Amino acid dipepetide frequency for Candidatus Saccharimonas aalborgensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.92AlaAla: 8.92 ± 0.234
0.657AlaCys: 0.657 ± 0.049
4.825AlaAsp: 4.825 ± 0.132
5.085AlaGlu: 5.085 ± 0.161
3.103AlaPhe: 3.103 ± 0.105
6.669AlaGly: 6.669 ± 0.193
2.074AlaHis: 2.074 ± 0.085
6.235AlaIle: 6.235 ± 0.152
4.802AlaLys: 4.802 ± 0.14
8.624AlaLeu: 8.624 ± 0.194
2.051AlaMet: 2.051 ± 0.086
3.205AlaAsn: 3.205 ± 0.105
3.175AlaPro: 3.175 ± 0.111
3.152AlaGln: 3.152 ± 0.088
4.864AlaArg: 4.864 ± 0.144
6.064AlaSer: 6.064 ± 0.169
6.038AlaThr: 6.038 ± 0.167
6.573AlaVal: 6.573 ± 0.139
0.963AlaTrp: 0.963 ± 0.058
2.853AlaTyr: 2.853 ± 0.108
0.0AlaXaa: 0.0 ± 0.0
Cys
0.483CysAla: 0.483 ± 0.038
0.03CysCys: 0.03 ± 0.009
0.509CysAsp: 0.509 ± 0.043
0.391CysGlu: 0.391 ± 0.04
0.247CysPhe: 0.247 ± 0.031
0.572CysGly: 0.572 ± 0.042
0.154CysHis: 0.154 ± 0.024
0.417CysIle: 0.417 ± 0.033
0.256CysLys: 0.256 ± 0.029
0.575CysLeu: 0.575 ± 0.045
0.135CysMet: 0.135 ± 0.021
0.296CysAsn: 0.296 ± 0.03
0.335CysPro: 0.335 ± 0.039
0.243CysGln: 0.243 ± 0.029
0.401CysArg: 0.401 ± 0.037
0.513CysSer: 0.513 ± 0.047
0.486CysThr: 0.486 ± 0.062
0.473CysVal: 0.473 ± 0.042
0.069CysTrp: 0.069 ± 0.015
0.266CysTyr: 0.266 ± 0.036
0.0CysXaa: 0.0 ± 0.0
Asp
4.776AspAla: 4.776 ± 0.128
0.365AspCys: 0.365 ± 0.037
3.484AspAsp: 3.484 ± 0.129
4.411AspGlu: 4.411 ± 0.156
2.077AspPhe: 2.077 ± 0.084
4.509AspGly: 4.509 ± 0.115
1.16AspHis: 1.16 ± 0.056
4.066AspIle: 4.066 ± 0.118
2.974AspLys: 2.974 ± 0.126
4.352AspLeu: 4.352 ± 0.14
1.403AspMet: 1.403 ± 0.065
2.074AspAsn: 2.074 ± 0.083
2.419AspPro: 2.419 ± 0.095
2.015AspGln: 2.015 ± 0.089
2.876AspArg: 2.876 ± 0.124
3.26AspSer: 3.26 ± 0.12
4.108AspThr: 4.108 ± 0.125
3.862AspVal: 3.862 ± 0.12
0.67AspTrp: 0.67 ± 0.05
2.149AspTyr: 2.149 ± 0.09
0.0AspXaa: 0.0 ± 0.0
Glu
5.213GluAla: 5.213 ± 0.141
0.325GluCys: 0.325 ± 0.035
2.527GluAsp: 2.527 ± 0.103
3.201GluGlu: 3.201 ± 0.113
2.041GluPhe: 2.041 ± 0.089
3.106GluGly: 3.106 ± 0.115
1.532GluHis: 1.532 ± 0.08
3.51GluIle: 3.51 ± 0.128
3.487GluLys: 3.487 ± 0.132
6.57GluLeu: 6.57 ± 0.168
1.364GluMet: 1.364 ± 0.065
1.9GluAsn: 1.9 ± 0.085
1.857GluPro: 1.857 ± 0.08
3.02GluGln: 3.02 ± 0.093
3.934GluArg: 3.934 ± 0.131
3.04GluSer: 3.04 ± 0.093
3.333GluThr: 3.333 ± 0.104
4.46GluVal: 4.46 ± 0.15
0.693GluTrp: 0.693 ± 0.05
2.038GluTyr: 2.038 ± 0.086
0.0GluXaa: 0.0 ± 0.0
Phe
3.346PheAla: 3.346 ± 0.096
0.345PheCys: 0.345 ± 0.034
2.35PheAsp: 2.35 ± 0.102
1.982PheGlu: 1.982 ± 0.092
1.472PhePhe: 1.472 ± 0.078
3.06PheGly: 3.06 ± 0.11
0.67PheHis: 0.67 ± 0.048
2.117PheIle: 2.117 ± 0.099
1.328PheLys: 1.328 ± 0.07
2.856PheLeu: 2.856 ± 0.111
0.93PheMet: 0.93 ± 0.054
1.384PheAsn: 1.384 ± 0.074
1.305PhePro: 1.305 ± 0.06
0.861PheGln: 0.861 ± 0.06
1.818PheArg: 1.818 ± 0.076
2.623PheSer: 2.623 ± 0.096
2.284PheThr: 2.284 ± 0.085
2.955PheVal: 2.955 ± 0.098
0.467PheTrp: 0.467 ± 0.038
1.259PheTyr: 1.259 ± 0.064
0.0PheXaa: 0.0 ± 0.0
Gly
5.847GlyAla: 5.847 ± 0.207
0.503GlyCys: 0.503 ± 0.049
4.092GlyAsp: 4.092 ± 0.138
3.964GlyGlu: 3.964 ± 0.115
2.639GlyPhe: 2.639 ± 0.108
5.683GlyGly: 5.683 ± 0.352
1.532GlyHis: 1.532 ± 0.07
4.953GlyIle: 4.953 ± 0.152
4.082GlyLys: 4.082 ± 0.126
6.015GlyLeu: 6.015 ± 0.146
1.699GlyMet: 1.699 ± 0.075
2.725GlyAsn: 2.725 ± 0.123
1.893GlyPro: 1.893 ± 0.078
2.547GlyGln: 2.547 ± 0.104
3.829GlyArg: 3.829 ± 0.121
4.815GlySer: 4.815 ± 0.185
4.864GlyThr: 4.864 ± 0.192
5.965GlyVal: 5.965 ± 0.141
0.917GlyTrp: 0.917 ± 0.061
2.738GlyTyr: 2.738 ± 0.101
0.0GlyXaa: 0.0 ± 0.0
His
1.965HisAla: 1.965 ± 0.078
0.177HisCys: 0.177 ± 0.024
1.275HisAsp: 1.275 ± 0.07
1.476HisGlu: 1.476 ± 0.069
0.786HisPhe: 0.786 ± 0.056
1.545HisGly: 1.545 ± 0.078
0.71HisHis: 0.71 ± 0.054
1.476HisIle: 1.476 ± 0.069
0.887HisLys: 0.887 ± 0.057
2.031HisLeu: 2.031 ± 0.092
0.486HisMet: 0.486 ± 0.041
0.766HisAsn: 0.766 ± 0.049
1.203HisPro: 1.203 ± 0.071
0.96HisGln: 0.96 ± 0.069
1.239HisArg: 1.239 ± 0.065
1.344HisSer: 1.344 ± 0.061
1.449HisThr: 1.449 ± 0.069
1.492HisVal: 1.492 ± 0.073
0.266HisTrp: 0.266 ± 0.034
0.812HisTyr: 0.812 ± 0.063
0.0HisXaa: 0.0 ± 0.0
Ile
6.895IleAla: 6.895 ± 0.164
0.414IleCys: 0.414 ± 0.032
4.608IleAsp: 4.608 ± 0.124
4.135IleGlu: 4.135 ± 0.143
1.906IlePhe: 1.906 ± 0.092
4.703IleGly: 4.703 ± 0.146
1.236IleHis: 1.236 ± 0.072
4.536IleIle: 4.536 ± 0.149
3.198IleLys: 3.198 ± 0.095
5.223IleLeu: 5.223 ± 0.157
1.394IleMet: 1.394 ± 0.071
2.573IleAsn: 2.573 ± 0.092
2.626IlePro: 2.626 ± 0.099
1.923IleGln: 1.923 ± 0.088
3.277IleArg: 3.277 ± 0.111
4.069IleSer: 4.069 ± 0.109
4.306IleThr: 4.306 ± 0.137
5.489IleVal: 5.489 ± 0.141
0.572IleTrp: 0.572 ± 0.04
1.896IleTyr: 1.896 ± 0.077
0.0IleXaa: 0.0 ± 0.0
Lys
4.22LysAla: 4.22 ± 0.141
0.217LysCys: 0.217 ± 0.027
2.843LysAsp: 2.843 ± 0.109
3.047LysGlu: 3.047 ± 0.115
1.318LysPhe: 1.318 ± 0.076
3.162LysGly: 3.162 ± 0.109
1.16LysHis: 1.16 ± 0.061
2.919LysIle: 2.919 ± 0.112
3.977LysLys: 3.977 ± 0.147
4.933LysLeu: 4.933 ± 0.151
1.295LysMet: 1.295 ± 0.064
2.159LysAsn: 2.159 ± 0.089
2.133LysPro: 2.133 ± 0.093
2.606LysGln: 2.606 ± 0.09
3.283LysArg: 3.283 ± 0.102
3.218LysSer: 3.218 ± 0.093
3.214LysThr: 3.214 ± 0.101
3.379LysVal: 3.379 ± 0.124
0.486LysTrp: 0.486 ± 0.039
1.778LysTyr: 1.778 ± 0.089
0.0LysXaa: 0.0 ± 0.0
Leu
8.956LeuAla: 8.956 ± 0.196
0.624LeuCys: 0.624 ± 0.04
5.196LeuAsp: 5.196 ± 0.147
4.907LeuGlu: 4.907 ± 0.151
3.609LeuPhe: 3.609 ± 0.132
6.396LeuGly: 6.396 ± 0.179
2.005LeuHis: 2.005 ± 0.086
5.955LeuIle: 5.955 ± 0.148
4.299LeuLys: 4.299 ± 0.13
9.232LeuLeu: 9.232 ± 0.226
2.192LeuMet: 2.192 ± 0.092
3.004LeuAsn: 3.004 ± 0.097
4.207LeuPro: 4.207 ± 0.123
3.175LeuGln: 3.175 ± 0.106
5.255LeuArg: 5.255 ± 0.146
6.813LeuSer: 6.813 ± 0.147
5.663LeuThr: 5.663 ± 0.153
7.162LeuVal: 7.162 ± 0.158
1.022LeuTrp: 1.022 ± 0.06
3.014LeuTyr: 3.014 ± 0.088
0.0LeuXaa: 0.0 ± 0.0
Met
2.212MetAla: 2.212 ± 0.08
0.141MetCys: 0.141 ± 0.021
1.039MetAsp: 1.039 ± 0.061
0.999MetGlu: 0.999 ± 0.059
0.687MetPhe: 0.687 ± 0.049
1.512MetGly: 1.512 ± 0.068
0.385MetHis: 0.385 ± 0.037
1.535MetIle: 1.535 ± 0.08
1.469MetLys: 1.469 ± 0.072
2.179MetLeu: 2.179 ± 0.087
0.657MetMet: 0.657 ± 0.051
1.025MetAsn: 1.025 ± 0.058
1.117MetPro: 1.117 ± 0.065
0.825MetGln: 0.825 ± 0.047
1.505MetArg: 1.505 ± 0.071
1.919MetSer: 1.919 ± 0.075
1.831MetThr: 1.831 ± 0.089
1.581MetVal: 1.581 ± 0.078
0.223MetTrp: 0.223 ± 0.026
0.631MetTyr: 0.631 ± 0.05
0.0MetXaa: 0.0 ± 0.0
Asn
3.293AsnAla: 3.293 ± 0.114
0.276AsnCys: 0.276 ± 0.028
2.182AsnAsp: 2.182 ± 0.091
2.057AsnGlu: 2.057 ± 0.09
1.19AsnPhe: 1.19 ± 0.063
2.882AsnGly: 2.882 ± 0.122
0.795AsnHis: 0.795 ± 0.048
2.432AsnIle: 2.432 ± 0.091
1.801AsnLys: 1.801 ± 0.086
2.823AsnLeu: 2.823 ± 0.103
0.779AsnMet: 0.779 ± 0.056
1.663AsnAsn: 1.663 ± 0.095
2.057AsnPro: 2.057 ± 0.09
1.492AsnGln: 1.492 ± 0.083
1.923AsnArg: 1.923 ± 0.075
2.403AsnSer: 2.403 ± 0.101
2.488AsnThr: 2.488 ± 0.103
2.458AsnVal: 2.458 ± 0.093
0.457AsnTrp: 0.457 ± 0.037
1.407AsnTyr: 1.407 ± 0.077
0.0AsnXaa: 0.0 ± 0.0
Pro
3.569ProAla: 3.569 ± 0.127
0.187ProCys: 0.187 ± 0.027
2.537ProAsp: 2.537 ± 0.101
2.833ProGlu: 2.833 ± 0.112
1.545ProPhe: 1.545 ± 0.079
2.787ProGly: 2.787 ± 0.109
1.035ProHis: 1.035 ± 0.057
2.396ProIle: 2.396 ± 0.093
2.087ProLys: 2.087 ± 0.092
3.698ProLeu: 3.698 ± 0.097
0.825ProMet: 0.825 ± 0.047
1.571ProAsn: 1.571 ± 0.065
1.624ProPro: 1.624 ± 0.085
1.545ProGln: 1.545 ± 0.08
2.018ProArg: 2.018 ± 0.09
3.106ProSer: 3.106 ± 0.116
2.892ProThr: 2.892 ± 0.098
3.119ProVal: 3.119 ± 0.105
0.434ProTrp: 0.434 ± 0.039
1.334ProTyr: 1.334 ± 0.065
0.0ProXaa: 0.0 ± 0.0
Gln
3.523GlnAla: 3.523 ± 0.11
0.227GlnCys: 0.227 ± 0.024
1.633GlnAsp: 1.633 ± 0.073
1.995GlnGlu: 1.995 ± 0.091
1.39GlnPhe: 1.39 ± 0.068
2.169GlnGly: 2.169 ± 0.092
1.029GlnHis: 1.029 ± 0.061
2.291GlnIle: 2.291 ± 0.095
2.126GlnLys: 2.126 ± 0.092
4.181GlnLeu: 4.181 ± 0.147
0.901GlnMet: 0.901 ± 0.053
1.288GlnAsn: 1.288 ± 0.072
1.683GlnPro: 1.683 ± 0.086
2.034GlnGln: 2.034 ± 0.095
2.32GlnArg: 2.32 ± 0.1
2.37GlnSer: 2.37 ± 0.1
2.58GlnThr: 2.58 ± 0.097
2.541GlnVal: 2.541 ± 0.098
0.486GlnTrp: 0.486 ± 0.044
1.486GlnTyr: 1.486 ± 0.067
0.0GlnXaa: 0.0 ± 0.0
Arg
4.496ArgAla: 4.496 ± 0.121
0.352ArgCys: 0.352 ± 0.037
3.205ArgAsp: 3.205 ± 0.115
3.78ArgGlu: 3.78 ± 0.134
2.107ArgPhe: 2.107 ± 0.083
3.372ArgGly: 3.372 ± 0.113
1.482ArgHis: 1.482 ± 0.08
3.29ArgIle: 3.29 ± 0.114
2.685ArgLys: 2.685 ± 0.099
5.338ArgLeu: 5.338 ± 0.151
1.466ArgMet: 1.466 ± 0.07
1.959ArgAsn: 1.959 ± 0.08
2.196ArgPro: 2.196 ± 0.103
2.682ArgGln: 2.682 ± 0.093
4.046ArgArg: 4.046 ± 0.139
3.497ArgSer: 3.497 ± 0.112
3.172ArgThr: 3.172 ± 0.112
3.941ArgVal: 3.941 ± 0.132
0.621ArgTrp: 0.621 ± 0.051
2.389ArgTyr: 2.389 ± 0.089
0.0ArgXaa: 0.0 ± 0.0
Ser
5.407SerAla: 5.407 ± 0.176
0.506SerCys: 0.506 ± 0.043
3.882SerAsp: 3.882 ± 0.115
3.474SerGlu: 3.474 ± 0.105
2.636SerPhe: 2.636 ± 0.09
5.535SerGly: 5.535 ± 0.198
1.486SerHis: 1.486 ± 0.074
4.223SerIle: 4.223 ± 0.13
2.988SerLys: 2.988 ± 0.099
6.32SerLeu: 6.32 ± 0.146
1.512SerMet: 1.512 ± 0.065
2.353SerAsn: 2.353 ± 0.118
2.945SerPro: 2.945 ± 0.095
2.636SerGln: 2.636 ± 0.106
3.481SerArg: 3.481 ± 0.107
5.144SerSer: 5.144 ± 0.155
4.555SerThr: 4.555 ± 0.177
5.081SerVal: 5.081 ± 0.135
0.832SerTrp: 0.832 ± 0.053
2.153SerTyr: 2.153 ± 0.086
0.0SerXaa: 0.0 ± 0.0
Thr
5.798ThrAla: 5.798 ± 0.16
0.457ThrCys: 0.457 ± 0.038
3.582ThrAsp: 3.582 ± 0.117
2.859ThrGlu: 2.859 ± 0.096
2.14ThrPhe: 2.14 ± 0.082
4.785ThrGly: 4.785 ± 0.171
1.443ThrHis: 1.443 ± 0.068
4.634ThrIle: 4.634 ± 0.156
3.323ThrLys: 3.323 ± 0.087
6.534ThrLeu: 6.534 ± 0.177
1.525ThrMet: 1.525 ± 0.075
2.524ThrAsn: 2.524 ± 0.106
3.461ThrPro: 3.461 ± 0.106
2.031ThrGln: 2.031 ± 0.082
3.172ThrArg: 3.172 ± 0.107
4.595ThrSer: 4.595 ± 0.174
5.019ThrThr: 5.019 ± 0.201
5.446ThrVal: 5.446 ± 0.164
0.703ThrTrp: 0.703 ± 0.054
2.176ThrTyr: 2.176 ± 0.1
0.0ThrXaa: 0.0 ± 0.0
Val
7.349ValAla: 7.349 ± 0.141
0.621ValCys: 0.621 ± 0.059
4.414ValAsp: 4.414 ± 0.131
4.158ValGlu: 4.158 ± 0.144
2.781ValPhe: 2.781 ± 0.107
5.61ValGly: 5.61 ± 0.151
1.311ValHis: 1.311 ± 0.063
5.354ValIle: 5.354 ± 0.142
3.556ValLys: 3.556 ± 0.12
6.688ValLeu: 6.688 ± 0.15
1.837ValMet: 1.837 ± 0.072
2.6ValAsn: 2.6 ± 0.119
3.126ValPro: 3.126 ± 0.119
2.409ValGln: 2.409 ± 0.114
3.842ValArg: 3.842 ± 0.124
5.377ValSer: 5.377 ± 0.142
5.147ValThr: 5.147 ± 0.167
6.744ValVal: 6.744 ± 0.166
0.825ValTrp: 0.825 ± 0.058
2.304ValTyr: 2.304 ± 0.097
0.0ValXaa: 0.0 ± 0.0
Trp
0.805TrpAla: 0.805 ± 0.056
0.099TrpCys: 0.099 ± 0.019
0.559TrpAsp: 0.559 ± 0.055
0.46TrpGlu: 0.46 ± 0.043
0.552TrpPhe: 0.552 ± 0.048
0.713TrpGly: 0.713 ± 0.055
0.312TrpHis: 0.312 ± 0.034
0.592TrpIle: 0.592 ± 0.042
0.404TrpLys: 0.404 ± 0.037
1.433TrpLeu: 1.433 ± 0.082
0.332TrpMet: 0.332 ± 0.033
0.45TrpAsn: 0.45 ± 0.042
0.411TrpPro: 0.411 ± 0.034
0.621TrpGln: 0.621 ± 0.05
0.822TrpArg: 0.822 ± 0.055
0.786TrpSer: 0.786 ± 0.059
0.578TrpThr: 0.578 ± 0.054
0.743TrpVal: 0.743 ± 0.055
0.194TrpTrp: 0.194 ± 0.027
0.463TrpTyr: 0.463 ± 0.041
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.856TyrAla: 2.856 ± 0.091
0.329TyrCys: 0.329 ± 0.032
2.268TyrAsp: 2.268 ± 0.093
1.939TyrGlu: 1.939 ± 0.085
1.186TyrPhe: 1.186 ± 0.067
2.531TyrGly: 2.531 ± 0.094
0.835TyrHis: 0.835 ± 0.054
2.048TyrIle: 2.048 ± 0.088
1.617TyrLys: 1.617 ± 0.071
3.086TyrLeu: 3.086 ± 0.086
0.687TyrMet: 0.687 ± 0.049
1.341TyrAsn: 1.341 ± 0.073
1.371TyrPro: 1.371 ± 0.06
1.476TyrGln: 1.476 ± 0.078
2.169TyrArg: 2.169 ± 0.092
2.192TyrSer: 2.192 ± 0.094
2.199TyrThr: 2.199 ± 0.09
2.59TyrVal: 2.59 ± 0.097
0.427TyrTrp: 0.427 ± 0.041
1.295TyrTyr: 1.295 ± 0.069
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1033 proteins (304259 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski