Amino acid dipepetide frequency for Human rotavirus A

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.938AlaAla: 1.938 ± 0.886
1.292AlaCys: 1.292 ± 0.654
4.522AlaAsp: 4.522 ± 0.913
2.584AlaGlu: 2.584 ± 0.917
1.615AlaPhe: 1.615 ± 0.776
1.938AlaGly: 1.938 ± 0.969
0.0AlaHis: 0.0 ± 0.0
2.907AlaIle: 2.907 ± 1.22
2.584AlaLys: 2.584 ± 1.131
4.199AlaLeu: 4.199 ± 1.041
0.323AlaMet: 0.323 ± 0.277
4.199AlaAsn: 4.199 ± 1.271
1.292AlaPro: 1.292 ± 0.684
1.615AlaGln: 1.615 ± 0.651
1.615AlaArg: 1.615 ± 1.233
3.23AlaSer: 3.23 ± 0.982
3.23AlaThr: 3.23 ± 0.897
5.168AlaVal: 5.168 ± 0.732
0.0AlaTrp: 0.0 ± 0.0
0.646AlaTyr: 0.646 ± 0.47
0.0AlaXaa: 0.0 ± 0.0
Cys
0.323CysAla: 0.323 ± 0.315
0.323CysCys: 0.323 ± 0.276
0.969CysAsp: 0.969 ± 0.433
0.969CysGlu: 0.969 ± 0.465
0.969CysPhe: 0.969 ± 0.435
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
1.615CysIle: 1.615 ± 0.656
1.615CysLys: 1.615 ± 0.722
0.969CysLeu: 0.969 ± 0.581
0.969CysMet: 0.969 ± 0.417
1.615CysAsn: 1.615 ± 0.689
0.323CysPro: 0.323 ± 0.326
1.292CysGln: 1.292 ± 0.587
1.292CysArg: 1.292 ± 0.803
1.615CysSer: 1.615 ± 1.127
1.292CysThr: 1.292 ± 0.661
0.646CysVal: 0.646 ± 0.422
0.0CysTrp: 0.0 ± 0.0
0.646CysTyr: 0.646 ± 0.365
0.0CysXaa: 0.0 ± 0.0
Asp
2.584AspAla: 2.584 ± 1.298
0.323AspCys: 0.323 ± 0.276
3.553AspAsp: 3.553 ± 1.519
3.553AspGlu: 3.553 ± 0.855
3.23AspPhe: 3.23 ± 0.893
2.261AspGly: 2.261 ± 0.672
0.969AspHis: 0.969 ± 0.5
4.845AspIle: 4.845 ± 1.085
4.845AspLys: 4.845 ± 0.944
4.199AspLeu: 4.199 ± 0.804
1.938AspMet: 1.938 ± 0.863
2.907AspAsn: 2.907 ± 1.04
1.938AspPro: 1.938 ± 0.797
3.23AspGln: 3.23 ± 1.346
2.584AspArg: 2.584 ± 0.848
6.783AspSer: 6.783 ± 1.969
2.907AspThr: 2.907 ± 0.552
5.814AspVal: 5.814 ± 1.591
0.646AspTrp: 0.646 ± 0.37
5.168AspTyr: 5.168 ± 1.304
0.0AspXaa: 0.0 ± 0.0
Glu
2.907GluAla: 2.907 ± 0.814
0.323GluCys: 0.323 ± 0.355
3.23GluAsp: 3.23 ± 1.24
1.615GluGlu: 1.615 ± 0.83
1.615GluPhe: 1.615 ± 0.546
0.646GluGly: 0.646 ± 0.409
0.646GluHis: 0.646 ± 0.394
5.168GluIle: 5.168 ± 1.532
4.522GluLys: 4.522 ± 1.041
5.814GluLeu: 5.814 ± 1.047
2.584GluMet: 2.584 ± 0.852
4.845GluAsn: 4.845 ± 1.163
1.938GluPro: 1.938 ± 0.91
2.261GluGln: 2.261 ± 1.045
2.261GluArg: 2.261 ± 0.659
3.876GluSer: 3.876 ± 1.1
1.938GluThr: 1.938 ± 0.794
4.522GluVal: 4.522 ± 0.763
1.615GluTrp: 1.615 ± 0.68
