Amino acid dipepetide frequency for Capnocytophaga canimorsus (strain 5)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.43AlaAla: 3.43 ± 0.086	0.608AlaCys: 0.608 ± 0.033	3.255AlaAsp: 3.255 ± 0.063	4.118AlaGlu: 4.118 ± 0.087	3.446AlaPhe: 3.446 ± 0.069	3.68AlaGly: 3.68 ± 0.077	1.118AlaHis: 1.118 ± 0.039	4.892AlaIle: 4.892 ± 0.096	4.684AlaLys: 4.684 ± 0.094	6.422AlaLeu: 6.422 ± 0.116	1.519AlaMet: 1.519 ± 0.046	3.257AlaAsn: 3.257 ± 0.082	1.959AlaPro: 1.959 ± 0.067	3.071AlaGln: 3.071 ± 0.082	2.138AlaArg: 2.138 ± 0.056	3.901AlaSer: 3.901 ± 0.085	3.858AlaThr: 3.858 ± 0.12	4.046AlaVal: 4.046 ± 0.078	0.591AlaTrp: 0.591 ± 0.03	2.652AlaTyr: 2.652 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	0.44CysAla: 0.44 ± 0.026	0.11CysCys: 0.11 ± 0.015	0.448CysAsp: 0.448 ± 0.031	0.535CysGlu: 0.535 ± 0.037	0.511CysPhe: 0.511 ± 0.028	0.677CysGly: 0.677 ± 0.035	0.179CysHis: 0.179 ± 0.023	0.536CysIle: 0.536 ± 0.025	0.539CysLys: 0.539 ± 0.025	0.679CysLeu: 0.679 ± 0.033	0.15CysMet: 0.15 ± 0.014	0.448CysAsn: 0.448 ± 0.024	0.344CysPro: 0.344 ± 0.029	0.355CysGln: 0.355 ± 0.022	0.223CysArg: 0.223 ± 0.017	0.567CysSer: 0.567 ± 0.028	0.459CysThr: 0.459 ± 0.029	0.487CysVal: 0.487 ± 0.029	0.074CysTrp: 0.074 ± 0.01	0.352CysTyr: 0.352 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	3.374AspAla: 3.374 ± 0.069	0.418AspCys: 0.418 ± 0.025	2.475AspAsp: 2.475 ± 0.07	3.407AspGlu: 3.407 ± 0.082	3.956AspPhe: 3.956 ± 0.074	2.932AspGly: 2.932 ± 0.084	0.64AspHis: 0.64 ± 0.026	4.105AspIle: 4.105 ± 0.083	4.118AspLys: 4.118 ± 0.086	4.711AspLeu: 4.711 ± 0.089	1.046AspMet: 1.046 ± 0.04	2.811AspAsn: 2.811 ± 0.063	1.457AspPro: 1.457 ± 0.058	1.26AspGln: 1.26 ± 0.041	1.728AspArg: 1.728 ± 0.05	2.581AspSer: 2.581 ± 0.062	2.651AspThr: 2.651 ± 0.059	3.271AspVal: 3.271 ± 0.067	0.68AspTrp: 0.68 ± 0.027	2.689AspTyr: 2.689 ± 0.059	0.0AspXaa: 0.0 ± 0.0
Glu	4.313GluAla: 4.313 ± 0.095	0.324GluCys: 0.324 ± 0.023	3.062GluAsp: 3.062 ± 0.073	4.702GluGlu: 4.702 ± 0.109	2.895GluPhe: 2.895 ± 0.072	3.742GluGly: 3.742 ± 0.069	1.092GluHis: 1.092 ± 0.039	6.023GluIle: 6.023 ± 0.107	7.228GluLys: 7.228 ± 0.125	5.727GluLeu: 5.727 ± 0.11	1.6GluMet: 1.6 ± 0.049	5.244GluAsn: 5.244 ± 0.095	1.481GluPro: 1.481 ± 0.046	3.006GluGln: 3.006 ± 0.077	2.811GluArg: 2.811 ± 0.079	3.252GluSer: 3.252 ± 0.077	3.264GluThr: 3.264 ± 0.067	4.561GluVal: 4.561 ± 0.071	0.559GluTrp: 0.559 ± 0.031	2.418GluTyr: 2.418 ± 0.067	0.0GluXaa: 0.0 ± 0.0
Phe	3.249PheAla: 3.249 ± 0.071	0.498PheCys: 0.498 ± 0.027	3.05PheAsp: 3.05 ± 0.068	3.793PheGlu: 3.793 ± 0.077	3.21PhePhe: 3.21 ± 0.095	3.477PheGly: 3.477 ± 0.078	0.927PheHis: 0.927 ± 0.033	3.803PheIle: 3.803 ± 0.089	3.373PheLys: 3.373 ± 0.071	5.363PheLeu: 5.363 ± 0.115	1.199PheMet: 1.199 ± 0.041	2.838PheAsn: 2.838 ± 0.057	1.883PhePro: 1.883 ± 0.052	1.871PheGln: 1.871 ± 0.048	1.94PheArg: 1.94 ± 0.052	4.317PheSer: 4.317 ± 0.094	2.985PheThr: 2.985 ± 0.074	3.534PheVal: 3.534 ± 0.083	0.656PheTrp: 0.656 ± 0.031	2.311PheTyr: 2.311 ± 0.063	0.0PheXaa: 0.0 ± 0.0
Gly	3.859GlyAla: 3.859 ± 0.083	0.698GlyCys: 0.698 ± 0.058	2.814GlyAsp: 2.814 ± 0.074	3.673GlyGlu: 3.673 ± 0.065	3.398GlyPhe: 3.398 ± 0.076	4.316GlyGly: 4.316 ± 0.1	1.049GlyHis: 1.049 ± 0.043	5.046GlyIle: 5.046 ± 0.093	5.633GlyLys: 5.633 ± 0.104	5.172GlyLeu: 5.172 ± 0.101	1.503GlyMet: 1.503 ± 0.049	3.747GlyAsn: 3.747 ± 0.094	0.829GlyPro: 0.829 ± 0.033	2.033GlyGln: 2.033 ± 0.054	2.034GlyArg: 2.034 ± 0.053	3.357GlySer: 3.357 ± 0.074	3.589GlyThr: 3.589 ± 0.132	4.56GlyVal: 4.56 ± 0.085	0.754GlyTrp: 0.754 ± 0.033	2.813GlyTyr: 2.813 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	0.801HisAla: 0.801 ± 0.034	0.239HisCys: 0.239 ± 0.017	0.741HisAsp: 0.741 ± 0.032	0.853HisGlu: 0.853 ± 0.034	1.361HisPhe: 1.361 ± 0.044	0.919HisGly: 0.919 ± 0.034	0.525HisHis: 0.525 ± 0.029	1.647HisIle: 1.647 ± 0.048	1.373HisLys: 1.373 ± 0.048	2.07HisLeu: 2.07 ± 0.061	0.226HisMet: 0.226 ± 0.017	1.036HisAsn: 1.036 ± 0.036	0.938HisPro: 0.938 ± 0.039	1.001HisGln: 1.001 ± 0.046	0.794HisArg: 0.794 ± 0.034	1.154HisSer: 1.154 ± 0.04	1.114HisThr: 1.114 ± 0.043	0.802HisVal: 0.802 ± 0.035	0.312HisTrp: 0.312 ± 0.023	0.918HisTyr: 0.918 ± 0.037	0.0HisXaa: 0.0 ± 0.0
Ile	5.488IleAla: 5.488 ± 0.093	0.702IleCys: 0.702 ± 0.03	4.491IleAsp: 4.491 ± 0.082	5.402IleGlu: 5.402 ± 0.093	4.106IlePhe: 4.106 ± 0.09	4.792IleGly: 4.792 ± 0.094	1.469IleHis: 1.469 ± 0.046	5.686IleIle: 5.686 ± 0.107	5.597IleLys: 5.597 ± 0.103	6.837IleLeu: 6.837 ± 0.132	1.276IleMet: 1.276 ± 0.044	3.992IleAsn: 3.992 ± 0.077	3.155IlePro: 3.155 ± 0.069	2.818IleGln: 2.818 ± 0.067	3.052IleArg: 3.052 ± 0.064	5.754IleSer: 5.754 ± 0.098	4.947IleThr: 4.947 ± 0.119	4.575IleVal: 4.575 ± 0.077	0.737IleTrp: 0.737 ± 0.032	2.867IleTyr: 2.867 ± 0.061	0.0IleXaa: 0.0 ± 0.0
Lys	5.135LysAla: 5.135 ± 0.096	0.385LysCys: 0.385 ± 0.023	4.249LysAsp: 4.249 ± 0.083	6.257LysGlu: 6.257 ± 0.123	2.74LysPhe: 2.74 ± 0.062	4.77LysGly: 4.77 ± 0.076	1.572LysHis: 1.572 ± 0.055	6.798LysIle: 6.798 ± 0.11	7.136LysLys: 7.136 ± 0.111	6.086LysLeu: 6.086 ± 0.102	2.369LysMet: 2.369 ± 0.061	5.812LysAsn: 5.812 ± 0.104	2.382LysPro: 2.382 ± 0.058	3.535LysGln: 3.535 ± 0.072	3.256LysArg: 3.256 ± 0.073	4.742LysSer: 4.742 ± 0.084	4.835LysThr: 4.835 ± 0.092	4.843LysVal: 4.843 ± 0.085	0.795LysTrp: 0.795 ± 0.036	3.445LysTyr: 3.445 ± 0.067	0.0LysXaa: 0.0 ± 0.0
Leu	5.684LeuAla: 5.684 ± 0.092	0.787LeuCys: 0.787 ± 0.037	4.243LeuAsp: 4.243 ± 0.094	6.051LeuGlu: 6.051 ± 0.105	5.135LeuPhe: 5.135 ± 0.107	5.703LeuGly: 5.703 ± 0.094	1.762LeuHis: 1.762 ± 0.053	6.282LeuIle: 6.282 ± 0.109	7.76LeuLys: 7.76 ± 0.109	9.003LeuLeu: 9.003 ± 0.162	2.097LeuMet: 2.097 ± 0.056	4.811LeuAsn: 4.811 ± 0.094	3.921LeuPro: 3.921 ± 0.075	4.048LeuGln: 4.048 ± 0.097	3.5LeuArg: 3.5 ± 0.068	6.873LeuSer: 6.873 ± 0.123	4.901LeuThr: 4.901 ± 0.085	5.229LeuVal: 5.229 ± 0.085	0.953LeuTrp: 0.953 ± 0.038	3.192LeuTyr: 3.192 ± 0.068	0.0LeuXaa: 0.0 ± 0.0
Met	1.676MetAla: 1.676 ± 0.049	0.114MetCys: 0.114 ± 0.013	0.971MetAsp: 0.971 ± 0.042	1.479MetGlu: 1.479 ± 0.047	0.981MetPhe: 0.981 ± 0.039	1.409MetGly: 1.409 ± 0.049	0.393MetHis: 0.393 ± 0.023	1.604MetIle: 1.604 ± 0.051	2.285MetLys: 2.285 ± 0.056	2.196MetLeu: 2.196 ± 0.055	0.636MetMet: 0.636 ± 0.03	1.195MetAsn: 1.195 ± 0.04	0.851MetPro: 0.851 ± 0.033	0.948MetGln: 0.948 ± 0.035	0.951MetArg: 0.951 ± 0.034	1.236MetSer: 1.236 ± 0.044	1.015MetThr: 1.015 ± 0.034	1.339MetVal: 1.339 ± 0.044	0.187MetTrp: 0.187 ± 0.017	0.777MetTyr: 0.777 ± 0.034	0.0MetXaa: 0.0 ± 0.0
Asn	3.504AsnAla: 3.504 ± 0.071	0.458AsnCys: 0.458 ± 0.03	2.827AsnAsp: 2.827 ± 0.067	3.708AsnGlu: 3.708 ± 0.074	2.952AsnPhe: 2.952 ± 0.068	3.592AsnGly: 3.592 ± 0.099	1.369AsnHis: 1.369 ± 0.042	4.561AsnIle: 4.561 ± 0.089	4.38AsnLys: 4.38 ± 0.087	4.993AsnLeu: 4.993 ± 0.075	1.082AsnMet: 1.082 ± 0.04	3.288AsnAsn: 3.288 ± 0.067	2.758AsnPro: 2.758 ± 0.058	2.836AsnGln: 2.836 ± 0.07	2.251AsnArg: 2.251 ± 0.06	3.146AsnSer: 3.146 ± 0.075	3.439AsnThr: 3.439 ± 0.074	3.51AsnVal: 3.51 ± 0.072	0.73AsnTrp: 0.73 ± 0.03	2.73AsnTyr: 2.73 ± 0.062	0.0AsnXaa: 0.0 ± 0.0
Pro	1.797ProAla: 1.797 ± 0.063	0.25ProCys: 0.25 ± 0.018	1.834ProAsp: 1.834 ± 0.052	2.771ProGlu: 2.771 ± 0.061	1.969ProPhe: 1.969 ± 0.056	1.348ProGly: 1.348 ± 0.047	0.671ProHis: 0.671 ± 0.032	2.886ProIle: 2.886 ± 0.062	2.839ProLys: 2.839 ± 0.067	3.022ProLeu: 3.022 ± 0.07	0.791ProMet: 0.791 ± 0.035	2.247ProAsn: 2.247 ± 0.056	0.923ProPro: 0.923 ± 0.054	1.684ProGln: 1.684 ± 0.044	0.907ProArg: 0.907 ± 0.033	2.032ProSer: 2.032 ± 0.054	2.134ProThr: 2.134 ± 0.074	2.045ProVal: 2.045 ± 0.062	0.349ProTrp: 0.349 ± 0.023	1.576ProTyr: 1.576 ± 0.049	0.0ProXaa: 0.0 ± 0.0
Gln	2.531GlnAla: 2.531 ± 0.063	0.259GlnCys: 0.259 ± 0.02	1.536GlnAsp: 1.536 ± 0.052	2.89GlnGlu: 2.89 ± 0.066	1.738GlnPhe: 1.738 ± 0.047	2.414GlnGly: 2.414 ± 0.06	0.803GlnHis: 0.803 ± 0.037	3.465GlnIle: 3.465 ± 0.076	4.142GlnLys: 4.142 ± 0.089	3.731GlnLeu: 3.731 ± 0.087	1.182GlnMet: 1.182 ± 0.041	2.785GlnAsn: 2.785 ± 0.067	1.25GlnPro: 1.25 ± 0.051	2.133GlnGln: 2.133 ± 0.072	1.672GlnArg: 1.672 ± 0.047	2.242GlnSer: 2.242 ± 0.056	2.435GlnThr: 2.435 ± 0.063	2.503GlnVal: 2.503 ± 0.071	0.612GlnTrp: 0.612 ± 0.031	1.615GlnTyr: 1.615 ± 0.059	0.0GlnXaa: 0.0 ± 0.0
Arg	2.127ArgAla: 2.127 ± 0.055	0.222ArgCys: 0.222 ± 0.018	1.609ArgAsp: 1.609 ± 0.048	2.481ArgGlu: 2.481 ± 0.063	2.118ArgPhe: 2.118 ± 0.06	2.034ArgGly: 2.034 ± 0.054	0.685ArgHis: 0.685 ± 0.031	3.111ArgIle: 3.111 ± 0.064	3.38ArgLys: 3.38 ± 0.074	3.512ArgLeu: 3.512 ± 0.066	1.032ArgMet: 1.032 ± 0.039	2.344ArgAsn: 2.344 ± 0.058	1.174ArgPro: 1.174 ± 0.043	1.345ArgGln: 1.345 ± 0.044	1.392ArgArg: 1.392 ± 0.044	1.779ArgSer: 1.779 ± 0.054	1.967ArgThr: 1.967 ± 0.058	2.265ArgVal: 2.265 ± 0.061	0.564ArgTrp: 0.564 ± 0.026	1.77ArgTyr: 1.77 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	3.733SerAla: 3.733 ± 0.072	0.637SerCys: 0.637 ± 0.034	3.429SerAsp: 3.429 ± 0.076	4.472SerGlu: 4.472 ± 0.102	3.714SerPhe: 3.714 ± 0.079	4.346SerGly: 4.346 ± 0.091	1.119SerHis: 1.119 ± 0.039	4.337SerIle: 4.337 ± 0.103	4.542SerLys: 4.542 ± 0.083	5.706SerLeu: 5.706 ± 0.098	1.129SerMet: 1.129 ± 0.041	3.187SerAsn: 3.187 ± 0.084	2.085SerPro: 2.085 ± 0.066	2.47SerGln: 2.47 ± 0.067	1.98SerArg: 1.98 ± 0.052	3.708SerSer: 3.708 ± 0.095	2.912SerThr: 2.912 ± 0.063	4.609SerVal: 4.609 ± 0.082	0.61SerTrp: 0.61 ± 0.031	2.592SerTyr: 2.592 ± 0.062	0.0SerXaa: 0.0 ± 0.0
Thr	3.705ThrAla: 3.705 ± 0.1	0.376ThrCys: 0.376 ± 0.029	3.397ThrAsp: 3.397 ± 0.067	3.498ThrGlu: 3.498 ± 0.082	3.149ThrPhe: 3.149 ± 0.072	3.394ThrGly: 3.394 ± 0.098	1.24ThrHis: 1.24 ± 0.048	4.506ThrIle: 4.506 ± 0.108	3.54ThrLys: 3.54 ± 0.068	5.827ThrLeu: 5.827 ± 0.106	0.961ThrMet: 0.961 ± 0.037	2.716ThrAsn: 2.716 ± 0.073	2.793ThrPro: 2.793 ± 0.105	2.73ThrGln: 2.73 ± 0.072	1.66ThrArg: 1.66 ± 0.053	3.403ThrSer: 3.403 ± 0.083	3.233ThrThr: 3.233 ± 0.111	3.012ThrVal: 3.012 ± 0.09	0.521ThrTrp: 0.521 ± 0.029	2.6ThrTyr: 2.6 ± 0.081	0.0ThrXaa: 0.0 ± 0.0
Val	4.524ValAla: 4.524 ± 0.086	0.576ValCys: 0.576 ± 0.031	3.024ValAsp: 3.024 ± 0.063	3.814ValGlu: 3.814 ± 0.075	3.66ValPhe: 3.66 ± 0.068	3.993ValGly: 3.993 ± 0.074	1.009ValHis: 1.009 ± 0.038	4.84ValIle: 4.84 ± 0.077	4.677ValLys: 4.677 ± 0.086	5.961ValLeu: 5.961 ± 0.085	1.397ValMet: 1.397 ± 0.043	3.357ValAsn: 3.357 ± 0.073	2.172ValPro: 2.172 ± 0.058	2.082ValGln: 2.082 ± 0.055	2.37ValArg: 2.37 ± 0.051	4.442ValSer: 4.442 ± 0.105	3.571ValThr: 3.571 ± 0.122	4.466ValVal: 4.466 ± 0.097	0.588ValTrp: 0.588 ± 0.028	2.41ValTyr: 2.41 ± 0.064	0.0ValXaa: 0.0 ± 0.0
Trp	0.677TrpAla: 0.677 ± 0.031	0.108TrpCys: 0.108 ± 0.012	0.554TrpAsp: 0.554 ± 0.033	0.754TrpGlu: 0.754 ± 0.033	0.627TrpPhe: 0.627 ± 0.029	0.724TrpGly: 0.724 ± 0.034	0.252TrpHis: 0.252 ± 0.02	0.793TrpIle: 0.793 ± 0.037	0.89TrpLys: 0.89 ± 0.038	1.06TrpLeu: 1.06 ± 0.044	0.3TrpMet: 0.3 ± 0.021	0.641TrpAsn: 0.641 ± 0.031	0.112TrpPro: 0.112 ± 0.012	0.6TrpGln: 0.6 ± 0.027	0.449TrpArg: 0.449 ± 0.029	0.539TrpSer: 0.539 ± 0.029	0.501TrpThr: 0.501 ± 0.031	0.76TrpVal: 0.76 ± 0.036	0.149TrpTrp: 0.149 ± 0.017	0.471TrpTyr: 0.471 ± 0.033	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.597TyrAla: 2.597 ± 0.068	0.343TyrCys: 0.343 ± 0.018	2.303TyrAsp: 2.303 ± 0.055	2.649TyrGlu: 2.649 ± 0.068	2.611TyrPhe: 2.611 ± 0.062	2.616TyrGly: 2.616 ± 0.067	0.947TyrHis: 0.947 ± 0.038	2.822TyrIle: 2.822 ± 0.064	3.028TyrLys: 3.028 ± 0.067	3.858TyrLeu: 3.858 ± 0.078	0.746TyrMet: 0.746 ± 0.034	2.36TyrAsn: 2.36 ± 0.056	1.609TyrPro: 1.609 ± 0.051	2.11TyrGln: 2.11 ± 0.059	1.805TyrArg: 1.805 ± 0.049	2.291TyrSer: 2.291 ± 0.054	2.45TyrThr: 2.45 ± 0.072	2.518TyrVal: 2.518 ± 0.054	0.536TyrTrp: 0.536 ± 0.027	1.87TyrTyr: 1.87 ± 0.059	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2394 proteins (753055 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---