Amino acid dipepetide frequency for Salinihabitans flavidus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.004AlaAla: 16.004 ± 0.157	1.084AlaCys: 1.084 ± 0.034	6.726AlaAsp: 6.726 ± 0.09	8.283AlaGlu: 8.283 ± 0.099	4.191AlaPhe: 4.191 ± 0.069	10.635AlaGly: 10.635 ± 0.113	2.463AlaHis: 2.463 ± 0.049	5.87AlaIle: 5.87 ± 0.079	3.038AlaLys: 3.038 ± 0.06	13.742AlaLeu: 13.742 ± 0.137	3.824AlaMet: 3.824 ± 0.06	2.529AlaAsn: 2.529 ± 0.049	5.941AlaPro: 5.941 ± 0.089	4.349AlaGln: 4.349 ± 0.06	9.751AlaArg: 9.751 ± 0.117	5.243AlaSer: 5.243 ± 0.064	5.608AlaThr: 5.608 ± 0.067	8.45AlaVal: 8.45 ± 0.097	1.399AlaTrp: 1.399 ± 0.035	2.336AlaTyr: 2.336 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	1.129CysAla: 1.129 ± 0.032	0.104CysCys: 0.104 ± 0.009	0.654CysAsp: 0.654 ± 0.025	0.47CysGlu: 0.47 ± 0.021	0.341CysPhe: 0.341 ± 0.019	0.989CysGly: 0.989 ± 0.032	0.286CysHis: 0.286 ± 0.016	0.393CysIle: 0.393 ± 0.018	0.209CysLys: 0.209 ± 0.014	0.842CysLeu: 0.842 ± 0.025	0.172CysMet: 0.172 ± 0.011	0.222CysAsn: 0.222 ± 0.014	0.531CysPro: 0.531 ± 0.027	0.21CysGln: 0.21 ± 0.013	0.612CysArg: 0.612 ± 0.023	0.429CysSer: 0.429 ± 0.019	0.462CysThr: 0.462 ± 0.02	0.591CysVal: 0.591 ± 0.023	0.12CysTrp: 0.12 ± 0.01	0.195CysTyr: 0.195 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.117AspAla: 7.117 ± 0.097	0.513AspCys: 0.513 ± 0.02	3.46AspAsp: 3.46 ± 0.073	3.647AspGlu: 3.647 ± 0.063	2.303AspPhe: 2.303 ± 0.049	5.546AspGly: 5.546 ± 0.087	1.455AspHis: 1.455 ± 0.036	2.94AspIle: 2.94 ± 0.051	1.578AspLys: 1.578 ± 0.044	6.501AspLeu: 6.501 ± 0.079	1.764AspMet: 1.764 ± 0.039	1.291AspAsn: 1.291 ± 0.038	3.693AspPro: 3.693 ± 0.056	1.699AspGln: 1.699 ± 0.036	4.56AspArg: 4.56 ± 0.072	2.342AspSer: 2.342 ± 0.049	3.152AspThr: 3.152 ± 0.058	4.232AspVal: 4.232 ± 0.067	1.223AspTrp: 1.223 ± 0.035	1.51AspTyr: 1.51 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	8.229GluAla: 8.229 ± 0.108	0.419GluCys: 0.419 ± 0.018	3.567GluAsp: 3.567 ± 0.061	3.99GluGlu: 3.99 ± 0.078	1.894GluPhe: 1.894 ± 0.039	5.249GluGly: 5.249 ± 0.08	1.216GluHis: 1.216 ± 0.031	3.981GluIle: 3.981 ± 0.055	2.116GluLys: 2.116 ± 0.049	5.124GluLeu: 5.124 ± 0.072	2.033GluMet: 2.033 ± 0.042	1.739GluAsn: 1.739 ± 0.044	2.586GluPro: 2.586 ± 0.05	1.985GluGln: 1.985 ± 0.046	4.84GluArg: 4.84 ± 0.085	2.572GluSer: 2.572 ± 0.047	3.99GluThr: 3.99 ± 0.059	4.574GluVal: 4.574 ± 0.069	0.739GluTrp: 0.739 ± 0.026	1.078GluTyr: 1.078 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.28PheAla: 4.28 ± 0.067	0.432PheCys: 0.432 ± 0.018	2.874PheAsp: 2.874 ± 0.049	2.343PheGlu: 2.343 ± 0.048	1.442PhePhe: 1.442 ± 0.041	3.764PheGly: 3.764 ± 0.057	0.771PheHis: 0.771 ± 0.024	1.61PheIle: 1.61 ± 0.039	0.822PheLys: 0.822 ± 0.024	3.421PheLeu: 3.421 ± 0.066	0.862PheMet: 0.862 ± 0.028	1.079PheAsn: 1.079 ± 0.03	1.588PhePro: 1.588 ± 0.035	0.926PheGln: 0.926 ± 0.026	2.317PheArg: 2.317 ± 0.041	2.134PheSer: 2.134 ± 0.04	2.085PheThr: 2.085 ± 0.042	2.654PheVal: 2.654 ± 0.051	0.552PheTrp: 0.552 ± 0.023	0.902PheTyr: 0.902 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	10.391GlyAla: 10.391 ± 0.117	0.847GlyCys: 0.847 ± 0.023	4.893GlyAsp: 4.893 ± 0.072	5.078GlyGlu: 5.078 ± 0.081	3.694GlyPhe: 3.694 ± 0.058	7.741GlyGly: 7.741 ± 0.117	2.108GlyHis: 2.108 ± 0.043	4.499GlyIle: 4.499 ± 0.071	2.86GlyLys: 2.86 ± 0.055	9.343GlyLeu: 9.343 ± 0.1	2.777GlyMet: 2.777 ± 0.049	2.078GlyAsn: 2.078 ± 0.055	3.815GlyPro: 3.815 ± 0.055	3.06GlyGln: 3.06 ± 0.056	6.245GlyArg: 6.245 ± 0.073	4.027GlySer: 4.027 ± 0.058	4.727GlyThr: 4.727 ± 0.077	6.551GlyVal: 6.551 ± 0.087	1.549GlyTrp: 1.549 ± 0.037	2.314GlyTyr: 2.314 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.363HisAla: 2.363 ± 0.043	0.26HisCys: 0.26 ± 0.016	1.404HisAsp: 1.404 ± 0.033	1.211HisGlu: 1.211 ± 0.033	0.862HisPhe: 0.862 ± 0.022	2.085HisGly: 2.085 ± 0.04	0.579HisHis: 0.579 ± 0.026	0.958HisIle: 0.958 ± 0.03	0.513HisLys: 0.513 ± 0.019	2.191HisLeu: 2.191 ± 0.047	0.571HisMet: 0.571 ± 0.023	0.478HisAsn: 0.478 ± 0.02	1.494HisPro: 1.494 ± 0.037	0.532HisGln: 0.532 ± 0.021	1.462HisArg: 1.462 ± 0.039	0.996HisSer: 0.996 ± 0.031	0.857HisThr: 0.857 ± 0.03	1.659HisVal: 1.659 ± 0.042	0.389HisTrp: 0.389 ± 0.019	0.629HisTyr: 0.629 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.015IleAla: 7.015 ± 0.087	0.658IleCys: 0.658 ± 0.024	3.324IleAsp: 3.324 ± 0.05	3.594IleGlu: 3.594 ± 0.065	1.819IlePhe: 1.819 ± 0.049	4.907IleGly: 4.907 ± 0.071	0.937IleHis: 0.937 ± 0.031	2.006IleIle: 2.006 ± 0.046	1.223IleLys: 1.223 ± 0.031	4.878IleLeu: 4.878 ± 0.073	1.095IleMet: 1.095 ± 0.033	1.231IleAsn: 1.231 ± 0.04	2.315IlePro: 2.315 ± 0.047	1.071IleGln: 1.071 ± 0.033	3.423IleArg: 3.423 ± 0.055	2.88IleSer: 2.88 ± 0.047	2.883IleThr: 2.883 ± 0.05	4.016IleVal: 4.016 ± 0.061	0.783IleTrp: 0.783 ± 0.028	1.156IleTyr: 1.156 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	3.421LysAla: 3.421 ± 0.05	0.178LysCys: 0.178 ± 0.012	1.528LysAsp: 1.528 ± 0.038	1.423LysGlu: 1.423 ± 0.043	0.816LysPhe: 0.816 ± 0.03	2.442LysGly: 2.442 ± 0.05	0.578LysHis: 0.578 ± 0.023	1.475LysIle: 1.475 ± 0.038	0.992LysLys: 0.992 ± 0.035	2.661LysLeu: 2.661 ± 0.057	0.765LysMet: 0.765 ± 0.027	0.727LysAsn: 0.727 ± 0.027	1.662LysPro: 1.662 ± 0.038	0.85LysGln: 0.85 ± 0.029	2.114LysArg: 2.114 ± 0.049	1.683LysSer: 1.683 ± 0.037	1.818LysThr: 1.818 ± 0.04	2.051LysVal: 2.051 ± 0.048	0.392LysTrp: 0.392 ± 0.018	0.6LysTyr: 0.6 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	12.36LeuAla: 12.36 ± 0.138	1.016LeuCys: 1.016 ± 0.032	6.165LeuAsp: 6.165 ± 0.083	5.604LeuGlu: 5.604 ± 0.077	3.515LeuPhe: 3.515 ± 0.065	8.349LeuGly: 8.349 ± 0.101	2.033LeuHis: 2.033 ± 0.044	5.272LeuIle: 5.272 ± 0.086	2.912LeuLys: 2.912 ± 0.06	9.076LeuLeu: 9.076 ± 0.131	2.642LeuMet: 2.642 ± 0.046	2.534LeuAsn: 2.534 ± 0.049	5.531LeuPro: 5.531 ± 0.071	2.596LeuGln: 2.596 ± 0.049	7.899LeuArg: 7.899 ± 0.094	6.848LeuSer: 6.848 ± 0.076	5.745LeuThr: 5.745 ± 0.061	6.847LeuVal: 6.847 ± 0.085	1.293LeuTrp: 1.293 ± 0.039	1.986LeuTyr: 1.986 ± 0.04	0.001LeuXaa: 0.001 ± 0.001
Met	3.505MetAla: 3.505 ± 0.056	0.195MetCys: 0.195 ± 0.013	1.4MetAsp: 1.4 ± 0.039	1.405MetGlu: 1.405 ± 0.036	0.814MetPhe: 0.814 ± 0.029	2.333MetGly: 2.333 ± 0.047	0.494MetHis: 0.494 ± 0.021	1.62MetIle: 1.62 ± 0.036	1.018MetLys: 1.018 ± 0.029	2.718MetLeu: 2.718 ± 0.053	0.795MetMet: 0.795 ± 0.03	0.827MetAsn: 0.827 ± 0.028	1.583MetPro: 1.583 ± 0.036	1.007MetGln: 1.007 ± 0.029	2.11MetArg: 2.11 ± 0.042	1.778MetSer: 1.778 ± 0.038	2.159MetThr: 2.159 ± 0.043	1.814MetVal: 1.814 ± 0.042	0.251MetTrp: 0.251 ± 0.014	0.336MetTyr: 0.336 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.008AsnAla: 3.008 ± 0.055	0.237AsnCys: 0.237 ± 0.014	1.387AsnAsp: 1.387 ± 0.043	1.175AsnGlu: 1.175 ± 0.032	0.86AsnPhe: 0.86 ± 0.027	2.233AsnGly: 2.233 ± 0.048	0.512AsnHis: 0.512 ± 0.018	1.287AsnIle: 1.287 ± 0.034	0.546AsnLys: 0.546 ± 0.023	2.435AsnLeu: 2.435 ± 0.045	0.659AsnMet: 0.659 ± 0.024	0.616AsnAsn: 0.616 ± 0.025	1.738AsnPro: 1.738 ± 0.04	0.666AsnGln: 0.666 ± 0.027	1.807AsnArg: 1.807 ± 0.035	1.114AsnSer: 1.114 ± 0.033	1.329AsnThr: 1.329 ± 0.032	1.748AsnVal: 1.748 ± 0.049	0.438AsnTrp: 0.438 ± 0.021	0.579AsnTyr: 0.579 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	5.556ProAla: 5.556 ± 0.077	0.364ProCys: 0.364 ± 0.017	4.147ProAsp: 4.147 ± 0.059	4.582ProGlu: 4.582 ± 0.076	1.986ProPhe: 1.986 ± 0.043	4.87ProGly: 4.87 ± 0.07	1.168ProHis: 1.168 ± 0.031	2.18ProIle: 2.18 ± 0.039	1.482ProLys: 1.482 ± 0.034	4.641ProLeu: 4.641 ± 0.063	1.325ProMet: 1.325 ± 0.032	1.17ProAsn: 1.17 ± 0.034	2.485ProPro: 2.485 ± 0.049	1.589ProGln: 1.589 ± 0.036	3.192ProArg: 3.192 ± 0.054	2.409ProSer: 2.409 ± 0.043	2.244ProThr: 2.244 ± 0.043	4.334ProVal: 4.334 ± 0.055	0.658ProTrp: 0.658 ± 0.024	1.123ProTyr: 1.123 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.839GlnAla: 3.839 ± 0.064	0.218GlnCys: 0.218 ± 0.014	1.668GlnAsp: 1.668 ± 0.04	1.758GlnGlu: 1.758 ± 0.038	1.013GlnPhe: 1.013 ± 0.033	2.556GlnGly: 2.556 ± 0.047	0.561GlnHis: 0.561 ± 0.022	1.974GlnIle: 1.974 ± 0.038	0.963GlnLys: 0.963 ± 0.028	2.506GlnLeu: 2.506 ± 0.051	0.997GlnMet: 0.997 ± 0.032	0.772GlnAsn: 0.772 ± 0.025	1.457GlnPro: 1.457 ± 0.031	0.969GlnGln: 0.969 ± 0.035	2.129GlnArg: 2.129 ± 0.045	1.822GlnSer: 1.822 ± 0.04	1.82GlnThr: 1.82 ± 0.039	2.305GlnVal: 2.305 ± 0.045	0.41GlnTrp: 0.41 ± 0.018	0.56GlnTyr: 0.56 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	8.88ArgAla: 8.88 ± 0.103	0.502ArgCys: 0.502 ± 0.022	4.684ArgAsp: 4.684 ± 0.069	4.53ArgGlu: 4.53 ± 0.074	2.905ArgPhe: 2.905 ± 0.05	5.325ArgGly: 5.325 ± 0.073	1.759ArgHis: 1.759 ± 0.037	4.162ArgIle: 4.162 ± 0.054	2.388ArgLys: 2.388 ± 0.055	7.853ArgLeu: 7.853 ± 0.096	2.171ArgMet: 2.171 ± 0.04	1.822ArgAsn: 1.822 ± 0.039	3.599ArgPro: 3.599 ± 0.057	2.393ArgGln: 2.393 ± 0.051	5.884ArgArg: 5.884 ± 0.085	3.297ArgSer: 3.297 ± 0.054	3.253ArgThr: 3.253 ± 0.054	5.071ArgVal: 5.071 ± 0.075	1.029ArgTrp: 1.029 ± 0.032	1.597ArgTyr: 1.597 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	5.667SerAla: 5.667 ± 0.074	0.412SerCys: 0.412 ± 0.02	3.273SerAsp: 3.273 ± 0.056	3.088SerGlu: 3.088 ± 0.056	2.164SerPhe: 2.164 ± 0.041	5.532SerGly: 5.532 ± 0.073	1.144SerHis: 1.144 ± 0.032	2.369SerIle: 2.369 ± 0.05	1.344SerLys: 1.344 ± 0.034	4.852SerLeu: 4.852 ± 0.072	1.344SerMet: 1.344 ± 0.029	1.251SerAsn: 1.251 ± 0.03	2.558SerPro: 2.558 ± 0.045	1.48SerGln: 1.48 ± 0.035	3.415SerArg: 3.415 ± 0.055	2.361SerSer: 2.361 ± 0.047	2.438SerThr: 2.438 ± 0.047	3.794SerVal: 3.794 ± 0.059	0.681SerTrp: 0.681 ± 0.025	1.265SerTyr: 1.265 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	6.059ThrAla: 6.059 ± 0.08	0.486ThrCys: 0.486 ± 0.022	3.169ThrAsp: 3.169 ± 0.057	3.088ThrGlu: 3.088 ± 0.067	1.878ThrPhe: 1.878 ± 0.041	5.597ThrGly: 5.597 ± 0.071	1.131ThrHis: 1.131 ± 0.031	2.6ThrIle: 2.6 ± 0.05	1.247ThrLys: 1.247 ± 0.034	6.083ThrLeu: 6.083 ± 0.068	1.32ThrMet: 1.32 ± 0.03	1.189ThrAsn: 1.189 ± 0.031	3.423ThrPro: 3.423 ± 0.047	1.565ThrGln: 1.565 ± 0.036	3.782ThrArg: 3.782 ± 0.061	2.558ThrSer: 2.558 ± 0.048	2.791ThrThr: 2.791 ± 0.051	4.178ThrVal: 4.178 ± 0.061	0.664ThrTrp: 0.664 ± 0.022	1.19ThrTyr: 1.19 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	8.741ValAla: 8.741 ± 0.1	0.631ValCys: 0.631 ± 0.022	3.926ValAsp: 3.926 ± 0.063	4.687ValGlu: 4.687 ± 0.063	2.928ValPhe: 2.928 ± 0.052	5.342ValGly: 5.342 ± 0.079	1.383ValHis: 1.383 ± 0.034	4.388ValIle: 4.388 ± 0.063	2.0ValLys: 2.0 ± 0.048	7.517ValLeu: 7.517 ± 0.093	2.167ValMet: 2.167 ± 0.04	1.844ValAsn: 1.844 ± 0.038	3.738ValPro: 3.738 ± 0.057	2.108ValGln: 2.108 ± 0.038	4.639ValArg: 4.639 ± 0.058	4.032ValSer: 4.032 ± 0.059	4.744ValThr: 4.744 ± 0.064	5.709ValVal: 5.709 ± 0.081	0.947ValTrp: 0.947 ± 0.03	1.444ValTyr: 1.444 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.46TrpAla: 1.46 ± 0.036	0.158TrpCys: 0.158 ± 0.013	0.778TrpAsp: 0.778 ± 0.028	0.669TrpGlu: 0.669 ± 0.025	0.553TrpPhe: 0.553 ± 0.021	1.031TrpGly: 1.031 ± 0.029	0.368TrpHis: 0.368 ± 0.017	0.712TrpIle: 0.712 ± 0.026	0.408TrpLys: 0.408 ± 0.018	1.6TrpLeu: 1.6 ± 0.038	0.405TrpMet: 0.405 ± 0.018	0.415TrpAsn: 0.415 ± 0.018	0.743TrpPro: 0.743 ± 0.026	0.603TrpGln: 0.603 ± 0.025	1.249TrpArg: 1.249 ± 0.032	0.796TrpSer: 0.796 ± 0.027	0.801TrpThr: 0.801 ± 0.026	0.856TrpVal: 0.856 ± 0.027	0.223TrpTrp: 0.223 ± 0.013	0.29TrpTyr: 0.29 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.439TyrAla: 2.439 ± 0.05	0.246TyrCys: 0.246 ± 0.014	1.497TyrAsp: 1.497 ± 0.035	1.297TyrGlu: 1.297 ± 0.04	0.883TyrPhe: 0.883 ± 0.027	2.071TyrGly: 2.071 ± 0.039	0.55TyrHis: 0.55 ± 0.021	0.92TyrIle: 0.92 ± 0.029	0.52TyrLys: 0.52 ± 0.022	2.239TyrLeu: 2.239 ± 0.049	0.47TyrMet: 0.47 ± 0.018	0.561TyrAsn: 0.561 ± 0.025	1.023TyrPro: 1.023 ± 0.027	0.643TyrGln: 0.643 ± 0.025	1.675TyrArg: 1.675 ± 0.042	1.112TyrSer: 1.112 ± 0.03	1.09TyrThr: 1.09 ± 0.03	1.477TyrVal: 1.477 ± 0.037	0.378TyrTrp: 0.378 ± 0.017	0.564TyrTyr: 0.564 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 3934 proteins (1213260 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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