5.168GluTyr: 5.168 ± 1.033
0.0GluXaa: 0.0 ± 0.0
Phe
1.292PheAla: 1.292 ± 0.71
0.323PheCys: 0.323 ± 0.343
2.261PheAsp: 2.261 ± 1.021
2.261PheGlu: 2.261 ± 0.832
0.323PhePhe: 0.323 ± 0.315
1.938PheGly: 1.938 ± 0.764
1.292PheHis: 1.292 ± 0.476
1.938PheIle: 1.938 ± 0.835
2.261PheLys: 2.261 ± 0.531
4.199PheLeu: 4.199 ± 1.097
0.0PheMet: 0.0 ± 0.222
4.199PheAsn: 4.199 ± 1.281
2.584PhePro: 2.584 ± 1.186
1.938PheGln: 1.938 ± 0.937
1.615PheArg: 1.615 ± 0.514
3.23PheSer: 3.23 ± 0.851
4.522PheThr: 4.522 ± 0.65
0.969PheVal: 0.969 ± 0.445
0.646PheTrp: 0.646 ± 0.317
1.938PheTyr: 1.938 ± 0.781
0.0PheXaa: 0.0 ± 0.0
Gly
1.292GlyAla: 1.292 ± 0.425
0.969GlyCys: 0.969 ± 0.447
0.646GlyAsp: 0.646 ± 0.383
2.584GlyGlu: 2.584 ± 1.0
0.646GlyPhe: 0.646 ± 0.629
1.292GlyGly: 1.292 ± 0.486
1.292GlyHis: 1.292 ± 0.446
4.845GlyIle: 4.845 ± 0.911
4.199GlyLys: 4.199 ± 1.346
1.938GlyLeu: 1.938 ± 0.632
1.292GlyMet: 1.292 ± 0.617
1.292GlyAsn: 1.292 ± 0.687
1.938GlyPro: 1.938 ± 0.674
0.646GlyGln: 0.646 ± 0.409
0.969GlyArg: 0.969 ± 0.472
2.261GlySer: 2.261 ± 1.054
0.969GlyThr: 0.969 ± 0.944
2.261GlyVal: 2.261 ± 0.582
0.969GlyTrp: 0.969 ± 0.427
1.292GlyTyr: 1.292 ± 0.622
0.0GlyXaa: 0.0 ± 0.0
His
1.292HisAla: 1.292 ± 0.458
0.323HisCys: 0.323 ± 0.276
0.969HisAsp: 0.969 ± 0.589
0.323HisGlu: 0.323 ± 0.276
0.323HisPhe: 0.323 ± 0.276
0.969HisGly: 0.969 ± 0.581
0.323HisHis: 0.323 ± 0.315
0.969HisIle: 0.969 ± 0.604
2.261HisLys: 2.261 ± 0.521
1.292HisLeu: 1.292 ± 0.73
0.0HisMet: 0.0 ± 0.0
1.292HisAsn: 1.292 ± 0.61
0.0HisPro: 0.0 ± 0.0
0.646HisGln: 0.646 ± 0.427
0.323HisArg: 0.323 ± 0.276
1.615HisSer: 1.615 ± 0.587
0.323HisThr: 0.323 ± 0.276
1.292HisVal: 1.292 ± 0.565
0.323HisTrp: 0.323 ± 0.283
1.292HisTyr: 1.292 ± 0.529
0.0HisXaa: 0.0 ± 0.0
Ile
2.907IleAla: 2.907 ± 1.056
0.323IleCys: 0.323 ± 0.327
4.845IleAsp: 4.845 ± 1.61
7.429IleGlu: 7.429 ± 0.827
2.584IlePhe: 2.584 ± 0.659
3.23IleGly: 3.23 ± 0.69
0.646IleHis: 0.646 ± 0.525
6.783IleIle: 6.783 ± 1.136
4.199IleLys: 4.199 ± 0.93
7.106IleLeu: 7.106 ± 1.61
1.615IleMet: 1.615 ± 0.646
7.106IleAsn: 7.106 ± 1.321
2.584IlePro: 2.584 ± 0.508
2.907IleGln: 2.907 ± 0.913
3.553IleArg: 3.553 ± 0.879
5.814IleSer: 5.814 ± 1.472
6.137IleThr: 6.137 ± 0.804
5.168IleVal: 5.168 ± 1.425
0.323IleTrp: 0.323 ± 0.263
3.23IleTyr: 3.23 ± 1.025
0.0IleXaa: 0.0 ± 0.0
Lys
