCys: 0.644 ± 0.028	5.321IleAsp: 5.321 ± 0.079	5.802IleGlu: 5.802 ± 0.096	3.614IlePhe: 3.614 ± 0.073	5.221IleGly: 5.221 ± 0.086	1.28IleHis: 1.28 ± 0.042	6.913IleIle: 6.913 ± 0.113	6.779IleLys: 6.779 ± 0.097	7.116IleLeu: 7.116 ± 0.111	1.446IleMet: 1.446 ± 0.047	5.6IleAsn: 5.6 ± 0.084	3.147IlePro: 3.147 ± 0.059	2.491IleGln: 2.491 ± 0.05	2.29IleArg: 2.29 ± 0.054	5.83IleSer: 5.83 ± 0.089	5.233IleThr: 5.233 ± 0.074	5.105IleVal: 5.105 ± 0.074	0.653IleTrp: 0.653 ± 0.031	2.945IleTyr: 2.945 ± 0.062	0.0IleXaa: 0.0 ± 0.0
Lys	5.322LysAla: 5.322 ± 0.095	0.368LysCys: 0.368 ± 0.019	4.729LysAsp: 4.729 ± 0.078	5.724LysGlu: 5.724 ± 0.108	3.138LysPhe: 3.138 ± 0.069	4.499LysGly: 4.499 ± 0.083	1.728LysHis: 1.728 ± 0.048	6.109LysIle: 6.109 ± 0.106	7.053LysLys: 7.053 ± 0.107	7.047LysLeu: 7.047 ± 0.105	1.836LysMet: 1.836 ± 0.05	5.514LysAsn: 5.514 ± 0.097	2.513LysPro: 2.513 ± 0.059	3.198LysGln: 3.198 ± 0.074	3.106LysArg: 3.106 ± 0.065	4.862LysSer: 4.862 ± 0.091	5.35LysThr: 5.35 ± 0.097	4.674LysVal: 4.674 ± 0.085	0.751LysTrp: 0.751 ± 0.029	3.041LysTyr: 3.041 ± 0.066	0.0LysXaa: 0.0 ± 0.0
Leu	5.441LeuAla: 5.441 ± 0.098	0.717LeuCys: 0.717 ± 0.031	5.384LeuAsp: 5.384 ± 0.076	5.849LeuGlu: 5.849 ± 0.09	5.069LeuPhe: 5.069 ± 0.093	5.541LeuGly: 5.541 ± 0.088	1.569LeuHis: 1.569 ± 0.042	7.538LeuIle: 7.538 ± 0.116	8.362LeuLys: 8.362 ± 0.126	8.488LeuLeu: 8.488 ± 0.126	1.918LeuMet: 1.918 ± 0.054	6.413LeuAsn: 6.413 ± 0.09	3.372LeuPro: 3.372 ± 0.065	3.096LeuGln: 3.096 ± 0.06	2.873LeuArg: 2.873 ± 0.063	6.618LeuSer: 6.618 ± 0.093	5.125LeuThr: 5.125 ± 0.079	5.346LeuVal: 5.346 ± 0.085	0.757LeuTrp: 0.757 ± 0.03	3.242LeuTyr: 3.242 ± 0.064	0.0LeuXaa: 0.0 ± 0.0
Met	1.44MetAla: 1.44 ± 0.045	0.142MetCys: 0.142 ± 0.013	0.894MetAsp: 0.894 ± 0.032	1.077MetGlu: 1.077 ± 0.038	0.932MetPhe: 0.932 ± 0.037	1.058MetGly: 1.058 ± 0.037	0.401MetHis: 0.401 ± 0.021	1.552MetIle: 1.552 ± 0.043	2.061MetLys: 2.061 ± 0.055	1.998MetLeu: 1.998 ± 0.052	0.512MetMet: 0.512 ± 0.026	1.293MetAsn: 1.293 ± 0.036	0.8MetPro: 0.8 ± 0.034	0.884MetGln: 0.884 ± 0.031	0.766MetArg: 0.766 ± 0.032	1.472MetSer: 1.472 ± 0.042	1.114MetThr: 1.114 ± 0.038	1.187MetVal: 1.187 ± 0.04	0.131MetTrp: 0.131 ± 0.012	0.789MetTyr: 0.789 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	4.197AsnAla: 4.197 ± 0.07	0.546AsnCys: 0.546 ± 0.032	3.822AsnAsp: 3.822 ± 0.078	4.003AsnGlu: 4.003 ± 0.069	3.217AsnPhe: 3.217 ± 0.059	4.168AsnGly: 4.168 ± 0.088	1.183AsnHis: 1.183 ± 0.035	5.386AsnIle: 5.386 ± 0.083	5.065AsnLys: 5.065 ± 0.091	5.845AsnLeu: 5.845 ± 0.083	1.348AsnMet: 1.348 ± 0.036	4.784AsnAsn: 4.784 ± 0.1	2.968AsnPro: 2.968 ± 0.079	2.445AsnGln: 2.445 ± 0.059	2.117AsnArg: 2.117 ± 0.051	4.296AsnSer: 4.296 ± 0.08	4.553AsnThr: 4.553 ± 0.098	4.023AsnVal: 4.023 ± 0.072	0.808AsnTrp: 0.808 ± 0.029	3.208AsnTyr: 3.208 ± 0.075	0.0AsnXaa: 0.0 ± 0.0
Pro	1.564ProAla: 1.564 ± 0.049	0.235ProCys: 0.235 ± 0.016	1.838ProAsp: 1.838 ± 0.053	2.569ProGlu: 2.569 ± 0.062	1.857ProPhe: 1.857 ± 0.045	1.613ProGly: 1.613 ± 0.046	0.56ProHis: 0.56 ± 0.024	2.764ProIle: 2.764 ± 0.057	2.676ProLys: 2.676 ± 0.062	2.765ProLeu: 2.765 ± 0.053	0.652ProMet: 0.652 ± 0.026	2.462ProAsn: 2.462 ± 0.057	0.715ProPro: 0.715 ± 0.037	1.07ProGln: 1.07 ± 0.035	0.837ProArg: 0.837 ± 0.033	2.065ProSer: 2.065 ± 0.053	1.975ProThr: 1.975 ± 0.065	1.961ProVal: 1.961 ± 0.05	0.308ProTrp: 0.308 ± 0.019	1.379ProTyr: 1.379 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	1.853GlnAla: 1.853 ± 0.055	0.182GlnCys: 0.182 ± 0.014	1.765GlnAsp: 1.765 ± 0.042	2.063GlnGlu: 2.063 ± 0.051	1.825GlnPhe: 1.825 ± 0.047	1.744GlnGly: 1.744 ± 0.046	0.644GlnHis: 0.644 ± 0.026	2.615GlnIle: 2.615 ± 0.052	2.718GlnLys: 2.718 ± 0.065	3.561GlnLeu: 3.561 ± 0.065	0.73GlnMet: 0.73 ± 0.028	2.302GlnAsn: 2.302 ± 0.054	1.122GlnPro: 1.122 ± 0.037	1.4GlnGln: 1.4 ± 0.049	1.197GlnArg: 1.197 ± 0.036	1.959GlnSer: 1.959 ± 0.045	2.024GlnThr: 2.024 ± 0.049	1.93GlnVal: 1.93 ± 0.046	0.308GlnTrp: 0.308 ± 0.019	1.295GlnTyr: 1.295 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	1.914ArgAla: 1.914 ± 0.047	0.188ArgCys: 0.188 ± 0.014	1.745ArgAsp: 1.745 ± 0.051	1.97ArgGlu: 1.97 ± 0.049	1.777ArgPhe: 1.777 ± 0.044	1.773ArgGly: 1.773 ± 0.052	0.621ArgHis: 0.621 ± 0.026	2.652ArgIle: 2.652 ± 0.059	2.521ArgLys: 2.521 ± 0.065	3.181ArgLeu: 3.181 ± 0.066	0.741ArgMet: 0.741 ± 0.026	1.928ArgAsn: 1.928 ± 0.051	0.972ArgPro: 0.972 ± 0.039	1.09ArgGln: 1.09 ± 0.032	1.191ArgArg: 1.191 ± 0.045	1.689ArgSer: 1.689 ± 0.048	1.689ArgThr: 1.689 ± 0.05	1.993ArgVal: 1.993 ± 0.048	0.329ArgTrp: 0.329 ± 0.021	1.429ArgTyr: 1.429 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	3.442SerAla: 3.442 ± 0.073	0.647SerCys: 0.647 ± 0.033	3.437SerAsp: 3.437 ± 0.063	3.863SerGlu: 3.863 ± 0.065	3.855SerPhe: 3.855 ± 0.064	4.585SerGly: 4.585 ± 0.108	1.095SerHis: 1.095 ± 0.036	5.739SerIle: 5.739 ± 0.087	5.405SerLys: 5.405 ± 0.102	5.884SerLeu: 5.884 ± 0.086	1.225SerMet: 1.225 ± 0.039	4.556SerAsn: 4.556 ± 0.082	1.913SerPro: 1.913 ± 0.046	2.225SerGln: 2.225 ± 0.052	1.955SerArg: 1.955 ± 0.048	4.313SerSer: 4.313 ± 0.088	3.822SerThr: 3.822 ± 0.079	4.019SerVal: 4.019 ± 0.083	0.64SerTrp: 0.64 ± 0.032	2.834SerTyr: 2.834 ± 0.065	0.0SerXaa: 0.0 ± 0.0
Thr	3.486ThrAla: 3.486 ± 0.091	0.441ThrCys: 0.441 ± 0.029	3.275ThrAsp: 3.275 ± 0.079	3.506ThrGlu: 3.506 ± 0.061	3.356ThrPhe: 3.356 ± 0.068	3.694ThrGly: 3.694 ± 0.095	1.102ThrHis: 1.102 ± 0.033	5.712ThrIle: 5.712 ± 0.098	4.298ThrLys: 4.298 ± 0.073	5.721ThrLeu: 5.721 ± 0.075	0.973ThrMet: 0.973 ± 0.033	4.026ThrAsn: 4.026 ± 0.086	2.374ThrPro: 2.374 ± 0.066	2.025ThrGln: 2.025 ± 0.056	1.531ThrArg: 1.531 ± 0.044	4.184ThrSer: 4.184 ± 0.081	3.902ThrThr: 3.902 ± 0.111	3.756ThrVal: 3.756 ± 0.08	0.6ThrTrp: 0.6 ± 0.033	2.75ThrTyr: 2.75 ± 0.066	0.0ThrXaa: 0.0 ± 0.0
Val	3.834ValAla: 3.834 ± 0.084	0.559ValCys: 0.559 ± 0.026	3.634ValAsp: 3.634 ± 0.073	3.958ValGlu: 3.958 ± 0.074	3.565ValPhe: 3.565 ± 0.064	3.605ValGly: 3.605 ± 0.066	0.937ValHis: 0.937 ± 0.033	5.185ValIle: 5.185 ± 0.087	4.437ValLys: 4.437 ± 0.075	6.016ValLeu: 6.016 ± 0.093	1.242ValMet: 1.242 ± 0.04	3.901ValAsn: 3.901 ± 0.075	1.912ValPro: 1.912 ± 0.049	1.54ValGln: 1.54 ± 0.041	1.778ValArg: 1.778 ± 0.049	4.467ValSer: 4.467 ± 0.076	3.634ValThr: 3.634 ± 0.098	4.121ValVal: 4.121 ± 0.079	0.514ValTrp: 0.514 ± 0.029	2.362ValTyr: 2.362 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.489TrpAla: 0.489 ± 0.026	0.083TrpCys: 0.083 ± 0.009	0.546TrpAsp: 0.546 ± 0.027	0.572TrpGlu: 0.572 ± 0.027	0.562TrpPhe: 0.562 ± 0.025	0.476TrpGly: 0.476 ± 0.027	0.216TrpHis: 0.216 ± 0.017	0.755TrpIle: 0.755 ± 0.031	0.718TrpLys: 0.718 ± 0.032	0.973TrpLeu: 0.973 ± 0.033	0.27TrpMet: 0.27 ± 0.018	0.732TrpAsn: 0.732 ± 0.033	0.188TrpPro: 0.188 ± 0.014	0.371TrpGln: 0.371 ± 0.019	0.328TrpArg: 0.328 ± 0.02	0.616TrpSer: 0.616 ± 0.031	0.561TrpThr: 0.561 ± 0.035	0.604TrpVal: 0.604 ± 0.024	0.145TrpTrp: 0.145 ± 0.014	0.428TrpTyr: 0.428 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.386TyrAla: 2.386 ± 0.049	0.364TyrCys: 0.364 ± 0.021	2.396TyrAsp: 2.396 ± 0.066	2.078TyrGlu: 2.078 ± 0.053	2.412TyrPhe: 2.412 ± 0.057	2.483TyrGly: 2.483 ± 0.061	0.805TyrHis: 0.805 ± 0.029	3.019TyrIle: 3.019 ± 0.064	3.584TyrLys: 3.584 ± 0.078	3.862TyrLeu: 3.862 ± 0.074	0.709TyrMet: 0.709 ± 0.03	3.151TyrAsn: 3.151 ± 0.063	1.339TyrPro: 1.339 ± 0.039	1.519TyrGln: 1.519 ± 0.05	1.508TyrArg: 1.508 ± 0.051	2.672TyrSer: 2.672 ± 0.054	2.537TyrThr: 2.537 ± 0.065	2.284TyrVal: 2.284 ± 0.054	0.448TyrTrp: 0.448 ± 0.025	1.946TyrTyr: 1.946 ± 0.059	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2733 proteins (911278 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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