1.292LysAla: 1.292 ± 0.661
2.584LysCys: 2.584 ± 0.61
3.876LysAsp: 3.876 ± 0.782
5.814LysGlu: 5.814 ± 2.597
2.584LysPhe: 2.584 ± 1.065
2.907LysGly: 2.907 ± 0.931
0.646LysHis: 0.646 ± 0.355
4.522LysIle: 4.522 ± 0.935
4.522LysLys: 4.522 ± 1.641
7.752LysLeu: 7.752 ± 1.575
2.261LysMet: 2.261 ± 0.8
5.168LysAsn: 5.168 ± 1.79
1.938LysPro: 1.938 ± 0.594
1.938LysGln: 1.938 ± 0.902
4.199LysArg: 4.199 ± 0.866
4.845LysSer: 4.845 ± 1.368
4.199LysThr: 4.199 ± 1.11
3.553LysVal: 3.553 ± 1.126
1.292LysTrp: 1.292 ± 0.606
4.522LysTyr: 4.522 ± 1.257
0.0LysXaa: 0.0 ± 0.0
Leu
3.876LeuAla: 3.876 ± 1.087
1.292LeuCys: 1.292 ± 0.675
6.783LeuAsp: 6.783 ± 1.315
4.522LeuGlu: 4.522 ± 1.174
4.199LeuPhe: 4.199 ± 0.982
1.615LeuGly: 1.615 ± 0.618
1.615LeuHis: 1.615 ± 0.812
7.106LeuIle: 7.106 ± 0.908
6.46LeuLys: 6.46 ± 1.538
8.721LeuLeu: 8.721 ± 1.182
3.876LeuMet: 3.876 ± 0.832
7.106LeuAsn: 7.106 ± 1.193
3.553LeuPro: 3.553 ± 1.098
2.907LeuGln: 2.907 ± 1.094
5.491LeuArg: 5.491 ± 1.288
6.783LeuSer: 6.783 ± 1.354
6.137LeuThr: 6.137 ± 1.186
2.907LeuVal: 2.907 ± 0.766
0.323LeuTrp: 0.323 ± 0.263
2.261LeuTyr: 2.261 ± 0.991
0.0LeuXaa: 0.0 ± 0.0
Met
1.615MetAla: 1.615 ± 0.534
0.0MetCys: 0.0 ± 0.065
3.553MetAsp: 3.553 ± 1.254
0.969MetGlu: 0.969 ± 0.698
1.292MetPhe: 1.292 ± 0.428
1.292MetGly: 1.292 ± 0.447
0.323MetHis: 0.323 ± 0.315
0.969MetIle: 0.969 ± 0.69
3.23MetLys: 3.23 ± 0.714
1.938MetLeu: 1.938 ± 0.547
0.646MetMet: 0.646 ± 0.441
1.292MetAsn: 1.292 ± 0.468
1.292MetPro: 1.292 ± 0.576
0.646MetGln: 0.646 ± 0.372
2.261MetArg: 2.261 ± 0.547
2.261MetSer: 2.261 ± 0.94
1.938MetThr: 1.938 ± 0.624
0.646MetVal: 0.646 ± 0.605
0.646MetTrp: 0.646 ± 0.409
1.615MetTyr: 1.615 ± 0.809
0.0MetXaa: 0.0 ± 0.0
Asn
4.522AsnAla: 4.522 ± 1.404
1.615AsnCys: 1.615 ± 0.819
3.876AsnAsp: 3.876 ± 1.086
5.168AsnGlu: 5.168 ± 0.642
2.584AsnPhe: 2.584 ± 0.951
3.23AsnGly: 3.23 ± 0.913
2.261AsnHis: 2.261 ± 1.065
3.876AsnIle: 3.876 ± 1.176
5.168AsnLys: 5.168 ± 1.747
7.752AsnLeu: 7.752 ± 0.866
0.646AsnMet: 0.646 ± 0.389
4.522AsnAsn: 4.522 ± 1.083
2.907AsnPro: 2.907 ± 0.646
1.938AsnGln: 1.938 ± 0.576
2.907AsnArg: 2.907 ± 0.889
5.168AsnSer: 5.168 ± 1.165
5.168AsnThr: 5.168 ± 0.939
5.168AsnVal: 5.168 ± 1.52
2.584AsnTrp: 2.584 ± 0.804
3.23AsnTyr: 3.23 ± 0.579
0.0AsnXaa: 0.0 ± 0.0
Pro
0.969ProAla: 0.969 ± 0.643
0.0ProCys: 0.0 ± 0.073
1.938ProAsp: 1.938 ± 0.808
0.646ProGlu: 0.646 ± 0.421
1.615ProPhe: 1.615 ± 0.639
1.615ProGly: 1.615 ± 0.523
0.969ProHis: 0.969 ± 0.4
4.522ProIle: 4.522 ± 0.458
0.646ProLys: 0.646 ± 0.427
1.615ProLeu: 1.615 ± 0.5
1.292ProMet: 1.292 ± 0.433
1.292ProAsn: 1.292 ± 0.953
2.261ProPro: 2.261 ± 0.863
2.584ProGln: 2.584 ± 0.666
2.261ProArg: 2.261 ± 0.679
2.584ProSer: 2.584 ± 0.996
2.584ProThr: 2.584 ± 1.128
1.938ProVal: 1.938 ± 0.896
0.0ProTrp: 0.0 ± 0.0
1.615ProTyr: 1.615 ± 0.773
0.0ProXaa: 0.0 ± 0.0
Gln
0.969GlnAla: 0.969 ± 0.467
0.323GlnCys: 0.323 ± 0.302
1.615GlnAsp: 1.615 ± 0.756
1.938GlnGlu: 1.938 ± 0.553
1.292GlnPhe: 1.292 ± 0.684
0.646GlnGly: 0.646 ± 0.44
1.615GlnHis: 1.615 ± 0.825
2.907GlnIle: 2.907 ± 0.851
1.938GlnLys: 1.938 ± 1.206
4.199GlnLeu: 4.199 ± 1.053
1.615GlnMet: 1.615 ± 0.534
4.199GlnAsn: 4.199 ± 1.103
1.292GlnPro: 1.292 ± 0.691
3.876GlnGln: 3.876 ± 1.463
1.615GlnArg: 1.615 ± 0.922
3.23GlnSer: 3.23 ± 0.784
2.261GlnThr: 2.261 ± 0.756
2.584GlnVal: 2.584 ± 1.131
0.646GlnTrp: 0.646 ± 0.553
2.584GlnTyr: 2.584 ± 0.756
0.0GlnXaa: 0.0 ± 0.0
Arg
1.615ArgAla: 1.615 ± 0.643
1.292ArgCys: 1.292 ± 0.61
1.615ArgAsp: 1.615 ± 0.691
2.261ArgGlu: 2.261 ± 0.928
2.584ArgPhe: 2.584 ± 0.591
1.938ArgGly: 1.938 ± 0.543
1.292ArgHis: 1.292 ± 0.698
4.199ArgIle: 4.199 ± 0.706
2.907ArgLys: 2.907 ± 0.822
2.261ArgLeu: 2.261 ± 0.555
2.584ArgMet: 2.584 ± 0.852
4.199ArgAsn: 4.199 ± 1.1
1.615ArgPro: 1.615 ± 0.704
2.584ArgGln: 2.584 ± 0.933
2.584ArgArg: 2.584 ± 1.064
2.907ArgSer: 2.907 ± 0.996
2.261ArgThr: 2.261 ± 0.704
3.876ArgVal: 3.876 ± 1.247
0.969ArgTrp: 0.969 ± 0.48
1.938ArgTyr: 1.938 ± 0.555
0.0ArgXaa: 0.0 ± 0.0
Ser
3.23SerAla: 3.23 ± 1.005
0.969SerCys: 0.969 ± 0.462
5.168SerAsp: 5.168 ± 1.31
4.522SerGlu: 4.522 ± 1.101
3.553SerPhe: 3.553 ± 0.929
2.261SerGly: 2.261 ± 0.48
0.646SerHis: 0.646 ± 0.365
8.398SerIle: 8.398 ± 1.516
5.168SerLys: 5.168 ± 0.916
5.491SerLeu: 5.491 ± 1.525
2.584SerMet: 2.584 ± 0.542
6.137SerAsn: 6.137 ± 1.45
1.615SerPro: 1.615 ± 0.613
3.553SerGln: 3.553 ± 0.792
3.553SerArg: 3.553 ± 0.763
7.752SerSer: 7.752 ± 2.28
5.168SerThr: 5.168 ± 1.355
4.845SerVal: 4.845 ± 1.296
0.0SerTrp: 0.0 ± 0.0
1.938SerTyr: 1.938 ± 0.755
0.0SerXaa: 0.0 ± 0.0
Thr
3.876ThrAla: 3.876 ± 1.092
0.323ThrCys: 0.323 ± 0.326
4.199ThrAsp: 4.199 ± 1.201
1.292ThrGlu: 1.292 ± 0.416
2.261ThrPhe: 2.261 ± 0.702
1.292ThrGly: 1.292 ± 0.793
0.646ThrHis: 0.646 ± 0.442
5.168ThrIle: 5.168 ± 1.096
2.907ThrLys: 2.907 ± 0.91
9.044ThrLeu: 9.044 ± 2.108
1.615ThrMet: 1.615 ± 0.67
2.907ThrAsn: 2.907 ± 0.794
1.615ThrPro: 1.615 ± 0.745
2.584ThrGln: 2.584 ± 0.662
4.845ThrArg: 4.845 ± 1.241
5.491ThrSer: 5.491 ± 1.0
6.46ThrThr: 6.46 ± 1.872
4.522ThrVal: 4.522 ± 1.179
1.292ThrTrp: 1.292 ± 0.439
2.907ThrTyr: 2.907 ± 1.218
0.0ThrXaa: 0.0 ± 0.0
Val
5.814ValAla: 5.814 ± 1.403
2.261ValCys: 2.261 ± 0.771
5.491ValAsp: 5.491 ± 1.63
4.845ValGlu: 4.845 ± 1.191
3.553ValPhe: 3.553 ± 0.887
2.584ValGly: 2.584 ± 0.572
0.646ValHis: 0.646 ± 0.553
3.876ValIle: 3.876 ± 0.566
4.522ValLys: 4.522 ± 1.285
5.491ValLeu: 5.491 ± 1.096
1.615ValMet: 1.615 ± 0.806
3.876ValAsn: 3.876 ± 0.852
0.969ValPro: 0.969 ± 0.378
2.584ValGln: 2.584 ± 0.671
1.292ValArg: 1.292 ± 0.485
2.584ValSer: 2.584 ± 1.174
4.199ValThr: 4.199 ± 0.88
2.261ValVal: 2.261 ± 0.832
0.323ValTrp: 0.323 ± 0.276
2.261ValTyr: 2.261 ± 0.679
0.0ValXaa: 0.0 ± 0.0
Trp
0.323TrpAla: 0.323 ± 0.257
0.969TrpCys: 0.969 ± 0.829
0.323TrpAsp: 0.323 ± 0.276
0.323TrpGlu: 0.323 ± 0.315
0.646TrpPhe: 0.646 ± 0.394
0.323TrpGly: 0.323 ± 0.263
0.0TrpHis: 0.0 ± 0.0
0.969TrpIle: 0.969 ± 0.474
2.907TrpLys: 2.907 ± 0.756
0.969TrpLeu: 0.969 ± 0.434
0.323TrpMet: 0.323 ± 0.302
0.969TrpAsn: 0.969 ± 0.604
0.323TrpPro: 0.323 ± 0.326
0.646TrpGln: 0.646 ± 0.421
0.323TrpArg: 0.323 ± 0.276
0.0TrpSer: 0.0 ± 0.0
1.292TrpThr: 1.292 ± 0.814
0.323TrpVal: 0.323 ± 0.302
0.323TrpTrp: 0.323 ± 0.326
1.292TrpTyr: 1.292 ± 0.494
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.261TyrAla: 2.261 ± 0.426
1.292TyrCys: 1.292 ± 0.469
4.845TyrAsp: 4.845 ± 1.384
3.876TyrGlu: 3.876 ± 0.986
2.261TyrPhe: 2.261 ± 0.6
1.615TyrGly: 1.615 ± 0.722
0.323TyrHis: 0.323 ± 0.276
2.907TyrIle: 2.907 ± 1.103
3.553TyrLys: 3.553 ± 1.179
2.907TyrLeu: 2.907 ± 1.395
0.646TyrMet: 0.646 ± 0.355
5.168TyrAsn: 5.168 ± 1.204
0.969TyrPro: 0.969 ± 0.495
0.969TyrGln: 0.969 ± 0.475
1.938TyrArg: 1.938 ± 0.873
4.522TyrSer: 4.522 ± 1.188
2.261TyrThr: 2.261 ± 0.744
2.584TyrVal: 2.584 ± 0.861
0.646TyrTrp: 0.646 ± 0.418
3.553TyrTyr: 3.553 ± 1.518
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11 proteins (3097 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski